PMC:7228307 / 58610-58930
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
1198 | 35-42 | Gene | denotes | FcγRIIb | Gene:2213 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T981 | 35-37 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
T982 | 148-156 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T80667 | 80-87 | Chemical | denotes | epitope | http://purl.obolibrary.org/obo/CHEBI_53000 |
T94340 | 227-234 | Chemical | denotes | epitope | http://purl.obolibrary.org/obo/CHEBI_53000 |
T17986 | 291-301 | Chemical | denotes | antagonist | http://purl.obolibrary.org/obo/CHEBI_48706 |
LitCovid-sample-Enju
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T199 | 0-2 | IN | denotes | In |
T200 | 3-6 | DT | denotes | the |
T201 | 7-11 | NN | denotes | case |
T202 | 12-14 | IN | denotes | of |
T203 | 15-19 | NN | denotes | CD40 |
T204 | 19-20 | -COMMA- | denotes | , |
T205 | 21-24 | DT | denotes | the |
T206 | 25-31 | NN | denotes | degree |
T207 | 32-34 | IN | denotes | of |
T208 | 35-42 | NN | denotes | FcγRIIb |
T209 | 43-54 | NN | denotes | scaffolding |
T210 | 55-62 | NN | denotes | potency |
T211 | 63-65 | VBZ | denotes | is |
T212 | 66-72 | VBN | denotes | linked |
T213 | 73-75 | TO | denotes | to |
T214 | 76-79 | DT | denotes | the |
T215 | 80-87 | NN | denotes | epitope |
T216 | 88-96 | NN | denotes | location |
T217 | 97-99 | IN | denotes | of |
T218 | 100-103 | DT | denotes | the |
T219 | 104-113 | VBG | denotes | targeting |
T220 | 114-117 | NN | denotes | mAb |
T221 | 118-122 | IN | denotes | with |
T222 | 123-130 | JJR | denotes | greater |
T223 | 131-138 | NN | denotes | potency |
T224 | 139-143 | VBN | denotes | seen |
T225 | 144-147 | IN | denotes | for |
T226 | 148-156 | NN | denotes | membrane |
T227 | 157-165 | JJ | denotes | proximal |
T228 | 166-177 | NN | denotes | epitopes.43 |
T229 | 177-178 | -COMMA- | denotes | , |
T230 | 179-182 | CD | denotes | 117 |
T231 | 183-185 | PRP | denotes | It |
T232 | 186-188 | VBZ | denotes | is |
T233 | 189-193 | RB | denotes | also |
T234 | 194-204 | JJ | denotes | noteworthy |
T235 | 205-209 | IN | denotes | that |
T236 | 210-219 | VBG | denotes | depending |
T237 | 220-222 | IN | denotes | on |
T238 | 223-226 | DT | denotes | the |
T239 | 227-234 | NN | denotes | epitope |
T240 | 235-243 | NN | denotes | location |
T241 | 243-244 | -COMMA- | denotes | , |
T242 | 245-248 | DT | denotes | the |
T243 | 249-260 | NN | denotes | scaffolding |
T244 | 261-263 | IN | denotes | of |
T245 | 264-273 | NN | denotes | anti‐CD40 |
T246 | 274-278 | NNS | denotes | mAbs |
T247 | 279-282 | MD | denotes | may |
T248 | 283-290 | VB | denotes | convert |
T249 | 291-301 | NN | denotes | antagonist |
T250 | 302-306 | NNS | denotes | mAbs |
T251 | 307-309 | TO | denotes | to |
T252 | 310-319 | JJ | denotes | agonistic |
R201 | T212 | T199 | arg1Of | linked,In |
R202 | T201 | T199 | arg2Of | case,In |
R203 | T201 | T200 | arg1Of | case,the |
R204 | T201 | T202 | arg1Of | case,of |
R205 | T203 | T202 | arg2Of | CD40,of |
R206 | T212 | T204 | arg1Of | linked,"," |
R207 | T206 | T205 | arg1Of | degree,the |
R208 | T206 | T207 | arg1Of | degree,of |
R209 | T210 | T207 | arg2Of | potency,of |
R210 | T210 | T208 | arg1Of | potency,FcγRIIb |
R211 | T210 | T209 | arg1Of | potency,scaffolding |
R212 | T206 | T211 | arg1Of | degree,is |
R213 | T212 | T211 | arg2Of | linked,is |
R214 | T232 | T211 | modOf | is,is |
R215 | T206 | T212 | arg2Of | degree,linked |
R216 | T212 | T213 | arg1Of | linked,to |
R217 | T216 | T213 | arg2Of | location,to |
R218 | T216 | T214 | arg1Of | location,the |
R219 | T216 | T215 | arg1Of | location,epitope |
R220 | T216 | T217 | arg1Of | location,of |
R221 | T219 | T217 | arg2Of | targeting,of |
R222 | T219 | T218 | arg1Of | targeting,the |
R223 | T218 | T219 | arg1Of | the,targeting |
R224 | T220 | T219 | arg2Of | mAb,targeting |
R225 | T219 | T221 | arg1Of | targeting,with |
R226 | T223 | T221 | arg2Of | potency,with |
R227 | T223 | T222 | arg1Of | potency,greater |
R228 | T223 | T224 | arg2Of | potency,seen |
R229 | T224 | T225 | arg1Of | seen,for |
R230 | T228 | T225 | arg2Of | epitopes.43,for |
R231 | T228 | T226 | arg1Of | epitopes.43,membrane |
R232 | T228 | T227 | arg1Of | epitopes.43,proximal |
R233 | T216 | T229 | arg1Of | location,"," |
R234 | T230 | T229 | arg2Of | 117,"," |
R235 | T248 | T231 | arg1Of | convert,It |
R236 | T248 | T232 | arg1Of | convert,is |
R237 | T234 | T232 | arg2Of | noteworthy,is |
R238 | T232 | T233 | arg1Of | is,also |
R239 | T248 | T234 | arg1Of | convert,noteworthy |
R240 | T248 | T235 | arg1Of | convert,that |
R241 | T248 | T236 | arg1Of | convert,depending |
R242 | T237 | T236 | arg2Of | on,depending |
R243 | T240 | T237 | arg2Of | location,on |
R244 | T240 | T238 | arg1Of | location,the |
R245 | T240 | T239 | arg1Of | location,epitope |
R246 | T248 | T241 | arg1Of | convert,"," |
R247 | T243 | T242 | arg1Of | scaffolding,the |
R248 | T243 | T244 | arg1Of | scaffolding,of |
R249 | T246 | T244 | arg2Of | mAbs,of |
R250 | T246 | T245 | arg1Of | mAbs,anti‐CD40 |
R251 | T243 | T247 | arg1Of | scaffolding,may |
R252 | T248 | T247 | arg2Of | convert,may |
R253 | T243 | T248 | arg1Of | scaffolding,convert |
R254 | T250 | T248 | arg2Of | mAbs,convert |
R255 | T250 | T249 | arg1Of | mAbs,antagonist |
R256 | T248 | T251 | arg1Of | convert,to |
R257 | T252 | T251 | arg2Of | agonistic,to |
LitCovid-sample-Pubtator
Id | Subject | Object | Predicate | Lexical cue | pubann:denotes |
---|---|---|---|---|---|
1198 | 35-42 | Gene | denotes | FcγRIIb | Gene:2213 |
LitCovid-sample-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T326 | 0-320 | Sentence | denotes | In the case of CD40, the degree of FcγRIIb scaffolding potency is linked to the epitope location of the targeting mAb with greater potency seen for membrane proximal epitopes.43, 117 It is also noteworthy that depending on the epitope location, the scaffolding of anti‐CD40 mAbs may convert antagonist mAbs to agonistic. |
LitCovid-sample-UniProt
Id | Subject | Object | Predicate | Lexical cue | uniprot_id |
---|---|---|---|---|---|
T773 | 15-19 | Protein | denotes | CD40 | https://www.uniprot.org/uniprot/Q9BYU0|https://www.uniprot.org/uniprot/Q99NE3|https://www.uniprot.org/uniprot/Q99NE2|https://www.uniprot.org/uniprot/Q99NE1|https://www.uniprot.org/uniprot/Q99NE0|https://www.uniprot.org/uniprot/Q8SQ34|https://www.uniprot.org/uniprot/Q8K2X6|https://www.uniprot.org/uniprot/Q86YK5|https://www.uniprot.org/uniprot/Q7YRL5|https://www.uniprot.org/uniprot/Q7M4Q8|https://www.uniprot.org/uniprot/Q5U007|https://www.uniprot.org/uniprot/Q5JY15|https://www.uniprot.org/uniprot/Q542B1|https://www.uniprot.org/uniprot/Q53GN5|https://www.uniprot.org/uniprot/Q3ZTK5|https://www.uniprot.org/uniprot/Q3UBH3|https://www.uniprot.org/uniprot/Q3U7C9|https://www.uniprot.org/uniprot/Q3U799|https://www.uniprot.org/uniprot/Q3TSL2|https://www.uniprot.org/uniprot/Q3TS33|https://www.uniprot.org/uniprot/Q3LRP1|https://www.uniprot.org/uniprot/Q28203|https://www.uniprot.org/uniprot/P27512|https://www.uniprot.org/uniprot/P25942|https://www.uniprot.org/uniprot/E1P5S9|https://www.uniprot.org/uniprot/A7YWS9 |
T799 | 269-273 | Protein | denotes | CD40 | https://www.uniprot.org/uniprot/Q9BYU0|https://www.uniprot.org/uniprot/Q99NE3|https://www.uniprot.org/uniprot/Q99NE2|https://www.uniprot.org/uniprot/Q99NE1|https://www.uniprot.org/uniprot/Q99NE0|https://www.uniprot.org/uniprot/Q8SQ34|https://www.uniprot.org/uniprot/Q8K2X6|https://www.uniprot.org/uniprot/Q86YK5|https://www.uniprot.org/uniprot/Q7YRL5|https://www.uniprot.org/uniprot/Q7M4Q8|https://www.uniprot.org/uniprot/Q5U007|https://www.uniprot.org/uniprot/Q5JY15|https://www.uniprot.org/uniprot/Q542B1|https://www.uniprot.org/uniprot/Q53GN5|https://www.uniprot.org/uniprot/Q3ZTK5|https://www.uniprot.org/uniprot/Q3UBH3|https://www.uniprot.org/uniprot/Q3U7C9|https://www.uniprot.org/uniprot/Q3U799|https://www.uniprot.org/uniprot/Q3TSL2|https://www.uniprot.org/uniprot/Q3TS33|https://www.uniprot.org/uniprot/Q3LRP1|https://www.uniprot.org/uniprot/Q28203|https://www.uniprot.org/uniprot/P27512|https://www.uniprot.org/uniprot/P25942|https://www.uniprot.org/uniprot/E1P5S9|https://www.uniprot.org/uniprot/A7YWS9 |
LitCovid-sample-PD-MAT
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T25 | 157-165 | http://purl.obolibrary.org/obo/MAT_0000491 | denotes | proximal |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T326 | 0-320 | Sentence | denotes | In the case of CD40, the degree of FcγRIIb scaffolding potency is linked to the epitope location of the targeting mAb with greater potency seen for membrane proximal epitopes.43, 117 It is also noteworthy that depending on the epitope location, the scaffolding of anti‐CD40 mAbs may convert antagonist mAbs to agonistic. |