PMC:7219429 / 25142-29595
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T156 | 291-298 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T157 | 437-444 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T158 | 445-456 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T159 | 565-576 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T160 | 669-681 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T161 | 859-875 | Body_part | denotes | oligosaccharides | http://purl.org/sig/ont/fma/fma82742 |
| T162 | 922-934 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T163 | 1023-1035 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T164 | 1148-1160 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T165 | 1220-1225 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T166 | 1305-1312 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T167 | 1413-1418 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T168 | 1616-1628 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T169 | 1660-1671 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T170 | 1803-1816 | Body_part | denotes | cell membrane | http://purl.org/sig/ont/fma/fma63841 |
| T171 | 1803-1807 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T172 | 1919-1922 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T173 | 1974-1982 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T174 | 2042-2059 | Body_part | denotes | glycosphingolipid | http://purl.org/sig/ont/fma/fma82814 |
| T175 | 2115-2122 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T176 | 2193-2205 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T177 | 2276-2281 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T178 | 2406-2418 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T179 | 2504-2509 | Body_part | denotes | sugar | http://purl.org/sig/ont/fma/fma82737 |
| T180 | 2531-2542 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T181 | 2571-2578 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T182 | 2611-2616 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T183 | 2642-2653 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T184 | 2862-2873 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T185 | 4041-4052 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T186 | 4422-4433 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T88 | 1294-1302 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T89 | 1474-1489 | Disease | denotes | virus infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T90 | 1480-1489 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T91 | 1879-1894 | Disease | denotes | virus infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T92 | 1885-1894 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T93 | 2081-2089 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T94 | 2385-2389 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T95 | 3101-3109 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T96 | 3618-3626 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T97 | 4135-4160 | Disease | denotes | rheumatological disorders | http://purl.obolibrary.org/obo/MONDO_0005554 |
| T98 | 4170-4175 | Disease | denotes | lupus | http://purl.obolibrary.org/obo/MONDO_0004670 |
| T99 | 4180-4200 | Disease | denotes | rheumatoid arthritis | http://purl.obolibrary.org/obo/MONDO_0008383 |
| T100 | 4191-4200 | Disease | denotes | arthritis | http://purl.obolibrary.org/obo/MONDO_0005578 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T237 | 86-91 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T238 | 225-226 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T239 | 273-275 | http://purl.obolibrary.org/obo/CLO_0007622 | denotes | MD |
| T240 | 593-601 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T241 | 682-685 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T242 | 686-687 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T243 | 1039-1047 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T244 | 1089-1091 | http://purl.obolibrary.org/obo/CLO_0007622 | denotes | MD |
| T245 | 1218-1219 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T246 | 1383-1385 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T247 | 1453-1454 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T248 | 1474-1479 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T249 | 1524-1529 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T250 | 1771-1772 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T251 | 1792-1797 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T252 | 1803-1807 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T253 | 1808-1816 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T254 | 1879-1884 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T255 | 1992-1993 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T256 | 2004-2007 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
| T257 | 2010-2011 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T258 | 2144-2151 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T259 | 2265-2272 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T260 | 2305-2307 | http://purl.obolibrary.org/obo/CLO_0007622 | denotes | MD |
| T261 | 2465-2468 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T262 | 2594-2599 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T263 | 2686-2691 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T264 | 2692-2700 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T265 | 2721-2722 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T266 | 2802-2807 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T267 | 2832-2837 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T268 | 3184-3185 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T269 | 3258-3259 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T270 | 3427-3430 | http://purl.obolibrary.org/obo/CLO_0001755 | denotes | ask |
| T271 | 3714-3715 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T272 | 4060-4061 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T273 | 4265-4266 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T477 | 135-144 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T478 | 168-171 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T479 | 273-275 | Chemical | denotes | MD | http://purl.obolibrary.org/obo/CHEBI_74699 |
| T480 | 291-298 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T481 | 299-305 | Chemical | denotes | ligand | http://purl.obolibrary.org/obo/CHEBI_52214 |
| T482 | 437-444 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T483 | 445-456 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T484 | 528-533 | Chemical | denotes | water | http://purl.obolibrary.org/obo/CHEBI_15377 |
| T485 | 542-552 | Chemical | denotes | saccharide | http://purl.obolibrary.org/obo/CHEBI_16646 |
| T486 | 565-576 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T487 | 611-619 | Chemical | denotes | ceramide | http://purl.obolibrary.org/obo/CHEBI_17761|http://purl.obolibrary.org/obo/CHEBI_52639 |
| T489 | 650-658 | Chemical | denotes | ceramide | http://purl.obolibrary.org/obo/CHEBI_17761|http://purl.obolibrary.org/obo/CHEBI_52639 |
| T491 | 669-681 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T492 | 709-719 | Chemical | denotes | saccharide | http://purl.obolibrary.org/obo/CHEBI_16646 |
| T493 | 859-875 | Chemical | denotes | oligosaccharides | http://purl.obolibrary.org/obo/CHEBI_50699 |
| T494 | 922-934 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T495 | 1023-1035 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T496 | 1089-1091 | Chemical | denotes | MD | http://purl.obolibrary.org/obo/CHEBI_74699 |
| T497 | 1148-1160 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T498 | 1175-1186 | Chemical | denotes | cholesterol | http://purl.obolibrary.org/obo/CHEBI_16113 |
| T499 | 1191-1204 | Chemical | denotes | sphingomyelin | http://purl.obolibrary.org/obo/CHEBI_17636|http://purl.obolibrary.org/obo/CHEBI_64583 |
| T501 | 1220-1225 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T502 | 1305-1312 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T503 | 1413-1418 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T504 | 1616-1628 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T505 | 1660-1671 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T506 | 1974-1982 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T507 | 2042-2059 | Chemical | denotes | glycosphingolipid | http://purl.obolibrary.org/obo/CHEBI_24402 |
| T508 | 2060-2069 | Chemical | denotes | cofactors | http://purl.obolibrary.org/obo/CHEBI_23357 |
| T509 | 2115-2122 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T510 | 2193-2205 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T511 | 2276-2281 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T512 | 2305-2307 | Chemical | denotes | MD | http://purl.obolibrary.org/obo/CHEBI_74699 |
| T513 | 2371-2374 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T514 | 2406-2418 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T515 | 2454-2457 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T516 | 2500-2503 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T519 | 2531-2542 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T520 | 2571-2578 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T521 | 2611-2616 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T522 | 2642-2653 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T523 | 2762-2767 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T524 | 2820-2823 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T525 | 2862-2873 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T526 | 2891-2896 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T527 | 3138-3141 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T528 | 3221-3224 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T529 | 3297-3300 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T530 | 3350-3353 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T531 | 3392-3402 | Chemical | denotes | saccharide | http://purl.obolibrary.org/obo/CHEBI_16646 |
| T532 | 3411-3414 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T535 | 3439-3442 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T536 | 3556-3559 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T537 | 3660-3664 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T538 | 3758-3761 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T539 | 3865-3868 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T540 | 3877-3887 | Chemical | denotes | saccharide | http://purl.obolibrary.org/obo/CHEBI_16646 |
| T541 | 3896-3899 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T544 | 3957-3977 | Chemical | denotes | macrolide antibiotic | http://purl.obolibrary.org/obo/CHEBI_25105 |
| T545 | 3957-3966 | Chemical | denotes | macrolide | http://purl.obolibrary.org/obo/CHEBI_25106 |
| T546 | 3967-3977 | Chemical | denotes | antibiotic | http://purl.obolibrary.org/obo/CHEBI_33281 |
| T547 | 4041-4056 | Chemical | denotes | ganglioside GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048 |
| T549 | 4041-4052 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T550 | 4053-4056 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_73110 |
| T551 | 4127-4131 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T552 | 4218-4221 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T555 | 4246-4249 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T558 | 4422-4433 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T5 | 86-109 | http://purl.obolibrary.org/obo/GO_0019048 | denotes | virus-host interactions |
LitCovid-PD-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T34 | 2500-2503 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T35 | 3411-3414 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T36 | 3896-3899 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T37 | 4053-4056 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T38 | 4218-4221 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T39 | 4241-4249 | GlycoEpitope | denotes | anti-GM1 | http://www.glycoepitope.jp/epitopes/AN0713 |
| T40 | 4246-4249 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 4180-4200 | Phenotype | denotes | rheumatoid arthritis | http://purl.obolibrary.org/obo/HP_0001370 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T185 | 0-13 | Sentence | denotes | 4 Discussion |
| T186 | 14-198 | Sentence | denotes | In this study, molecular modelling approaches specifically dedicated to virus-host interactions were used to unravel the antiviral mechanism of action of ATM and CLQ-OH in combination. |
| T187 | 199-363 | Sentence | denotes | The study method included a first round of molecular docking, followed by MD simulations of protein-ligand interactions to assess the robustness of each model [25]. |
| T188 | 364-630 | Sentence | denotes | Such computer-assisted simulations are particularly helpful for studying protein-ganglioside interactions as crystallographic approaches are usually limited to the water-soluble saccharide part of the ganglioside, neglecting the membrane embedded-ceramide part [31]. |
| T189 | 631-828 | Sentence | denotes | Unfortunately, the ceramide moiety of gangliosides has a marked effect on the saccharide part with which it interacts, resulting in significant restriction of its conformational possibilities [32]. |
| T190 | 829-935 | Sentence | denotes | Therefore, data obtained with oligosaccharides cannot be systematically transposed to intact gangliosides. |
| T191 | 936-1084 | Sentence | denotes | Molecular modelling approaches circumvented this difficulty and enabled study of whole gangliosides in membrane-compatible conformations [16,32,33]. |
| T192 | 1085-1243 | Sentence | denotes | The MD simulations performed in the present study were done on gangliosides surrounded by cholesterol and sphingomyelin, which mimic a lipid raft environment. |
| T193 | 1244-1391 | Sentence | denotes | To date, there are several structural data of the SARS-CoV-2 protein in the prefusion conformation or bound to its primary receptor ACE-2 [11, 20]. |
| T194 | 1392-1495 | Sentence | denotes | However, ACE-2 is in lipid rafts and raft disruption induces a marked decrease of virus infection [15]. |
| T195 | 1496-1629 | Sentence | denotes | Thus, it is likely that the virus interacts with the raft surface through multivalent contacts involving both ACE-2 and gangliosides. |
| T196 | 1630-1765 | Sentence | denotes | The fact that the RBD and the ganglioside-binding domain belong to distinct parts of the trimeric spike is consistent with this notion. |
| T197 | 1766-1906 | Sentence | denotes | Such a complex network of virus-host cell membrane interactions is also consistent with previously characterized virus infection strategies. |
| T198 | 1907-2075 | Sentence | denotes | Indeed, the HIV-1 fusion process driven by gp120 and gp41 envelope proteins involves a receptor (CD4), a coreceptor (chiefly CCR5) and glycosphingolipid cofactors [39]. |
| T199 | 2076-2300 | Sentence | denotes | Like SARS-CoV-2, the pentameric capsid protein of SV40, and polyoma viruses display three distinct binding sites for gangliosides, which serve as critical receptors for these non-enveloped viruses in lipid raft domains [40]. |
| T200 | 2301-2453 | Sentence | denotes | The MD simulations in the current study indicate that both CLQ-OH and ATM may block SARS-CoV2 binding to gangliosides via mirror competitive mechanisms. |
| T201 | 2454-2623 | Sentence | denotes | ATM, which has some molecular similarity with GM1 sugar, can thus occupy the ganglioside-binding domain of the spike protein and neutralize virus binding to lipid rafts. |
| T202 | 2624-2747 | Sentence | denotes | CLQ-OH covers the ganglioside surface, and thus also prevents virus-membrane interaction through a complementary mechanism. |
| T203 | 2748-2882 | Sentence | denotes | Each of these drugs might be efficient alone to block virus attachment, ATM through virus binding, CLQ-OH through ganglioside binding. |
| T204 | 2883-3056 | Sentence | denotes | As both drugs interfere with the same mechanism but with distinct molecular targets, they are expected to work together in synergy, as indicated by recent clinical data [3]. |
| T205 | 3057-3157 | Sentence | denotes | The posology of the combination therapy for COVID-19 is 600 mg CLQ-OH and 250 mg ATM per day [3,34]. |
| T206 | 3158-3225 | Sentence | denotes | This ratio corresponds to a molar ratio of five CLQ-OH for one ATM. |
| T207 | 3226-3333 | Sentence | denotes | In silico calculations indicate a binding ratio of four CLQ-OH for one ATM, which is close to the posology. |
| T208 | 3334-3543 | Sentence | denotes | Furthermore, as ATM shares structural similarity with the saccharide part of GM1, one should ask whether ATM could bind to CLQ-OH and by this way reduce the potential effectiveness of this combination therapy. |
| T209 | 3544-3703 | Sentence | denotes | However, as ATM and CLQ-OH have been reported to synergistically decrease SARS-CoV-2 load in infected patients [3], drug cross-neutralization is very unlikely. |
| T210 | 3704-3834 | Sentence | denotes | There was a consistent lack of evidence of any stable ATM-CLQ-OH complexes using the molecular modelling approaches in this study. |
| T211 | 3835-4016 | Sentence | denotes | The molecular mimicry between ATM and the saccharide part of GM1 gives new perspectives on the therapeutic effect of this macrolide antibiotic and this warrants further exploration. |
| T212 | 4017-4209 | Sentence | denotes | Moreover, the fact that ganglioside GM1 is a molecular target for CLQ-OH might explain the indication of this drug in rheumatological disorders, such as lupus and rheumatoid arthritis [35,36]. |
| T213 | 4210-4302 | Sentence | denotes | Indeed, GM1 overexpression and anti-GM1 antibodies are a hallmark of these diseases [37,38]. |
| T214 | 4303-4453 | Sentence | denotes | Thus, our data incidentally indicate that the therapeutic effect of CLQ-OH in these cases could also be related to its ganglioside-binding properties. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 696 | 176-182 | Chemical | denotes | CLQ-OH | |
| 697 | 445-456 | Chemical | denotes | ganglioside | MESH:D005732 |
| 698 | 528-533 | Chemical | denotes | water | MESH:D014867 |
| 699 | 542-552 | Chemical | denotes | saccharide | MESH:D002241 |
| 700 | 565-576 | Chemical | denotes | ganglioside | MESH:D005732 |
| 701 | 611-619 | Chemical | denotes | ceramide | MESH:D002518 |
| 702 | 650-658 | Chemical | denotes | ceramide | MESH:D002518 |
| 703 | 669-681 | Chemical | denotes | gangliosides | MESH:D005732 |
| 704 | 709-719 | Chemical | denotes | saccharide | MESH:D002241 |
| 705 | 859-875 | Chemical | denotes | oligosaccharides | MESH:D009844 |
| 706 | 922-934 | Chemical | denotes | gangliosides | MESH:D005732 |
| 707 | 1023-1035 | Chemical | denotes | gangliosides | MESH:D005732 |
| 708 | 1148-1160 | Chemical | denotes | gangliosides | MESH:D005732 |
| 709 | 1175-1186 | Chemical | denotes | cholesterol | MESH:D002784 |
| 710 | 1191-1204 | Chemical | denotes | sphingomyelin | MESH:D013109 |
| 711 | 1220-1225 | Chemical | denotes | lipid | MESH:D008055 |
| 729 | 1376-1381 | Gene | denotes | ACE-2 | Gene:59272 |
| 730 | 1401-1406 | Gene | denotes | ACE-2 | Gene:59272 |
| 731 | 1606-1611 | Gene | denotes | ACE-2 | Gene:59272 |
| 732 | 1950-1955 | Gene | denotes | gp120 | Gene:3700 |
| 733 | 2004-2007 | Gene | denotes | CD4 | Gene:920 |
| 734 | 2032-2036 | Gene | denotes | CCR5 | Gene:1234 |
| 735 | 1728-1733 | Gene | denotes | spike | Gene:43740568 |
| 736 | 1294-1304 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 737 | 1919-1924 | Species | denotes | HIV-1 | Tax:11676 |
| 738 | 2081-2091 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 739 | 1413-1418 | Chemical | denotes | lipid | MESH:D008055 |
| 740 | 1616-1628 | Chemical | denotes | gangliosides | MESH:D005732 |
| 741 | 1660-1671 | Chemical | denotes | ganglioside | MESH:D005732 |
| 742 | 2193-2205 | Chemical | denotes | gangliosides | MESH:D005732 |
| 743 | 2276-2281 | Chemical | denotes | lipid | MESH:D008055 |
| 744 | 1462-1489 | Disease | denotes | decrease of virus infection | MESH:D001102 |
| 745 | 1879-1894 | Disease | denotes | virus infection | MESH:D001102 |
| 757 | 2565-2570 | Gene | denotes | spike | Gene:43740568 |
| 758 | 2385-2394 | Species | denotes | SARS-CoV2 | Tax:2697049 |
| 759 | 2360-2366 | Chemical | denotes | CLQ-OH | |
| 760 | 2406-2418 | Chemical | denotes | gangliosides | MESH:D005732 |
| 761 | 2500-2509 | Chemical | denotes | GM1 sugar | |
| 762 | 2531-2542 | Chemical | denotes | ganglioside | MESH:D005732 |
| 763 | 2611-2616 | Chemical | denotes | lipid | MESH:D008055 |
| 764 | 2624-2630 | Chemical | denotes | CLQ-OH | |
| 765 | 2642-2653 | Chemical | denotes | ganglioside | MESH:D005732 |
| 766 | 2847-2853 | Chemical | denotes | CLQ-OH | |
| 767 | 2862-2873 | Chemical | denotes | ganglioside | MESH:D005732 |
| 779 | 3618-3628 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 780 | 3646-3654 | Species | denotes | patients | Tax:9606 |
| 781 | 3120-3126 | Chemical | denotes | CLQ-OH | |
| 782 | 3206-3212 | Chemical | denotes | CLQ-OH | |
| 783 | 3282-3288 | Chemical | denotes | CLQ-OH | |
| 784 | 3411-3414 | Chemical | denotes | GM1 | MESH:D005677 |
| 785 | 3457-3463 | Chemical | denotes | CLQ-OH | |
| 786 | 3564-3570 | Chemical | denotes | CLQ-OH | |
| 787 | 3762-3768 | Chemical | denotes | CLQ-OH | |
| 788 | 3101-3109 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 789 | 3637-3645 | Disease | denotes | infected | MESH:D007239 |
| 799 | 3896-3899 | Chemical | denotes | GM1 | MESH:D005677 |
| 800 | 3957-3966 | Chemical | denotes | macrolide | MESH:D018942 |
| 801 | 4041-4056 | Chemical | denotes | ganglioside GM1 | MESH:D005677 |
| 802 | 4083-4089 | Chemical | denotes | CLQ-OH | |
| 803 | 4371-4377 | Chemical | denotes | CLQ-OH | |
| 804 | 4422-4433 | Chemical | denotes | ganglioside | MESH:D005732 |
| 805 | 4135-4160 | Disease | denotes | rheumatological disorders | MESH:D012216 |
| 806 | 4170-4175 | Disease | denotes | lupus | MESH:D008180 |
| 807 | 4180-4200 | Disease | denotes | rheumatoid arthritis | MESH:D001172 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32405156-30236283-48151027 | 359-361 | 30236283 | denotes | 25 |
| 32405156-23807078-48151028 | 626-628 | 23807078 | denotes | 31 |
| 32405156-23772214-48151029 | 824-826 | 23772214 | denotes | 32 |
| 32405156-31431523-48151030 | 1074-1076 | 31431523 | denotes | 16 |
| 32405156-23772214-48151031 | 1077-1079 | 23772214 | denotes | 32 |
| 32405156-27352802-48151032 | 1080-1082 | 27352802 | denotes | 33 |
| 32405156-32132184-48151033 | 1383-1385 | 32132184 | denotes | 11 |
| 32405156-32075877-48151034 | 1387-1389 | 32075877 | denotes | 20 |
| 32405156-18814896-48151035 | 1491-1493 | 18814896 | denotes | 15 |
| 32405156-10233996-48151036 | 2071-2073 | 10233996 | denotes | 39 |
| 32405156-18353982-48151037 | 2296-2298 | 18353982 | denotes | 40 |
| 32405156-27927040-48151038 | 4202-4204 | 27927040 | denotes | 35 |
| 32405156-32034323-48151039 | 4205-4207 | 32034323 | denotes | 36 |
| 32405156-7869176-48151040 | 4295-4297 | 7869176 | denotes | 37 |
| 32405156-24463447-48151041 | 4298-4300 | 24463447 | denotes | 38 |
| T72401 | 359-361 | 30236283 | denotes | 25 |
| T44542 | 626-628 | 23807078 | denotes | 31 |
| T20321 | 824-826 | 23772214 | denotes | 32 |
| T12506 | 1074-1076 | 31431523 | denotes | 16 |
| T69993 | 1077-1079 | 23772214 | denotes | 32 |
| T86224 | 1080-1082 | 27352802 | denotes | 33 |
| T12821 | 1383-1385 | 32132184 | denotes | 11 |
| T54020 | 1387-1389 | 32075877 | denotes | 20 |
| T89246 | 1491-1493 | 18814896 | denotes | 15 |
| T51159 | 2071-2073 | 10233996 | denotes | 39 |
| T64785 | 2296-2298 | 18353982 | denotes | 40 |
| T46993 | 4202-4204 | 27927040 | denotes | 35 |
| T37791 | 4205-4207 | 32034323 | denotes | 36 |
| T3943 | 4295-4297 | 7869176 | denotes | 37 |
| T30913 | 4298-4300 | 24463447 | denotes | 38 |