PMC:7228307 / 24052-24379 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"426","span":{"begin":274,"end":278},"obj":"Gene"},{"id":"427","span":{"begin":165,"end":169},"obj":"Gene"},{"id":"428","span":{"begin":115,"end":119},"obj":"Chemical"},{"id":"429","span":{"begin":98,"end":110},"obj":"Disease"}],"attributes":[{"id":"A426","pred":"tao:has_database_id","subj":"426","obj":"Gene:2213"},{"id":"A427","pred":"tao:has_database_id","subj":"427","obj":"Gene:2213"},{"id":"A429","pred":"tao:has_database_id","subj":"429","obj":"MESH:D064420"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Although the action of agonistic/antagonistic mAbs is mechanistically distinct to those eliciting cytotoxicity and ADCP, the distance segregation between target and FcγR+ cells is also important. Indeed, the membrane proximal epitopes of CD28 and CD40 are important for the FcγR function in the complex MOA of these mAbs.43, 44"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T247","span":{"begin":171,"end":176},"obj":"Body_part"}],"attributes":[{"id":"A247","pred":"fma_id","subj":"T247","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Although the action of agonistic/antagonistic mAbs is mechanistically distinct to those eliciting cytotoxicity and ADCP, the distance segregation between target and FcγR+ cells is also important. Indeed, the membrane proximal epitopes of CD28 and CD40 are important for the FcγR function in the complex MOA of these mAbs.43, 44"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T40","span":{"begin":115,"end":119},"obj":"Disease"},{"id":"T41","span":{"begin":303,"end":306},"obj":"Disease"}],"attributes":[{"id":"A40","pred":"mondo_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/MONDO_0022697"},{"id":"A41","pred":"mondo_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/MONDO_0016702"}],"text":"Although the action of agonistic/antagonistic mAbs is mechanistically distinct to those eliciting cytotoxicity and ADCP, the distance segregation between target and FcγR+ cells is also important. Indeed, the membrane proximal epitopes of CD28 and CD40 are important for the FcγR function in the complex MOA of these mAbs.43, 44"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T464","span":{"begin":165,"end":167},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T465","span":{"begin":171,"end":176},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T466","span":{"begin":208,"end":216},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T467","span":{"begin":274,"end":276},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"}],"text":"Although the action of agonistic/antagonistic mAbs is mechanistically distinct to those eliciting cytotoxicity and ADCP, the distance segregation between target and FcγR+ cells is also important. Indeed, the membrane proximal epitopes of CD28 and CD40 are important for the FcγR function in the complex MOA of these mAbs.43, 44"}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T141","span":{"begin":171,"end":176},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T142","span":{"begin":279,"end":287},"obj":"http://purl.obolibrary.org/obo/BFO_0000034"}],"text":"Although the action of agonistic/antagonistic mAbs is mechanistically distinct to those eliciting cytotoxicity and ADCP, the distance segregation between target and FcγR+ cells is also important. Indeed, the membrane proximal epitopes of CD28 and CD40 are important for the FcγR function in the complex MOA of these mAbs.43, 44"}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"426","span":{"begin":274,"end":278},"obj":"Gene"},{"id":"427","span":{"begin":165,"end":169},"obj":"Gene"},{"id":"428","span":{"begin":115,"end":119},"obj":"Chemical"},{"id":"429","span":{"begin":98,"end":110},"obj":"Disease"}],"attributes":[{"id":"A427","pred":"pubann:denotes","subj":"427","obj":"Gene:2213"},{"id":"A426","pred":"pubann:denotes","subj":"426","obj":"Gene:2213"},{"id":"A429","pred":"pubann:denotes","subj":"429","obj":"MESH:D064420"}],"text":"Although the action of agonistic/antagonistic mAbs is mechanistically distinct to those eliciting cytotoxicity and ADCP, the distance segregation between target and FcγR+ cells is also important. Indeed, the membrane proximal epitopes of CD28 and CD40 are important for the FcγR function in the complex MOA of these mAbs.43, 44"}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T139","span":{"begin":0,"end":195},"obj":"Sentence"},{"id":"T140","span":{"begin":196,"end":327},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Although the action of agonistic/antagonistic mAbs is mechanistically distinct to those eliciting cytotoxicity and ADCP, the distance segregation between target and FcγR+ cells is also important. Indeed, the membrane proximal epitopes of CD28 and CD40 are important for the FcγR function in the complex MOA of these mAbs.43, 44"}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T250","span":{"begin":238,"end":242},"obj":"Protein"},{"id":"T266","span":{"begin":247,"end":251},"obj":"Protein"}],"attributes":[{"id":"A250","pred":"uniprot_id","subj":"T250","obj":"https://www.uniprot.org/uniprot/Q9BYV0"},{"id":"A251","pred":"uniprot_id","subj":"T250","obj":"https://www.uniprot.org/uniprot/Q8WXJ2"},{"id":"A252","pred":"uniprot_id","subj":"T250","obj":"https://www.uniprot.org/uniprot/Q8NI56"},{"id":"A253","pred":"uniprot_id","subj":"T250","obj":"https://www.uniprot.org/uniprot/Q8NI55"},{"id":"A254","pred":"uniprot_id","subj":"T250","obj":"https://www.uniprot.org/uniprot/Q8NI54"},{"id":"A255","pred":"uniprot_id","subj":"T250","obj":"https://www.uniprot.org/uniprot/Q70WG0"},{"id":"A256","pred":"uniprot_id","subj":"T250","obj":"https://www.uniprot.org/uniprot/Q6GSH7"},{"id":"A257","pred":"uniprot_id","subj":"T250","obj":"https://www.uniprot.org/uniprot/Q52M23"},{"id":"A258","pred":"uniprot_id","subj":"T250","obj":"https://www.uniprot.org/uniprot/Q28071"},{"id":"A259","pred":"uniprot_id","subj":"T250","obj":"https://www.uniprot.org/uniprot/Q13964"},{"id":"A260","pred":"uniprot_id","subj":"T250","obj":"https://www.uniprot.org/uniprot/P42069"},{"id":"A261","pred":"uniprot_id","subj":"T250","obj":"https://www.uniprot.org/uniprot/P31042"},{"id":"A262","pred":"uniprot_id","subj":"T250","obj":"https://www.uniprot.org/uniprot/P31041"},{"id":"A263","pred":"uniprot_id","subj":"T250","obj":"https://www.uniprot.org/uniprot/P10747"},{"id":"A264","pred":"uniprot_id","subj":"T250","obj":"https://www.uniprot.org/uniprot/O02757"},{"id":"A265","pred":"uniprot_id","subj":"T250","obj":"https://www.uniprot.org/uniprot/A8KAC1"},{"id":"A266","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/Q9BYU0"},{"id":"A267","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/Q99NE3"},{"id":"A268","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/Q99NE2"},{"id":"A269","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/Q99NE1"},{"id":"A270","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/Q99NE0"},{"id":"A271","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/Q8SQ34"},{"id":"A272","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/Q8K2X6"},{"id":"A273","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/Q86YK5"},{"id":"A274","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/Q7YRL5"},{"id":"A275","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/Q7M4Q8"},{"id":"A276","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/Q5U007"},{"id":"A277","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/Q5JY15"},{"id":"A278","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/Q542B1"},{"id":"A279","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/Q53GN5"},{"id":"A280","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/Q3ZTK5"},{"id":"A281","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/Q3UBH3"},{"id":"A282","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/Q3U7C9"},{"id":"A283","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/Q3U799"},{"id":"A284","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/Q3TSL2"},{"id":"A285","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/Q3TS33"},{"id":"A286","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/Q3LRP1"},{"id":"A287","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/Q28203"},{"id":"A288","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/P27512"},{"id":"A289","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/P25942"},{"id":"A290","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/E1P5S9"},{"id":"A291","pred":"uniprot_id","subj":"T266","obj":"https://www.uniprot.org/uniprot/A7YWS9"}],"text":"Although the action of agonistic/antagonistic mAbs is mechanistically distinct to those eliciting cytotoxicity and ADCP, the distance segregation between target and FcγR+ cells is also important. Indeed, the membrane proximal epitopes of CD28 and CD40 are important for the FcγR function in the complex MOA of these mAbs.43, 44"}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T246","span":{"begin":171,"end":176},"obj":"Body_part"}],"attributes":[{"id":"A246","pred":"fma_id","subj":"T246","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Although the action of agonistic/antagonistic mAbs is mechanistically distinct to those eliciting cytotoxicity and ADCP, the distance segregation between target and FcγR+ cells is also important. Indeed, the membrane proximal epitopes of CD28 and CD40 are important for the FcγR function in the complex MOA of these mAbs.43, 44"}

{"project":"LitCovid-sample-PD-MAT","denotations":[{"id":"T10","span":{"begin":217,"end":225},"obj":"http://purl.obolibrary.org/obo/MAT_0000491"}],"text":"Although the action of agonistic/antagonistic mAbs is mechanistically distinct to those eliciting cytotoxicity and ADCP, the distance segregation between target and FcγR+ cells is also important. Indeed, the membrane proximal epitopes of CD28 and CD40 are important for the FcγR function in the complex MOA of these mAbs.43, 44"}

{"project":"LitCovid-sentences","denotations":[{"id":"T139","span":{"begin":0,"end":195},"obj":"Sentence"},{"id":"T140","span":{"begin":196,"end":327},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Although the action of agonistic/antagonistic mAbs is mechanistically distinct to those eliciting cytotoxicity and ADCP, the distance segregation between target and FcγR+ cells is also important. Indeed, the membrane proximal epitopes of CD28 and CD40 are important for the FcγR function in the complex MOA of these mAbs.43, 44"}