PMC:7219429 / 21527-22690
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T127 | 100-107 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T128 | 120-131 | Body_part | denotes | Ganglioside | http://purl.org/sig/ont/fma/fma82816 |
T129 | 243-248 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
T130 | 293-300 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T131 | 332-344 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
T132 | 393-404 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
T133 | 437-444 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T134 | 475-487 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
T135 | 602-613 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
T136 | 784-791 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T137 | 828-839 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
T138 | 935-942 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T82 | 83-91 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T83 | 276-284 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T84 | 420-428 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T85 | 767-775 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T86 | 918-926 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T209 | 63-64 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T210 | 117-118 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
T211 | 183-184 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T212 | 568-573 | http://purl.obolibrary.org/obo/CLO_0050605 | denotes | (d) 4 |
T213 | 600-601 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T396 | 14-17 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
T397 | 66-69 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
T398 | 100-107 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T399 | 120-131 | Chemical | denotes | Ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
T400 | 166-169 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
T403 | 170-179 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
T404 | 243-248 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
T405 | 293-300 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T406 | 324-327 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
T407 | 332-344 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
T408 | 380-383 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
T409 | 393-404 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
T410 | 437-444 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T411 | 475-487 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
T412 | 581-590 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
T413 | 602-613 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
T414 | 626-629 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
T417 | 630-638 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
T418 | 664-673 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
T419 | 724-734 | Chemical | denotes | saccharide | http://purl.obolibrary.org/obo/CHEBI_16646 |
T420 | 784-791 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T421 | 809-812 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
T424 | 828-839 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
T425 | 935-942 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T426 | 960-963 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
T427 | 1086-1089 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
T428 | 1094-1097 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
LitCovid-PD-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
---|---|---|---|---|---|
T24 | 166-169 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
T25 | 626-629 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
T26 | 809-812 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
T27 | 1094-1097 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T161 | 0-308 | Sentence | denotes | Fig. 8 CLQ-OH/ATM combination therapy at the molecular level. (a) ATM bound to the SARS-CoV-2 spike protein trimer. (b) Ganglioside dimer (two symmetrically arranged GM1 molecules in a typical chalice-like shape, just like the one observed in lipid raft simulations) bound to SARS-CoV-2 spike protein trimer. |
T162 | 309-452 | Sentence | denotes | Note that both ATM and gangliosides share the same binding region. (c) ATM prevents ganglioside binding to the SARS-CoV-2 spike protein trimer. |
T163 | 453-620 | Sentence | denotes | CLQ-OH, once bound to gangliosides (blue and orange surfaces), also prevents any interaction with the viral spike. (d) 4 CLQ-OH molecules bound to a ganglioside dimer. |
T164 | 621-813 | Sentence | denotes | Each GM1 molecule is blocked by two CLQ-OH molecules (blue and orange surfaces), which wrap around the saccharide part. (e) Detail of the 134-138 SARS-CoV-2 spike protein stretch bound to GM1. |
T165 | 814-964 | Sentence | denotes | Note that the ganglioside interacts with Q-134 and F-135, but not with D-138. (f) Detail of the 134-138 SARS-CoV-2 spike protein stretch bound to ATM. |
T166 | 965-1042 | Sentence | denotes | In this case, the binding site includes D-138 in addition to Q-134 and F-135. |
T167 | 1043-1163 | Sentence | denotes | Note that N-137, which interacts with both ATM and GM1, is not visible in these representations as it is located behind. |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
567 | 929-934 | Gene | denotes | spike | Gene:43740568 |
568 | 778-783 | Gene | denotes | spike | Gene:43740568 |
569 | 561-566 | Gene | denotes | spike | Gene:43740568 |
570 | 431-436 | Gene | denotes | spike | Gene:43740568 |
571 | 287-292 | Gene | denotes | spike | Gene:43740568 |
572 | 94-99 | Gene | denotes | spike | Gene:43740568 |
573 | 83-93 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
574 | 276-286 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
575 | 420-430 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
576 | 767-777 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
577 | 918-928 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
578 | 7-13 | Chemical | denotes | CLQ-OH | |
579 | 120-131 | Chemical | denotes | Ganglioside | MESH:D005732 |
580 | 166-169 | Chemical | denotes | GM1 | MESH:D005677 |
581 | 243-248 | Chemical | denotes | lipid | MESH:D008055 |
582 | 332-344 | Chemical | denotes | gangliosides | MESH:D005732 |
583 | 393-404 | Chemical | denotes | ganglioside | MESH:D005732 |
584 | 453-459 | Chemical | denotes | CLQ-OH | |
585 | 475-487 | Chemical | denotes | gangliosides | MESH:D005732 |
586 | 574-580 | Chemical | denotes | CLQ-OH | |
587 | 602-613 | Chemical | denotes | ganglioside | MESH:D005732 |
588 | 626-629 | Chemical | denotes | GM1 | MESH:D005677 |
589 | 657-663 | Chemical | denotes | CLQ-OH | |
590 | 809-812 | Chemical | denotes | GM1 | MESH:D005677 |
591 | 828-839 | Chemical | denotes | ganglioside | MESH:D005732 |
592 | 1005-1010 | Chemical | denotes | D-138 | |
593 | 1026-1031 | Chemical | denotes | Q-134 | |
594 | 1053-1058 | Chemical | denotes | N-137 | MESH:C022084 |
595 | 1094-1097 | Chemical | denotes | GM1 | MESH:D005677 |