PMC:7219429 / 24676-25040 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T152","span":{"begin":176,"end":181},"obj":"Body_part"},{"id":"T153","span":{"begin":346,"end":357},"obj":"Body_part"}],"attributes":[{"id":"A152","pred":"fma_id","subj":"T152","obj":"http://purl.org/sig/ont/fma/fma67264"},{"id":"A153","pred":"fma_id","subj":"T153","obj":"http://purl.org/sig/ont/fma/fma82816"}],"text":"Taken together, these molecular modelling studies indicate that CLQ-OH and ATM, when bound to their respective targets, totally mask the complementary surfaces provided by the lipid raft and the virus spike (Fig. 8c): CLQ-OH binds to GM1 and covers the wing, ATM binds to the virus spike and prevents any interaction with the central area of the ganglioside dimer."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T15","span":{"begin":253,"end":257},"obj":"Body_part"}],"attributes":[{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/UBERON_0000023"}],"text":"Taken together, these molecular modelling studies indicate that CLQ-OH and ATM, when bound to their respective targets, totally mask the complementary surfaces provided by the lipid raft and the virus spike (Fig. 8c): CLQ-OH binds to GM1 and covers the wing, ATM binds to the virus spike and prevents any interaction with the central area of the ganglioside dimer."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T233","span":{"begin":195,"end":200},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T234","span":{"begin":276,"end":281},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"text":"Taken together, these molecular modelling studies indicate that CLQ-OH and ATM, when bound to their respective targets, totally mask the complementary surfaces provided by the lipid raft and the virus spike (Fig. 8c): CLQ-OH binds to GM1 and covers the wing, ATM binds to the virus spike and prevents any interaction with the central area of the ganglioside dimer."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T468","span":{"begin":75,"end":78},"obj":"Chemical"},{"id":"T469","span":{"begin":176,"end":181},"obj":"Chemical"},{"id":"T470","span":{"begin":234,"end":237},"obj":"Chemical"},{"id":"T473","span":{"begin":259,"end":262},"obj":"Chemical"},{"id":"T474","span":{"begin":346,"end":357},"obj":"Chemical"}],"attributes":[{"id":"A468","pred":"chebi_id","subj":"T468","obj":"http://purl.obolibrary.org/obo/CHEBI_2955"},{"id":"A469","pred":"chebi_id","subj":"T469","obj":"http://purl.obolibrary.org/obo/CHEBI_18059"},{"id":"A470","pred":"chebi_id","subj":"T470","obj":"http://purl.obolibrary.org/obo/CHEBI_18216"},{"id":"A471","pred":"chebi_id","subj":"T470","obj":"http://purl.obolibrary.org/obo/CHEBI_61048"},{"id":"A472","pred":"chebi_id","subj":"T470","obj":"http://purl.obolibrary.org/obo/CHEBI_73110"},{"id":"A473","pred":"chebi_id","subj":"T473","obj":"http://purl.obolibrary.org/obo/CHEBI_2955"},{"id":"A474","pred":"chebi_id","subj":"T474","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"}],"text":"Taken together, these molecular modelling studies indicate that CLQ-OH and ATM, when bound to their respective targets, totally mask the complementary surfaces provided by the lipid raft and the virus spike (Fig. 8c): CLQ-OH binds to GM1 and covers the wing, ATM binds to the virus spike and prevents any interaction with the central area of the ganglioside dimer."}

{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T33","span":{"begin":234,"end":237},"obj":"GlycoEpitope"}],"attributes":[{"id":"A33","pred":"glyco_epitope_db_id","subj":"T33","obj":"http://www.glycoepitope.jp/epitopes/EP0050"}],"text":"Taken together, these molecular modelling studies indicate that CLQ-OH and ATM, when bound to their respective targets, totally mask the complementary surfaces provided by the lipid raft and the virus spike (Fig. 8c): CLQ-OH binds to GM1 and covers the wing, ATM binds to the virus spike and prevents any interaction with the central area of the ganglioside dimer."}

{"project":"LitCovid-sentences","denotations":[{"id":"T183","span":{"begin":0,"end":364},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Taken together, these molecular modelling studies indicate that CLQ-OH and ATM, when bound to their respective targets, totally mask the complementary surfaces provided by the lipid raft and the virus spike (Fig. 8c): CLQ-OH binds to GM1 and covers the wing, ATM binds to the virus spike and prevents any interaction with the central area of the ganglioside dimer."}

{"project":"LitCovid-PubTator","denotations":[{"id":"650","span":{"begin":282,"end":287},"obj":"Gene"},{"id":"651","span":{"begin":201,"end":206},"obj":"Gene"},{"id":"675","span":{"begin":64,"end":70},"obj":"Chemical"},{"id":"676","span":{"begin":176,"end":181},"obj":"Chemical"},{"id":"677","span":{"begin":218,"end":224},"obj":"Chemical"},{"id":"678","span":{"begin":234,"end":237},"obj":"Chemical"},{"id":"679","span":{"begin":346,"end":357},"obj":"Chemical"}],"attributes":[{"id":"A650","pred":"tao:has_database_id","subj":"650","obj":"Gene:43740568"},{"id":"A651","pred":"tao:has_database_id","subj":"651","obj":"Gene:43740568"},{"id":"A676","pred":"tao:has_database_id","subj":"676","obj":"MESH:D008055"},{"id":"A678","pred":"tao:has_database_id","subj":"678","obj":"MESH:D005677"},{"id":"A679","pred":"tao:has_database_id","subj":"679","obj":"MESH:D005732"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Taken together, these molecular modelling studies indicate that CLQ-OH and ATM, when bound to their respective targets, totally mask the complementary surfaces provided by the lipid raft and the virus spike (Fig. 8c): CLQ-OH binds to GM1 and covers the wing, ATM binds to the virus spike and prevents any interaction with the central area of the ganglioside dimer."}