PMC:7228307 / 36832-37441 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"630","span":{"begin":98,"end":101},"obj":"Gene"},{"id":"631","span":{"begin":240,"end":243},"obj":"Gene"},{"id":"632","span":{"begin":552,"end":556},"obj":"Gene"}],"attributes":[{"id":"A630","pred":"tao:has_database_id","subj":"630","obj":"Gene:51430"},{"id":"A631","pred":"tao:has_database_id","subj":"631","obj":"Gene:51430"},{"id":"A632","pred":"tao:has_database_id","subj":"632","obj":"Gene:2213"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The distinct conformers are formed when (1) each light chain is attached to the Cys131 residue of CH1 in the heavy chain (IgG2‐A conformer), (2) both light chains attach to the upper hinge (IgG2‐B) or (3) one light chain is attached to the CH1 Cys131 and one to the upper hinge of the other heavy chain (IgG2‐AB).71 This results in distinct positioning of the Fabs relative to the Fc portions in the different conformers, which has implications for the interaction with antigen and the capacity of IgG2 to cross‐link target molecules in the absence of FcγR binding, for example, in an agonistic mAb setting.72"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T682","span":{"begin":98,"end":101},"obj":"http://purl.obolibrary.org/obo/CLO_0002408"},{"id":"T683","span":{"begin":127,"end":128},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T684","span":{"begin":195,"end":196},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T685","span":{"begin":240,"end":243},"obj":"http://purl.obolibrary.org/obo/CLO_0002408"},{"id":"T686","span":{"begin":313,"end":315},"obj":"http://purl.obolibrary.org/obo/CLO_0054055"},{"id":"T687","span":{"begin":381,"end":383},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T688","span":{"begin":428,"end":431},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T689","span":{"begin":552,"end":554},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"}],"text":"The distinct conformers are formed when (1) each light chain is attached to the Cys131 residue of CH1 in the heavy chain (IgG2‐A conformer), (2) both light chains attach to the upper hinge (IgG2‐B) or (3) one light chain is attached to the CH1 Cys131 and one to the upper hinge of the other heavy chain (IgG2‐AB).71 This results in distinct positioning of the Fabs relative to the Fc portions in the different conformers, which has implications for the interaction with antigen and the capacity of IgG2 to cross‐link target molecules in the absence of FcγR binding, for example, in an agonistic mAb setting.72"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T201","span":{"begin":470,"end":477},"obj":"Chemical"},{"id":"T202","span":{"begin":524,"end":533},"obj":"Chemical"}],"attributes":[{"id":"A201","pred":"chebi_id","subj":"T201","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A202","pred":"chebi_id","subj":"T202","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"}],"text":"The distinct conformers are formed when (1) each light chain is attached to the Cys131 residue of CH1 in the heavy chain (IgG2‐A conformer), (2) both light chains attach to the upper hinge (IgG2‐B) or (3) one light chain is attached to the CH1 Cys131 and one to the upper hinge of the other heavy chain (IgG2‐AB).71 This results in distinct positioning of the Fabs relative to the Fc portions in the different conformers, which has implications for the interaction with antigen and the capacity of IgG2 to cross‐link target molecules in the absence of FcγR binding, for example, in an agonistic mAb setting.72"}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"630","span":{"begin":98,"end":101},"obj":"Gene"},{"id":"631","span":{"begin":240,"end":243},"obj":"Gene"},{"id":"632","span":{"begin":552,"end":556},"obj":"Gene"}],"attributes":[{"id":"A630","pred":"pubann:denotes","subj":"630","obj":"Gene:51430"},{"id":"A631","pred":"pubann:denotes","subj":"631","obj":"Gene:51430"},{"id":"A632","pred":"pubann:denotes","subj":"632","obj":"Gene:2213"}],"text":"The distinct conformers are formed when (1) each light chain is attached to the Cys131 residue of CH1 in the heavy chain (IgG2‐A conformer), (2) both light chains attach to the upper hinge (IgG2‐B) or (3) one light chain is attached to the CH1 Cys131 and one to the upper hinge of the other heavy chain (IgG2‐AB).71 This results in distinct positioning of the Fabs relative to the Fc portions in the different conformers, which has implications for the interaction with antigen and the capacity of IgG2 to cross‐link target molecules in the absence of FcγR binding, for example, in an agonistic mAb setting.72"}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T211","span":{"begin":0,"end":609},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The distinct conformers are formed when (1) each light chain is attached to the Cys131 residue of CH1 in the heavy chain (IgG2‐A conformer), (2) both light chains attach to the upper hinge (IgG2‐B) or (3) one light chain is attached to the CH1 Cys131 and one to the upper hinge of the other heavy chain (IgG2‐AB).71 This results in distinct positioning of the Fabs relative to the Fc portions in the different conformers, which has implications for the interaction with antigen and the capacity of IgG2 to cross‐link target molecules in the absence of FcγR binding, for example, in an agonistic mAb setting.72"}

{"project":"LitCovid-sentences","denotations":[{"id":"T211","span":{"begin":0,"end":609},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The distinct conformers are formed when (1) each light chain is attached to the Cys131 residue of CH1 in the heavy chain (IgG2‐A conformer), (2) both light chains attach to the upper hinge (IgG2‐B) or (3) one light chain is attached to the CH1 Cys131 and one to the upper hinge of the other heavy chain (IgG2‐AB).71 This results in distinct positioning of the Fabs relative to the Fc portions in the different conformers, which has implications for the interaction with antigen and the capacity of IgG2 to cross‐link target molecules in the absence of FcγR binding, for example, in an agonistic mAb setting.72"}