PMC:7228307 / 6915-7616 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"88","span":{"begin":106,"end":113},"obj":"Gene"},{"id":"92","span":{"begin":219,"end":223},"obj":"Gene"},{"id":"94","span":{"begin":536,"end":539},"obj":"Gene"},{"id":"101","span":{"begin":509,"end":521},"obj":"Disease"},{"id":"133","span":{"begin":676,"end":680},"obj":"Gene"},{"id":"137","span":{"begin":607,"end":611},"obj":"Gene"}],"attributes":[{"id":"A88","pred":"tao:has_database_id","subj":"88","obj":"Gene:2213"},{"id":"A92","pred":"tao:has_database_id","subj":"92","obj":"Gene:2213"},{"id":"A94","pred":"tao:has_database_id","subj":"94","obj":"Gene:613"},{"id":"A101","pred":"tao:has_database_id","subj":"101","obj":"MESH:D064420"},{"id":"A133","pred":"tao:has_database_id","subj":"133","obj":"Gene:2213"},{"id":"A137","pred":"tao:has_database_id","subj":"137","obj":"Gene:2213"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer.\nTable 1 FcγR responses relevant to therapeutic monoclonal antibodies (mAbs).\nFcγR‐mediated mechanism o"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T52","span":{"begin":154,"end":158},"obj":"Body_part"},{"id":"T53","span":{"begin":203,"end":211},"obj":"Body_part"},{"id":"T54","span":{"begin":231,"end":235},"obj":"Body_part"},{"id":"T55","span":{"begin":280,"end":284},"obj":"Body_part"},{"id":"T56","span":{"begin":362,"end":367},"obj":"Body_part"},{"id":"T57","span":{"begin":394,"end":403},"obj":"Body_part"},{"id":"T58","span":{"begin":454,"end":462},"obj":"Body_part"},{"id":"T59","span":{"begin":476,"end":484},"obj":"Body_part"},{"id":"T60","span":{"begin":495,"end":499},"obj":"Body_part"},{"id":"T61","span":{"begin":523,"end":525},"obj":"Body_part"},{"id":"T62","span":{"begin":543,"end":547},"obj":"Body_part"},{"id":"T63","span":{"begin":558,"end":560},"obj":"Body_part"},{"id":"T64","span":{"begin":562,"end":576},"obj":"Body_part"}],"attributes":[{"id":"A52","pred":"fma_id","subj":"T52","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A53","pred":"fma_id","subj":"T53","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A54","pred":"fma_id","subj":"T54","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A55","pred":"fma_id","subj":"T55","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A56","pred":"fma_id","subj":"T56","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A57","pred":"fma_id","subj":"T57","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A58","pred":"fma_id","subj":"T58","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A59","pred":"fma_id","subj":"T59","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A60","pred":"fma_id","subj":"T60","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A61","pred":"fma_id","subj":"T61","obj":"http://purl.org/sig/ont/fma/fma61898"},{"id":"A62","pred":"fma_id","subj":"T62","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A63","pred":"fma_id","subj":"T63","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A64","pred":"fma_id","subj":"T64","obj":"http://purl.org/sig/ont/fma/fma62871"}],"text":"to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer.\nTable 1 FcγR responses relevant to therapeutic monoclonal antibodies (mAbs).\nFcγR‐mediated mechanism o"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T19","span":{"begin":470,"end":474},"obj":"Disease"}],"attributes":[{"id":"A19","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0008734"}],"text":"to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer.\nTable 1 FcγR responses relevant to therapeutic monoclonal antibodies (mAbs).\nFcγR‐mediated mechanism o"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T100","span":{"begin":59,"end":61},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T101","span":{"begin":62,"end":64},"obj":"http://purl.obolibrary.org/obo/CLO_0008882"},{"id":"T102","span":{"begin":70,"end":71},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T103","span":{"begin":106,"end":108},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T104","span":{"begin":118,"end":124},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T105","span":{"begin":154,"end":158},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T106","span":{"begin":219,"end":221},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T107","span":{"begin":231,"end":235},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T108","span":{"begin":246,"end":247},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T109","span":{"begin":248,"end":254},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T110","span":{"begin":280,"end":284},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T111","span":{"begin":325,"end":335},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T112","span":{"begin":362,"end":367},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T113","span":{"begin":408,"end":415},"obj":"http://www.ebi.ac.uk/efo/EFO_0000876"},{"id":"T114","span":{"begin":495,"end":499},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T115","span":{"begin":541,"end":547},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T116","span":{"begin":607,"end":609},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T117","span":{"begin":676,"end":678},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"}],"text":"to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer.\nTable 1 FcγR responses relevant to therapeutic monoclonal antibodies (mAbs).\nFcγR‐mediated mechanism o"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T26","span":{"begin":145,"end":153},"obj":"Chemical"},{"id":"T27","span":{"begin":523,"end":525},"obj":"Chemical"},{"id":"T29","span":{"begin":527,"end":534},"obj":"Chemical"}],"attributes":[{"id":"A26","pred":"chebi_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/CHEBI_35224"},{"id":"A27","pred":"chebi_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/CHEBI_30512"},{"id":"A28","pred":"chebi_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/CHEBI_9141"},{"id":"A29","pred":"chebi_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"}],"text":"to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer.\nTable 1 FcγR responses relevant to therapeutic monoclonal antibodies (mAbs).\nFcγR‐mediated mechanism o"}

{"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T8","span":{"begin":558,"end":560},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"},{"id":"T9","span":{"begin":562,"end":576},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A8","pred":"meddra_id","subj":"T8","obj":"http://purl.bioontology.org/ontology/MEDDRA/10021496"},{"id":"A9","pred":"meddra_id","subj":"T9","obj":"http://purl.bioontology.org/ontology/MEDDRA/10021496"}],"text":"to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer.\nTable 1 FcγR responses relevant to therapeutic monoclonal antibodies (mAbs).\nFcγR‐mediated mechanism o"}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T39","span":{"begin":12,"end":28},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T40","span":{"begin":154,"end":158},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T41","span":{"begin":231,"end":235},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T42","span":{"begin":280,"end":284},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T43","span":{"begin":362,"end":367},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T44","span":{"begin":495,"end":499},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T45","span":{"begin":543,"end":547},"obj":"http://purl.obolibrary.org/obo/CL_0000000"}],"text":"to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer.\nTable 1 FcγR responses relevant to therapeutic monoclonal antibodies (mAbs).\nFcγR‐mediated mechanism o"}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"101","span":{"begin":509,"end":521},"obj":"Disease"},{"id":"88","span":{"begin":106,"end":113},"obj":"Gene"},{"id":"92","span":{"begin":219,"end":223},"obj":"Gene"},{"id":"94","span":{"begin":536,"end":539},"obj":"Gene"}],"attributes":[{"id":"A101","pred":"pubann:denotes","subj":"101","obj":"MESH:D064420"},{"id":"A88","pred":"pubann:denotes","subj":"88","obj":"Gene:2213"},{"id":"A92","pred":"pubann:denotes","subj":"92","obj":"Gene:2213"},{"id":"A94","pred":"pubann:denotes","subj":"94","obj":"Gene:613"}],"text":"to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer.\nTable 1 FcγR responses relevant to therapeutic monoclonal antibodies (mAbs).\nFcγR‐mediated mechanism o"}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T34","span":{"begin":86,"end":404},"obj":"Sentence"},{"id":"T35","span":{"begin":405,"end":469},"obj":"Sentence"},{"id":"T36","span":{"begin":470,"end":597},"obj":"Sentence"},{"id":"T37","span":{"begin":598,"end":675},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer.\nTable 1 FcγR responses relevant to therapeutic monoclonal antibodies (mAbs).\nFcγR‐mediated mechanism o"}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T52","span":{"begin":154,"end":158},"obj":"Body_part"},{"id":"T53","span":{"begin":203,"end":211},"obj":"Body_part"},{"id":"T54","span":{"begin":231,"end":235},"obj":"Body_part"},{"id":"T55","span":{"begin":280,"end":284},"obj":"Body_part"},{"id":"T56","span":{"begin":362,"end":367},"obj":"Body_part"},{"id":"T57","span":{"begin":394,"end":403},"obj":"Body_part"},{"id":"T58","span":{"begin":454,"end":462},"obj":"Body_part"},{"id":"T59","span":{"begin":476,"end":484},"obj":"Body_part"},{"id":"T60","span":{"begin":495,"end":499},"obj":"Body_part"},{"id":"T61","span":{"begin":543,"end":547},"obj":"Body_part"},{"id":"T62","span":{"begin":558,"end":560},"obj":"Body_part"},{"id":"T63","span":{"begin":562,"end":576},"obj":"Body_part"}],"attributes":[{"id":"A59","pred":"fma_id","subj":"T59","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A52","pred":"fma_id","subj":"T52","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A57","pred":"fma_id","subj":"T57","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A54","pred":"fma_id","subj":"T54","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A53","pred":"fma_id","subj":"T53","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A58","pred":"fma_id","subj":"T58","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A60","pred":"fma_id","subj":"T60","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A62","pred":"fma_id","subj":"T62","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A56","pred":"fma_id","subj":"T56","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A63","pred":"fma_id","subj":"T63","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A55","pred":"fma_id","subj":"T55","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A61","pred":"fma_id","subj":"T61","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer.\nTable 1 FcγR responses relevant to therapeutic monoclonal antibodies (mAbs).\nFcγR‐mediated mechanism o"}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T21","span":{"begin":12,"end":28},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T22","span":{"begin":299,"end":321},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T23","span":{"begin":312,"end":321},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T24","span":{"begin":381,"end":390},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T25","span":{"begin":470,"end":474},"obj":"http://purl.obolibrary.org/obo/GO_0001788"}],"text":"to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer.\nTable 1 FcγR responses relevant to therapeutic monoclonal antibodies (mAbs).\nFcγR‐mediated mechanism o"}

{"project":"LitCovid-sample-PD-HP","denotations":[{"id":"T4","span":{"begin":454,"end":468},"obj":"Phenotype"}],"attributes":[{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/HP_0033041"}],"text":"to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer.\nTable 1 FcγR responses relevant to therapeutic monoclonal antibodies (mAbs).\nFcγR‐mediated mechanism o"}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T21","span":{"begin":12,"end":28},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T22","span":{"begin":299,"end":321},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T23","span":{"begin":312,"end":321},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T24","span":{"begin":381,"end":390},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T25","span":{"begin":470,"end":474},"obj":"http://purl.obolibrary.org/obo/GO_0001788"}],"text":"to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer.\nTable 1 FcγR responses relevant to therapeutic monoclonal antibodies (mAbs).\nFcγR‐mediated mechanism o"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T21","span":{"begin":12,"end":28},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T22","span":{"begin":299,"end":321},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T23","span":{"begin":312,"end":321},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T24","span":{"begin":381,"end":390},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T25","span":{"begin":470,"end":474},"obj":"http://purl.obolibrary.org/obo/GO_0001788"}],"text":"to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer.\nTable 1 FcγR responses relevant to therapeutic monoclonal antibodies (mAbs).\nFcγR‐mediated mechanism o"}

{"project":"LitCovid-sentences","denotations":[{"id":"T34","span":{"begin":86,"end":404},"obj":"Sentence"},{"id":"T35","span":{"begin":405,"end":469},"obj":"Sentence"},{"id":"T36","span":{"begin":470,"end":597},"obj":"Sentence"},{"id":"T37","span":{"begin":598,"end":675},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer.\nTable 1 FcγR responses relevant to therapeutic monoclonal antibodies (mAbs).\nFcγR‐mediated mechanism o"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T4","span":{"begin":454,"end":468},"obj":"Phenotype"}],"attributes":[{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/HP_0033041"}],"text":"to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer.\nTable 1 FcγR responses relevant to therapeutic monoclonal antibodies (mAbs).\nFcγR‐mediated mechanism o"}