PMC:7228307 / 58610-58930 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"1198","span":{"begin":35,"end":42},"obj":"Gene"}],"attributes":[{"id":"A1198","pred":"tao:has_database_id","subj":"1198","obj":"Gene:2213"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In the case of CD40, the degree of FcγRIIb scaffolding potency is linked to the epitope location of the targeting mAb with greater potency seen for membrane proximal epitopes.43, 117 It is also noteworthy that depending on the epitope location, the scaffolding of anti‐CD40 mAbs may convert antagonist mAbs to agonistic."}

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{"project":"LitCovid-sample-PD-MAT","denotations":[{"id":"T25","span":{"begin":157,"end":165},"obj":"http://purl.obolibrary.org/obo/MAT_0000491"}],"text":"In the case of CD40, the degree of FcγRIIb scaffolding potency is linked to the epitope location of the targeting mAb with greater potency seen for membrane proximal epitopes.43, 117 It is also noteworthy that depending on the epitope location, the scaffolding of anti‐CD40 mAbs may convert antagonist mAbs to agonistic."}

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