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PMC:7228307 / 36832-37441 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
630 98-101 Gene denotes CH1 Gene:51430
631 240-243 Gene denotes CH1 Gene:51430
632 552-556 Gene denotes FcγR Gene:2213

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T682 98-101 http://purl.obolibrary.org/obo/CLO_0002408 denotes CH1
T683 127-128 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T684 195-196 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T685 240-243 http://purl.obolibrary.org/obo/CLO_0002408 denotes CH1
T686 313-315 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T687 381-383 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T688 428-431 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T689 552-554 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T201 470-477 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T202 524-533 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
630 98-101 Gene denotes CH1 Gene:51430
631 240-243 Gene denotes CH1 Gene:51430
632 552-556 Gene denotes FcγR Gene:2213

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T211 0-609 Sentence denotes The distinct conformers are formed when (1) each light chain is attached to the Cys131 residue of CH1 in the heavy chain (IgG2‐A conformer), (2) both light chains attach to the upper hinge (IgG2‐B) or (3) one light chain is attached to the CH1 Cys131 and one to the upper hinge of the other heavy chain (IgG2‐AB).71 This results in distinct positioning of the Fabs relative to the Fc portions in the different conformers, which has implications for the interaction with antigen and the capacity of IgG2 to cross‐link target molecules in the absence of FcγR binding, for example, in an agonistic mAb setting.72

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T211 0-609 Sentence denotes The distinct conformers are formed when (1) each light chain is attached to the Cys131 residue of CH1 in the heavy chain (IgG2‐A conformer), (2) both light chains attach to the upper hinge (IgG2‐B) or (3) one light chain is attached to the CH1 Cys131 and one to the upper hinge of the other heavy chain (IgG2‐AB).71 This results in distinct positioning of the Fabs relative to the Fc portions in the different conformers, which has implications for the interaction with antigen and the capacity of IgG2 to cross‐link target molecules in the absence of FcγR binding, for example, in an agonistic mAb setting.72