PMC:7228307 / 59886-60294 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7228307","sourcedb":"PMC","sourceid":"7228307","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7228307","text":"Further understanding of how antibody structure affects FcγR function is essential for future development of more potent and effective mAbs. Already, engineering of the IgG Fc and its glycan has proved a potent and effective approach for increasing the clinical effectiveness, functional specificity and safety of therapeutic mAbs and is an emerging pathway to the development of the “next‐gen” therapeutics.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"1220","span":{"begin":56,"end":60},"obj":"Gene"},{"id":"1221","span":{"begin":184,"end":190},"obj":"Chemical"}],"attributes":[{"id":"A1220","pred":"tao:has_database_id","subj":"1220","obj":"Gene:2213"},{"id":"A1221","pred":"tao:has_database_id","subj":"1221","obj":"MESH:D011134"},{"subj":"1220","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1221","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T454","span":{"begin":29,"end":37},"obj":"Body_part"},{"id":"T455","span":{"begin":169,"end":172},"obj":"Body_part"}],"attributes":[{"id":"A454","pred":"fma_id","subj":"T454","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A455","pred":"fma_id","subj":"T455","obj":"http://purl.org/sig/ont/fma/fma62872"},{"subj":"T454","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T455","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T991","span":{"begin":56,"end":58},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T992","span":{"begin":173,"end":175},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T993","span":{"begin":191,"end":194},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T994","span":{"begin":202,"end":203},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T991","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T992","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T993","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T994","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T254","span":{"begin":61,"end":69},"obj":"http://purl.obolibrary.org/obo/BFO_0000034"},{"id":"T255","span":{"begin":277,"end":287},"obj":"http://purl.obolibrary.org/obo/BFO_0000034"}],"attributes":[{"subj":"T254","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T255","pred":"source","obj":"LitCovid-sample-PD-IDO"}]},{"project":"LitCovid-sample-Enju","denotations":[{"id":"T393","span":{"begin":0,"end":7},"obj":"JJ"},{"id":"T394","span":{"begin":8,"end":21},"obj":"NN"},{"id":"T395","span":{"begin":22,"end":24},"obj":"IN"},{"id":"T396","span":{"begin":25,"end":28},"obj":"WRB"},{"id":"T397","span":{"begin":29,"end":37},"obj":"NN"},{"id":"T398","span":{"begin":38,"end":47},"obj":"NN"},{"id":"T399","span":{"begin":48,"end":55},"obj":"VBZ"},{"id":"T400","span":{"begin":56,"end":60},"obj":"NN"},{"id":"T401","span":{"begin":61,"end":69},"obj":"NN"},{"id":"T402","span":{"begin":70,"end":72},"obj":"VBZ"},{"id":"T403","span":{"begin":73,"end":82},"obj":"JJ"},{"id":"T404","span":{"begin":83,"end":86},"obj":"IN"},{"id":"T405","span":{"begin":87,"end":93},"obj":"JJ"},{"id":"T406","span":{"begin":94,"end":105},"obj":"NN"},{"id":"T407","span":{"begin":106,"end":108},"obj":"IN"},{"id":"T408","span":{"begin":109,"end":113},"obj":"RBR"},{"id":"T409","span":{"begin":114,"end":120},"obj":"JJ"},{"id":"T410","span":{"begin":121,"end":124},"obj":"CC"},{"id":"T411","span":{"begin":125,"end":134},"obj":"JJ"},{"id":"T412","span":{"begin":135,"end":139},"obj":"NNS"},{"id":"T413","span":{"begin":141,"end":148},"obj":"RB"},{"id":"T414","span":{"begin":148,"end":149},"obj":"-COMMA-"},{"id":"T415","span":{"begin":150,"end":161},"obj":"NN"},{"id":"T416","span":{"begin":162,"end":164},"obj":"IN"},{"id":"T417","span":{"begin":165,"end":168},"obj":"DT"},{"id":"T418","span":{"begin":169,"end":172},"obj":"NN"},{"id":"T419","span":{"begin":173,"end":175},"obj":"NN"},{"id":"T420","span":{"begin":176,"end":179},"obj":"CC"},{"id":"T421","span":{"begin":180,"end":183},"obj":"PRP-DOLLAR-"},{"id":"T422","span":{"begin":184,"end":190},"obj":"NN"},{"id":"T423","span":{"begin":191,"end":194},"obj":"VBZ"},{"id":"T424","span":{"begin":195,"end":201},"obj":"VBN"},{"id":"T425","span":{"begin":202,"end":203},"obj":"DT"},{"id":"T426","span":{"begin":204,"end":210},"obj":"JJ"},{"id":"T427","span":{"begin":211,"end":214},"obj":"CC"},{"id":"T428","span":{"begin":215,"end":224},"obj":"JJ"},{"id":"T429","span":{"begin":225,"end":233},"obj":"NN"},{"id":"T430","span":{"begin":234,"end":237},"obj":"IN"},{"id":"T431","span":{"begin":238,"end":248},"obj":"VBG"},{"id":"T432","span":{"begin":249,"end":252},"obj":"DT"},{"id":"T433","span":{"begin":253,"end":261},"obj":"JJ"},{"id":"T434","span":{"begin":262,"end":275},"obj":"NN"},{"id":"T435","span":{"begin":275,"end":276},"obj":"-COMMA-"},{"id":"T436","span":{"begin":277,"end":287},"obj":"JJ"},{"id":"T437","span":{"begin":288,"end":299},"obj":"NN"},{"id":"T438","span":{"begin":300,"end":303},"obj":"CC"},{"id":"T439","span":{"begin":304,"end":310},"obj":"NN"},{"id":"T440","span":{"begin":311,"end":313},"obj":"IN"},{"id":"T441","span":{"begin":314,"end":325},"obj":"JJ"},{"id":"T442","span":{"begin":326,"end":330},"obj":"NNS"},{"id":"T443","span":{"begin":331,"end":334},"obj":"CC"},{"id":"T444","span":{"begin":335,"end":337},"obj":"VBZ"},{"id":"T445","span":{"begin":338,"end":340},"obj":"DT"},{"id":"T446","span":{"begin":341,"end":349},"obj":"VBG"},{"id":"T447","span":{"begin":350,"end":357},"obj":"NN"},{"id":"T448","span":{"begin":358,"end":360},"obj":"TO"},{"id":"T449","span":{"begin":361,"end":364},"obj":"DT"},{"id":"T450","span":{"begin":365,"end":376},"obj":"NN"},{"id":"T451","span":{"begin":377,"end":379},"obj":"IN"},{"id":"T452","span":{"begin":380,"end":383},"obj":"DT"},{"id":"T453","span":{"begin":384,"end":394},"obj":"NN"},{"id":"T454","span":{"begin":395,"end":407},"obj":"NNS"}],"relations":[{"id":"R402","pred":"arg1Of","subj":"T394","obj":"T393"},{"id":"R403","pred":"arg1Of","subj":"T394","obj":"T395"},{"id":"R404","pred":"arg2Of","subj":"T396","obj":"T395"},{"id":"R405","pred":"arg1Of","subj":"T399","obj":"T396"},{"id":"R406","pred":"arg1Of","subj":"T398","obj":"T397"},{"id":"R407","pred":"arg1Of","subj":"T398","obj":"T399"},{"id":"R408","pred":"arg2Of","subj":"T401","obj":"T399"},{"id":"R409","pred":"arg1Of","subj":"T401","obj":"T400"},{"id":"R410","pred":"arg1Of","subj":"T394","obj":"T402"},{"id":"R411","pred":"arg2Of","subj":"T403","obj":"T402"},{"id":"R412","pred":"arg1Of","subj":"T394","obj":"T403"},{"id":"R413","pred":"arg1Of","subj":"T403","obj":"T404"},{"id":"R414","pred":"arg2Of","subj":"T406","obj":"T404"},{"id":"R415","pred":"arg1Of","subj":"T406","obj":"T405"},{"id":"R416","pred":"arg1Of","subj":"T406","obj":"T407"},{"id":"R417","pred":"arg2Of","subj":"T412","obj":"T407"},{"id":"R418","pred":"arg1Of","subj":"T412","obj":"T408"},{"id":"R419","pred":"arg1Of","subj":"T412","obj":"T409"},{"id":"R420","pred":"arg1Of","subj":"T409","obj":"T410"},{"id":"R421","pred":"arg2Of","subj":"T411","obj":"T410"},{"id":"R422","pred":"arg1Of","subj":"T412","obj":"T411"},{"id":"R423","pred":"arg1Of","subj":"T443","obj":"T413"},{"id":"R424","pred":"arg1Of","subj":"T443","obj":"T414"},{"id":"R425","pred":"arg1Of","subj":"T415","obj":"T416"},{"id":"R426","pred":"arg2Of","subj":"T420","obj":"T416"},{"id":"R427","pred":"arg1Of","subj":"T419","obj":"T417"},{"id":"R428","pred":"arg1Of","subj":"T419","obj":"T418"},{"id":"R429","pred":"arg1Of","subj":"T419","obj":"T420"},{"id":"R430","pred":"arg2Of","subj":"T422","obj":"T420"},{"id":"R431","pred":"arg1Of","subj":"T422","obj":"T421"},{"id":"R432","pred":"arg1Of","subj":"T415","obj":"T423"},{"id":"R433","pred":"arg2Of","subj":"T424","obj":"T423"},{"id":"R434","pred":"arg1Of","subj":"T415","obj":"T424"},{"id":"R435","pred":"arg2Of","subj":"T435","obj":"T424"},{"id":"R436","pred":"arg1Of","subj":"T429","obj":"T425"},{"id":"R437","pred":"arg1Of","subj":"T429","obj":"T426"},{"id":"R438","pred":"arg1Of","subj":"T426","obj":"T427"},{"id":"R439","pred":"arg2Of","subj":"T428","obj":"T427"},{"id":"R440","pred":"arg1Of","subj":"T429","obj":"T428"},{"id":"R441","pred":"arg1Of","subj":"T429","obj":"T430"},{"id":"R442","pred":"arg2Of","subj":"T431","obj":"T430"},{"id":"R443","pred":"arg2Of","subj":"T434","obj":"T431"},{"id":"R444","pred":"arg1Of","subj":"T434","obj":"T432"},{"id":"R445","pred":"arg1Of","subj":"T434","obj":"T433"},{"id":"R446","pred":"arg1Of","subj":"T429","obj":"T435"},{"id":"R447","pred":"arg2Of","subj":"T438","obj":"T435"},{"id":"R448","pred":"arg1Of","subj":"T438","obj":"T436"},{"id":"R449","pred":"arg1Of","subj":"T437","obj":"T438"},{"id":"R450","pred":"arg2Of","subj":"T439","obj":"T438"},{"id":"R451","pred":"arg1Of","subj":"T438","obj":"T440"},{"id":"R452","pred":"arg2Of","subj":"T442","obj":"T440"},{"id":"R453","pred":"arg1Of","subj":"T442","obj":"T441"},{"id":"R454","pred":"arg1Of","subj":"T424","obj":"T443"},{"id":"R455","pred":"arg2Of","subj":"T444","obj":"T443"},{"id":"R456","pred":"arg1Of","subj":"T415","obj":"T444"},{"id":"R457","pred":"arg2Of","subj":"T447","obj":"T444"},{"id":"R458","pred":"arg1Of","subj":"T447","obj":"T445"},{"id":"R459","pred":"arg1Of","subj":"T447","obj":"T446"},{"id":"R460","pred":"arg1Of","subj":"T447","obj":"T448"},{"id":"R461","pred":"arg2Of","subj":"T450","obj":"T448"},{"id":"R462","pred":"arg1Of","subj":"T450","obj":"T449"},{"id":"R463","pred":"arg1Of","subj":"T450","obj":"T451"},{"id":"R464","pred":"arg2Of","subj":"T454","obj":"T451"},{"id":"R465","pred":"arg1Of","subj":"T454","obj":"T452"},{"id":"R466","pred":"arg1Of","subj":"T454","obj":"T453"}],"attributes":[{"subj":"T393","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T394","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T395","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T396","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T397","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T398","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T399","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T400","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T401","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T402","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T403","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T404","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T405","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T406","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T407","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T408","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T409","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T410","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T411","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T412","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T413","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T414","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T415","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T416","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T417","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T418","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T419","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T420","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T421","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T422","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T423","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T424","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T425","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T426","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T427","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T428","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T429","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T430","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T431","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T432","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T433","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T434","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T435","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T436","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T437","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T438","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T439","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T440","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T441","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T442","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T443","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T444","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T445","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T446","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T447","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T448","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T449","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T450","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T451","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T452","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T453","pred":"source","obj":"LitCovid-sample-Enju"},{"subj":"T454","pred":"source","obj":"LitCovid-sample-Enju"}]},{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"1220","span":{"begin":56,"end":60},"obj":"Gene"},{"id":"1221","span":{"begin":184,"end":190},"obj":"Chemical"}],"attributes":[{"id":"A1220","pred":"pubann:denotes","subj":"1220","obj":"Gene:2213"},{"id":"A1221","pred":"pubann:denotes","subj":"1221","obj":"MESH:D011134"},{"subj":"1220","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1221","pred":"source","obj":"LitCovid-sample-Pubtator"}]},{"project":"LitCovid-sample-sentences","denotations":[{"id":"T332","span":{"begin":0,"end":140},"obj":"Sentence"},{"id":"T333","span":{"begin":141,"end":408},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T332","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T333","pred":"source","obj":"LitCovid-sample-sentences"}]},{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T453","span":{"begin":29,"end":37},"obj":"Body_part"},{"id":"T454","span":{"begin":169,"end":172},"obj":"Body_part"}],"attributes":[{"id":"A453","pred":"fma_id","subj":"T453","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A454","pred":"fma_id","subj":"T454","obj":"http://purl.org/sig/ont/fma/fma62872"},{"subj":"T453","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T454","pred":"source","obj":"LitCovid-sample-PD-FMA"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T332","span":{"begin":0,"end":140},"obj":"Sentence"},{"id":"T333","span":{"begin":141,"end":408},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T332","pred":"source","obj":"LitCovid-sentences"},{"subj":"T333","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#daec93","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#e493ec"},{"id":"LitCovid-PD-CLO","color":"#93ecca"},{"id":"LitCovid-sample-PD-IDO","color":"#ecb093"},{"id":"LitCovid-sample-Enju","color":"#9693ec"},{"id":"LitCovid-sample-Pubtator","color":"#aaec93"},{"id":"LitCovid-sample-sentences","color":"#ec93c4"},{"id":"LitCovid-sample-PD-FMA","color":"#93deec"},{"id":"LitCovid-sentences","color":"#ece093"}]}]}}