PMC:7228253 / 1674-2797 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"52","span":{"begin":152,"end":156},"obj":"Gene"},{"id":"53","span":{"begin":302,"end":306},"obj":"Gene"},{"id":"54","span":{"begin":28,"end":73},"obj":"Species"},{"id":"55","span":{"begin":75,"end":83},"obj":"Species"},{"id":"56","span":{"begin":103,"end":113},"obj":"Species"},{"id":"57","span":{"begin":123,"end":128},"obj":"Species"},{"id":"58","span":{"begin":426,"end":431},"obj":"Species"},{"id":"59","span":{"begin":449,"end":467},"obj":"Disease"},{"id":"60","span":{"begin":906,"end":914},"obj":"Disease"},{"id":"61","span":{"begin":1044,"end":1052},"obj":"Disease"}],"attributes":[{"id":"A52","pred":"tao:has_database_id","subj":"52","obj":"Gene:59272"},{"id":"A53","pred":"tao:has_database_id","subj":"53","obj":"Gene:59272"},{"id":"A54","pred":"tao:has_database_id","subj":"54","obj":"Tax:694009"},{"id":"A55","pred":"tao:has_database_id","subj":"55","obj":"Tax:694009"},{"id":"A56","pred":"tao:has_database_id","subj":"56","obj":"Tax:2697049"},{"id":"A57","pred":"tao:has_database_id","subj":"57","obj":"Tax:9606"},{"id":"A58","pred":"tao:has_database_id","subj":"58","obj":"Tax:9606"},{"id":"A59","pred":"tao:has_database_id","subj":"59","obj":"MESH:D003316"},{"id":"A60","pred":"tao:has_database_id","subj":"60","obj":"MESH:C000657245"},{"id":"A61","pred":"tao:has_database_id","subj":"61","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Studies show that, like the severe acute respiratory syndrome coronavirus (SARS‐CoV) that caused SARS, SARS‐CoV‐2 binds to human angiotensin‐enzyme II (ACE2), using it as a cell entry receptor to invade respiratory and lung epithelium through the spike (S) protein (Zhou et al., 2020a,2020b). However, ACE2 is mainly expressed in posterior tissues of the eye, such as the retina and the retinal pigment epithelium, not in the human conjunctival and corneal epithelium (Choudhary et al. 2017). We presume that these previous studies ignored the characteristics of lacrimal drainage. Tears are constantly renewed by the lacrimal system. Therefore, we speculate that the virus enters the tears through droplets, which may pass through the nasolacrimal ducts and then into the respiratory tract. Combined with all this information, we assert that, when coming into contact with confirmed or suspected cases of COVID‐19, healthcare workers should wear eye safety goggles. This should become one of the critical measures for preventing the spread of COVID‐19. The authors hope this topic is helpful for work in the outbreak area."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T6","span":{"begin":173,"end":177},"obj":"Body_part"},{"id":"T7","span":{"begin":219,"end":223},"obj":"Body_part"},{"id":"T8","span":{"begin":224,"end":234},"obj":"Body_part"},{"id":"T9","span":{"begin":257,"end":264},"obj":"Body_part"},{"id":"T10","span":{"begin":340,"end":347},"obj":"Body_part"},{"id":"T11","span":{"begin":355,"end":358},"obj":"Body_part"},{"id":"T12","span":{"begin":372,"end":378},"obj":"Body_part"},{"id":"T13","span":{"begin":387,"end":413},"obj":"Body_part"},{"id":"T14","span":{"begin":403,"end":413},"obj":"Body_part"},{"id":"T15","span":{"begin":449,"end":467},"obj":"Body_part"},{"id":"T16","span":{"begin":457,"end":467},"obj":"Body_part"},{"id":"T17","span":{"begin":582,"end":587},"obj":"Body_part"},{"id":"T18","span":{"begin":685,"end":690},"obj":"Body_part"},{"id":"T19","span":{"begin":736,"end":754},"obj":"Body_part"},{"id":"T20","span":{"begin":773,"end":790},"obj":"Body_part"},{"id":"T21","span":{"begin":947,"end":950},"obj":"Body_part"}],"attributes":[{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma9639"},{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma54448"},{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma58301"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma58627"},{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma9639"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma58263"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma9639"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma59756"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma59756"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma9703"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma265130"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma54448"}],"text":"Studies show that, like the severe acute respiratory syndrome coronavirus (SARS‐CoV) that caused SARS, SARS‐CoV‐2 binds to human angiotensin‐enzyme II (ACE2), using it as a cell entry receptor to invade respiratory and lung epithelium through the spike (S) protein (Zhou et al., 2020a,2020b). However, ACE2 is mainly expressed in posterior tissues of the eye, such as the retina and the retinal pigment epithelium, not in the human conjunctival and corneal epithelium (Choudhary et al. 2017). We presume that these previous studies ignored the characteristics of lacrimal drainage. Tears are constantly renewed by the lacrimal system. Therefore, we speculate that the virus enters the tears through droplets, which may pass through the nasolacrimal ducts and then into the respiratory tract. Combined with all this information, we assert that, when coming into contact with confirmed or suspected cases of COVID‐19, healthcare workers should wear eye safety goggles. This should become one of the critical measures for preventing the spread of COVID‐19. The authors hope this topic is helpful for work in the outbreak area."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T8","span":{"begin":219,"end":234},"obj":"Body_part"},{"id":"T9","span":{"begin":219,"end":223},"obj":"Body_part"},{"id":"T10","span":{"begin":224,"end":234},"obj":"Body_part"},{"id":"T11","span":{"begin":355,"end":358},"obj":"Body_part"},{"id":"T12","span":{"begin":372,"end":378},"obj":"Body_part"},{"id":"T13","span":{"begin":403,"end":413},"obj":"Body_part"},{"id":"T14","span":{"begin":449,"end":467},"obj":"Body_part"},{"id":"T15","span":{"begin":457,"end":467},"obj":"Body_part"},{"id":"T16","span":{"begin":563,"end":571},"obj":"Body_part"},{"id":"T17","span":{"begin":618,"end":626},"obj":"Body_part"},{"id":"T18","span":{"begin":736,"end":754},"obj":"Body_part"},{"id":"T19","span":{"begin":773,"end":790},"obj":"Body_part"},{"id":"T20","span":{"begin":947,"end":950},"obj":"Body_part"}],"attributes":[{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0000115"},{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0000483"},{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_0000970"},{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/UBERON_0000966"},{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0000483"},{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_0001772"},{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/UBERON_0000483"},{"id":"A16","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_3010146"},{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_3010146"},{"id":"A18","pred":"uberon_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/UBERON_0002392"},{"id":"A19","pred":"uberon_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/UBERON_0000065"},{"id":"A20","pred":"uberon_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/UBERON_0000970"}],"text":"Studies show that, like the severe acute respiratory syndrome coronavirus (SARS‐CoV) that caused SARS, SARS‐CoV‐2 binds to human angiotensin‐enzyme II (ACE2), using it as a cell entry receptor to invade respiratory and lung epithelium through the spike (S) protein (Zhou et al., 2020a,2020b). However, ACE2 is mainly expressed in posterior tissues of the eye, such as the retina and the retinal pigment epithelium, not in the human conjunctival and corneal epithelium (Choudhary et al. 2017). We presume that these previous studies ignored the characteristics of lacrimal drainage. Tears are constantly renewed by the lacrimal system. Therefore, we speculate that the virus enters the tears through droplets, which may pass through the nasolacrimal ducts and then into the respiratory tract. Combined with all this information, we assert that, when coming into contact with confirmed or suspected cases of COVID‐19, healthcare workers should wear eye safety goggles. This should become one of the critical measures for preventing the spread of COVID‐19. The authors hope this topic is helpful for work in the outbreak area."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T16","span":{"begin":28,"end":61},"obj":"Disease"},{"id":"T17","span":{"begin":75,"end":79},"obj":"Disease"},{"id":"T18","span":{"begin":97,"end":101},"obj":"Disease"},{"id":"T19","span":{"begin":103,"end":107},"obj":"Disease"},{"id":"T20","span":{"begin":906,"end":914},"obj":"Disease"},{"id":"T21","span":{"begin":1044,"end":1052},"obj":"Disease"}],"attributes":[{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A18","pred":"mondo_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A19","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A20","pred":"mondo_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A21","pred":"mondo_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Studies show that, like the severe acute respiratory syndrome coronavirus (SARS‐CoV) that caused SARS, SARS‐CoV‐2 binds to human angiotensin‐enzyme II (ACE2), using it as a cell entry receptor to invade respiratory and lung epithelium through the spike (S) protein (Zhou et al., 2020a,2020b). However, ACE2 is mainly expressed in posterior tissues of the eye, such as the retina and the retinal pigment epithelium, not in the human conjunctival and corneal epithelium (Choudhary et al. 2017). We presume that these previous studies ignored the characteristics of lacrimal drainage. Tears are constantly renewed by the lacrimal system. Therefore, we speculate that the virus enters the tears through droplets, which may pass through the nasolacrimal ducts and then into the respiratory tract. Combined with all this information, we assert that, when coming into contact with confirmed or suspected cases of COVID‐19, healthcare workers should wear eye safety goggles. This should become one of the critical measures for preventing the spread of COVID‐19. The authors hope this topic is helpful for work in the outbreak area."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T20","span":{"begin":123,"end":128},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T21","span":{"begin":171,"end":177},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T22","span":{"begin":219,"end":234},"obj":"http://purl.obolibrary.org/obo/UBERON_0000115"},{"id":"T23","span":{"begin":330,"end":339},"obj":"http://purl.obolibrary.org/obo/UBERON_0001353"},{"id":"T24","span":{"begin":355,"end":358},"obj":"http://www.ebi.ac.uk/efo/EFO_0000827"},{"id":"T25","span":{"begin":360,"end":378},"obj":"http://www.ebi.ac.uk/efo/EFO_0000832"},{"id":"T26","span":{"begin":403,"end":413},"obj":"http://purl.obolibrary.org/obo/UBERON_0000483"},{"id":"T27","span":{"begin":426,"end":431},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T28","span":{"begin":457,"end":467},"obj":"http://purl.obolibrary.org/obo/UBERON_0000483"},{"id":"T29","span":{"begin":668,"end":673},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T30","span":{"begin":749,"end":754},"obj":"http://purl.obolibrary.org/obo/UBERON_0000025"},{"id":"T31","span":{"begin":749,"end":754},"obj":"http://purl.obolibrary.org/obo/UBERON_0000058"},{"id":"T32","span":{"begin":947,"end":950},"obj":"http://www.ebi.ac.uk/efo/EFO_0000827"}],"text":"Studies show that, like the severe acute respiratory syndrome coronavirus (SARS‐CoV) that caused SARS, SARS‐CoV‐2 binds to human angiotensin‐enzyme II (ACE2), using it as a cell entry receptor to invade respiratory and lung epithelium through the spike (S) protein (Zhou et al., 2020a,2020b). However, ACE2 is mainly expressed in posterior tissues of the eye, such as the retina and the retinal pigment epithelium, not in the human conjunctival and corneal epithelium (Choudhary et al. 2017). We presume that these previous studies ignored the characteristics of lacrimal drainage. Tears are constantly renewed by the lacrimal system. Therefore, we speculate that the virus enters the tears through droplets, which may pass through the nasolacrimal ducts and then into the respiratory tract. Combined with all this information, we assert that, when coming into contact with confirmed or suspected cases of COVID‐19, healthcare workers should wear eye safety goggles. This should become one of the critical measures for preventing the spread of COVID‐19. The authors hope this topic is helpful for work in the outbreak area."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T7","span":{"begin":129,"end":140},"obj":"Chemical"},{"id":"T8","span":{"begin":148,"end":150},"obj":"Chemical"},{"id":"T9","span":{"begin":257,"end":264},"obj":"Chemical"},{"id":"T10","span":{"begin":387,"end":394},"obj":"Chemical"}],"attributes":[{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_15035"}],"text":"Studies show that, like the severe acute respiratory syndrome coronavirus (SARS‐CoV) that caused SARS, SARS‐CoV‐2 binds to human angiotensin‐enzyme II (ACE2), using it as a cell entry receptor to invade respiratory and lung epithelium through the spike (S) protein (Zhou et al., 2020a,2020b). However, ACE2 is mainly expressed in posterior tissues of the eye, such as the retina and the retinal pigment epithelium, not in the human conjunctival and corneal epithelium (Choudhary et al. 2017). We presume that these previous studies ignored the characteristics of lacrimal drainage. Tears are constantly renewed by the lacrimal system. Therefore, we speculate that the virus enters the tears through droplets, which may pass through the nasolacrimal ducts and then into the respiratory tract. Combined with all this information, we assert that, when coming into contact with confirmed or suspected cases of COVID‐19, healthcare workers should wear eye safety goggles. This should become one of the critical measures for preventing the spread of COVID‐19. The authors hope this topic is helpful for work in the outbreak area."}

{"project":"LitCovid-sentences","denotations":[{"id":"T17","span":{"begin":0,"end":292},"obj":"Sentence"},{"id":"T18","span":{"begin":293,"end":485},"obj":"Sentence"},{"id":"T19","span":{"begin":486,"end":492},"obj":"Sentence"},{"id":"T20","span":{"begin":493,"end":581},"obj":"Sentence"},{"id":"T21","span":{"begin":582,"end":634},"obj":"Sentence"},{"id":"T22","span":{"begin":635,"end":791},"obj":"Sentence"},{"id":"T23","span":{"begin":792,"end":966},"obj":"Sentence"},{"id":"T24","span":{"begin":967,"end":1053},"obj":"Sentence"},{"id":"T25","span":{"begin":1054,"end":1123},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Studies show that, like the severe acute respiratory syndrome coronavirus (SARS‐CoV) that caused SARS, SARS‐CoV‐2 binds to human angiotensin‐enzyme II (ACE2), using it as a cell entry receptor to invade respiratory and lung epithelium through the spike (S) protein (Zhou et al., 2020a,2020b). However, ACE2 is mainly expressed in posterior tissues of the eye, such as the retina and the retinal pigment epithelium, not in the human conjunctival and corneal epithelium (Choudhary et al. 2017). We presume that these previous studies ignored the characteristics of lacrimal drainage. Tears are constantly renewed by the lacrimal system. Therefore, we speculate that the virus enters the tears through droplets, which may pass through the nasolacrimal ducts and then into the respiratory tract. Combined with all this information, we assert that, when coming into contact with confirmed or suspected cases of COVID‐19, healthcare workers should wear eye safety goggles. This should become one of the critical measures for preventing the spread of COVID‐19. The authors hope this topic is helpful for work in the outbreak area."}