PMC:7228307 / 12574-13723 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"246","span":{"begin":643,"end":648},"obj":"Gene"},{"id":"247","span":{"begin":650,"end":657},"obj":"Gene"},{"id":"248","span":{"begin":668,"end":671},"obj":"Gene"},{"id":"249","span":{"begin":307,"end":310},"obj":"Gene"},{"id":"250","span":{"begin":166,"end":170},"obj":"Gene"},{"id":"251","span":{"begin":69,"end":73},"obj":"Gene"},{"id":"252","span":{"begin":659,"end":666},"obj":"Gene"},{"id":"253","span":{"begin":291,"end":298},"obj":"Gene"},{"id":"254","span":{"begin":386,"end":395},"obj":"Chemical"},{"id":"255","span":{"begin":625,"end":635},"obj":"Chemical"},{"id":"257","span":{"begin":924,"end":932},"obj":"Disease"}],"attributes":[{"id":"A246","pred":"tao:has_database_id","subj":"246","obj":"Gene:2214"},{"id":"A247","pred":"tao:has_database_id","subj":"247","obj":"Gene:2213"},{"id":"A248","pred":"tao:has_database_id","subj":"248","obj":"Gene:51430"},{"id":"A249","pred":"tao:has_database_id","subj":"249","obj":"Gene:51430"},{"id":"A250","pred":"tao:has_database_id","subj":"250","obj":"Gene:2213"},{"id":"A251","pred":"tao:has_database_id","subj":"251","obj":"Gene:2213"},{"id":"A252","pred":"tao:has_database_id","subj":"252","obj":"Gene:9103"},{"id":"A253","pred":"tao:has_database_id","subj":"253","obj":"Gene:2212"},{"id":"A254","pred":"tao:has_database_id","subj":"254","obj":"MESH:D004220"},{"id":"A255","pred":"tao:has_database_id","subj":"255","obj":"MESH:D004220"},{"id":"A257","pred":"tao:has_database_id","subj":"257","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Table 3 Unique features of IgG subclass Fc and hinge.\nIgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange\nIg, immunoglobulin.\nJohn Wiley \u0026 Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T131","span":{"begin":28,"end":31},"obj":"Body_part"},{"id":"T132","span":{"begin":55,"end":58},"obj":"Body_part"},{"id":"T133","span":{"begin":777,"end":780},"obj":"Body_part"},{"id":"T134","span":{"begin":799,"end":801},"obj":"Body_part"},{"id":"T135","span":{"begin":803,"end":817},"obj":"Body_part"}],"attributes":[{"id":"A131","pred":"fma_id","subj":"T131","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A132","pred":"fma_id","subj":"T132","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A133","pred":"fma_id","subj":"T133","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A134","pred":"fma_id","subj":"T134","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A135","pred":"fma_id","subj":"T135","obj":"http://purl.org/sig/ont/fma/fma62871"}],"text":"Table 3 Unique features of IgG subclass Fc and hinge.\nIgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange\nIg, immunoglobulin.\nJohn Wiley \u0026 Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T23","span":{"begin":924,"end":932},"obj":"Disease"}],"attributes":[{"id":"A23","pred":"mondo_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Table 3 Unique features of IgG subclass Fc and hinge.\nIgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange\nIg, immunoglobulin.\nJohn Wiley \u0026 Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T228","span":{"begin":41,"end":43},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T229","span":{"begin":69,"end":71},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T230","span":{"begin":134,"end":136},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T231","span":{"begin":166,"end":168},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T232","span":{"begin":217,"end":219},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T233","span":{"begin":291,"end":293},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T234","span":{"begin":307,"end":310},"obj":"http://purl.obolibrary.org/obo/CLO_0002408"},{"id":"T235","span":{"begin":585,"end":586},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T236","span":{"begin":643,"end":645},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T237","span":{"begin":650,"end":652},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T238","span":{"begin":659,"end":661},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T239","span":{"begin":668,"end":671},"obj":"http://purl.obolibrary.org/obo/CLO_0002408"}],"text":"Table 3 Unique features of IgG subclass Fc and hinge.\nIgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange\nIg, immunoglobulin.\nJohn Wiley \u0026 Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T58","span":{"begin":87,"end":92},"obj":"Chemical"},{"id":"T59","span":{"begin":185,"end":190},"obj":"Chemical"},{"id":"T60","span":{"begin":386,"end":395},"obj":"Chemical"},{"id":"T61","span":{"begin":564,"end":572},"obj":"Chemical"},{"id":"T62","span":{"begin":625,"end":635},"obj":"Chemical"},{"id":"T64","span":{"begin":646,"end":648},"obj":"Chemical"},{"id":"T66","span":{"begin":781,"end":789},"obj":"Chemical"}],"attributes":[{"id":"A58","pred":"chebi_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/CHEBI_30212"},{"id":"A59","pred":"chebi_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/CHEBI_30212"},{"id":"A60","pred":"chebi_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/CHEBI_48343"},{"id":"A61","pred":"chebi_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A62","pred":"chebi_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/CHEBI_35489"},{"id":"A63","pred":"chebi_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/CHEBI_48343"},{"id":"A64","pred":"chebi_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/CHEBI_73814"},{"id":"A65","pred":"chebi_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/CHEBI_8753"},{"id":"A66","pred":"chebi_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"}],"text":"Table 3 Unique features of IgG subclass Fc and hinge.\nIgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange\nIg, immunoglobulin.\nJohn Wiley \u0026 Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency."}

{"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T12","span":{"begin":799,"end":801},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"},{"id":"T13","span":{"begin":803,"end":817},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A12","pred":"meddra_id","subj":"T12","obj":"http://purl.bioontology.org/ontology/MEDDRA/10021496"},{"id":"A13","pred":"meddra_id","subj":"T13","obj":"http://purl.bioontology.org/ontology/MEDDRA/10021496"}],"text":"Table 3 Unique features of IgG subclass Fc and hinge.\nIgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange\nIg, immunoglobulin.\nJohn Wiley \u0026 Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency."}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T9","span":{"begin":386,"end":395},"obj":"Chemical"},{"id":"T10","span":{"begin":625,"end":635},"obj":"Chemical"}],"attributes":[{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_48343"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_35489"},{"id":"A11","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_48343"}],"text":"Table 3 Unique features of IgG subclass Fc and hinge.\nIgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange\nIg, immunoglobulin.\nJohn Wiley \u0026 Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"246","span":{"begin":643,"end":648},"obj":"Gene"},{"id":"247","span":{"begin":650,"end":657},"obj":"Gene"},{"id":"248","span":{"begin":668,"end":671},"obj":"Gene"},{"id":"249","span":{"begin":307,"end":310},"obj":"Gene"},{"id":"250","span":{"begin":166,"end":170},"obj":"Gene"},{"id":"252","span":{"begin":659,"end":666},"obj":"Gene"},{"id":"253","span":{"begin":291,"end":298},"obj":"Gene"},{"id":"254","span":{"begin":386,"end":395},"obj":"Chemical"},{"id":"255","span":{"begin":625,"end":635},"obj":"Chemical"}],"attributes":[{"id":"A253","pred":"pubann:denotes","subj":"253","obj":"Gene:2212"},{"id":"A249","pred":"pubann:denotes","subj":"249","obj":"Gene:51430"},{"id":"A250","pred":"pubann:denotes","subj":"250","obj":"Gene:2213"},{"id":"A247","pred":"pubann:denotes","subj":"247","obj":"Gene:2213"},{"id":"A254","pred":"pubann:denotes","subj":"254","obj":"MESH:D004220"},{"id":"A248","pred":"pubann:denotes","subj":"248","obj":"Gene:51430"},{"id":"A246","pred":"pubann:denotes","subj":"246","obj":"Gene:2214"},{"id":"A255","pred":"pubann:denotes","subj":"255","obj":"MESH:D004220"},{"id":"A252","pred":"pubann:denotes","subj":"252","obj":"Gene:9103"}],"text":"Table 3 Unique features of IgG subclass Fc and hinge.\nIgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange\nIg, immunoglobulin.\nJohn Wiley \u0026 Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency."}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T13","span":{"begin":924,"end":932},"obj":"Species"}],"attributes":[{"id":"A13","pred":"ncbi_taxonomy_id","subj":"T13","obj":"NCBItxid:2697049"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"Table 3 Unique features of IgG subclass Fc and hinge.\nIgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange\nIg, immunoglobulin.\nJohn Wiley \u0026 Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T76","span":{"begin":0,"end":54},"obj":"Sentence"},{"id":"T77","span":{"begin":55,"end":155},"obj":"Sentence"},{"id":"T78","span":{"begin":156,"end":266},"obj":"Sentence"},{"id":"T79","span":{"begin":267,"end":284},"obj":"Sentence"},{"id":"T80","span":{"begin":285,"end":421},"obj":"Sentence"},{"id":"T81","span":{"begin":423,"end":504},"obj":"Sentence"},{"id":"T82","span":{"begin":505,"end":636},"obj":"Sentence"},{"id":"T83","span":{"begin":637,"end":798},"obj":"Sentence"},{"id":"T84","span":{"begin":799,"end":818},"obj":"Sentence"},{"id":"T85","span":{"begin":819,"end":966},"obj":"Sentence"},{"id":"T86","span":{"begin":967,"end":1149},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Table 3 Unique features of IgG subclass Fc and hinge.\nIgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange\nIg, immunoglobulin.\nJohn Wiley \u0026 Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T130","span":{"begin":28,"end":31},"obj":"Body_part"},{"id":"T131","span":{"begin":55,"end":58},"obj":"Body_part"},{"id":"T132","span":{"begin":777,"end":780},"obj":"Body_part"},{"id":"T133","span":{"begin":799,"end":801},"obj":"Body_part"},{"id":"T134","span":{"begin":803,"end":817},"obj":"Body_part"}],"attributes":[{"id":"A130","pred":"fma_id","subj":"T130","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A131","pred":"fma_id","subj":"T131","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A132","pred":"fma_id","subj":"T132","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A133","pred":"fma_id","subj":"T133","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A134","pred":"fma_id","subj":"T134","obj":"http://purl.org/sig/ont/fma/fma62871"}],"text":"Table 3 Unique features of IgG subclass Fc and hinge.\nIgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange\nIg, immunoglobulin.\nJohn Wiley \u0026 Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency."}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T34","span":{"begin":573,"end":581},"obj":"http://purl.obolibrary.org/obo/GO_0015297"},{"id":"T35","span":{"begin":790,"end":798},"obj":"http://purl.obolibrary.org/obo/GO_0015297"}],"text":"Table 3 Unique features of IgG subclass Fc and hinge.\nIgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange\nIg, immunoglobulin.\nJohn Wiley \u0026 Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency."}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T13","span":{"begin":924,"end":932},"obj":"Disease"}],"attributes":[{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Table 3 Unique features of IgG subclass Fc and hinge.\nIgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange\nIg, immunoglobulin.\nJohn Wiley \u0026 Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency."}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T34","span":{"begin":573,"end":581},"obj":"http://purl.obolibrary.org/obo/GO_0015297"},{"id":"T35","span":{"begin":790,"end":798},"obj":"http://purl.obolibrary.org/obo/GO_0015297"}],"text":"Table 3 Unique features of IgG subclass Fc and hinge.\nIgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange\nIg, immunoglobulin.\nJohn Wiley \u0026 Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T34","span":{"begin":573,"end":581},"obj":"http://purl.obolibrary.org/obo/GO_0015297"},{"id":"T35","span":{"begin":790,"end":798},"obj":"http://purl.obolibrary.org/obo/GO_0015297"}],"text":"Table 3 Unique features of IgG subclass Fc and hinge.\nIgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange\nIg, immunoglobulin.\nJohn Wiley \u0026 Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency."}

{"project":"LitCovid-sentences","denotations":[{"id":"T76","span":{"begin":0,"end":54},"obj":"Sentence"},{"id":"T77","span":{"begin":55,"end":155},"obj":"Sentence"},{"id":"T78","span":{"begin":156,"end":266},"obj":"Sentence"},{"id":"T79","span":{"begin":267,"end":284},"obj":"Sentence"},{"id":"T80","span":{"begin":285,"end":421},"obj":"Sentence"},{"id":"T81","span":{"begin":423,"end":504},"obj":"Sentence"},{"id":"T82","span":{"begin":505,"end":636},"obj":"Sentence"},{"id":"T83","span":{"begin":637,"end":798},"obj":"Sentence"},{"id":"T84","span":{"begin":799,"end":818},"obj":"Sentence"},{"id":"T85","span":{"begin":819,"end":966},"obj":"Sentence"},{"id":"T86","span":{"begin":967,"end":1149},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Table 3 Unique features of IgG subclass Fc and hinge.\nIgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange\nIg, immunoglobulin.\nJohn Wiley \u0026 Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency."}

{"project":"LitCovid-sample-Glycan","denotations":[{"id":"T2","span":{"begin":162,"end":165},"obj":"https://glytoucan.org/Structures/Glycans/G05518TD"}],"text":"Table 3 Unique features of IgG subclass Fc and hinge.\nIgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange\nIg, immunoglobulin.\nJohn Wiley \u0026 Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency."}