PMC:7228307 / 26930-27768 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7228307","sourcedb":"PMC","sourceid":"7228307","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7228307","text":"The removal of immune complexes in humans depends primarily on the complement receptor pathway and to a lesser degree the FcγR. Among the FcγRs, it has been widely believed that immune complex removal only occurs by phagocytosis/endocytosis of activating‐type FcγR. Surprisingly, the inhibitory FcγRIIb, which lacks intrinsic activating function, plays a major role in clearance, and rapidly “sweeps” away small complexes from the circulation (Figure 1d).48, 49 A major tissue involved in the clearance is likely to be the LSEC, where FcγRIIb is expressed abundantly in mice and humans. This role is potentially important in resistance to viruses and toxins but may also be key to optimal performance of therapeutic IgG mAbs whose primary MOA is believed to be only neutralization of soluble macromolecules, for example, cytokines or IgE.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"481","span":{"begin":295,"end":302},"obj":"Gene"},{"id":"482","span":{"begin":535,"end":542},"obj":"Gene"},{"id":"483","span":{"begin":260,"end":264},"obj":"Gene"},{"id":"484","span":{"begin":122,"end":126},"obj":"Gene"},{"id":"485","span":{"begin":35,"end":41},"obj":"Species"},{"id":"486","span":{"begin":570,"end":574},"obj":"Species"},{"id":"487","span":{"begin":579,"end":585},"obj":"Species"}],"attributes":[{"id":"A481","pred":"tao:has_database_id","subj":"481","obj":"Gene:14130"},{"id":"A482","pred":"tao:has_database_id","subj":"482","obj":"Gene:14130"},{"id":"A483","pred":"tao:has_database_id","subj":"483","obj":"Gene:2213"},{"id":"A484","pred":"tao:has_database_id","subj":"484","obj":"Gene:2213"},{"id":"A485","pred":"tao:has_database_id","subj":"485","obj":"Tax:9606"},{"id":"A486","pred":"tao:has_database_id","subj":"486","obj":"Tax:10090"},{"id":"A487","pred":"tao:has_database_id","subj":"487","obj":"Tax:9606"},{"subj":"481","pred":"source","obj":"LitCovid-PubTator"},{"subj":"482","pred":"source","obj":"LitCovid-PubTator"},{"subj":"483","pred":"source","obj":"LitCovid-PubTator"},{"subj":"484","pred":"source","obj":"LitCovid-PubTator"},{"subj":"485","pred":"source","obj":"LitCovid-PubTator"},{"subj":"486","pred":"source","obj":"LitCovid-PubTator"},{"subj":"487","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T266","span":{"begin":470,"end":476},"obj":"Body_part"},{"id":"T267","span":{"begin":716,"end":719},"obj":"Body_part"},{"id":"T268","span":{"begin":821,"end":830},"obj":"Body_part"},{"id":"T269","span":{"begin":834,"end":837},"obj":"Body_part"}],"attributes":[{"id":"A266","pred":"fma_id","subj":"T266","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A267","pred":"fma_id","subj":"T267","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A268","pred":"fma_id","subj":"T268","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A269","pred":"fma_id","subj":"T269","obj":"http://purl.org/sig/ont/fma/fma62875"},{"subj":"T266","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T267","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T268","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T269","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T17","span":{"begin":470,"end":476},"obj":"Body_part"}],"attributes":[{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T51","span":{"begin":739,"end":742},"obj":"Disease"}],"attributes":[{"id":"A51","pred":"mondo_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/MONDO_0016702"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T517","span":{"begin":35,"end":41},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T518","span":{"begin":102,"end":103},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T519","span":{"begin":122,"end":124},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T520","span":{"begin":138,"end":140},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T521","span":{"begin":141,"end":143},"obj":"http://purl.obolibrary.org/obo/CLO_0008882"},{"id":"T522","span":{"begin":148,"end":151},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T523","span":{"begin":244,"end":254},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T524","span":{"begin":260,"end":262},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T525","span":{"begin":295,"end":297},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T526","span":{"begin":326,"end":336},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T527","span":{"begin":353,"end":354},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T528","span":{"begin":455,"end":457},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"},{"id":"T529","span":{"begin":462,"end":463},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T530","span":{"begin":535,"end":537},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T531","span":{"begin":579,"end":585},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T532","span":{"begin":639,"end":646},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"attributes":[{"subj":"T517","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T518","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T519","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T520","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T521","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T522","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T523","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T524","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T525","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T526","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T527","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T528","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T529","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T530","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T531","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T532","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T143","span":{"begin":651,"end":657},"obj":"Chemical"},{"id":"T144","span":{"begin":792,"end":806},"obj":"Chemical"}],"attributes":[{"id":"A143","pred":"chebi_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/CHEBI_27026"},{"id":"A144","pred":"chebi_id","subj":"T144","obj":"http://purl.obolibrary.org/obo/CHEBI_33839"},{"subj":"T143","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T144","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T162","span":{"begin":337,"end":345},"obj":"http://purl.obolibrary.org/obo/BFO_0000034"},{"id":"T163","span":{"begin":639,"end":646},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T164","span":{"begin":651,"end":657},"obj":"http://purl.obolibrary.org/obo/IDO_0000549"}],"attributes":[{"subj":"T162","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T163","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T164","pred":"source","obj":"LitCovid-sample-PD-IDO"}]},{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T28","span":{"begin":792,"end":806},"obj":"Chemical"}],"attributes":[{"id":"A28","pred":"chebi_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_33839"},{"subj":"T28","pred":"source","obj":"LitCovid-sample-CHEBI"}]},{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"481","span":{"begin":295,"end":302},"obj":"Gene"},{"id":"482","span":{"begin":535,"end":542},"obj":"Gene"},{"id":"483","span":{"begin":260,"end":264},"obj":"Gene"},{"id":"484","span":{"begin":122,"end":126},"obj":"Gene"},{"id":"485","span":{"begin":35,"end":41},"obj":"Species"},{"id":"486","span":{"begin":570,"end":574},"obj":"Species"},{"id":"487","span":{"begin":579,"end":585},"obj":"Species"}],"attributes":[{"id":"A481","pred":"pubann:denotes","subj":"481","obj":"Gene:14130"},{"id":"A482","pred":"pubann:denotes","subj":"482","obj":"Gene:14130"},{"id":"A483","pred":"pubann:denotes","subj":"483","obj":"Gene:2213"},{"id":"A484","pred":"pubann:denotes","subj":"484","obj":"Gene:2213"},{"id":"A485","pred":"pubann:denotes","subj":"485","obj":"Tax:9606"},{"id":"A486","pred":"pubann:denotes","subj":"486","obj":"Tax:10090"},{"id":"A487","pred":"pubann:denotes","subj":"487","obj":"Tax:9606"},{"subj":"481","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"482","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"483","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"484","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"485","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"486","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"487","pred":"source","obj":"LitCovid-sample-Pubtator"}]},{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T27","span":{"begin":35,"end":41},"obj":"Species"},{"id":"T28","span":{"begin":570,"end":574},"obj":"Species"},{"id":"T30","span":{"begin":579,"end":585},"obj":"Species"},{"id":"T31","span":{"begin":639,"end":646},"obj":"Species"}],"attributes":[{"id":"A27","pred":"ncbi_taxonomy_id","subj":"T27","obj":"NCBItxid:9605"},{"id":"A28","pred":"ncbi_taxonomy_id","subj":"T28","obj":"NCBItxid:10095"},{"id":"A29","pred":"ncbi_taxonomy_id","subj":"T28","obj":"NCBItxid:10088"},{"id":"A30","pred":"ncbi_taxonomy_id","subj":"T30","obj":"NCBItxid:9605"},{"id":"A31","pred":"ncbi_taxonomy_id","subj":"T31","obj":"NCBItxid:10239"},{"subj":"T27","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T28","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T30","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T31","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}]},{"project":"LitCovid-sample-sentences","denotations":[{"id":"T156","span":{"begin":0,"end":127},"obj":"Sentence"},{"id":"T157","span":{"begin":128,"end":265},"obj":"Sentence"},{"id":"T158","span":{"begin":266,"end":586},"obj":"Sentence"},{"id":"T159","span":{"begin":587,"end":838},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T156","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T157","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T158","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T159","pred":"source","obj":"LitCovid-sample-sentences"}]},{"project":"LitCovid-sample-PD-UBERON","denotations":[{"id":"T17","span":{"begin":470,"end":476},"obj":"Body_part"}],"attributes":[{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"subj":"T17","pred":"source","obj":"LitCovid-sample-PD-UBERON"}]},{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T265","span":{"begin":470,"end":476},"obj":"Body_part"},{"id":"T266","span":{"begin":716,"end":719},"obj":"Body_part"},{"id":"T267","span":{"begin":821,"end":830},"obj":"Body_part"},{"id":"T268","span":{"begin":834,"end":837},"obj":"Body_part"}],"attributes":[{"id":"A265","pred":"fma_id","subj":"T265","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A266","pred":"fma_id","subj":"T266","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A267","pred":"fma_id","subj":"T267","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A268","pred":"fma_id","subj":"T268","obj":"http://purl.org/sig/ont/fma/fma62875"},{"subj":"T265","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T266","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T267","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T268","pred":"source","obj":"LitCovid-sample-PD-FMA"}]},{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T76","span":{"begin":216,"end":228},"obj":"http://purl.obolibrary.org/obo/GO_0006909"},{"id":"T77","span":{"begin":229,"end":240},"obj":"http://purl.obolibrary.org/obo/GO_0006897"}],"attributes":[{"subj":"T76","pred":"source","obj":"LitCovid-sample-PD-GO-BP-0"},{"subj":"T77","pred":"source","obj":"LitCovid-sample-PD-GO-BP-0"}]},{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T76","span":{"begin":216,"end":228},"obj":"http://purl.obolibrary.org/obo/GO_0006909"},{"id":"T77","span":{"begin":229,"end":240},"obj":"http://purl.obolibrary.org/obo/GO_0006897"}],"attributes":[{"subj":"T76","pred":"source","obj":"LitCovid-sample-GO-BP"},{"subj":"T77","pred":"source","obj":"LitCovid-sample-GO-BP"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T76","span":{"begin":216,"end":228},"obj":"http://purl.obolibrary.org/obo/GO_0006909"},{"id":"T77","span":{"begin":229,"end":240},"obj":"http://purl.obolibrary.org/obo/GO_0006897"}],"attributes":[{"subj":"T76","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T77","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T156","span":{"begin":0,"end":127},"obj":"Sentence"},{"id":"T157","span":{"begin":128,"end":265},"obj":"Sentence"},{"id":"T158","span":{"begin":266,"end":586},"obj":"Sentence"},{"id":"T159","span":{"begin":587,"end":838},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T156","pred":"source","obj":"LitCovid-sentences"},{"subj":"T157","pred":"source","obj":"LitCovid-sentences"},{"subj":"T158","pred":"source","obj":"LitCovid-sentences"},{"subj":"T159","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#a7ec93","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#ec93c1"},{"id":"LitCovid-PD-UBERON","color":"#93dbec"},{"id":"LitCovid-PD-MONDO","color":"#ece393"},{"id":"LitCovid-PD-CLO","color":"#c993ec"},{"id":"LitCovid-PD-CHEBI","color":"#93ecaf"},{"id":"LitCovid-sample-PD-IDO","color":"#ec9493"},{"id":"LitCovid-sample-CHEBI","color":"#93abec"},{"id":"LitCovid-sample-Pubtator","color":"#c5ec93"},{"id":"LitCovid-sample-PD-NCBITaxon","color":"#ec93df"},{"id":"LitCovid-sample-sentences","color":"#93ecdf"},{"id":"LitCovid-sample-PD-UBERON","color":"#ecc593"},{"id":"LitCovid-sample-PD-FMA","color":"#ab93ec"},{"id":"LitCovid-sample-PD-GO-BP-0","color":"#95ec93"},{"id":"LitCovid-sample-GO-BP","color":"#ec93af"},{"id":"LitCovid-PD-GO-BP","color":"#93c9ec"},{"id":"LitCovid-sentences","color":"#e3ec93"}]}]}}