PMC:7219429 / 15164-16049 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T83","span":{"begin":54,"end":61},"obj":"Body_part"},{"id":"T84","span":{"begin":144,"end":151},"obj":"Body_part"},{"id":"T85","span":{"begin":337,"end":344},"obj":"Body_part"},{"id":"T86","span":{"begin":518,"end":525},"obj":"Body_part"}],"attributes":[{"id":"A83","pred":"fma_id","subj":"T83","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A84","pred":"fma_id","subj":"T84","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A85","pred":"fma_id","subj":"T85","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A86","pred":"fma_id","subj":"T86","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Fig. 2 Molecular complex between the SARS-CoV-2 spike protein trimer and ATM. (a) Detailed view of ATM bound to the NTD tip of SARS-CoV-2 spike protein chain A, shown at two distinct magnifications and orientations (left and right panels). Note that the NTD tip displays a complementary landing surface for ATM (highlighted in red). The protein stretch 134-138, which contains the QFN triad, is highlighted in green. (b) The trimeric structure of the SARS-CoV-2 spike is represented in surface rendition with subunit (protein chain A, B and C) in cyan, yellow and purple, respectively. AMT (in red) is bound to the tip of the NTD domain of the A subunit (left panel). The ribbon structure of the cyan (chain A) subunit is shown in the right panel. (c) Above views of the spike-ATM complex. Note that the B and C subunits also display a fully accessible ATM binding site (red asterisk)."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T9","span":{"begin":120,"end":123},"obj":"Body_part"},{"id":"T10","span":{"begin":258,"end":261},"obj":"Body_part"},{"id":"T11","span":{"begin":615,"end":618},"obj":"Body_part"}],"attributes":[{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/UBERON_2001840"},{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_2001840"},{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_2001840"}],"text":"Fig. 2 Molecular complex between the SARS-CoV-2 spike protein trimer and ATM. (a) Detailed view of ATM bound to the NTD tip of SARS-CoV-2 spike protein chain A, shown at two distinct magnifications and orientations (left and right panels). Note that the NTD tip displays a complementary landing surface for ATM (highlighted in red). The protein stretch 134-138, which contains the QFN triad, is highlighted in green. (b) The trimeric structure of the SARS-CoV-2 spike is represented in surface rendition with subunit (protein chain A, B and C) in cyan, yellow and purple, respectively. AMT (in red) is bound to the tip of the NTD domain of the A subunit (left panel). The ribbon structure of the cyan (chain A) subunit is shown in the right panel. (c) Above views of the spike-ATM complex. Note that the B and C subunits also display a fully accessible ATM binding site (red asterisk)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T52","span":{"begin":37,"end":45},"obj":"Disease"},{"id":"T53","span":{"begin":116,"end":119},"obj":"Disease"},{"id":"T55","span":{"begin":127,"end":135},"obj":"Disease"},{"id":"T56","span":{"begin":254,"end":257},"obj":"Disease"},{"id":"T58","span":{"begin":451,"end":459},"obj":"Disease"},{"id":"T59","span":{"begin":626,"end":629},"obj":"Disease"}],"attributes":[{"id":"A52","pred":"mondo_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A53","pred":"mondo_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A54","pred":"mondo_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"},{"id":"A55","pred":"mondo_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A56","pred":"mondo_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A57","pred":"mondo_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"},{"id":"A58","pred":"mondo_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A59","pred":"mondo_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A60","pred":"mondo_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"}],"text":"Fig. 2 Molecular complex between the SARS-CoV-2 spike protein trimer and ATM. (a) Detailed view of ATM bound to the NTD tip of SARS-CoV-2 spike protein chain A, shown at two distinct magnifications and orientations (left and right panels). Note that the NTD tip displays a complementary landing surface for ATM (highlighted in red). The protein stretch 134-138, which contains the QFN triad, is highlighted in green. (b) The trimeric structure of the SARS-CoV-2 spike is represented in surface rendition with subunit (protein chain A, B and C) in cyan, yellow and purple, respectively. AMT (in red) is bound to the tip of the NTD domain of the A subunit (left panel). The ribbon structure of the cyan (chain A) subunit is shown in the right panel. (c) Above views of the spike-ATM complex. Note that the B and C subunits also display a fully accessible ATM binding site (red asterisk)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T151","span":{"begin":79,"end":80},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T152","span":{"begin":158,"end":159},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T153","span":{"begin":271,"end":272},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T154","span":{"begin":418,"end":419},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T155","span":{"begin":532,"end":533},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T156","span":{"begin":535,"end":536},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T157","span":{"begin":644,"end":645},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T158","span":{"begin":708,"end":709},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T159","span":{"begin":804,"end":805},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T160","span":{"begin":834,"end":835},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Fig. 2 Molecular complex between the SARS-CoV-2 spike protein trimer and ATM. (a) Detailed view of ATM bound to the NTD tip of SARS-CoV-2 spike protein chain A, shown at two distinct magnifications and orientations (left and right panels). Note that the NTD tip displays a complementary landing surface for ATM (highlighted in red). The protein stretch 134-138, which contains the QFN triad, is highlighted in green. (b) The trimeric structure of the SARS-CoV-2 spike is represented in surface rendition with subunit (protein chain A, B and C) in cyan, yellow and purple, respectively. AMT (in red) is bound to the tip of the NTD domain of the A subunit (left panel). The ribbon structure of the cyan (chain A) subunit is shown in the right panel. (c) Above views of the spike-ATM complex. Note that the B and C subunits also display a fully accessible ATM binding site (red asterisk)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T252","span":{"begin":54,"end":61},"obj":"Chemical"},{"id":"T253","span":{"begin":73,"end":76},"obj":"Chemical"},{"id":"T254","span":{"begin":99,"end":102},"obj":"Chemical"},{"id":"T255","span":{"begin":144,"end":151},"obj":"Chemical"},{"id":"T256","span":{"begin":307,"end":310},"obj":"Chemical"},{"id":"T257","span":{"begin":337,"end":344},"obj":"Chemical"},{"id":"T258","span":{"begin":518,"end":525},"obj":"Chemical"},{"id":"T259","span":{"begin":777,"end":780},"obj":"Chemical"},{"id":"T260","span":{"begin":853,"end":856},"obj":"Chemical"}],"attributes":[{"id":"A252","pred":"chebi_id","subj":"T252","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A253","pred":"chebi_id","subj":"T253","obj":"http://purl.obolibrary.org/obo/CHEBI_2955"},{"id":"A254","pred":"chebi_id","subj":"T254","obj":"http://purl.obolibrary.org/obo/CHEBI_2955"},{"id":"A255","pred":"chebi_id","subj":"T255","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A256","pred":"chebi_id","subj":"T256","obj":"http://purl.obolibrary.org/obo/CHEBI_2955"},{"id":"A257","pred":"chebi_id","subj":"T257","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A258","pred":"chebi_id","subj":"T258","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A259","pred":"chebi_id","subj":"T259","obj":"http://purl.obolibrary.org/obo/CHEBI_2955"},{"id":"A260","pred":"chebi_id","subj":"T260","obj":"http://purl.obolibrary.org/obo/CHEBI_2955"}],"text":"Fig. 2 Molecular complex between the SARS-CoV-2 spike protein trimer and ATM. (a) Detailed view of ATM bound to the NTD tip of SARS-CoV-2 spike protein chain A, shown at two distinct magnifications and orientations (left and right panels). Note that the NTD tip displays a complementary landing surface for ATM (highlighted in red). The protein stretch 134-138, which contains the QFN triad, is highlighted in green. (b) The trimeric structure of the SARS-CoV-2 spike is represented in surface rendition with subunit (protein chain A, B and C) in cyan, yellow and purple, respectively. AMT (in red) is bound to the tip of the NTD domain of the A subunit (left panel). The ribbon structure of the cyan (chain A) subunit is shown in the right panel. (c) Above views of the spike-ATM complex. Note that the B and C subunits also display a fully accessible ATM binding site (red asterisk)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T109","span":{"begin":0,"end":239},"obj":"Sentence"},{"id":"T110","span":{"begin":240,"end":332},"obj":"Sentence"},{"id":"T111","span":{"begin":333,"end":585},"obj":"Sentence"},{"id":"T112","span":{"begin":586,"end":667},"obj":"Sentence"},{"id":"T113","span":{"begin":668,"end":789},"obj":"Sentence"},{"id":"T114","span":{"begin":790,"end":885},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Fig. 2 Molecular complex between the SARS-CoV-2 spike protein trimer and ATM. (a) Detailed view of ATM bound to the NTD tip of SARS-CoV-2 spike protein chain A, shown at two distinct magnifications and orientations (left and right panels). Note that the NTD tip displays a complementary landing surface for ATM (highlighted in red). The protein stretch 134-138, which contains the QFN triad, is highlighted in green. (b) The trimeric structure of the SARS-CoV-2 spike is represented in surface rendition with subunit (protein chain A, B and C) in cyan, yellow and purple, respectively. AMT (in red) is bound to the tip of the NTD domain of the A subunit (left panel). The ribbon structure of the cyan (chain A) subunit is shown in the right panel. (c) Above views of the spike-ATM complex. Note that the B and C subunits also display a fully accessible ATM binding site (red asterisk)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"379","span":{"begin":138,"end":143},"obj":"Gene"},{"id":"380","span":{"begin":771,"end":776},"obj":"Gene"},{"id":"381","span":{"begin":48,"end":53},"obj":"Gene"},{"id":"382","span":{"begin":804,"end":811},"obj":"Gene"},{"id":"383","span":{"begin":462,"end":467},"obj":"Gene"},{"id":"384","span":{"begin":535,"end":542},"obj":"Gene"},{"id":"385","span":{"begin":37,"end":47},"obj":"Species"},{"id":"386","span":{"begin":127,"end":137},"obj":"Species"},{"id":"387","span":{"begin":451,"end":461},"obj":"Species"}],"attributes":[{"id":"A379","pred":"tao:has_database_id","subj":"379","obj":"Gene:43740568"},{"id":"A380","pred":"tao:has_database_id","subj":"380","obj":"Gene:43740568"},{"id":"A381","pred":"tao:has_database_id","subj":"381","obj":"Gene:43740568"},{"id":"A383","pred":"tao:has_database_id","subj":"383","obj":"Gene:43740568"},{"id":"A385","pred":"tao:has_database_id","subj":"385","obj":"Tax:2697049"},{"id":"A386","pred":"tao:has_database_id","subj":"386","obj":"Tax:2697049"},{"id":"A387","pred":"tao:has_database_id","subj":"387","obj":"Tax:2697049"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Fig. 2 Molecular complex between the SARS-CoV-2 spike protein trimer and ATM. (a) Detailed view of ATM bound to the NTD tip of SARS-CoV-2 spike protein chain A, shown at two distinct magnifications and orientations (left and right panels). Note that the NTD tip displays a complementary landing surface for ATM (highlighted in red). The protein stretch 134-138, which contains the QFN triad, is highlighted in green. (b) The trimeric structure of the SARS-CoV-2 spike is represented in surface rendition with subunit (protein chain A, B and C) in cyan, yellow and purple, respectively. AMT (in red) is bound to the tip of the NTD domain of the A subunit (left panel). The ribbon structure of the cyan (chain A) subunit is shown in the right panel. (c) Above views of the spike-ATM complex. Note that the B and C subunits also display a fully accessible ATM binding site (red asterisk)."}