PMC:7219429 / 29611-30795 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7219429","sourcedb":"PMC","sourceid":"7219429","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7219429","text":"In conclusion, ATM and CLQ-OH have synergistic antiviral effects on SARS-CoV-2 infection, which supports the use of this combination therapy for the COVID-19 pandemic. In this bitherapy, one molecule (ATM) is directed against the virus, while the other (CLQ-OH) is directed against cellular attachment cofactors. However, the two drugs are predicted to act in synergy to prevent the first step of SARS-CoV-2 infection, at the plasma membrane level, where therapeutic intervention is likely to be most efficient. The conserved QFN triad of the SARS-CoV-2 spike protein, which is recognized by both gangliosides and ATM, should be considered as a target for neutralizing antibodies in vaccine strategies. The molecular modelling approaches used here are based on the search for ganglioside saccharide mimicry and might be useful to identify other ATM binding sites on virus proteins, and more generally to predict the efficacy of any potential repurposed and/or innovative drug candidates before clinical evaluation. In this respect, we suggest testing the antiviral association of ATM with short synthetic peptides specifically designed to target gangliosides without toxicity [17,33].","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T187","span":{"begin":426,"end":441},"obj":"Body_part"},{"id":"T188","span":{"begin":560,"end":567},"obj":"Body_part"},{"id":"T189","span":{"begin":597,"end":609},"obj":"Body_part"},{"id":"T190","span":{"begin":776,"end":787},"obj":"Body_part"},{"id":"T191","span":{"begin":872,"end":880},"obj":"Body_part"},{"id":"T192","span":{"begin":1146,"end":1158},"obj":"Body_part"}],"attributes":[{"id":"A187","pred":"fma_id","subj":"T187","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A188","pred":"fma_id","subj":"T188","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A189","pred":"fma_id","subj":"T189","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A190","pred":"fma_id","subj":"T190","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A191","pred":"fma_id","subj":"T191","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A192","pred":"fma_id","subj":"T192","obj":"http://purl.org/sig/ont/fma/fma82816"},{"subj":"T187","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T188","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T189","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T190","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T191","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T192","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T101","span":{"begin":68,"end":76},"obj":"Disease"},{"id":"T102","span":{"begin":79,"end":88},"obj":"Disease"},{"id":"T103","span":{"begin":149,"end":157},"obj":"Disease"},{"id":"T104","span":{"begin":397,"end":405},"obj":"Disease"},{"id":"T105","span":{"begin":408,"end":417},"obj":"Disease"},{"id":"T106","span":{"begin":543,"end":551},"obj":"Disease"}],"attributes":[{"id":"A101","pred":"mondo_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A102","pred":"mondo_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A103","pred":"mondo_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A104","pred":"mondo_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A105","pred":"mondo_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A106","pred":"mondo_id","subj":"T106","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T101","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T102","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T103","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T104","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T105","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T106","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T274","span":{"begin":230,"end":235},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T275","span":{"begin":426,"end":432},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T276","span":{"begin":433,"end":441},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T277","span":{"begin":643,"end":644},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T278","span":{"begin":866,"end":871},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T279","span":{"begin":1043,"end":1050},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T280","span":{"begin":1105,"end":1113},"obj":"http://purl.obolibrary.org/obo/PR_000018263"}],"attributes":[{"subj":"T274","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T275","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T276","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T277","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T278","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T279","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T280","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T559","span":{"begin":15,"end":18},"obj":"Chemical"},{"id":"T560","span":{"begin":47,"end":56},"obj":"Chemical"},{"id":"T561","span":{"begin":191,"end":199},"obj":"Chemical"},{"id":"T562","span":{"begin":201,"end":204},"obj":"Chemical"},{"id":"T563","span":{"begin":302,"end":311},"obj":"Chemical"},{"id":"T564","span":{"begin":330,"end":335},"obj":"Chemical"},{"id":"T565","span":{"begin":560,"end":567},"obj":"Chemical"},{"id":"T566","span":{"begin":597,"end":609},"obj":"Chemical"},{"id":"T567","span":{"begin":614,"end":617},"obj":"Chemical"},{"id":"T568","span":{"begin":776,"end":787},"obj":"Chemical"},{"id":"T569","span":{"begin":788,"end":798},"obj":"Chemical"},{"id":"T570","span":{"begin":845,"end":848},"obj":"Chemical"},{"id":"T571","span":{"begin":872,"end":880},"obj":"Chemical"},{"id":"T572","span":{"begin":971,"end":975},"obj":"Chemical"},{"id":"T573","span":{"begin":1055,"end":1064},"obj":"Chemical"},{"id":"T574","span":{"begin":1080,"end":1083},"obj":"Chemical"},{"id":"T575","span":{"begin":1105,"end":1113},"obj":"Chemical"},{"id":"T576","span":{"begin":1146,"end":1158},"obj":"Chemical"}],"attributes":[{"id":"A559","pred":"chebi_id","subj":"T559","obj":"http://purl.obolibrary.org/obo/CHEBI_2955"},{"id":"A560","pred":"chebi_id","subj":"T560","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A561","pred":"chebi_id","subj":"T561","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A562","pred":"chebi_id","subj":"T562","obj":"http://purl.obolibrary.org/obo/CHEBI_2955"},{"id":"A563","pred":"chebi_id","subj":"T563","obj":"http://purl.obolibrary.org/obo/CHEBI_23357"},{"id":"A564","pred":"chebi_id","subj":"T564","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A565","pred":"chebi_id","subj":"T565","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A566","pred":"chebi_id","subj":"T566","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A567","pred":"chebi_id","subj":"T567","obj":"http://purl.obolibrary.org/obo/CHEBI_2955"},{"id":"A568","pred":"chebi_id","subj":"T568","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A569","pred":"chebi_id","subj":"T569","obj":"http://purl.obolibrary.org/obo/CHEBI_16646"},{"id":"A570","pred":"chebi_id","subj":"T570","obj":"http://purl.obolibrary.org/obo/CHEBI_2955"},{"id":"A571","pred":"chebi_id","subj":"T571","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A572","pred":"chebi_id","subj":"T572","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A573","pred":"chebi_id","subj":"T573","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A574","pred":"chebi_id","subj":"T574","obj":"http://purl.obolibrary.org/obo/CHEBI_2955"},{"id":"A575","pred":"chebi_id","subj":"T575","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A576","pred":"chebi_id","subj":"T576","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"subj":"T559","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T560","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T561","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T562","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T563","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T564","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T565","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T566","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T567","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T568","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T569","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T570","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T571","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T572","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T573","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T574","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T575","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T576","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T216","span":{"begin":0,"end":167},"obj":"Sentence"},{"id":"T217","span":{"begin":168,"end":312},"obj":"Sentence"},{"id":"T218","span":{"begin":313,"end":511},"obj":"Sentence"},{"id":"T219","span":{"begin":512,"end":702},"obj":"Sentence"},{"id":"T220","span":{"begin":703,"end":1014},"obj":"Sentence"},{"id":"T221","span":{"begin":1015,"end":1184},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T216","pred":"source","obj":"LitCovid-sentences"},{"subj":"T217","pred":"source","obj":"LitCovid-sentences"},{"subj":"T218","pred":"source","obj":"LitCovid-sentences"},{"subj":"T219","pred":"source","obj":"LitCovid-sentences"},{"subj":"T220","pred":"source","obj":"LitCovid-sentences"},{"subj":"T221","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"821","span":{"begin":554,"end":559},"obj":"Gene"},{"id":"822","span":{"begin":543,"end":553},"obj":"Species"},{"id":"823","span":{"begin":15,"end":18},"obj":"Chemical"},{"id":"824","span":{"begin":23,"end":29},"obj":"Chemical"},{"id":"825","span":{"begin":254,"end":260},"obj":"Chemical"},{"id":"826","span":{"begin":526,"end":529},"obj":"Chemical"},{"id":"827","span":{"begin":597,"end":609},"obj":"Chemical"},{"id":"828","span":{"begin":776,"end":798},"obj":"Chemical"},{"id":"829","span":{"begin":1146,"end":1158},"obj":"Chemical"},{"id":"830","span":{"begin":73,"end":88},"obj":"Disease"},{"id":"831","span":{"begin":149,"end":157},"obj":"Disease"},{"id":"832","span":{"begin":397,"end":417},"obj":"Disease"},{"id":"833","span":{"begin":1167,"end":1175},"obj":"Disease"}],"attributes":[{"id":"A821","pred":"tao:has_database_id","subj":"821","obj":"Gene:43740568"},{"id":"A822","pred":"tao:has_database_id","subj":"822","obj":"Tax:2697049"},{"id":"A823","pred":"tao:has_database_id","subj":"823","obj":"MESH:D017963"},{"id":"A827","pred":"tao:has_database_id","subj":"827","obj":"MESH:D005732"},{"id":"A829","pred":"tao:has_database_id","subj":"829","obj":"MESH:D005732"},{"id":"A830","pred":"tao:has_database_id","subj":"830","obj":"MESH:C000657245"},{"id":"A831","pred":"tao:has_database_id","subj":"831","obj":"MESH:C000657245"},{"id":"A832","pred":"tao:has_database_id","subj":"832","obj":"MESH:C000657245"},{"id":"A833","pred":"tao:has_database_id","subj":"833","obj":"MESH:D064420"},{"subj":"821","pred":"source","obj":"LitCovid-PubTator"},{"subj":"822","pred":"source","obj":"LitCovid-PubTator"},{"subj":"823","pred":"source","obj":"LitCovid-PubTator"},{"subj":"824","pred":"source","obj":"LitCovid-PubTator"},{"subj":"825","pred":"source","obj":"LitCovid-PubTator"},{"subj":"826","pred":"source","obj":"LitCovid-PubTator"},{"subj":"827","pred":"source","obj":"LitCovid-PubTator"},{"subj":"828","pred":"source","obj":"LitCovid-PubTator"},{"subj":"829","pred":"source","obj":"LitCovid-PubTator"},{"subj":"830","pred":"source","obj":"LitCovid-PubTator"},{"subj":"831","pred":"source","obj":"LitCovid-PubTator"},{"subj":"832","pred":"source","obj":"LitCovid-PubTator"},{"subj":"833","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"2_test","denotations":[{"id":"32405156-27352802-48151042","span":{"begin":1180,"end":1182},"obj":"27352802"},{"id":"T72900","span":{"begin":1180,"end":1182},"obj":"27352802"}],"attributes":[{"subj":"32405156-27352802-48151042","pred":"source","obj":"2_test"},{"subj":"T72900","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#d193ec","default":true},{"id":"LitCovid-PD-MONDO","color":"#93ecb7"},{"id":"LitCovid-PD-CLO","color":"#ec9d93"},{"id":"LitCovid-PD-CHEBI","color":"#93a2ec"},{"id":"LitCovid-sentences","color":"#bcec93"},{"id":"LitCovid-PubTator","color":"#ec93d6"},{"id":"2_test","color":"#93ece7"}]}]}}