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PMC:7228307 / 9471-21313 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
156 6-10 Gene denotes FcγR Gene:2213
157 0-5 Species denotes Human Tax:9606
170 145-150 Gene denotes FcγRI Gene:2214
171 161-168 Gene denotes FcγRIIc Gene:9103
172 170-178 Gene denotes FcγRIIIa Gene:2214
173 223-228 Gene denotes CD32a Gene:2212
174 230-235 Gene denotes CD32c Gene:9103
175 237-242 Gene denotes CD16a Gene:2214
176 247-252 Gene denotes CD16b Gene:2215
177 322-329 Gene denotes FcγRIIb Gene:2213
178 342-347 Gene denotes CD32b Gene:2213
179 152-159 Gene denotes FcγRIIa Gene:2212
180 34-39 Species denotes human Tax:9606
181 183-191 Gene denotes FcγRIIIb Gene:2215
189 1213-1217 Gene denotes FcγR Gene:2213
190 1697-1701 Gene denotes FcγR Gene:2213
191 1475-1479 Gene denotes FcγR Gene:2213
192 1317-1321 Gene denotes FcγR Gene:2213
193 984-988 Gene denotes FcγR Gene:2213
194 1197-1202 Species denotes human Tax:9606
195 1469-1474 Species denotes human Tax:9606
213 1847-1852 Gene denotes FcγRI Gene:2214
214 1866-1870 Gene denotes IgG3 Gene:3502
215 1889-1901 Gene denotes interferon‐γ Gene:3458
216 2004-2008 Gene denotes IgG3 Gene:3502
217 2153-2157 Gene denotes IgG3 Gene:3502
218 2174-2182 Gene denotes FcγRIIIa Gene:2214
219 2195-2199 Gene denotes IgG3 Gene:3502
220 2389-2393 Gene denotes IgG3 Gene:3502
221 2407-2414 Gene denotes FcγRIIb Gene:2213
222 2427-2431 Gene denotes IgG3 Gene:3502
223 2591-2599 Gene denotes FcγRIIIb Gene:2215
224 2066-2072 Species denotes people Tax:9606
225 2368-2376 Gene denotes FcγRIIIb Gene:2215
226 1984-1991 Gene denotes FcγRIIa Gene:2212
227 2348-2351 Chemical denotes Phe MESH:D010649
228 2265-2282 Disease denotes myeloid dendritic MESH:D007635
229 2532-2549 Disease denotes myeloid dendritic MESH:D007635
231 1786-1790 Gene denotes FcγR Gene:2213
233 2764-2770 Species denotes people Tax:9606
235 2877-2885 Disease denotes COVID-19 MESH:C000657245
246 3746-3751 Gene denotes FcγRI Gene:2214
247 3753-3760 Gene denotes FcγRIIb Gene:2213
248 3771-3774 Gene denotes CH1 Gene:51430
249 3410-3413 Gene denotes CH1 Gene:51430
250 3269-3273 Gene denotes FcγR Gene:2213
251 3172-3176 Gene denotes FcγR Gene:2213
252 3762-3769 Gene denotes FcγRIIc Gene:9103
253 3394-3401 Gene denotes FcγRIIa Gene:2212
254 3489-3498 Chemical denotes disulfide MESH:D004220
255 3728-3738 Chemical denotes disulfides MESH:D004220
257 4027-4035 Disease denotes COVID-19 MESH:C000657245
259 4254-4258 Gene denotes FcγR Gene:2213
262 4338-4342 Gene denotes FcγR Gene:2213
263 4322-4327 Species denotes human Tax:9606
275 4974-4979 Gene denotes FcγRI Gene:2214
276 4984-4991 Gene denotes FcγRIIb Gene:2213
277 5099-5104 Gene denotes FcγRI Gene:2214
278 5106-5113 Gene denotes FcγRIIa Gene:2212
279 5118-5126 Gene denotes FcγRIIIa Gene:2214
280 5134-5141 Gene denotes FcγRIIb Gene:2213
281 5057-5064 Gene denotes FcγRIIa Gene:2212
282 4940-4944 Gene denotes FcγR Gene:2213
283 4686-4690 Gene denotes FcγR Gene:2213
284 4556-4560 Gene denotes FcγR Gene:2213
285 4632-4637 Species denotes human Tax:9606
287 5188-5192 Gene denotes FcγR Gene:2213
293 5231-5236 Gene denotes FcγRI Gene:2214
294 5297-5309 Gene denotes interferon‐γ Gene:3458
295 5432-5437 Gene denotes FcγRI Gene:14129
296 5441-5453 Gene denotes interferon‐γ Gene:15978
297 5538-5543 Species denotes mouse Tax:10090
305 5699-5706 Gene denotes FcγRIIa Gene:2212
306 6016-6021 Species denotes human Tax:9606
307 6204-6209 Species denotes human Tax:9606
308 6035-6040 Species denotes human Tax:9606
309 5949-5966 Disease denotes thrombocytopenias MESH:D013921
310 6285-6313 Disease denotes systemic lupus erythematosus MESH:D008180
311 6367-6383 Disease denotes hyper‐responsive MESH:D012130
318 6793-6800 Gene denotes FcγRIIb Gene:2213
319 6914-6921 Gene denotes FcγRIIc Gene:9103
320 6494-6498 Gene denotes FcγR Gene:2213
321 6469-6476 Gene denotes FcγRIIc Gene:9103
322 6608-6614 Species denotes humans Tax:9606
323 6900-6907 Gene denotes FcγRIIa Gene:2212
335 7161-7168 Gene denotes FcγRIII Gene:2214
336 7213-7221 Gene denotes FcγRIIIa Gene:2214
337 7226-7234 Gene denotes FcγRIIIb Gene:2215
338 7240-7248 Gene denotes FcγRIIIa Gene:2214
339 7363-7371 Gene denotes FcγRIIIa Gene:2214
340 7811-7818 Gene denotes FcγRIIa Gene:2212
341 7483-7489 Species denotes humans Tax:9606
342 7627-7632 Species denotes human Tax:9606
343 7731-7739 Gene denotes FcγRIIIb Gene:2215
344 7461-7469 Gene denotes FcγRIIIb Gene:2215
345 7710-7717 Gene denotes FcγRIIa Gene:2212
354 8213-8220 Gene denotes FcγRIIb Gene:2213
355 8273-8281 Gene denotes FcγRIIb1 Gene:1555
356 8427-8450 Gene denotes B‐cell antigen receptor Gene:613
357 8452-8455 Gene denotes BCR Gene:613
358 8678-8686 Gene denotes FcγRIIb1 Gene:1555
359 8148-8152 Gene denotes FcγR Gene:2213
360 7866-7870 Gene denotes FcγR Gene:2213
361 8836-8841 Species denotes human Tax:9606
369 9085-9093 Gene denotes FcγRIIIa Gene:2214
370 9128-9135 Gene denotes FcγRIIa Gene:2212
371 9137-9144 Gene denotes FcγRIIb Gene:2213
372 9148-9156 Gene denotes FcγRIIIa Gene:2214
373 8905-8909 Gene denotes FcγR Gene:2213
374 9055-9059 Gene denotes FcγR Gene:2213
375 9098-9102 Disease denotes αβ T MESH:D001260
382 9492-9496 Gene denotes FcγR Gene:2213
383 9696-9703 Gene denotes FcγRIIb Gene:2213
384 9917-9924 Gene denotes FcγRIIb Gene:2213
385 9954-9961 Gene denotes FcγRIIb Gene:2213
386 10366-10373 Gene denotes FcγRIIb Gene:2213
387 9330-9334 Gene denotes FcγR Gene:2213
389 10527-10531 Gene denotes FcγR Gene:2213
395 11043-11046 Gene denotes BCR Gene:613
396 10738-10741 Gene denotes BCR Gene:613
397 10984-10988 Gene denotes FcγR Gene:2213
398 10629-10633 Gene denotes FcγR Gene:2213
399 11106-11114 Chemical denotes tyrosine MESH:D014443
402 11236-11244 Gene denotes FcγRIIb1 Gene:1555
403 11339-11342 Gene denotes BCR Gene:613

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T85 40-49 Body_part denotes leukocyte http://purl.org/sig/ont/fma/fma62852
T86 490-494 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T87 851-855 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T88 895-899 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T89 1203-1212 Body_part denotes leukocyte http://purl.org/sig/ont/fma/fma62852
T90 1812-1815 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T91 1829-1833 Body_part denotes Cell http://purl.org/sig/ont/fma/fma68646
T92 1905-1914 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T93 1916-1927 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T94 1929-1940 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T95 1942-1956 Body_part denotes dendritic cell http://purl.org/sig/ont/fma/fma273565
T96 1952-1956 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T97 1973-1983 Body_part denotes mast cells http://purl.org/sig/ont/fma/fma66784
T98 1978-1983 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T99 2079-2089 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T100 2094-2103 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T101 2117-2130 Body_part denotes B lymphocytes http://purl.org/sig/ont/fma/fma62869
T102 2165-2173 Body_part denotes NK cells http://purl.org/sig/ont/fma/fma63147
T103 2168-2173 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T104 2202-2210 Body_part denotes NK cells http://purl.org/sig/ont/fma/fma63147
T105 2205-2210 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T106 2212-2223 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T107 2254-2263 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T108 2273-2288 Body_part denotes dendritic cells http://purl.org/sig/ont/fma/fma273565
T109 2283-2288 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T110 2290-2301 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T111 2395-2406 Body_part denotes Neutrophils http://purl.org/sig/ont/fma/fma62860
T112 2439-2452 Body_part denotes B lymphocytes http://purl.org/sig/ont/fma/fma62869
T113 2459-2468 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T114 2491-2500 Body_part denotes basophils http://purl.org/sig/ont/fma/fma62862
T115 2502-2513 Body_part denotes eosinophils http://purl.org/sig/ont/fma/fma62861
T116 2540-2555 Body_part denotes dendritic cells http://purl.org/sig/ont/fma/fma273565
T117 2550-2555 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T118 2557-2565 Body_part denotes NK cells http://purl.org/sig/ont/fma/fma63147
T119 2560-2565 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T120 2600-2604 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T121 2641-2647 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T122 2655-2663 Body_part denotes placenta http://purl.org/sig/ont/fma/fma63934
T123 2665-2690 Body_part denotes follicular dendritic cell http://purl.org/sig/ont/fma/fma83037
T124 2686-2690 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T125 2691-2693 Body_part denotes Ig http://purl.org/sig/ont/fma/fma62871
T126 2695-2709 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T127 2711-2718 Body_part denotes NK cell http://purl.org/sig/ont/fma/fma63147
T128 2714-2718 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T129 2720-2739 Body_part denotes natural killer cell http://purl.org/sig/ont/fma/fma63147
T130 2735-2739 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T131 3131-3134 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T132 3158-3161 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T133 3880-3883 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T134 3902-3904 Body_part denotes Ig http://purl.org/sig/ont/fma/fma62871
T135 3906-3920 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T136 4273-4290 Body_part denotes hemopoietic cells http://purl.org/sig/ont/fma/fma83598
T137 4285-4290 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T138 4295-4301 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T139 4328-4337 Body_part denotes leukocyte http://purl.org/sig/ont/fma/fma62852
T140 4596-4600 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T141 4638-4648 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T142 4654-4663 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T143 4868-4873 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T144 4903-4911 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T145 5016-5024 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T146 5079-5090 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T147 5178-5187 Body_part denotes leukocyte http://purl.org/sig/ont/fma/fma62852
T148 5279-5288 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T149 5313-5322 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T150 5324-5335 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T151 5337-5348 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T152 5350-5366 Body_part denotes microglial cells http://purl.org/sig/ont/fma/fma54539
T153 5361-5366 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T154 5374-5379 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T155 5381-5396 Body_part denotes dendritic cells http://purl.org/sig/ont/fma/fma273565
T156 5391-5396 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T157 5401-5411 Body_part denotes mast cells http://purl.org/sig/ont/fma/fma66784
T158 5406-5411 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T159 5813-5823 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T160 5847-5856 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T161 6125-6136 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835
T162 6210-6220 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T163 6410-6420 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T164 6443-6445 Body_part denotes Ig http://purl.org/sig/ont/fma/fma62871
T165 6536-6546 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T166 6684-6689 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T167 6710-6714 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T168 6848-6859 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835
T169 7198-7202 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T170 7265-7273 Body_part denotes NK cells http://purl.org/sig/ont/fma/fma63147
T171 7268-7273 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T172 7316-7327 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T173 7388-7399 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T174 7531-7544 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T175 7531-7535 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T176 7633-7644 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T177 7751-7762 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T178 7895-7899 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T179 8077-8081 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T180 8172-8177 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T181 8245-8251 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T182 8310-8323 Body_part denotes B lymphocytes http://purl.org/sig/ont/fma/fma62869
T183 8338-8348 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T184 8349-8360 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835
T185 8429-8433 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T186 8515-8524 Body_part denotes basophils http://purl.org/sig/ont/fma/fma62862
T187 8529-8540 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T188 8574-8584 Body_part denotes mast cells http://purl.org/sig/ont/fma/fma66784
T189 8579-8584 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T190 8586-8601 Body_part denotes dendritic cells http://purl.org/sig/ont/fma/fma273565
T191 8596-8601 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T192 8611-8620 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T193 8621-8632 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T194 8653-8664 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835
T195 8844-8849 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T196 8877-8883 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T197 8926-8931 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T198 9022-9034 Body_part denotes T‐lymphocyte http://purl.org/sig/ont/fma/fma62870
T199 9071-9076 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T200 9103-9108 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T201 9224-9232 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T202 9303-9308 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T203 9398-9416 Body_part denotes hematopoietic cell http://purl.org/sig/ont/fma/fma83598
T204 9412-9416 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T205 9526-9531 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T206 9726-9751 Body_part denotes follicular dendritic cell http://purl.org/sig/ont/fma/fma83037
T207 9747-9751 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T208 9767-9773 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T209 9778-9783 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T210 9784-9795 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T211 9824-9829 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T212 9830-9840 Body_part denotes sinusoidal http://purl.org/sig/ont/fma/fma63131
T213 9841-9858 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T214 9853-9858 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T215 10047-10052 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T216 10145-10151 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T217 10748-10752 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T218 10776-10779 Body_part denotes IgE http://purl.org/sig/ont/fma/fma62875
T219 10799-10802 Body_part denotes IgA http://purl.org/sig/ont/fma/fma62874
T220 11072-11085 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T221 11072-11076 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T222 11106-11114 Body_part denotes tyrosine http://purl.org/sig/ont/fma/fma82768
T223 11279-11283 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T224 11439-11447 Body_part denotes tyrosine http://purl.org/sig/ont/fma/fma82768
T225 11474-11485 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835
T226 11570-11578 Body_part denotes tyrosine http://purl.org/sig/ont/fma/fma82768
T227 11663-11671 Body_part denotes tyrosine http://purl.org/sig/ont/fma/fma82768
T228 11689-11697 Body_part denotes tyrosine http://purl.org/sig/ont/fma/fma82768
T229 11747-11752 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T230 11756-11763 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T231 11764-11772 Body_part denotes tyrosine http://purl.org/sig/ont/fma/fma82768
T232 11826-11830 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T3 2655-2663 Body_part denotes placenta http://purl.obolibrary.org/obo/UBERON_0001987
T4 4295-4301 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T5 5374-5379 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T6 6137-6141 Body_part denotes tail http://purl.obolibrary.org/obo/UBERON_0002415
T7 6860-6864 Body_part denotes tail http://purl.obolibrary.org/obo/UBERON_0002415
T8 8245-8251 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T9 8877-8883 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T10 9778-9783 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T11 9784-9795 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T12 9824-9829 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T13 10145-10151 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T14 11486-11490 Body_part denotes tail http://purl.obolibrary.org/obo/UBERON_0002415

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T21 932-935 Disease denotes MOA http://purl.obolibrary.org/obo/MONDO_0016702
T22 2877-2885 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T23 4027-4035 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T24 5644-5647 Disease denotes MOA http://purl.obolibrary.org/obo/MONDO_0016702
T25 5942-5966 Disease denotes immune thrombocytopenias http://purl.obolibrary.org/obo/MONDO_0002048|http://purl.obolibrary.org/obo/MONDO_0008558
T27 6285-6313 Disease denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/MONDO_0007915
T28 6294-6313 Disease denotes lupus erythematosus http://purl.obolibrary.org/obo/MONDO_0004670
T29 6428-6439 Disease denotes anaphylaxis http://purl.obolibrary.org/obo/MONDO_0100053
T30 9608-9611 Disease denotes MOA http://purl.obolibrary.org/obo/MONDO_0016702

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T161 0-5 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T162 6-8 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T163 34-39 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T164 118-128 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T165 145-147 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T166 152-154 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T167 161-163 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T168 170-172 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T169 183-185 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T170 322-324 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T171 404-406 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T172 407-409 http://purl.obolibrary.org/obo/CLO_0008882 denotes Rs
T173 490-494 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T174 596-598 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T175 599-601 http://purl.obolibrary.org/obo/CLO_0008882 denotes Rs
T176 613-614 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T177 827-829 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T178 830-832 http://purl.obolibrary.org/obo/CLO_0008882 denotes Rs
T179 851-861 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T180 895-899 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T181 984-986 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T182 1197-1202 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T183 1213-1215 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T184 1262-1263 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T185 1317-1319 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T186 1382-1384 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T187 1469-1474 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T188 1475-1477 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T189 1507-1515 http://purl.obolibrary.org/obo/NCBITaxon_9443 denotes primates
T190 1517-1523 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T191 1687-1696 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humanized
T192 1697-1699 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T193 1786-1788 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T194 1829-1833 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T195 1847-1849 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T196 1905-1914 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T197 1942-1956 http://purl.obolibrary.org/obo/CL_0000451 denotes dendritic cell
T198 1978-1983 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T199 1984-1986 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T200 2042-2044 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T201 2117-2118 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T202 2131-2133 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T203 2139-2140 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T204 2165-2173 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cells
T205 2174-2176 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T206 2202-2210 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cells
T207 2254-2263 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T208 2265-2288 http://purl.obolibrary.org/obo/CL_0000782 denotes myeloid dendritic cells
T209 2368-2370 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T210 2407-2409 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T211 2439-2440 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T212 2459-2468 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T213 2532-2555 http://purl.obolibrary.org/obo/CL_0000782 denotes myeloid dendritic cells
T214 2557-2565 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cells
T215 2591-2593 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T216 2600-2604 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T217 2627-2633 http://purl.obolibrary.org/obo/UBERON_0001005 denotes Airway
T218 2641-2647 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T219 2641-2647 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T220 2641-2647 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T221 2641-2647 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T222 2655-2663 http://purl.obolibrary.org/obo/UBERON_0001987 denotes placenta
T223 2655-2663 http://www.ebi.ac.uk/efo/EFO_0001407 denotes placenta
T224 2676-2690 http://purl.obolibrary.org/obo/CL_0000451 denotes dendritic cell
T225 2711-2718 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cell
T226 2720-2739 http://purl.obolibrary.org/obo/CL_0000623 denotes natural killer cell
T227 2741-2742 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T228 3144-3146 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T229 3172-3174 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T230 3237-3239 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T231 3269-3271 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T232 3320-3322 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T233 3394-3396 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T234 3410-3413 http://purl.obolibrary.org/obo/CLO_0002408 denotes CH1
T235 3688-3689 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T236 3746-3748 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T237 3753-3755 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T238 3762-3764 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T239 3771-3774 http://purl.obolibrary.org/obo/CLO_0002408 denotes CH1
T240 4254-4256 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T241 4285-4290 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T242 4322-4327 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T243 4338-4340 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T244 4404-4406 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T245 4556-4558 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T246 4596-4600 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T247 4632-4637 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T248 4686-4688 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T249 4844-4854 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T250 4868-4873 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T251 4940-4942 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T252 4974-4976 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T253 4984-4986 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T254 4992-4994 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T255 5016-5024 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T256 5057-5059 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T257 5069-5078 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T258 5099-5101 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T259 5106-5108 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T260 5118-5120 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T261 5134-5136 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T262 5188-5190 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T263 5231-5233 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T264 5313-5322 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T265 5350-5366 http://purl.obolibrary.org/obo/CL_0000129 denotes microglial cells
T266 5374-5379 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T267 5374-5379 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T268 5381-5396 http://purl.obolibrary.org/obo/CL_0000451 denotes dendritic cells
T269 5406-5411 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T270 5432-5434 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T271 5480-5488 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T272 5515-5525 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T273 5538-5543 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T274 5575-5578 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T275 5579-5580 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T276 5699-5701 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T277 5728-5736 http://purl.obolibrary.org/obo/NCBITaxon_9443 denotes primates
T278 5778-5780 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T279 5781-5783 http://purl.obolibrary.org/obo/CLO_0008882 denotes Rs
T280 5968-5969 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T281 6016-6021 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T282 6035-6040 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T283 6137-6141 http://purl.obolibrary.org/obo/UBERON_0002415 denotes tail
T284 6169-6171 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T285 6183-6184 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T286 6204-6209 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T287 6346-6355 http://purl.obolibrary.org/obo/OBI_0100026 denotes organisms
T288 6346-6355 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organisms
T289 6356-6358 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T290 6359-6360 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T291 6392-6393 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T292 6466-6468 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T293 6469-6471 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T294 6483-6493 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T295 6494-6496 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T296 6608-6614 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T297 6682-6689 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T298 6690-6692 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T299 6696-6699 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T300 6710-6714 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T301 6793-6795 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T302 6860-6864 http://purl.obolibrary.org/obo/UBERON_0002415 denotes tail
T303 6880-6890 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T304 6900-6902 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T305 6914-6916 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T306 6944-6954 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T307 6984-6985 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T308 7103-7110 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T309 7161-7163 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T310 7198-7202 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T311 7213-7215 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T312 7226-7228 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T313 7240-7242 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T314 7265-7273 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cells
T315 7291-7301 http://purl.obolibrary.org/obo/CL_0000234 denotes phagocytes
T316 7363-7365 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T317 7433-7434 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T318 7461-7463 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T319 7483-7489 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T320 7507-7509 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T321 7510-7512 http://purl.obolibrary.org/obo/CLO_0008882 denotes Rs
T322 7531-7535 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T323 7536-7544 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T324 7549-7550 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T325 7627-7632 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T326 7710-7712 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T327 7731-7733 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T328 7811-7813 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T329 7833-7835 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T330 7866-7868 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T331 7886-7887 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T332 7895-7899 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T333 7937-7946 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T334 8075-8081 http://purl.obolibrary.org/obo/CL_0000236 denotes B‐cell
T335 8082-8092 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T336 8132-8142 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T337 8148-8150 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T338 8172-8177 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T339 8213-8215 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T340 8273-8275 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T341 8310-8311 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T342 8333-8337 http://purl.obolibrary.org/obo/CLO_0001564 denotes a 20
T343 8333-8337 http://purl.obolibrary.org/obo/CLO_0050194 denotes a 20
T344 8385-8393 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T345 8427-8433 http://purl.obolibrary.org/obo/CL_0000236 denotes B‐cell
T346 8458-8460 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T347 8579-8584 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T348 8586-8601 http://purl.obolibrary.org/obo/CL_0000451 denotes dendritic cells
T349 8611-8620 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T350 8634-8636 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T351 8678-8680 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T352 8747-8757 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T353 8792-8794 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T354 8836-8841 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T355 8842-8849 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T356 8905-8907 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T357 8924-8931 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T358 8932-8935 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T359 9055-9057 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T360 9069-9076 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T361 9085-9087 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T362 9101-9108 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T363 9128-9130 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T364 9137-9139 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T365 9148-9150 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T366 9266-9268 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T367 9303-9308 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T368 9330-9332 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T369 9398-9416 http://purl.obolibrary.org/obo/CL_0000988 denotes hematopoietic cell
T370 9492-9494 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T371 9526-9531 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T372 9696-9698 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T373 9737-9751 http://purl.obolibrary.org/obo/CL_0000451 denotes dendritic cell
T374 9753-9759 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T375 9767-9773 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T376 9767-9773 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T377 9767-9773 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T378 9767-9773 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T379 9778-9783 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T380 9778-9783 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T381 9784-9795 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium
T382 9824-9829 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T383 9824-9829 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T384 9841-9858 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T385 9917-9919 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T386 9954-9956 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T387 9994-10003 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T388 10047-10052 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T389 10250-10251 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T390 10315-10320 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T391 10366-10368 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T392 10527-10529 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T393 10532-10542 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T394 10557-10566 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T395 10613-10623 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T396 10629-10631 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T397 10643-10652 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T398 10746-10752 http://purl.obolibrary.org/obo/CL_0000084 denotes T‐cell
T399 10789-10791 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T400 10812-10814 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T401 10880-10882 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T402 10927-10937 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T403 10938-10944 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T404 10973-10983 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T405 10984-10986 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T406 11072-11076 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T407 11077-11085 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T408 11146-11149 http://purl.obolibrary.org/obo/CLO_0009132 denotes Src
T409 11179-11189 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T410 11206-11208 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T411 11229-11231 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T412 11232-11234 http://purl.obolibrary.org/obo/CLO_0008882 denotes Rs
T413 11236-11238 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T414 11249-11251 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T415 11279-11283 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T416 11322-11331 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T417 11350-11360 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T418 11366-11368 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T419 11369-11371 http://purl.obolibrary.org/obo/CLO_0008882 denotes Rs
T420 11386-11388 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T421 11486-11490 http://purl.obolibrary.org/obo/UBERON_0002415 denotes tail
T422 11535-11537 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T423 11599-11608 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T424 11609-11625 http://purl.obolibrary.org/obo/GO_0043235 denotes receptor complex
T425 11826-11830 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T426 11831-11841 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T44 148-150 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T46 315-320 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T47 567-576 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T48 627-635 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T49 906-914 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T50 1099-1107 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T51 1242-1250 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T52 1538-1546 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T53 1850-1852 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T55 1889-1899 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T56 2348-2351 Chemical denotes Phe http://purl.obolibrary.org/obo/CHEBI_17295|http://purl.obolibrary.org/obo/CHEBI_29997
T58 3190-3195 Chemical denotes Light http://purl.obolibrary.org/obo/CHEBI_30212
T59 3288-3293 Chemical denotes Light http://purl.obolibrary.org/obo/CHEBI_30212
T60 3489-3498 Chemical denotes disulfide http://purl.obolibrary.org/obo/CHEBI_48343
T61 3667-3675 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T62 3728-3738 Chemical denotes disulfides http://purl.obolibrary.org/obo/CHEBI_35489|http://purl.obolibrary.org/obo/CHEBI_48343
T64 3749-3751 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T66 3884-3892 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T67 4429-4437 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T68 4977-4979 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T70 5102-5104 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T72 5234-5236 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T74 5297-5307 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T75 5435-5437 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T77 5441-5451 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T78 5873-5881 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T79 6536-6546 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T80 7651-7659 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T81 8105-8112 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T82 8338-8348 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T83 8338-8343 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T84 8344-8348 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T85 8434-8441 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T86 9194-9202 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T87 10324-10338 Chemical denotes macromolecules http://purl.obolibrary.org/obo/CHEBI_33839
T88 10479-10488 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T89 10753-10760 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T90 10792-10794 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T92 10815-10817 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T94 11016-11023 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T95 11106-11114 Chemical denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T96 11439-11447 Chemical denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T97 11570-11578 Chemical denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T98 11663-11671 Chemical denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T99 11689-11697 Chemical denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T100 11747-11752 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T101 11756-11763 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T102 11764-11772 Chemical denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186

LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T10 2691-2693 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes Ig http://purl.bioontology.org/ontology/MEDDRA/10021496
T11 2695-2709 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes immunoglobulin http://purl.bioontology.org/ontology/MEDDRA/10021496
T12 3902-3904 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes Ig http://purl.bioontology.org/ontology/MEDDRA/10021496
T13 3906-3920 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes immunoglobulin http://purl.bioontology.org/ontology/MEDDRA/10021496
T14 6443-6445 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes Ig http://purl.bioontology.org/ontology/MEDDRA/10021496
T15 9448-9462 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigations http://purl.bioontology.org/ontology/MEDDRA/10062026
T16 11747-11752 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes lipid http://purl.bioontology.org/ontology/MEDDRA/10024587

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T60 40-49 http://purl.obolibrary.org/obo/CL_0000738 denotes leukocyte
T61 74-84 http://purl.obolibrary.org/obo/BFO_0000034 denotes functional
T62 490-494 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T63 739-747 http://purl.obolibrary.org/obo/GO_0085030 denotes mutually
T64 851-855 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T65 895-899 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T66 915-927 http://purl.obolibrary.org/obo/BFO_0000034 denotes functions in
T67 1203-1212 http://purl.obolibrary.org/obo/CL_0000738 denotes leukocyte
T68 1251-1260 http://purl.obolibrary.org/obo/BFO_0000034 denotes functions
T69 1547-1555 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T70 1829-1833 http://purl.obolibrary.org/obo/CL_0000000 denotes Cell
T71 1952-1956 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T72 1978-1983 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T73 2079-2089 http://purl.obolibrary.org/obo/CL_0000738 denotes leukocytes
T74 2168-2173 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T75 2205-2210 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T76 2283-2288 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T77 2550-2555 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T78 2560-2565 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T79 2686-2690 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T80 2714-2718 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T81 2735-2739 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T82 4285-4290 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T83 4328-4337 http://purl.obolibrary.org/obo/CL_0000738 denotes leukocyte
T84 4438-4447 http://purl.obolibrary.org/obo/BFO_0000034 denotes functions
T85 4596-4600 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T86 4638-4648 http://purl.obolibrary.org/obo/CL_0000738 denotes leukocytes
T87 4868-4873 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T88 5178-5187 http://purl.obolibrary.org/obo/CL_0000738 denotes leukocyte
T89 5361-5366 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T90 5391-5396 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T91 5406-5411 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T92 5604-5620 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T93 5813-5823 http://purl.obolibrary.org/obo/CL_0000738 denotes leukocytes
T94 5882-5891 http://purl.obolibrary.org/obo/BFO_0000034 denotes functions
T95 6192-6200 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T96 6210-6220 http://purl.obolibrary.org/obo/CL_0000738 denotes leukocytes
T97 6346-6355 http://purl.obolibrary.org/obo/OBI_0100026 denotes organisms
T98 6684-6689 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T99 7203-7211 http://purl.obolibrary.org/obo/IDO_0000607 denotes products
T100 7268-7273 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T101 7449-7457 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T102 7531-7535 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T103 7660-7668 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T104 8077-8081 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T105 8153-8161 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T106 8172-8177 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T107 8429-8433 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T108 8579-8584 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T109 8596-8601 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T110 8844-8849 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T111 8926-8931 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T112 9071-9076 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T113 9103-9108 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T114 9203-9211 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T115 9303-9308 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T116 9412-9416 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T117 9417-9425 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T118 9526-9531 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T119 9588-9596 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T120 9747-9751 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T121 9853-9858 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T122 10004-10012 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T123 10047-10052 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T124 10315-10320 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T125 10479-10488 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral
T126 10576-10585 http://purl.obolibrary.org/obo/BFO_0000034 denotes functions
T127 10748-10752 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T128 11072-11076 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T129 11279-11283 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T130 11395-11403 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T131 11826-11830 http://purl.obolibrary.org/obo/CL_0000000 denotes cell

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T7 2348-2351 Chemical denotes Phe http://purl.obolibrary.org/obo/CHEBI_17295|http://purl.obolibrary.org/obo/CHEBI_29997
T9 3489-3498 Chemical denotes disulfide http://purl.obolibrary.org/obo/CHEBI_48343
T10 3728-3738 Chemical denotes disulfides http://purl.obolibrary.org/obo/CHEBI_35489|http://purl.obolibrary.org/obo/CHEBI_48343
T12 6536-6546 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T13 8338-8348 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T14 10324-10338 Chemical denotes macromolecules http://purl.obolibrary.org/obo/CHEBI_33839
T15 11106-11114 Chemical denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T16 11439-11447 Chemical denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T17 11570-11578 Chemical denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T18 11663-11671 Chemical denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T19 11689-11697 Chemical denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T20 11747-11752 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T21 11756-11763 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T22 11764-11772 Chemical denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
170 145-150 Gene denotes FcγRI Gene:2214
171 161-168 Gene denotes FcγRIIc Gene:9103
172 170-178 Gene denotes FcγRIIIa Gene:2214
173 223-228 Gene denotes CD32a Gene:2212
174 230-235 Gene denotes CD32c Gene:9103
175 237-242 Gene denotes CD16a Gene:2214
176 247-252 Gene denotes CD16b Gene:2215
177 322-329 Gene denotes FcγRIIb Gene:2213
178 342-347 Gene denotes CD32b Gene:2213
179 152-159 Gene denotes FcγRIIa Gene:2212
180 34-39 Species denotes human Tax:9606
181 183-191 Gene denotes FcγRIIIb Gene:2215
189 1213-1217 Gene denotes FcγR Gene:2213
190 1697-1701 Gene denotes FcγR Gene:2213
191 1475-1479 Gene denotes FcγR Gene:2213
192 1317-1321 Gene denotes FcγR Gene:2213
193 984-988 Gene denotes FcγR Gene:2213
194 1197-1202 Species denotes human Tax:9606
195 1469-1474 Species denotes human Tax:9606
213 1847-1852 Gene denotes FcγRI Gene:2214
214 1866-1870 Gene denotes IgG3 Gene:3502
215 1889-1901 Gene denotes interferon‐γ Gene:3458
216 2004-2008 Gene denotes IgG3 Gene:3502
217 2153-2157 Gene denotes IgG3 Gene:3502
218 2174-2182 Gene denotes FcγRIIIa Gene:2214
219 2195-2199 Gene denotes IgG3 Gene:3502
220 2389-2393 Gene denotes IgG3 Gene:3502
221 2407-2414 Gene denotes FcγRIIb Gene:2213
222 2427-2431 Gene denotes IgG3 Gene:3502
223 2591-2599 Gene denotes FcγRIIIb Gene:2215
224 2066-2072 Species denotes people Tax:9606
225 2368-2376 Gene denotes FcγRIIIb Gene:2215
226 1984-1991 Gene denotes FcγRIIa Gene:2212
227 2348-2351 Chemical denotes Phe MESH:D010649
228 2265-2282 Disease denotes myeloid dendritic MESH:D007635
229 2532-2549 Disease denotes myeloid dendritic MESH:D007635
233 2764-2770 Species denotes people Tax:9606
246 3746-3751 Gene denotes FcγRI Gene:2214
247 3753-3760 Gene denotes FcγRIIb Gene:2213
248 3771-3774 Gene denotes CH1 Gene:51430
249 3410-3413 Gene denotes CH1 Gene:51430
250 3269-3273 Gene denotes FcγR Gene:2213
252 3762-3769 Gene denotes FcγRIIc Gene:9103
253 3394-3401 Gene denotes FcγRIIa Gene:2212
254 3489-3498 Chemical denotes disulfide MESH:D004220
255 3728-3738 Chemical denotes disulfides MESH:D004220
262 4338-4342 Gene denotes FcγR Gene:2213
263 4322-4327 Species denotes human Tax:9606
275 4974-4979 Gene denotes FcγRI Gene:2214
276 4984-4991 Gene denotes FcγRIIb Gene:2213
277 5099-5104 Gene denotes FcγRI Gene:2214
278 5106-5113 Gene denotes FcγRIIa Gene:2212
279 5118-5126 Gene denotes FcγRIIIa Gene:2214
280 5134-5141 Gene denotes FcγRIIb Gene:2213
281 5057-5064 Gene denotes FcγRIIa Gene:2212
282 4940-4944 Gene denotes FcγR Gene:2213
283 4686-4690 Gene denotes FcγR Gene:2213
285 4632-4637 Species denotes human Tax:9606
287 5188-5192 Gene denotes FcγR Gene:2213
294 5297-5309 Gene denotes interferon‐γ Gene:3458
295 5432-5437 Gene denotes FcγRI Gene:14129
296 5441-5453 Gene denotes interferon‐γ Gene:15978
297 5538-5543 Species denotes mouse Tax:10090
306 6016-6021 Species denotes human Tax:9606
307 6204-6209 Species denotes human Tax:9606
308 6035-6040 Species denotes human Tax:9606
309 5949-5966 Disease denotes thrombocytopenias MESH:D013921
310 6285-6313 Disease denotes systemic lupus erythematosus MESH:D008180
311 6367-6383 Disease denotes hyper‐responsive MESH:D012130
318 6793-6800 Gene denotes FcγRIIb Gene:2213
319 6914-6921 Gene denotes FcγRIIc Gene:9103
320 6494-6498 Gene denotes FcγR Gene:2213
322 6608-6614 Species denotes humans Tax:9606
323 6900-6907 Gene denotes FcγRIIa Gene:2212
335 7161-7168 Gene denotes FcγRIII Gene:2214
336 7213-7221 Gene denotes FcγRIIIa Gene:2214
337 7226-7234 Gene denotes FcγRIIIb Gene:2215
338 7240-7248 Gene denotes FcγRIIIa Gene:2214
339 7363-7371 Gene denotes FcγRIIIa Gene:2214
340 7811-7818 Gene denotes FcγRIIa Gene:2212
341 7483-7489 Species denotes humans Tax:9606
342 7627-7632 Species denotes human Tax:9606
343 7731-7739 Gene denotes FcγRIIIb Gene:2215
344 7461-7469 Gene denotes FcγRIIIb Gene:2215
345 7710-7717 Gene denotes FcγRIIa Gene:2212
354 8213-8220 Gene denotes FcγRIIb Gene:2213
355 8273-8281 Gene denotes FcγRIIb1 Gene:1555
356 8427-8450 Gene denotes B‐cell antigen receptor Gene:613
357 8452-8455 Gene denotes BCR Gene:613
358 8678-8686 Gene denotes FcγRIIb1 Gene:1555
359 8148-8152 Gene denotes FcγR Gene:2213
360 7866-7870 Gene denotes FcγR Gene:2213
361 8836-8841 Species denotes human Tax:9606
369 9085-9093 Gene denotes FcγRIIIa Gene:2214
370 9128-9135 Gene denotes FcγRIIa Gene:2212
371 9137-9144 Gene denotes FcγRIIb Gene:2213
372 9148-9156 Gene denotes FcγRIIIa Gene:2214
373 8905-8909 Gene denotes FcγR Gene:2213
374 9055-9059 Gene denotes FcγR Gene:2213
375 9098-9102 Disease denotes αβ T MESH:D001260
382 9492-9496 Gene denotes FcγR Gene:2213
383 9696-9703 Gene denotes FcγRIIb Gene:2213
384 9917-9924 Gene denotes FcγRIIb Gene:2213
385 9954-9961 Gene denotes FcγRIIb Gene:2213
386 10366-10373 Gene denotes FcγRIIb Gene:2213
395 11043-11046 Gene denotes BCR Gene:613
396 10738-10741 Gene denotes BCR Gene:613
397 10984-10988 Gene denotes FcγR Gene:2213
398 10629-10633 Gene denotes FcγR Gene:2213
399 11106-11114 Chemical denotes tyrosine MESH:D014443
403 11339-11342 Gene denotes BCR Gene:613

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T6 0-5 Species denotes Human NCBItxid:9606
T7 34-39 Species denotes human NCBItxid:9606
T8 1197-1202 Species denotes human NCBItxid:9606
T9 1469-1474 Species denotes human NCBItxid:9606
T10 1487-1494 Species denotes rodents NCBItxid:9989
T11 1507-1515 Species denotes primates NCBItxid:9443
T12 2877-2885 Species denotes COVID-19 NCBItxid:2697049
T13 4027-4035 Species denotes COVID-19 NCBItxid:2697049
T14 4322-4327 Species denotes human NCBItxid:9606
T15 4632-4637 Species denotes human NCBItxid:9606
T16 5538-5543 Species denotes mouse NCBItxid:10090|NCBItxid:10088
T18 5728-5736 Species denotes primates NCBItxid:9443
T19 6016-6021 Species denotes human NCBItxid:9606
T20 6035-6040 Species denotes human NCBItxid:9606
T21 6204-6209 Species denotes human NCBItxid:9606
T22 6608-6614 Species denotes humans NCBItxid:9605
T23 7483-7489 Species denotes humans NCBItxid:9605
T24 7627-7632 Species denotes human NCBItxid:9606
T25 7743-7750 Species denotes macaque NCBItxid:9539
T26 8836-8841 Species denotes human NCBItxid:9606

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T52 0-29 Sentence denotes Human FcγR General Properties
T53 30-397 Sentence denotes The human leukocyte receptors fall into two functional groups, namely, proinflammatory, activating‐type receptors (FcγRI, FcγRIIa, FcγRIIc, FcγRIIIa and FcγRIIIb, which are also known as CD64, CD32a, CD32c, CD16a and CD16b, respectively) and the anti‐inflammatory, inhibitory‐receptor group (FcγRIIb also called CD32b) which was the first immune checkpoint described.
T54 398-505 Sentence denotes These FcγRs are high‐avidity sensors of immune complexes which initiate, and then modulate, cell responses.
T55 506-714 Sentence denotes In the context of normal immune physiology, opsonized target molecules can engage various FcγRs and induce a spectrum of effector responses which can be harnessed by many therapeutic mAbs (Figure 1, Table 1).
T56 715-862 Sentence denotes These responses are not mutually exclusive and one therapeutic mAb may initiate various responses via different FcγRs and via different cell types.
T57 863-1118 Sentence denotes Understanding the importance of cell‐based effector functions in the MOA of therapeutic mAbs requires an appreciation of FcγR biology (Tables 1, 2, 3) which also underpins future efforts to tailor new mAbs for the exploitation‐specific effector responses.
T58 1119-1261 Sentence denotes In this review, we address only key aspects of the extensive knowledge of the human leukocyte FcγR family as it relates to effector functions.
T59 1262-1762 Sentence denotes A number of other reviews more comprehensively explore FcγR biology physiology, biochemistry, genetics and structure.7, 11, 12, 13, 14 Notwithstanding the recognized differences between the immunobiology of human FcγR and of rodents or nonhuman primates, animal models of FcR effector function in vivo have helped shape the strategies for the development of current therapeutic mAbs and are well reviewed.12, 15 Furthermore, humanized FcγR models will provide even greater insights into the future.16
T60 1763-1791 Sentence denotes Table 2 Properties of FcγR.
T61 1792-1846 Sentence denotes Receptor Affinity IgG specificity Cell distribution
T62 1847-1983 Sentence denotes FcγRI High IgG1, IgG3, IgG4 Induced by interferon‐γ on monocytes, neutrophils, macrophages, dendritic cell subpopulations; mast cells
T63 1984-2130 Sentence denotes FcγRIIa Low IgG1, IgG3, but IgG2 binding limited to the FcγRIIa‐H131 form, ~70% people) All leukocytes and platelets except T and B lymphocytes
T64 2131-2173 Sentence denotes FcγRIIc a Low IgG1, IgG3, IgG4 NK cells
T65 2174-2200 Sentence denotes FcγRIIIa Low IgG1, IgG3.
T66 2202-2320 Sentence denotes NK cells, macrophages, subpopulation of circulating monocytes, myeloid dendritic cells, neutrophils at very low levels
T67 2321-2367 Sentence denotes Binding avidity reduced by Phe at position 158
T68 2368-2406 Sentence denotes FcγRIIIb Low IgG1, IgG3 Neutrophils
T69 2407-2514 Sentence denotes FcγRIIb Low IgG1, IgG3, IgG4 B lymphocytes, some monocytes (can be upregulated); basophils; eosinophils?
T70 2515-2626 Sentence denotes Plasmacytoid and myeloid dendritic cells; NK cells only of individuals with FcγRIIIb gene copy number variation
T71 2627-2690 Sentence denotes Airway smooth muscle, LSEC, placenta, follicular dendritic cell
T72 2691-2740 Sentence denotes Ig, immunoglobulin; NK cell, natural killer cell.
T73 2741-2771 Sentence denotes a Expressed in 20% of people.
T74 2772-2919 Sentence denotes John Wiley & Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response.
T75 2920-3102 Sentence denotes It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.
T76 3103-3157 Sentence denotes Table 3 Unique features of IgG subclass Fc and hinge.
T77 3158-3258 Sentence denotes IgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment
T78 3259-3369 Sentence denotes IgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is >100× times more stable than IgG4 and IgG2.
T79 3370-3387 Sentence denotes Stable core hinge
T80 3388-3524 Sentence denotes IgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge.
T81 3526-3607 Sentence denotes Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers.
T82 3608-3739 Sentence denotes Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.
T83 3740-3901 Sentence denotes IgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange
T84 3902-3921 Sentence denotes Ig, immunoglobulin.
T85 3922-4069 Sentence denotes John Wiley & Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response.
T86 4070-4252 Sentence denotes It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.
T87 4254-4290 Sentence denotes FcγR expression on hemopoietic cells
T88 4291-4555 Sentence denotes The tissue distribution of the human leukocyte FcγR is well documented and reviewed comprehensively elsewhere.7, 11, 17 In the context of effector functions harnessed by therapeutic mAbs, several aspects of the cellular distribution (Table 2) should be emphasized.
T89 4556-4701 Sentence denotes FcγR expression profiles differ between cell lineages but almost all mature human leukocytes, and platelets, express at least one FcγR (Table 2).
T90 4702-5143 Sentence denotes It should also be appreciated that the cellular expression levels and receptor diversity as will be described later is also influenced by the activation state of the cells, anatomical location and the cytokine environment which modulates FcγR expression, particularly for FcγRI and FcγRIIb.18 For example, resting monocyte subpopulations may express only FcγRIIa but activated macrophages express FcγRI, FcγRIIa and FcγRIIIa and/or FcγRIIb.7
T91 5144-5230 Sentence denotes Thus, specific characteristics of leukocyte FcγR expression are summarized as follows:
T92 5231-5412 Sentence denotes FcγRI is not usually expressed until induced by cytokines such as interferon‐γ on monocytes, neutrophils, macrophages, microglial cells in the brain, dendritic cells and mast cells.
T93 5413-5698 Sentence denotes The sensitivity of FcγRI to interferon‐γ suggests that its in vivo activity is closely tied to immune activation events, and mouse studies have suggested that it has a critical role early in immune responses.19, 20 Its role in the MOA of antibodies may vary with anatomical location.21
T94 5699-5824 Sentence denotes FcγRIIa is expressed only in primates and shows the broadest expression of all FcγRs, being present on all innate leukocytes.
T95 5825-5967 Sentence denotes It is also present on platelets but its role in effector functions is not established but it is important in certain immune thrombocytopenias.
T96 5968-6046 Sentence denotes A polymorphic form of this receptor is the only human receptor for human IgG2.
T97 6047-6221 Sentence denotes This, together with its limited species expression and unique ITAM‐containing cytoplasmic tail (reviewed by Anania et al. 11), suggests a unique function in human leukocytes.
T98 6222-6468 Sentence denotes Interestingly, polymorphism of the receptor is associated with systemic lupus erythematosus and resistance to Gram‐negative organisms.11 A rare, hyper‐responsive form is a risk factor for neutrophil‐driven anaphylaxis in Ig replacement therapy.22
T99 6469-6908 Sentence denotes FcγRIIc is an activating FcγR whose expression is regulated single nucleotide polymorphism that permits expression in approximately 20% of humans and in whom it is present at low levels on natural killer (NK) and B cells.11 It has arisen by gene duplication/recombination resulting in an extracellular region  derived from  FcγRIIb, which binds IgG4, and with an ITAM‐containing cytoplasmic tail related to the activating receptor FcγRIIa.
T100 6909-7027 Sentence denotes Thus FcγRIIc provides IgG4 with an activation receptor pathway and confers a new biology of IgG4 in these individuals.
T101 7028-7160 Sentence denotes Its low frequency in the population may also confound in vivo mAb clinical testing or use, but as yet there is no evidence for this.
T102 7161-7235 Sentence denotes FcγRIII forms are two highly related gene products, FcγRIIIa and FcγRIIIb.
T103 7236-7328 Sentence denotes The FcγRIIIa is expressed on NK cells and professional phagocytes, particularly macrophages.
T104 7329-7576 Sentence denotes It is only recently apparent that FcγRIIIa is expressed on neutrophils, albeit at low levels, but plays a role in their function.23 FcγRIIIb is unique to humans and unlike other FcγRs it is attached to cell membrane via a glycophosphatidyl anchor.
T105 7577-7718 Sentence denotes It is expressed, predominantly and abundantly, on human neutrophils.7 Its effector function depends in part on its coexpression with FcγRIIa.
T106 7719-7832 Sentence denotes The lack of FcγRIIIb on macaque neutrophils appears to be compensated for by an increase in FcγRIIa expression.15
T107 7833-7900 Sentence denotes FcγRIIbs are the inhibitory‐type FcγR and arise from a single gene.
T108 7901-7982 Sentence denotes They lack intrinsic proinflammatory signaling and are instead immune checkpoints.
T109 7983-8113 Sentence denotes They provide feedback regulation by antibodies, in the form of immune complexes, to inhibit B‐cell activation by specific antigen.
T110 8114-8178 Sentence denotes They also control activating‐type FcγR function on innate cells.
T111 8179-8272 Sentence denotes Two major splice variant forms of FcγRIIb exist with differential tissue expression profiles.
T112 8273-8457 Sentence denotes FcγRIIb1 preferentially expressed on B lymphocytes contains a 20‐amino acid cytoplasmic insertion necessary for membrane retention and cocapping with the B‐cell antigen receptor (BCR).
T113 8458-8633 Sentence denotes FcγRIIb2 is the predominant inhibitory receptor found on basophils and neutrophils, as well as on subpopulations of mast cells, dendritic cells and some monocytes/macrophages.
T114 8634-8850 Sentence denotes FcγRIIb2 lacks the cytoplasmic insertion of FcγRIIb1 and consequently can internalize rapidly including with the activating FcR when they are co‐cross‐linked.11 It is not clear which form is present on human T cells.
T115 8851-8978 Sentence denotes One additional comment on tissue distribution is that FcγR expression on T cells has been difficult to establish unequivocally.
T116 8979-9060 Sentence denotes However, there is increasing evidence that T‐lymphocyte populations express FcγR.
T117 9061-9272 Sentence denotes Some γδ T cells express FcγRIIIa and αβ T cells reportedly express FcγRIIa, FcγRIIb or FcγRIIIa but the significance with respect to effector function mediated by antibody is presently unclear.24, 25, 26, 27, 28
T118 9274-9308 Sentence denotes Expression on nonhemopoietic cells
T119 9309-9532 Sentence denotes The immunobiology of FcγR is studied and understood almost exclusively in the context of hematopoietic cell function but relatively recent investigations have identified and explored FcγR expression on nonhemopoietic cells.
T120 9533-9637 Sentence denotes These studies suggest important roles in normal immune function and in the MOA of some therapeutic mAbs.
T121 9638-9796 Sentence denotes The most extensively characterized receptor expression is FcγRIIb which is expressed on follicular dendritic cell, airway smooth muscle and liver endothelium.
T122 9797-10187 Sentence denotes Its abundant expression on liver sinusoidal endothelial cells (LSECs) is estimated to represent the majority of in vivo FcγRIIb expression.17, 29, 30, 31 As FcγRIIb lacks intrinsic proinflammatory signaling function, its role on these nonhemopoietic cells involves immune complex handling without the danger of, or the need for, induction of local tissue destructive inflammatory responses.
T123 10188-10525 Sentence denotes On LSEC its major role appears to be immune complex sweeping, a process of removal of small immune complexes such as opsonized virus or macromolecules.17 This scavenging role by FcγRIIb on LSEC can be exploited in principle by mAbs forming small soluble complexes with their targets such as antiviral, anticytokine or similar antibodies.
T124 10527-10566 Sentence denotes FcγR activating or inhibitory signaling
T125 10567-10694 Sentence denotes Effector functions that are initiated via the activating‐type FcγR occur by signaling via the ITAM pathway of immune receptors.
T126 10695-10879 Sentence denotes This well‐characterized pathway is used by BCR and T‐cell antigen receptors, the IgE receptor FcεRI and IgA receptor FcαRI (reviewed extensively by Hogarth and Pietersz 7 Anania et al.
T127 10880-11047 Sentence denotes 11 and Getahun and Cambier 32) Induction of an activating signal requires the aggregation of activating FcγR by immune complexes, or by antigen in the case of the BCR.
T128 11048-11208 Sentence denotes This aggregation at the cell membrane results in specific tyrosine phosphorylation of the ITAM by Src kinases, thus initiating the activation cascade.32, 33, 34
T129 11209-11842 Sentence denotes The inhibitory‐type FcγRs, FcγRIIb1 and FcγRIIb2, whose expression is cell lineage restricted, modulate the ITAM signaling of the BCR or the activating‐type FcγRs, respectively.11 Their function is dependent on the immunoreceptor tyrosine inhibition motif in their cytoplasmic tail.32, 33 This checkpoint action requires that FcγRIIbs are coaggregated with the tyrosine‐phosphorylated ITAM‐signaling receptor complex which results also in immunoreceptor tyrosine inhibition motif tyrosine phosphorylation and consequential recruitment of lipid or protein tyrosine phosphatases that powerfully dampen the ITAM‐induced cell activation.

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T3 2655-2663 Body_part denotes placenta http://purl.obolibrary.org/obo/UBERON_0001987
T4 4295-4301 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T5 5374-5379 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T6 6137-6141 Body_part denotes tail http://purl.obolibrary.org/obo/UBERON_0002415
T7 6860-6864 Body_part denotes tail http://purl.obolibrary.org/obo/UBERON_0002415
T8 8245-8251 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T9 8877-8883 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T10 9778-9783 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T11 9784-9795 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T12 9824-9829 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T13 10145-10151 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T14 11486-11490 Body_part denotes tail http://purl.obolibrary.org/obo/UBERON_0002415

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T62 217-221 Protein denotes CD64 https://www.uniprot.org/uniprot/Q92663|https://www.uniprot.org/uniprot/Q92495|https://www.uniprot.org/uniprot/Q5QNW7|https://www.uniprot.org/uniprot/P26151|https://www.uniprot.org/uniprot/P12315|https://www.uniprot.org/uniprot/P12314
T68 237-242 Protein denotes CD16a https://www.uniprot.org/uniprot/Q6PIJ0|https://www.uniprot.org/uniprot/Q65ZM6|https://www.uniprot.org/uniprot/Q5EBR4|https://www.uniprot.org/uniprot/Q53FL6|https://www.uniprot.org/uniprot/Q53FJ0|https://www.uniprot.org/uniprot/P08637|https://www.uniprot.org/uniprot/A2N6W9
T75 247-252 Protein denotes CD16b https://www.uniprot.org/uniprot/O75015
T76 1889-1899 Protein denotes interferon https://www.uniprot.org/uniprot/P51527|https://www.uniprot.org/uniprot/P51526
T78 1973-1977 Protein denotes mast https://www.uniprot.org/uniprot/Q9NL57|https://www.uniprot.org/uniprot/Q9NBD7|https://www.uniprot.org/uniprot/A4V279
T81 2634-2640 Protein denotes smooth https://www.uniprot.org/uniprot/Q9VPM8|https://www.uniprot.org/uniprot/P91682|https://www.uniprot.org/uniprot/B7FNK1
T84 5297-5307 Protein denotes interferon https://www.uniprot.org/uniprot/P51527|https://www.uniprot.org/uniprot/P51526
T86 5401-5405 Protein denotes mast https://www.uniprot.org/uniprot/Q9NL57|https://www.uniprot.org/uniprot/Q9NBD7|https://www.uniprot.org/uniprot/A4V279
T89 5441-5451 Protein denotes interferon https://www.uniprot.org/uniprot/P51527|https://www.uniprot.org/uniprot/P51526
T91 8574-8578 Protein denotes mast https://www.uniprot.org/uniprot/Q9NL57|https://www.uniprot.org/uniprot/Q9NBD7|https://www.uniprot.org/uniprot/A4V279
T94 9760-9766 Protein denotes smooth https://www.uniprot.org/uniprot/Q9VPM8|https://www.uniprot.org/uniprot/P91682|https://www.uniprot.org/uniprot/B7FNK1

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T84 40-49 Body_part denotes leukocyte http://purl.org/sig/ont/fma/fma62852
T85 490-494 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T86 851-855 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T87 895-899 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T88 1203-1212 Body_part denotes leukocyte http://purl.org/sig/ont/fma/fma62852
T89 1812-1815 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T90 1829-1833 Body_part denotes Cell http://purl.org/sig/ont/fma/fma68646
T91 1905-1914 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T92 1916-1927 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T93 1929-1940 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T94 1942-1956 Body_part denotes dendritic cell http://purl.org/sig/ont/fma/fma273565
T95 1952-1956 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T96 1973-1983 Body_part denotes mast cells http://purl.org/sig/ont/fma/fma66784
T97 1978-1983 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T98 2079-2089 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T99 2094-2103 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T100 2117-2130 Body_part denotes B lymphocytes http://purl.org/sig/ont/fma/fma62869
T101 2165-2173 Body_part denotes NK cells http://purl.org/sig/ont/fma/fma63147
T102 2168-2173 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T103 2202-2210 Body_part denotes NK cells http://purl.org/sig/ont/fma/fma63147
T104 2205-2210 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T105 2212-2223 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T106 2254-2263 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T107 2273-2288 Body_part denotes dendritic cells http://purl.org/sig/ont/fma/fma273565
T108 2283-2288 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T109 2290-2301 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T110 2395-2406 Body_part denotes Neutrophils http://purl.org/sig/ont/fma/fma62860
T111 2439-2452 Body_part denotes B lymphocytes http://purl.org/sig/ont/fma/fma62869
T112 2459-2468 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T113 2491-2500 Body_part denotes basophils http://purl.org/sig/ont/fma/fma62862
T114 2502-2513 Body_part denotes eosinophils http://purl.org/sig/ont/fma/fma62861
T115 2540-2555 Body_part denotes dendritic cells http://purl.org/sig/ont/fma/fma273565
T116 2550-2555 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T117 2557-2565 Body_part denotes NK cells http://purl.org/sig/ont/fma/fma63147
T118 2560-2565 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T119 2600-2604 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T120 2641-2647 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T121 2655-2663 Body_part denotes placenta http://purl.org/sig/ont/fma/fma63934
T122 2665-2690 Body_part denotes follicular dendritic cell http://purl.org/sig/ont/fma/fma83037
T123 2686-2690 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T124 2691-2693 Body_part denotes Ig http://purl.org/sig/ont/fma/fma62871
T125 2695-2709 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T126 2711-2718 Body_part denotes NK cell http://purl.org/sig/ont/fma/fma63147
T127 2714-2718 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T128 2720-2739 Body_part denotes natural killer cell http://purl.org/sig/ont/fma/fma63147
T129 2735-2739 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T130 3131-3134 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T131 3158-3161 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T132 3880-3883 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T133 3902-3904 Body_part denotes Ig http://purl.org/sig/ont/fma/fma62871
T134 3906-3920 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T135 4273-4290 Body_part denotes hemopoietic cells http://purl.org/sig/ont/fma/fma83598
T136 4285-4290 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T137 4295-4301 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T138 4328-4337 Body_part denotes leukocyte http://purl.org/sig/ont/fma/fma62852
T139 4596-4600 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T140 4638-4648 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T141 4654-4663 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T142 4868-4873 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T143 4903-4911 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T144 5016-5024 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T145 5079-5090 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T146 5178-5187 Body_part denotes leukocyte http://purl.org/sig/ont/fma/fma62852
T147 5279-5288 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T148 5313-5322 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T149 5324-5335 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T150 5337-5348 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T151 5350-5366 Body_part denotes microglial cells http://purl.org/sig/ont/fma/fma54539
T152 5361-5366 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T153 5374-5379 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T154 5381-5396 Body_part denotes dendritic cells http://purl.org/sig/ont/fma/fma273565
T155 5391-5396 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T156 5401-5411 Body_part denotes mast cells http://purl.org/sig/ont/fma/fma66784
T157 5406-5411 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T158 5813-5823 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T159 5847-5856 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T160 6125-6136 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835
T161 6210-6220 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T162 6410-6420 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T163 6443-6445 Body_part denotes Ig http://purl.org/sig/ont/fma/fma62871
T164 6536-6546 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T165 6684-6689 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T166 6710-6714 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T167 6848-6859 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835
T168 7198-7202 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T169 7265-7273 Body_part denotes NK cells http://purl.org/sig/ont/fma/fma63147
T170 7268-7273 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T171 7316-7327 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T172 7388-7399 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T173 7531-7544 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T174 7531-7535 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T175 7633-7644 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T176 7751-7762 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T177 7895-7899 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T178 8077-8081 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T179 8172-8177 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T180 8245-8251 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T181 8310-8323 Body_part denotes B lymphocytes http://purl.org/sig/ont/fma/fma62869
T182 8338-8348 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T183 8349-8360 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835
T184 8429-8433 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T185 8515-8524 Body_part denotes basophils http://purl.org/sig/ont/fma/fma62862
T186 8529-8540 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T187 8574-8584 Body_part denotes mast cells http://purl.org/sig/ont/fma/fma66784
T188 8579-8584 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T189 8586-8601 Body_part denotes dendritic cells http://purl.org/sig/ont/fma/fma273565
T190 8596-8601 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T191 8611-8620 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T192 8621-8632 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T193 8653-8664 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835
T194 8844-8849 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T195 8877-8883 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T196 8926-8931 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T197 9022-9034 Body_part denotes T‐lymphocyte http://purl.org/sig/ont/fma/fma62870
T198 9071-9076 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T199 9103-9108 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T200 9224-9232 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T201 9303-9308 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T202 9398-9416 Body_part denotes hematopoietic cell http://purl.org/sig/ont/fma/fma83598
T203 9412-9416 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T204 9526-9531 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T205 9726-9751 Body_part denotes follicular dendritic cell http://purl.org/sig/ont/fma/fma83037
T206 9747-9751 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T207 9767-9773 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T208 9778-9783 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T209 9784-9795 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T210 9824-9829 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T211 9830-9840 Body_part denotes sinusoidal http://purl.org/sig/ont/fma/fma63131
T212 9841-9858 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T213 9853-9858 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T214 10047-10052 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T215 10145-10151 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T216 10748-10752 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T217 10776-10779 Body_part denotes IgE http://purl.org/sig/ont/fma/fma62875
T218 10799-10802 Body_part denotes IgA http://purl.org/sig/ont/fma/fma62874
T219 11072-11085 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T220 11072-11076 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T221 11106-11114 Body_part denotes tyrosine http://purl.org/sig/ont/fma/fma82768
T222 11279-11283 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T223 11439-11447 Body_part denotes tyrosine http://purl.org/sig/ont/fma/fma82768
T224 11474-11485 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835
T225 11570-11578 Body_part denotes tyrosine http://purl.org/sig/ont/fma/fma82768
T226 11663-11671 Body_part denotes tyrosine http://purl.org/sig/ont/fma/fma82768
T227 11689-11697 Body_part denotes tyrosine http://purl.org/sig/ont/fma/fma82768
T228 11747-11752 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T229 11756-11763 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T230 11764-11772 Body_part denotes tyrosine http://purl.org/sig/ont/fma/fma82768
T231 11826-11830 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T1 2634-2647 http://purl.obolibrary.org/obo/MAT_0000303 denotes smooth muscle
T2 2641-2647 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T3 2655-2663 http://purl.obolibrary.org/obo/MAT_0000279 denotes placenta
T4 4812-4817 http://purl.obolibrary.org/obo/MAT_0000488 denotes later
T5 5374-5379 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T6 9760-9773 http://purl.obolibrary.org/obo/MAT_0000303 denotes smooth muscle
T7 9767-9773 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T8 9778-9783 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T9 9824-9829 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T34 3676-3684 http://purl.obolibrary.org/obo/GO_0015297 denotes exchange
T35 3893-3901 http://purl.obolibrary.org/obo/GO_0015297 denotes exchange
T36 5604-5620 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T37 7937-7946 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T38 8005-8015 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T39 8067-8092 http://purl.obolibrary.org/obo/GO_0050869 denotes inhibit B‐cell activation
T40 8075-8092 http://purl.obolibrary.org/obo/GO_0042113 denotes B‐cell activation
T41 8077-8092 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T42 8394-8403 http://purl.obolibrary.org/obo/GO_0051235 denotes retention
T43 9994-10003 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T44 10164-10186 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T45 10557-10566 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T46 10643-10652 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T47 11115-11130 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T48 11322-11331 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T49 11599-11608 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T50 11698-11713 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T51 11773-11785 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatases
T52 11826-11841 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T12 2877-2885 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T13 4027-4035 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T14 5942-5966 Disease denotes immune thrombocytopenias http://purl.obolibrary.org/obo/MONDO_0002048
T15 6285-6313 Disease denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/MONDO_0007915
T16 6428-6439 Disease denotes anaphylaxis http://purl.obolibrary.org/obo/MONDO_0100053

LitCovid-sample-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T5 5942-5966 Phenotype denotes immune thrombocytopenias http://purl.obolibrary.org/obo/HP_0001973
T6 6285-6313 Phenotype denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/HP_0002725
T7 6428-6439 Phenotype denotes anaphylaxis http://purl.obolibrary.org/obo/HP_0100845

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T34 3676-3684 http://purl.obolibrary.org/obo/GO_0015297 denotes exchange
T35 3893-3901 http://purl.obolibrary.org/obo/GO_0015297 denotes exchange
T36 5604-5620 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T37 7937-7946 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T38 8005-8015 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T39 8067-8092 http://purl.obolibrary.org/obo/GO_0050869 denotes inhibit B‐cell activation
T40 8075-8092 http://purl.obolibrary.org/obo/GO_0042113 denotes B‐cell activation
T41 8077-8092 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T42 8394-8403 http://purl.obolibrary.org/obo/GO_0051235 denotes retention
T43 9994-10003 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T44 10164-10186 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T45 10557-10566 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T46 10643-10652 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T47 11115-11130 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T48 11322-11331 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T49 11599-11608 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T50 11698-11713 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T51 11773-11785 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatases
T52 11826-11841 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T34 3676-3684 http://purl.obolibrary.org/obo/GO_0015297 denotes exchange
T35 3893-3901 http://purl.obolibrary.org/obo/GO_0015297 denotes exchange
T36 5604-5620 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T37 7937-7946 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T38 8005-8015 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T39 8067-8092 http://purl.obolibrary.org/obo/GO_0050869 denotes inhibit B‐cell activation
T40 8075-8092 http://purl.obolibrary.org/obo/GO_0042113 denotes B‐cell activation
T41 8077-8092 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T42 8394-8403 http://purl.obolibrary.org/obo/GO_0051235 denotes retention
T43 9994-10003 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T44 10164-10186 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T45 10557-10566 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T46 10643-10652 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T47 11115-11130 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T48 11322-11331 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T49 11599-11608 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T50 11698-11713 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T51 11773-11785 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatases
T52 11826-11841 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T52 0-29 Sentence denotes Human FcγR General Properties
T53 30-397 Sentence denotes The human leukocyte receptors fall into two functional groups, namely, proinflammatory, activating‐type receptors (FcγRI, FcγRIIa, FcγRIIc, FcγRIIIa and FcγRIIIb, which are also known as CD64, CD32a, CD32c, CD16a and CD16b, respectively) and the anti‐inflammatory, inhibitory‐receptor group (FcγRIIb also called CD32b) which was the first immune checkpoint described.
T54 398-505 Sentence denotes These FcγRs are high‐avidity sensors of immune complexes which initiate, and then modulate, cell responses.
T55 506-714 Sentence denotes In the context of normal immune physiology, opsonized target molecules can engage various FcγRs and induce a spectrum of effector responses which can be harnessed by many therapeutic mAbs (Figure 1, Table 1).
T56 715-862 Sentence denotes These responses are not mutually exclusive and one therapeutic mAb may initiate various responses via different FcγRs and via different cell types.
T57 863-1118 Sentence denotes Understanding the importance of cell‐based effector functions in the MOA of therapeutic mAbs requires an appreciation of FcγR biology (Tables 1, 2, 3) which also underpins future efforts to tailor new mAbs for the exploitation‐specific effector responses.
T58 1119-1261 Sentence denotes In this review, we address only key aspects of the extensive knowledge of the human leukocyte FcγR family as it relates to effector functions.
T59 1262-1762 Sentence denotes A number of other reviews more comprehensively explore FcγR biology physiology, biochemistry, genetics and structure.7, 11, 12, 13, 14 Notwithstanding the recognized differences between the immunobiology of human FcγR and of rodents or nonhuman primates, animal models of FcR effector function in vivo have helped shape the strategies for the development of current therapeutic mAbs and are well reviewed.12, 15 Furthermore, humanized FcγR models will provide even greater insights into the future.16
T60 1763-1791 Sentence denotes Table 2 Properties of FcγR.
T61 1792-1846 Sentence denotes Receptor Affinity IgG specificity Cell distribution
T62 1847-1983 Sentence denotes FcγRI High IgG1, IgG3, IgG4 Induced by interferon‐γ on monocytes, neutrophils, macrophages, dendritic cell subpopulations; mast cells
T63 1984-2130 Sentence denotes FcγRIIa Low IgG1, IgG3, but IgG2 binding limited to the FcγRIIa‐H131 form, ~70% people) All leukocytes and platelets except T and B lymphocytes
T64 2131-2173 Sentence denotes FcγRIIc a Low IgG1, IgG3, IgG4 NK cells
T65 2174-2200 Sentence denotes FcγRIIIa Low IgG1, IgG3.
T66 2202-2320 Sentence denotes NK cells, macrophages, subpopulation of circulating monocytes, myeloid dendritic cells, neutrophils at very low levels
T67 2321-2367 Sentence denotes Binding avidity reduced by Phe at position 158
T68 2368-2406 Sentence denotes FcγRIIIb Low IgG1, IgG3 Neutrophils
T69 2407-2514 Sentence denotes FcγRIIb Low IgG1, IgG3, IgG4 B lymphocytes, some monocytes (can be upregulated); basophils; eosinophils?
T70 2515-2626 Sentence denotes Plasmacytoid and myeloid dendritic cells; NK cells only of individuals with FcγRIIIb gene copy number variation
T71 2627-2690 Sentence denotes Airway smooth muscle, LSEC, placenta, follicular dendritic cell
T72 2691-2740 Sentence denotes Ig, immunoglobulin; NK cell, natural killer cell.
T73 2741-2771 Sentence denotes a Expressed in 20% of people.
T74 2772-2919 Sentence denotes John Wiley & Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response.
T75 2920-3102 Sentence denotes It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.
T76 3103-3157 Sentence denotes Table 3 Unique features of IgG subclass Fc and hinge.
T77 3158-3258 Sentence denotes IgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment
T78 3259-3369 Sentence denotes IgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is >100× times more stable than IgG4 and IgG2.
T79 3370-3387 Sentence denotes Stable core hinge
T80 3388-3524 Sentence denotes IgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge.
T81 3526-3607 Sentence denotes Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers.
T82 3608-3739 Sentence denotes Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.
T83 3740-3901 Sentence denotes IgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange
T84 3902-3921 Sentence denotes Ig, immunoglobulin.
T85 3922-4069 Sentence denotes John Wiley & Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response.
T86 4070-4252 Sentence denotes It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.
T87 4254-4290 Sentence denotes FcγR expression on hemopoietic cells
T88 4291-4555 Sentence denotes The tissue distribution of the human leukocyte FcγR is well documented and reviewed comprehensively elsewhere.7, 11, 17 In the context of effector functions harnessed by therapeutic mAbs, several aspects of the cellular distribution (Table 2) should be emphasized.
T89 4556-4701 Sentence denotes FcγR expression profiles differ between cell lineages but almost all mature human leukocytes, and platelets, express at least one FcγR (Table 2).
T90 4702-5143 Sentence denotes It should also be appreciated that the cellular expression levels and receptor diversity as will be described later is also influenced by the activation state of the cells, anatomical location and the cytokine environment which modulates FcγR expression, particularly for FcγRI and FcγRIIb.18 For example, resting monocyte subpopulations may express only FcγRIIa but activated macrophages express FcγRI, FcγRIIa and FcγRIIIa and/or FcγRIIb.7
T91 5144-5230 Sentence denotes Thus, specific characteristics of leukocyte FcγR expression are summarized as follows:
T92 5231-5412 Sentence denotes FcγRI is not usually expressed until induced by cytokines such as interferon‐γ on monocytes, neutrophils, macrophages, microglial cells in the brain, dendritic cells and mast cells.
T93 5413-5698 Sentence denotes The sensitivity of FcγRI to interferon‐γ suggests that its in vivo activity is closely tied to immune activation events, and mouse studies have suggested that it has a critical role early in immune responses.19, 20 Its role in the MOA of antibodies may vary with anatomical location.21
T94 5699-5824 Sentence denotes FcγRIIa is expressed only in primates and shows the broadest expression of all FcγRs, being present on all innate leukocytes.
T95 5825-5967 Sentence denotes It is also present on platelets but its role in effector functions is not established but it is important in certain immune thrombocytopenias.
T96 5968-6046 Sentence denotes A polymorphic form of this receptor is the only human receptor for human IgG2.
T97 6047-6221 Sentence denotes This, together with its limited species expression and unique ITAM‐containing cytoplasmic tail (reviewed by Anania et al. 11), suggests a unique function in human leukocytes.
T98 6222-6468 Sentence denotes Interestingly, polymorphism of the receptor is associated with systemic lupus erythematosus and resistance to Gram‐negative organisms.11 A rare, hyper‐responsive form is a risk factor for neutrophil‐driven anaphylaxis in Ig replacement therapy.22
T99 6469-6908 Sentence denotes FcγRIIc is an activating FcγR whose expression is regulated single nucleotide polymorphism that permits expression in approximately 20% of humans and in whom it is present at low levels on natural killer (NK) and B cells.11 It has arisen by gene duplication/recombination resulting in an extracellular region  derived from  FcγRIIb, which binds IgG4, and with an ITAM‐containing cytoplasmic tail related to the activating receptor FcγRIIa.
T100 6909-7027 Sentence denotes Thus FcγRIIc provides IgG4 with an activation receptor pathway and confers a new biology of IgG4 in these individuals.
T101 7028-7160 Sentence denotes Its low frequency in the population may also confound in vivo mAb clinical testing or use, but as yet there is no evidence for this.
T102 7161-7235 Sentence denotes FcγRIII forms are two highly related gene products, FcγRIIIa and FcγRIIIb.
T103 7236-7328 Sentence denotes The FcγRIIIa is expressed on NK cells and professional phagocytes, particularly macrophages.
T104 7329-7576 Sentence denotes It is only recently apparent that FcγRIIIa is expressed on neutrophils, albeit at low levels, but plays a role in their function.23 FcγRIIIb is unique to humans and unlike other FcγRs it is attached to cell membrane via a glycophosphatidyl anchor.
T105 7577-7718 Sentence denotes It is expressed, predominantly and abundantly, on human neutrophils.7 Its effector function depends in part on its coexpression with FcγRIIa.
T106 7719-7832 Sentence denotes The lack of FcγRIIIb on macaque neutrophils appears to be compensated for by an increase in FcγRIIa expression.15
T107 7833-7900 Sentence denotes FcγRIIbs are the inhibitory‐type FcγR and arise from a single gene.
T108 7901-7982 Sentence denotes They lack intrinsic proinflammatory signaling and are instead immune checkpoints.
T109 7983-8113 Sentence denotes They provide feedback regulation by antibodies, in the form of immune complexes, to inhibit B‐cell activation by specific antigen.
T110 8114-8178 Sentence denotes They also control activating‐type FcγR function on innate cells.
T111 8179-8272 Sentence denotes Two major splice variant forms of FcγRIIb exist with differential tissue expression profiles.
T112 8273-8457 Sentence denotes FcγRIIb1 preferentially expressed on B lymphocytes contains a 20‐amino acid cytoplasmic insertion necessary for membrane retention and cocapping with the B‐cell antigen receptor (BCR).
T113 8458-8633 Sentence denotes FcγRIIb2 is the predominant inhibitory receptor found on basophils and neutrophils, as well as on subpopulations of mast cells, dendritic cells and some monocytes/macrophages.
T114 8634-8850 Sentence denotes FcγRIIb2 lacks the cytoplasmic insertion of FcγRIIb1 and consequently can internalize rapidly including with the activating FcR when they are co‐cross‐linked.11 It is not clear which form is present on human T cells.
T115 8851-8978 Sentence denotes One additional comment on tissue distribution is that FcγR expression on T cells has been difficult to establish unequivocally.
T116 8979-9060 Sentence denotes However, there is increasing evidence that T‐lymphocyte populations express FcγR.
T117 9061-9272 Sentence denotes Some γδ T cells express FcγRIIIa and αβ T cells reportedly express FcγRIIa, FcγRIIb or FcγRIIIa but the significance with respect to effector function mediated by antibody is presently unclear.24, 25, 26, 27, 28
T118 9274-9308 Sentence denotes Expression on nonhemopoietic cells
T119 9309-9532 Sentence denotes The immunobiology of FcγR is studied and understood almost exclusively in the context of hematopoietic cell function but relatively recent investigations have identified and explored FcγR expression on nonhemopoietic cells.
T120 9533-9637 Sentence denotes These studies suggest important roles in normal immune function and in the MOA of some therapeutic mAbs.
T121 9638-9796 Sentence denotes The most extensively characterized receptor expression is FcγRIIb which is expressed on follicular dendritic cell, airway smooth muscle and liver endothelium.
T122 9797-10187 Sentence denotes Its abundant expression on liver sinusoidal endothelial cells (LSECs) is estimated to represent the majority of in vivo FcγRIIb expression.17, 29, 30, 31 As FcγRIIb lacks intrinsic proinflammatory signaling function, its role on these nonhemopoietic cells involves immune complex handling without the danger of, or the need for, induction of local tissue destructive inflammatory responses.
T123 10188-10525 Sentence denotes On LSEC its major role appears to be immune complex sweeping, a process of removal of small immune complexes such as opsonized virus or macromolecules.17 This scavenging role by FcγRIIb on LSEC can be exploited in principle by mAbs forming small soluble complexes with their targets such as antiviral, anticytokine or similar antibodies.
T124 10527-10566 Sentence denotes FcγR activating or inhibitory signaling
T125 10567-10694 Sentence denotes Effector functions that are initiated via the activating‐type FcγR occur by signaling via the ITAM pathway of immune receptors.
T126 10695-10879 Sentence denotes This well‐characterized pathway is used by BCR and T‐cell antigen receptors, the IgE receptor FcεRI and IgA receptor FcαRI (reviewed extensively by Hogarth and Pietersz 7 Anania et al.
T127 10880-11047 Sentence denotes 11 and Getahun and Cambier 32) Induction of an activating signal requires the aggregation of activating FcγR by immune complexes, or by antigen in the case of the BCR.
T128 11048-11208 Sentence denotes This aggregation at the cell membrane results in specific tyrosine phosphorylation of the ITAM by Src kinases, thus initiating the activation cascade.32, 33, 34
T129 11209-11842 Sentence denotes The inhibitory‐type FcγRs, FcγRIIb1 and FcγRIIb2, whose expression is cell lineage restricted, modulate the ITAM signaling of the BCR or the activating‐type FcγRs, respectively.11 Their function is dependent on the immunoreceptor tyrosine inhibition motif in their cytoplasmic tail.32, 33 This checkpoint action requires that FcγRIIbs are coaggregated with the tyrosine‐phosphorylated ITAM‐signaling receptor complex which results also in immunoreceptor tyrosine inhibition motif tyrosine phosphorylation and consequential recruitment of lipid or protein tyrosine phosphatases that powerfully dampen the ITAM‐induced cell activation.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T5 5942-5966 Phenotype denotes immune thrombocytopenias http://purl.obolibrary.org/obo/HP_0001973
T6 6285-6313 Phenotype denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/HP_0002725
T7 6428-6439 Phenotype denotes anaphylaxis http://purl.obolibrary.org/obo/HP_0100845

LitCovid-sample-Glycan

Id Subject Object Predicate Lexical cue
T1 2075-2078 https://glytoucan.org/Structures/Glycans/G05518TD denotes All
T2 3265-3268 https://glytoucan.org/Structures/Glycans/G05518TD denotes All