PMC:7219429 / 5620-6011 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T35","span":{"begin":21,"end":28},"obj":"Body_part"}],"attributes":[{"id":"A35","pred":"fma_id","subj":"T35","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"The SARS-CoV-2 spike protein trimer in the prefusion conformation was obtained from pdb file # 6VSB [20]. Hydroxychloroquine (CLQ-OH) is (RS)-2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol. CLQ-OH was generated by hydroxylation of chloroquine (CLQ) and validated as previously described [10]. CLQ was retrieved from pdb file # 4V2O (CLQ co-crystallized with saposin B) [21]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T29","span":{"begin":4,"end":12},"obj":"Disease"},{"id":"T30","span":{"begin":138,"end":140},"obj":"Disease"}],"attributes":[{"id":"A29","pred":"mondo_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A30","pred":"mondo_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/MONDO_0010725"}],"text":"The SARS-CoV-2 spike protein trimer in the prefusion conformation was obtained from pdb file # 6VSB [20]. Hydroxychloroquine (CLQ-OH) is (RS)-2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol. CLQ-OH was generated by hydroxylation of chloroquine (CLQ) and validated as previously described [10]. CLQ was retrieved from pdb file # 4V2O (CLQ co-crystallized with saposin B) [21]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T62","span":{"begin":138,"end":140},"obj":"http://purl.obolibrary.org/obo/CLO_0008882"},{"id":"T63","span":{"begin":383,"end":384},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"}],"text":"The SARS-CoV-2 spike protein trimer in the prefusion conformation was obtained from pdb file # 6VSB [20]. Hydroxychloroquine (CLQ-OH) is (RS)-2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol. CLQ-OH was generated by hydroxylation of chloroquine (CLQ) and validated as previously described [10]. CLQ was retrieved from pdb file # 4V2O (CLQ co-crystallized with saposin B) [21]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T76","span":{"begin":21,"end":28},"obj":"Chemical"},{"id":"T77","span":{"begin":138,"end":140},"obj":"Chemical"},{"id":"T78","span":{"begin":172,"end":177},"obj":"Chemical"},{"id":"T79","span":{"begin":178,"end":184},"obj":"Chemical"},{"id":"T80","span":{"begin":186,"end":191},"obj":"Chemical"},{"id":"T82","span":{"begin":192,"end":197},"obj":"Chemical"},{"id":"T83","span":{"begin":198,"end":205},"obj":"Chemical"},{"id":"T84","span":{"begin":248,"end":259},"obj":"Chemical"}],"attributes":[{"id":"A76","pred":"chebi_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A77","pred":"chebi_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/CHEBI_73819"},{"id":"A78","pred":"chebi_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A79","pred":"chebi_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/CHEBI_25902"},{"id":"A80","pred":"chebi_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/CHEBI_37807"},{"id":"A81","pred":"chebi_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/CHEBI_62801"},{"id":"A82","pred":"chebi_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A83","pred":"chebi_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/CHEBI_16236"},{"id":"A84","pred":"chebi_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"}],"text":"The SARS-CoV-2 spike protein trimer in the prefusion conformation was obtained from pdb file # 6VSB [20]. Hydroxychloroquine (CLQ-OH) is (RS)-2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol. CLQ-OH was generated by hydroxylation of chloroquine (CLQ) and validated as previously described [10]. CLQ was retrieved from pdb file # 4V2O (CLQ co-crystallized with saposin B) [21]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T2","span":{"begin":375,"end":382},"obj":"http://purl.obolibrary.org/obo/GO_0030290"}],"text":"The SARS-CoV-2 spike protein trimer in the prefusion conformation was obtained from pdb file # 6VSB [20]. Hydroxychloroquine (CLQ-OH) is (RS)-2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol. CLQ-OH was generated by hydroxylation of chloroquine (CLQ) and validated as previously described [10]. CLQ was retrieved from pdb file # 4V2O (CLQ co-crystallized with saposin B) [21]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T45","span":{"begin":0,"end":105},"obj":"Sentence"},{"id":"T46","span":{"begin":106,"end":206},"obj":"Sentence"},{"id":"T47","span":{"begin":207,"end":309},"obj":"Sentence"},{"id":"T48","span":{"begin":310,"end":391},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The SARS-CoV-2 spike protein trimer in the prefusion conformation was obtained from pdb file # 6VSB [20]. Hydroxychloroquine (CLQ-OH) is (RS)-2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol. CLQ-OH was generated by hydroxylation of chloroquine (CLQ) and validated as previously described [10]. CLQ was retrieved from pdb file # 4V2O (CLQ co-crystallized with saposin B) [21]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"200","span":{"begin":15,"end":20},"obj":"Gene"},{"id":"201","span":{"begin":333,"end":336},"obj":"Gene"},{"id":"202","span":{"begin":84,"end":87},"obj":"Gene"},{"id":"203","span":{"begin":4,"end":14},"obj":"Species"},{"id":"204","span":{"begin":106,"end":124},"obj":"Chemical"},{"id":"205","span":{"begin":126,"end":132},"obj":"Chemical"},{"id":"206","span":{"begin":137,"end":205},"obj":"Chemical"},{"id":"207","span":{"begin":207,"end":213},"obj":"Chemical"},{"id":"208","span":{"begin":248,"end":259},"obj":"Chemical"},{"id":"209","span":{"begin":261,"end":264},"obj":"Chemical"}],"attributes":[{"id":"A200","pred":"tao:has_database_id","subj":"200","obj":"Gene:43740568"},{"id":"A201","pred":"tao:has_database_id","subj":"201","obj":"Gene:5131"},{"id":"A202","pred":"tao:has_database_id","subj":"202","obj":"Gene:5131"},{"id":"A203","pred":"tao:has_database_id","subj":"203","obj":"Tax:2697049"},{"id":"A204","pred":"tao:has_database_id","subj":"204","obj":"MESH:D006886"},{"id":"A208","pred":"tao:has_database_id","subj":"208","obj":"MESH:D002738"},{"id":"A209","pred":"tao:has_database_id","subj":"209","obj":"MESH:D002738"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The SARS-CoV-2 spike protein trimer in the prefusion conformation was obtained from pdb file # 6VSB [20]. Hydroxychloroquine (CLQ-OH) is (RS)-2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol. CLQ-OH was generated by hydroxylation of chloroquine (CLQ) and validated as previously described [10]. CLQ was retrieved from pdb file # 4V2O (CLQ co-crystallized with saposin B) [21]."}

{"project":"2_test","denotations":[{"id":"32405156-32075877-48151011","span":{"begin":101,"end":103},"obj":"32075877"},{"id":"32405156-26616259-48151012","span":{"begin":387,"end":389},"obj":"26616259"},{"id":"T51455","span":{"begin":101,"end":103},"obj":"32075877"},{"id":"T56339","span":{"begin":387,"end":389},"obj":"26616259"}],"text":"The SARS-CoV-2 spike protein trimer in the prefusion conformation was obtained from pdb file # 6VSB [20]. Hydroxychloroquine (CLQ-OH) is (RS)-2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol. CLQ-OH was generated by hydroxylation of chloroquine (CLQ) and validated as previously described [10]. CLQ was retrieved from pdb file # 4V2O (CLQ co-crystallized with saposin B) [21]."}