PMC:7228307 / 6915-7616
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 88 | 106-113 | Gene | denotes | FcγRIIb | Gene:2213 |
| 92 | 219-223 | Gene | denotes | FcγR | Gene:2213 |
| 94 | 536-539 | Gene | denotes | BCR | Gene:613 |
| 101 | 509-521 | Disease | denotes | cytotoxicity | MESH:D064420 |
| 133 | 676-680 | Gene | denotes | FcγR | Gene:2213 |
| 137 | 607-611 | Gene | denotes | FcγR | Gene:2213 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T52 | 154-158 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T53 | 203-211 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T54 | 231-235 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T55 | 280-284 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T56 | 362-367 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T57 | 394-403 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T58 | 454-462 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T59 | 476-484 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T60 | 495-499 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T61 | 523-525 | Body_part | denotes | Ag | http://purl.org/sig/ont/fma/fma61898 |
| T62 | 543-547 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T63 | 558-560 | Body_part | denotes | Ig | http://purl.org/sig/ont/fma/fma62871 |
| T64 | 562-576 | Body_part | denotes | immunoglobulin | http://purl.org/sig/ont/fma/fma62871 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T19 | 470-474 | Disease | denotes | ADCC | http://purl.obolibrary.org/obo/MONDO_0008734 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T100 | 59-61 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T101 | 62-64 | http://purl.obolibrary.org/obo/CLO_0008882 | denotes | Rs |
| T102 | 70-71 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T103 | 106-108 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T104 | 118-124 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
| T105 | 154-158 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T106 | 219-221 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T107 | 231-235 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T108 | 246-247 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T109 | 248-254 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
| T110 | 280-284 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T111 | 325-335 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T112 | 362-367 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T113 | 408-415 | http://www.ebi.ac.uk/efo/EFO_0000876 | denotes | extreme |
| T114 | 495-499 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T115 | 541-547 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B‐cell |
| T116 | 607-609 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T117 | 676-678 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T26 | 145-153 | Chemical | denotes | effector | http://purl.obolibrary.org/obo/CHEBI_35224 |
| T27 | 523-525 | Chemical | denotes | Ag | http://purl.obolibrary.org/obo/CHEBI_30512|http://purl.obolibrary.org/obo/CHEBI_9141 |
| T29 | 527-534 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
LitCovid-sample-MedDRA
| Id | Subject | Object | Predicate | Lexical cue | meddra_id |
|---|---|---|---|---|---|
| T8 | 558-560 | http://purl.bioontology.org/ontology/MEDDRA/10022891 | denotes | Ig | http://purl.bioontology.org/ontology/MEDDRA/10021496 |
| T9 | 562-576 | http://purl.bioontology.org/ontology/MEDDRA/10022891 | denotes | immunoglobulin | http://purl.bioontology.org/ontology/MEDDRA/10021496 |
LitCovid-sample-PD-IDO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T39 | 12-28 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune responses |
| T40 | 154-158 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
| T41 | 231-235 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
| T42 | 280-284 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
| T43 | 362-367 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
| T44 | 495-499 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
| T45 | 543-547 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
LitCovid-sample-Pubtator
| Id | Subject | Object | Predicate | Lexical cue | pubann:denotes |
|---|---|---|---|---|---|
| 101 | 509-521 | Disease | denotes | cytotoxicity | MESH:D064420 |
| 88 | 106-113 | Gene | denotes | FcγRIIb | Gene:2213 |
| 92 | 219-223 | Gene | denotes | FcγR | Gene:2213 |
| 94 | 536-539 | Gene | denotes | BCR | Gene:613 |
LitCovid-sample-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T34 | 86-404 | Sentence | denotes | Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. |
| T35 | 405-469 | Sentence | denotes | In extreme cases, this leads to life‐threatening cytokine storm. |
| T36 | 470-597 | Sentence | denotes | ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer. |
| T37 | 598-675 | Sentence | denotes | Table 1 FcγR responses relevant to therapeutic monoclonal antibodies (mAbs). |
LitCovid-sample-PD-FMA
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T52 | 154-158 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T53 | 203-211 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T54 | 231-235 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T55 | 280-284 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T56 | 362-367 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T57 | 394-403 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T58 | 454-462 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T59 | 476-484 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T60 | 495-499 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T61 | 543-547 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T62 | 558-560 | Body_part | denotes | Ig | http://purl.org/sig/ont/fma/fma62871 |
| T63 | 562-576 | Body_part | denotes | immunoglobulin | http://purl.org/sig/ont/fma/fma62871 |
LitCovid-sample-PD-GO-BP-0
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T21 | 12-28 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune responses |
| T22 | 299-321 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | induction of apoptosis |
| T23 | 312-321 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
| T24 | 381-390 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
| T25 | 470-474 | http://purl.obolibrary.org/obo/GO_0001788 | denotes | ADCC |
LitCovid-sample-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T4 | 454-468 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
LitCovid-sample-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T21 | 12-28 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune responses |
| T22 | 299-321 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | induction of apoptosis |
| T23 | 312-321 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
| T24 | 381-390 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
| T25 | 470-474 | http://purl.obolibrary.org/obo/GO_0001788 | denotes | ADCC |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T21 | 12-28 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune responses |
| T22 | 299-321 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | induction of apoptosis |
| T23 | 312-321 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
| T24 | 381-390 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
| T25 | 470-474 | http://purl.obolibrary.org/obo/GO_0001788 | denotes | ADCC |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T34 | 86-404 | Sentence | denotes | Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. |
| T35 | 405-469 | Sentence | denotes | In extreme cases, this leads to life‐threatening cytokine storm. |
| T36 | 470-597 | Sentence | denotes | ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer. |
| T37 | 598-675 | Sentence | denotes | Table 1 FcγR responses relevant to therapeutic monoclonal antibodies (mAbs). |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T4 | 454-468 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |