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PMC:7219429 / 29611-30795 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T187 426-441 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T188 560-567 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T189 597-609 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T190 776-787 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T191 872-880 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T192 1146-1158 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T101 68-76 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T102 79-88 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T103 149-157 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T104 397-405 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T105 408-417 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T106 543-551 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T274 230-235 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T275 426-432 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T276 433-441 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T277 643-644 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T278 866-871 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T279 1043-1050 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T280 1105-1113 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T559 15-18 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T560 47-56 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T561 191-199 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T562 201-204 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T563 302-311 Chemical denotes cofactors http://purl.obolibrary.org/obo/CHEBI_23357
T564 330-335 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T565 560-567 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T566 597-609 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T567 614-617 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T568 776-787 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T569 788-798 Chemical denotes saccharide http://purl.obolibrary.org/obo/CHEBI_16646
T570 845-848 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T571 872-880 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T572 971-975 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T573 1055-1064 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T574 1080-1083 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T575 1105-1113 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T576 1146-1158 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T216 0-167 Sentence denotes In conclusion, ATM and CLQ-OH have synergistic antiviral effects on SARS-CoV-2 infection, which supports the use of this combination therapy for the COVID-19 pandemic.
T217 168-312 Sentence denotes In this bitherapy, one molecule (ATM) is directed against the virus, while the other (CLQ-OH) is directed against cellular attachment cofactors.
T218 313-511 Sentence denotes However, the two drugs are predicted to act in synergy to prevent the first step of SARS-CoV-2 infection, at the plasma membrane level, where therapeutic intervention is likely to be most efficient.
T219 512-702 Sentence denotes The conserved QFN triad of the SARS-CoV-2 spike protein, which is recognized by both gangliosides and ATM, should be considered as a target for neutralizing antibodies in vaccine strategies.
T220 703-1014 Sentence denotes The molecular modelling approaches used here are based on the search for ganglioside saccharide mimicry and might be useful to identify other ATM binding sites on virus proteins, and more generally to predict the efficacy of any potential repurposed and/or innovative drug candidates before clinical evaluation.
T221 1015-1184 Sentence denotes In this respect, we suggest testing the antiviral association of ATM with short synthetic peptides specifically designed to target gangliosides without toxicity [17,33].

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
821 554-559 Gene denotes spike Gene:43740568
822 543-553 Species denotes SARS-CoV-2 Tax:2697049
823 15-18 Chemical denotes ATM MESH:D017963
824 23-29 Chemical denotes CLQ-OH
825 254-260 Chemical denotes CLQ-OH
826 526-529 Chemical denotes QFN
827 597-609 Chemical denotes gangliosides MESH:D005732
828 776-798 Chemical denotes ganglioside saccharide
829 1146-1158 Chemical denotes gangliosides MESH:D005732
830 73-88 Disease denotes CoV-2 infection MESH:C000657245
831 149-157 Disease denotes COVID-19 MESH:C000657245
832 397-417 Disease denotes SARS-CoV-2 infection MESH:C000657245
833 1167-1175 Disease denotes toxicity MESH:D064420

2_test

Id Subject Object Predicate Lexical cue
32405156-27352802-48151042 1180-1182 27352802 denotes 33
T72900 1180-1182 27352802 denotes 33