PMC:7228307 / 12574-13723
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 246 | 643-648 | Gene | denotes | FcγRI | Gene:2214 |
| 247 | 650-657 | Gene | denotes | FcγRIIb | Gene:2213 |
| 248 | 668-671 | Gene | denotes | CH1 | Gene:51430 |
| 249 | 307-310 | Gene | denotes | CH1 | Gene:51430 |
| 250 | 166-170 | Gene | denotes | FcγR | Gene:2213 |
| 251 | 69-73 | Gene | denotes | FcγR | Gene:2213 |
| 252 | 659-666 | Gene | denotes | FcγRIIc | Gene:9103 |
| 253 | 291-298 | Gene | denotes | FcγRIIa | Gene:2212 |
| 254 | 386-395 | Chemical | denotes | disulfide | MESH:D004220 |
| 255 | 625-635 | Chemical | denotes | disulfides | MESH:D004220 |
| 257 | 924-932 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T131 | 28-31 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
| T132 | 55-58 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
| T133 | 777-780 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
| T134 | 799-801 | Body_part | denotes | Ig | http://purl.org/sig/ont/fma/fma62871 |
| T135 | 803-817 | Body_part | denotes | immunoglobulin | http://purl.org/sig/ont/fma/fma62871 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T23 | 924-932 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T228 | 41-43 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T229 | 69-71 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T230 | 134-136 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T231 | 166-168 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T232 | 217-219 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T233 | 291-293 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T234 | 307-310 | http://purl.obolibrary.org/obo/CLO_0002408 | denotes | CH1 |
| T235 | 585-586 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T236 | 643-645 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T237 | 650-652 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T238 | 659-661 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T239 | 668-671 | http://purl.obolibrary.org/obo/CLO_0002408 | denotes | CH1 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T58 | 87-92 | Chemical | denotes | Light | http://purl.obolibrary.org/obo/CHEBI_30212 |
| T59 | 185-190 | Chemical | denotes | Light | http://purl.obolibrary.org/obo/CHEBI_30212 |
| T60 | 386-395 | Chemical | denotes | disulfide | http://purl.obolibrary.org/obo/CHEBI_48343 |
| T61 | 564-572 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T62 | 625-635 | Chemical | denotes | disulfides | http://purl.obolibrary.org/obo/CHEBI_35489|http://purl.obolibrary.org/obo/CHEBI_48343 |
| T64 | 646-648 | Chemical | denotes | RI | http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753 |
| T66 | 781-789 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
LitCovid-sample-MedDRA
| Id | Subject | Object | Predicate | Lexical cue | meddra_id |
|---|---|---|---|---|---|
| T12 | 799-801 | http://purl.bioontology.org/ontology/MEDDRA/10022891 | denotes | Ig | http://purl.bioontology.org/ontology/MEDDRA/10021496 |
| T13 | 803-817 | http://purl.bioontology.org/ontology/MEDDRA/10022891 | denotes | immunoglobulin | http://purl.bioontology.org/ontology/MEDDRA/10021496 |
LitCovid-sample-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T9 | 386-395 | Chemical | denotes | disulfide | http://purl.obolibrary.org/obo/CHEBI_48343 |
| T10 | 625-635 | Chemical | denotes | disulfides | http://purl.obolibrary.org/obo/CHEBI_35489|http://purl.obolibrary.org/obo/CHEBI_48343 |
LitCovid-sample-Pubtator
| Id | Subject | Object | Predicate | Lexical cue | pubann:denotes |
|---|---|---|---|---|---|
| 246 | 643-648 | Gene | denotes | FcγRI | Gene:2214 |
| 247 | 650-657 | Gene | denotes | FcγRIIb | Gene:2213 |
| 248 | 668-671 | Gene | denotes | CH1 | Gene:51430 |
| 249 | 307-310 | Gene | denotes | CH1 | Gene:51430 |
| 250 | 166-170 | Gene | denotes | FcγR | Gene:2213 |
| 252 | 659-666 | Gene | denotes | FcγRIIc | Gene:9103 |
| 253 | 291-298 | Gene | denotes | FcγRIIa | Gene:2212 |
| 254 | 386-395 | Chemical | denotes | disulfide | MESH:D004220 |
| 255 | 625-635 | Chemical | denotes | disulfides | MESH:D004220 |
LitCovid-sample-PD-NCBITaxon
| Id | Subject | Object | Predicate | Lexical cue | ncbi_taxonomy_id |
|---|---|---|---|---|---|
| T13 | 924-932 | Species | denotes | COVID-19 | NCBItxid:2697049 |
LitCovid-sample-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T76 | 0-54 | Sentence | denotes | Table 3 Unique features of IgG subclass Fc and hinge. |
| T77 | 55-155 | Sentence | denotes | IgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment |
| T78 | 156-266 | Sentence | denotes | IgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is >100× times more stable than IgG4 and IgG2. |
| T79 | 267-284 | Sentence | denotes | Stable core hinge |
| T80 | 285-421 | Sentence | denotes | IgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. |
| T81 | 423-504 | Sentence | denotes | Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. |
| T82 | 505-636 | Sentence | denotes | Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides. |
| T83 | 637-798 | Sentence | denotes | IgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange |
| T84 | 799-818 | Sentence | denotes | Ig, immunoglobulin. |
| T85 | 819-966 | Sentence | denotes | John Wiley & Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. |
| T86 | 967-1149 | Sentence | denotes | It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency. |
LitCovid-sample-PD-FMA
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T130 | 28-31 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
| T131 | 55-58 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
| T132 | 777-780 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
| T133 | 799-801 | Body_part | denotes | Ig | http://purl.org/sig/ont/fma/fma62871 |
| T134 | 803-817 | Body_part | denotes | immunoglobulin | http://purl.org/sig/ont/fma/fma62871 |
LitCovid-sample-PD-GO-BP-0
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T34 | 573-581 | http://purl.obolibrary.org/obo/GO_0015297 | denotes | exchange |
| T35 | 790-798 | http://purl.obolibrary.org/obo/GO_0015297 | denotes | exchange |
LitCovid-sample-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T13 | 924-932 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-sample-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T34 | 573-581 | http://purl.obolibrary.org/obo/GO_0015297 | denotes | exchange |
| T35 | 790-798 | http://purl.obolibrary.org/obo/GO_0015297 | denotes | exchange |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T34 | 573-581 | http://purl.obolibrary.org/obo/GO_0015297 | denotes | exchange |
| T35 | 790-798 | http://purl.obolibrary.org/obo/GO_0015297 | denotes | exchange |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T76 | 0-54 | Sentence | denotes | Table 3 Unique features of IgG subclass Fc and hinge. |
| T77 | 55-155 | Sentence | denotes | IgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment |
| T78 | 156-266 | Sentence | denotes | IgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is >100× times more stable than IgG4 and IgG2. |
| T79 | 267-284 | Sentence | denotes | Stable core hinge |
| T80 | 285-421 | Sentence | denotes | IgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. |
| T81 | 423-504 | Sentence | denotes | Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. |
| T82 | 505-636 | Sentence | denotes | Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides. |
| T83 | 637-798 | Sentence | denotes | IgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange |
| T84 | 799-818 | Sentence | denotes | Ig, immunoglobulin. |
| T85 | 819-966 | Sentence | denotes | John Wiley & Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. |
| T86 | 967-1149 | Sentence | denotes | It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency. |
LitCovid-sample-Glycan
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2 | 162-165 | https://glytoucan.org/Structures/Glycans/G05518TD | denotes | All |