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PMC:7228307 / 160-1974 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
16 1594-1601 Gene denotes FcγRIIb Gene:2213
17 1710-1714 Gene denotes FcγR Gene:2213
18 1640-1644 Gene denotes FcγR Gene:2213
19 1225-1229 Gene denotes FcγR Gene:2213
20 780-784 Gene denotes FcγR Gene:2213
21 423-427 Gene denotes FcγR Gene:2213
22 4-9 Species denotes human Tax:9606
23 1029-1076 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
24 1078-1088 Species denotes SARS‐CoV‐2 Tax:2697049
25 1433-1439 Chemical denotes glycan MESH:D011134
26 520-526 Disease denotes cancer MESH:D009369
27 967-974 Disease denotes cancers MESH:D009369
28 976-997 Disease denotes inflammatory diseases MESH:D007249
29 1010-1020 Disease denotes infections MESH:D007239

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T2 86-100 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T3 101-106 Body_part denotes (Ig)G http://purl.org/sig/ont/fma/fma62872
T4 102-104 Body_part denotes Ig http://purl.org/sig/ont/fma/fma62871
T5 527-532 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T6 542-550 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T7 685-694 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T8 1443-1450 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T9 1719-1722 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T2 520-526 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T3 976-997 Disease denotes inflammatory diseases http://purl.obolibrary.org/obo/MONDO_0021166
T4 1010-1020 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T5 1029-1076 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T6 1029-1062 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T7 1078-1082 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T5 4-9 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T6 35-37 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T7 123-131 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T8 145-146 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T9 423-425 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T10 527-532 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11 737-740 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T12 755-756 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T13 780-782 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T14 1163-1164 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T15 1225-1227 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T16 1287-1289 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T17 1290-1292 http://purl.obolibrary.org/obo/CLO_0008882 denotes Rs
T18 1425-1432 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T19 1470-1472 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T20 1559-1569 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T21 1570-1572 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T22 1573-1575 http://purl.obolibrary.org/obo/CLO_0008882 denotes Rs
T23 1594-1596 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T24 1640-1642 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T25 1710-1712 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 68-75 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T2 107-114 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T3 196-204 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T4 437-445 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T5 662-676 Chemical denotes macromolecules http://purl.obolibrary.org/obo/CHEBI_33839
T6 1443-1450 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T1 86-100 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes immunoglobulin http://purl.bioontology.org/ontology/MEDDRA/10021496
T2 102-104 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes Ig http://purl.bioontology.org/ontology/MEDDRA/10021496

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T2 180-184 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T3 205-214 http://purl.obolibrary.org/obo/BFO_0000034 denotes functions
T4 277-286 http://purl.obolibrary.org/obo/IDO_0000528 denotes pathogens
T5 527-532 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T6 989-997 http://purl.obolibrary.org/obo/OGMS_0000031 denotes diseases
T7 1010-1020 http://purl.obolibrary.org/obo/IDO_0000586 denotes infections
T8 1230-1238 http://purl.obolibrary.org/obo/BFO_0000034 denotes function

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 662-676 Chemical denotes macromolecules http://purl.obolibrary.org/obo/CHEBI_33839
T2 1443-1450 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
16 1594-1601 Gene denotes FcγRIIb Gene:2213
17 1710-1714 Gene denotes FcγR Gene:2213
18 1640-1644 Gene denotes FcγR Gene:2213
19 1225-1229 Gene denotes FcγR Gene:2213
20 780-784 Gene denotes FcγR Gene:2213
21 423-427 Gene denotes FcγR Gene:2213
22 4-9 Species denotes human Tax:9606
23 1029-1076 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
24 1078-1088 Species denotes SARS‐CoV‐2 Tax:2697049
25 1433-1439 Chemical denotes glycan MESH:D011134
26 520-526 Disease denotes cancer MESH:D009369
27 967-974 Disease denotes cancers MESH:D009369
28 976-997 Disease denotes inflammatory diseases MESH:D007249
29 1010-1020 Disease denotes infections MESH:D007239

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T1 4-9 Species denotes human NCBItxid:9606
T2 1029-1076 Species denotes severe acute respiratory syndrome coronavirus 2 NCBItxid:2697049
T3 1078-1088 Species denotes SARS‐CoV‐2 NCBItxid:2697049

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T6 0-287 Sentence denotes The human fragment crystallizable (Fc)γ receptor (R) interacts with antigen‐complexed immunoglobulin (Ig)G ligands to both activate and modulate a powerful network of inflammatory host‐protective effector functions that are key to the normal physiology of immune resistance to pathogens.
T7 288-473 Sentence denotes More than 100 therapeutic monoclonal antibodies (mAbs) are approved or in late stage clinical trials, many of which harness the potent FcγR‐mediated effector systems to varying degrees.
T8 474-708 Sentence denotes This is most evident for antibodies targeting cancer cells inducing antibody‐dependent killing or phagocytosis but is also true to some degree for the mAbs that neutralize or remove small macromolecules such as cytokines or other Igs.
T9 709-925 Sentence denotes The use of mAb therapeutics has also revealed a “scaffolding” role for FcγR which, in different contexts, may either underpin the therapeutic mAb action such as immune agonism or trigger catastrophic adverse effects.
T10 926-1162 Sentence denotes The still unmet therapeutic need in many cancers, inflammatory diseases or emerging infections such as severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) requires increased effort on the development of improved and novel mAbs.
T11 1163-1384 Sentence denotes A more mature appreciation of the immunobiology of individual FcγR function and the complexity of the relationships between FcγRs and antibodies is fueling efforts to develop more potent “next‐gen” therapeutic antibodies.
T12 1385-1668 Sentence denotes Such development strategies now include focused glycan or protein engineering of the Fc to increase affinity and/or tailor specificity for selective engagement of individual activating FcγRs or the inhibitory FcγRIIb or alternatively, for the ablation of FcγR interaction altogether.
T13 1669-1814 Sentence denotes This review touches on recent aspects of FcγR and IgG immunobiology and its relationship with the present and future actions of therapeutic mAbs.

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T2 86-100 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T3 101-106 Body_part denotes (Ig)G http://purl.org/sig/ont/fma/fma62872
T4 102-104 Body_part denotes Ig http://purl.org/sig/ont/fma/fma62871
T5 527-532 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T6 542-550 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T7 685-694 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T8 1443-1450 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T9 1719-1722 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T1 572-584 http://purl.obolibrary.org/obo/GO_0006909 denotes phagocytosis

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 520-526 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T2 976-997 Disease denotes inflammatory diseases http://purl.obolibrary.org/obo/MONDO_0021166
T3 1010-1020 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T4 1029-1076 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T5 1078-1088 Disease denotes SARS‐CoV‐2 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-sample-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 520-526 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T1 572-584 http://purl.obolibrary.org/obo/GO_0006909 denotes phagocytosis

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 572-584 http://purl.obolibrary.org/obo/GO_0006909 denotes phagocytosis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T6 0-287 Sentence denotes The human fragment crystallizable (Fc)γ receptor (R) interacts with antigen‐complexed immunoglobulin (Ig)G ligands to both activate and modulate a powerful network of inflammatory host‐protective effector functions that are key to the normal physiology of immune resistance to pathogens.
T7 288-473 Sentence denotes More than 100 therapeutic monoclonal antibodies (mAbs) are approved or in late stage clinical trials, many of which harness the potent FcγR‐mediated effector systems to varying degrees.
T8 474-708 Sentence denotes This is most evident for antibodies targeting cancer cells inducing antibody‐dependent killing or phagocytosis but is also true to some degree for the mAbs that neutralize or remove small macromolecules such as cytokines or other Igs.
T9 709-925 Sentence denotes The use of mAb therapeutics has also revealed a “scaffolding” role for FcγR which, in different contexts, may either underpin the therapeutic mAb action such as immune agonism or trigger catastrophic adverse effects.
T10 926-1162 Sentence denotes The still unmet therapeutic need in many cancers, inflammatory diseases or emerging infections such as severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) requires increased effort on the development of improved and novel mAbs.
T11 1163-1384 Sentence denotes A more mature appreciation of the immunobiology of individual FcγR function and the complexity of the relationships between FcγRs and antibodies is fueling efforts to develop more potent “next‐gen” therapeutic antibodies.
T12 1385-1668 Sentence denotes Such development strategies now include focused glycan or protein engineering of the Fc to increase affinity and/or tailor specificity for selective engagement of individual activating FcγRs or the inhibitory FcγRIIb or alternatively, for the ablation of FcγR interaction altogether.
T13 1669-1814 Sentence denotes This review touches on recent aspects of FcγR and IgG immunobiology and its relationship with the present and future actions of therapeutic mAbs.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 520-526 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664