PMC:7219429 / 28199-28976 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7219429","sourcedb":"PMC","sourceid":"7219429","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7219429","text":"The posology of the combination therapy for COVID-19 is 600 mg CLQ-OH and 250 mg ATM per day [3,34]. This ratio corresponds to a molar ratio of five CLQ-OH for one ATM. In silico calculations indicate a binding ratio of four CLQ-OH for one ATM, which is close to the posology. Furthermore, as ATM shares structural similarity with the saccharide part of GM1, one should ask whether ATM could bind to CLQ-OH and by this way reduce the potential effectiveness of this combination therapy. However, as ATM and CLQ-OH have been reported to synergistically decrease SARS-CoV-2 load in infected patients [3], drug cross-neutralization is very unlikely. There was a consistent lack of evidence of any stable ATM-CLQ-OH complexes using the molecular modelling approaches in this 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