PMC:7228253 / 1674-2797
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 52 | 152-156 | Gene | denotes | ACE2 | Gene:59272 |
| 53 | 302-306 | Gene | denotes | ACE2 | Gene:59272 |
| 54 | 28-73 | Species | denotes | severe acute respiratory syndrome coronavirus | Tax:694009 |
| 55 | 75-83 | Species | denotes | SARS‐CoV | Tax:694009 |
| 56 | 103-113 | Species | denotes | SARS‐CoV‐2 | Tax:2697049 |
| 57 | 123-128 | Species | denotes | human | Tax:9606 |
| 58 | 426-431 | Species | denotes | human | Tax:9606 |
| 59 | 449-467 | Disease | denotes | corneal epithelium | MESH:D003316 |
| 60 | 906-914 | Disease | denotes | COVID‐19 | MESH:C000657245 |
| 61 | 1044-1052 | Disease | denotes | COVID‐19 | MESH:C000657245 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T6 | 173-177 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T7 | 219-223 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T8 | 224-234 | Body_part | denotes | epithelium | http://purl.org/sig/ont/fma/fma9639 |
| T9 | 257-264 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T10 | 340-347 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
| T11 | 355-358 | Body_part | denotes | eye | http://purl.org/sig/ont/fma/fma54448 |
| T12 | 372-378 | Body_part | denotes | retina | http://purl.org/sig/ont/fma/fma58301 |
| T13 | 387-413 | Body_part | denotes | retinal pigment epithelium | http://purl.org/sig/ont/fma/fma58627 |
| T14 | 403-413 | Body_part | denotes | epithelium | http://purl.org/sig/ont/fma/fma9639 |
| T15 | 449-467 | Body_part | denotes | corneal epithelium | http://purl.org/sig/ont/fma/fma58263 |
| T16 | 457-467 | Body_part | denotes | epithelium | http://purl.org/sig/ont/fma/fma9639 |
| T17 | 582-587 | Body_part | denotes | Tears | http://purl.org/sig/ont/fma/fma59756 |
| T18 | 685-690 | Body_part | denotes | tears | http://purl.org/sig/ont/fma/fma59756 |
| T19 | 736-754 | Body_part | denotes | nasolacrimal ducts | http://purl.org/sig/ont/fma/fma9703 |
| T20 | 773-790 | Body_part | denotes | respiratory tract | http://purl.org/sig/ont/fma/fma265130 |
| T21 | 947-950 | Body_part | denotes | eye | http://purl.org/sig/ont/fma/fma54448 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T8 | 219-234 | Body_part | denotes | lung epithelium | http://purl.obolibrary.org/obo/UBERON_0000115 |
| T9 | 219-223 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T10 | 224-234 | Body_part | denotes | epithelium | http://purl.obolibrary.org/obo/UBERON_0000483 |
| T11 | 355-358 | Body_part | denotes | eye | http://purl.obolibrary.org/obo/UBERON_0000970 |
| T12 | 372-378 | Body_part | denotes | retina | http://purl.obolibrary.org/obo/UBERON_0000966 |
| T13 | 403-413 | Body_part | denotes | epithelium | http://purl.obolibrary.org/obo/UBERON_0000483 |
| T14 | 449-467 | Body_part | denotes | corneal epithelium | http://purl.obolibrary.org/obo/UBERON_0001772 |
| T15 | 457-467 | Body_part | denotes | epithelium | http://purl.obolibrary.org/obo/UBERON_0000483 |
| T16 | 563-571 | Body_part | denotes | lacrimal | http://purl.obolibrary.org/obo/UBERON_3010146 |
| T17 | 618-626 | Body_part | denotes | lacrimal | http://purl.obolibrary.org/obo/UBERON_3010146 |
| T18 | 736-754 | Body_part | denotes | nasolacrimal ducts | http://purl.obolibrary.org/obo/UBERON_0002392 |
| T19 | 773-790 | Body_part | denotes | respiratory tract | http://purl.obolibrary.org/obo/UBERON_0000065 |
| T20 | 947-950 | Body_part | denotes | eye | http://purl.obolibrary.org/obo/UBERON_0000970 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T16 | 28-61 | Disease | denotes | severe acute respiratory syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T17 | 75-79 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T18 | 97-101 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T19 | 103-107 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T20 | 906-914 | Disease | denotes | COVID‐19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T21 | 1044-1052 | Disease | denotes | COVID‐19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T20 | 123-128 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T21 | 171-177 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a cell |
| T22 | 219-234 | http://purl.obolibrary.org/obo/UBERON_0000115 | denotes | lung epithelium |
| T23 | 330-339 | http://purl.obolibrary.org/obo/UBERON_0001353 | denotes | posterior |
| T24 | 355-358 | http://www.ebi.ac.uk/efo/EFO_0000827 | denotes | eye |
| T25 | 360-378 | http://www.ebi.ac.uk/efo/EFO_0000832 | denotes | such as the retina |
| T26 | 403-413 | http://purl.obolibrary.org/obo/UBERON_0000483 | denotes | epithelium |
| T27 | 426-431 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T28 | 457-467 | http://purl.obolibrary.org/obo/UBERON_0000483 | denotes | epithelium |
| T29 | 668-673 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T30 | 749-754 | http://purl.obolibrary.org/obo/UBERON_0000025 | denotes | ducts |
| T31 | 749-754 | http://purl.obolibrary.org/obo/UBERON_0000058 | denotes | ducts |
| T32 | 947-950 | http://www.ebi.ac.uk/efo/EFO_0000827 | denotes | eye |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T7 | 129-140 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T8 | 148-150 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T9 | 257-264 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T10 | 387-394 | Chemical | denotes | retinal | http://purl.obolibrary.org/obo/CHEBI_15035 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T17 | 0-292 | Sentence | denotes | Studies show that, like the severe acute respiratory syndrome coronavirus (SARS‐CoV) that caused SARS, SARS‐CoV‐2 binds to human angiotensin‐enzyme II (ACE2), using it as a cell entry receptor to invade respiratory and lung epithelium through the spike (S) protein (Zhou et al., 2020a,2020b). |
| T18 | 293-485 | Sentence | denotes | However, ACE2 is mainly expressed in posterior tissues of the eye, such as the retina and the retinal pigment epithelium, not in the human conjunctival and corneal epithelium (Choudhary et al. |
| T19 | 486-492 | Sentence | denotes | 2017). |
| T20 | 493-581 | Sentence | denotes | We presume that these previous studies ignored the characteristics of lacrimal drainage. |
| T21 | 582-634 | Sentence | denotes | Tears are constantly renewed by the lacrimal system. |
| T22 | 635-791 | Sentence | denotes | Therefore, we speculate that the virus enters the tears through droplets, which may pass through the nasolacrimal ducts and then into the respiratory tract. |
| T23 | 792-966 | Sentence | denotes | Combined with all this information, we assert that, when coming into contact with confirmed or suspected cases of COVID‐19, healthcare workers should wear eye safety goggles. |
| T24 | 967-1053 | Sentence | denotes | This should become one of the critical measures for preventing the spread of COVID‐19. |
| T25 | 1054-1123 | Sentence | denotes | The authors hope this topic is helpful for work in the outbreak area. |