PMC:7219429 / 28199-28976
Annnotations
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T95 | 44-52 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T96 | 561-569 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T268 | 127-128 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T269 | 201-202 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T270 | 370-373 | http://purl.obolibrary.org/obo/CLO_0001755 | denotes | ask |
| T271 | 657-658 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T527 | 81-84 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T528 | 164-167 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T529 | 240-243 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T530 | 293-296 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T531 | 335-345 | Chemical | denotes | saccharide | http://purl.obolibrary.org/obo/CHEBI_16646 |
| T532 | 354-357 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T535 | 382-385 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T536 | 499-502 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T537 | 603-607 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T538 | 701-704 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
LitCovid-PD-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T35 | 354-357 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T205 | 0-100 | Sentence | denotes | The posology of the combination therapy for COVID-19 is 600 mg CLQ-OH and 250 mg ATM per day [3,34]. |
| T206 | 101-168 | Sentence | denotes | This ratio corresponds to a molar ratio of five CLQ-OH for one ATM. |
| T207 | 169-276 | Sentence | denotes | In silico calculations indicate a binding ratio of four CLQ-OH for one ATM, which is close to the posology. |
| T208 | 277-486 | Sentence | denotes | Furthermore, as ATM shares structural similarity with the saccharide part of GM1, one should ask whether ATM could bind to CLQ-OH and by this way reduce the potential effectiveness of this combination therapy. |
| T209 | 487-646 | Sentence | denotes | However, as ATM and CLQ-OH have been reported to synergistically decrease SARS-CoV-2 load in infected patients [3], drug cross-neutralization is very unlikely. |
| T210 | 647-777 | Sentence | denotes | There was a consistent lack of evidence of any stable ATM-CLQ-OH complexes using the molecular modelling approaches in this study. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 779 | 561-571 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 780 | 589-597 | Species | denotes | patients | Tax:9606 |
| 781 | 63-69 | Chemical | denotes | CLQ-OH | |
| 782 | 149-155 | Chemical | denotes | CLQ-OH | |
| 783 | 225-231 | Chemical | denotes | CLQ-OH | |
| 784 | 354-357 | Chemical | denotes | GM1 | MESH:D005677 |
| 785 | 400-406 | Chemical | denotes | CLQ-OH | |
| 786 | 507-513 | Chemical | denotes | CLQ-OH | |
| 787 | 705-711 | Chemical | denotes | CLQ-OH | |
| 788 | 44-52 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 789 | 580-588 | Disease | denotes | infected | MESH:D007239 |