PMC:7212965 / 5490-8748 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7212965","sourcedb":"PMC","sourceid":"7212965","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7212965","text":"Scope and Purpose\nWe seek to summarize international data on the Gl and liver manifestations of COVID-19 infection and treatment. Additionally, this document provides evidence-based clinical guidance on clinical questions that gastroenterologists may be consulted for. This rapid review document was commissioned and approved by the AGA Institute Clinical Guidelines Committee, AGA Institute Clinical Practice Updates Committee, and the AGA Governing Board to provide timely, methodologically rigorous guidance on a topic of high clinical importance to the AGA members and the public. Table 1 provides a summary of the recommendations and best practice statements.\nTable 1 Summary of Best Practice Statements: Consultative Management of Coronavirus Disease 2019\nStatement no. Statement\n1 In outpatients with new-onset diarrhea, ascertain information about high-risk contact exposure; obtain a detailed history of symptoms associated with COVID-19, including fever, cough, shortness of breath, chills, muscle pain, headache, sore throat, or new loss of taste or smell; and obtain a thorough history for other Gl symptoms, including nausea, vomiting, and abdominal pain.\n2 In outpatients with new-onset Gl symptoms (eg, nausea, vomiting, abdominal pain, and diarrhea), monitor for symptoms associated with COVID-19, as GI symptoms may precede COVID-related symptoms by a few days. In a high COVID-19 prevalence setting, COVID-19 testing should be considered.\n3 In hospitalized patients with suspected or known COVID-19, obtain a thorough history of GI symptoms (ie, nausea, vomiting, abdominal pain, and diarrhea), including onset, characteristics, duration, and severity.\n4 There is presently inadequate evidence to support stool testing for diagnosis or monitoring of COVID-19 as part of routine clinical practice.\n5 In patients (outpatients or inpatients) with elevated LFTs in context of suspected or known COVID-19, evaluate for alternative etiologies.\n6 In hospitalized patients with suspected or known COVID-19, obtain baseline LFTs at the time of admission and consider LFT monitoring throughout the hospitalization, particularly in the context of drug treatment for COVID-19\n7 In hospitalized patients undergoing drug treatment for COVID-19, evaluate for treatment-related Gl and hepatic adverse effects.\n\nPanel Composition and Conflict of Interest Management\nThis rapid review and guideline was developed by gastroenterologists and guideline methodologists from the 2 AGA committees. The guideline panel worked collaboratively with the AGA Governing Board to develop the clinical questions, review the evidence profiles, and develop the recommendations. Panel members disclosed all potential conflicts of interest according to AGA Institute policy.\n\nTarget Audience\nThe target audience of this guideline includes gastroenterologists, advanced practice providers, nurses, and other health care professionals. Patients as well as policy-makers can benefit from these guidelines. These guidelines are not intended to impose a standard of care for individual institutions, health care systems, or countries. They provide the basis for rational informed decisions for clinicians, patients, and other health care professionals in the setting of a pandemic.","divisions":[{"label":"title","span":{"begin":0,"end":17}},{"label":"p","span":{"begin":18,"end":2311}},{"label":"table-wrap","span":{"begin":665,"end":2311}},{"label":"label","span":{"begin":665,"end":672}},{"label":"caption","span":{"begin":673,"end":761}},{"label":"p","span":{"begin":673,"end":761}},{"label":"table","span":{"begin":762,"end":2311}},{"label":"tr","span":{"begin":762,"end":785}},{"label":"th","span":{"begin":762,"end":775}},{"label":"th","span":{"begin":776,"end":785}},{"label":"tr","span":{"begin":786,"end":1168}},{"label":"td","span":{"begin":786,"end":787}},{"label":"td","span":{"begin":788,"end":1168}},{"label":"tr","span":{"begin":1169,"end":1456}},{"label":"td","span":{"begin":1169,"end":1170}},{"label":"td","span":{"begin":1171,"end":1456}},{"label":"tr","span":{"begin":1457,"end":1670}},{"label":"td","span":{"begin":1457,"end":1458}},{"label":"td","span":{"begin":1459,"end":1670}},{"label":"tr","span":{"begin":1671,"end":1814}},{"label":"td","span":{"begin":1671,"end":1672}},{"label":"td","span":{"begin":1673,"end":1814}},{"label":"tr","span":{"begin":1815,"end":1955}},{"label":"td","span":{"begin":1815,"end":1816}},{"label":"td","span":{"begin":1817,"end":1955}},{"label":"tr","span":{"begin":1956,"end":2181}},{"label":"td","span":{"begin":1956,"end":1957}},{"label":"td","span":{"begin":1958,"end":2181}},{"label":"tr","span":{"begin":2182,"end":2311}},{"label":"td","span":{"begin":2182,"end":2183}},{"label":"td","span":{"begin":2184,"end":2311}},{"label":"sec","span":{"begin":2313,"end":2756}},{"label":"title","span":{"begin":2313,"end":2366}},{"label":"p","span":{"begin":2367,"end":2756}},{"label":"title","span":{"begin":2758,"end":2773}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T18","span":{"begin":72,"end":77},"obj":"Body_part"},{"id":"T19","span":{"begin":1001,"end":1007},"obj":"Body_part"},{"id":"T20","span":{"begin":1029,"end":1035},"obj":"Body_part"},{"id":"T21","span":{"begin":1723,"end":1728},"obj":"Body_part"}],"attributes":[{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma7197"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma228738"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma64183"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T14","span":{"begin":72,"end":77},"obj":"Body_part"},{"id":"T15","span":{"begin":1029,"end":1035},"obj":"Body_part"},{"id":"T16","span":{"begin":1723,"end":1728},"obj":"Body_part"}],"attributes":[{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/UBERON_0000341"},{"id":"A16","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_0001988"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T40","span":{"begin":96,"end":104},"obj":"Disease"},{"id":"T41","span":{"begin":105,"end":114},"obj":"Disease"},{"id":"T42","span":{"begin":737,"end":761},"obj":"Disease"},{"id":"T43","span":{"begin":818,"end":826},"obj":"Disease"},{"id":"T44","span":{"begin":938,"end":946},"obj":"Disease"},{"id":"T45","span":{"begin":1024,"end":1035},"obj":"Disease"},{"id":"T46","span":{"begin":1256,"end":1264},"obj":"Disease"},{"id":"T47","span":{"begin":1304,"end":1312},"obj":"Disease"},{"id":"T48","span":{"begin":1389,"end":1397},"obj":"Disease"},{"id":"T49","span":{"begin":1418,"end":1426},"obj":"Disease"},{"id":"T50","span":{"begin":1508,"end":1516},"obj":"Disease"},{"id":"T51","span":{"begin":1602,"end":1610},"obj":"Disease"},{"id":"T52","span":{"begin":1768,"end":1776},"obj":"Disease"},{"id":"T53","span":{"begin":1909,"end":1917},"obj":"Disease"},{"id":"T54","span":{"begin":2007,"end":2015},"obj":"Disease"},{"id":"T55","span":{"begin":2173,"end":2181},"obj":"Disease"},{"id":"T56","span":{"begin":2239,"end":2247},"obj":"Disease"}],"attributes":[{"id":"A40","pred":"mondo_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A41","pred":"mondo_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A42","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A43","pred":"mondo_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/MONDO_0001673"},{"id":"A44","pred":"mondo_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A45","pred":"mondo_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/MONDO_0002258"},{"id":"A46","pred":"mondo_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/MONDO_0001673"},{"id":"A47","pred":"mondo_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A48","pred":"mondo_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A49","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A50","pred":"mondo_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A51","pred":"mondo_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/MONDO_0001673"},{"id":"A52","pred":"mondo_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A53","pred":"mondo_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A54","pred":"mondo_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A55","pred":"mondo_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A56","pred":"mondo_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T53","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T46","span":{"begin":72,"end":77},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"T47","span":{"begin":72,"end":77},"obj":"http://www.ebi.ac.uk/efo/EFO_0000887"},{"id":"T48","span":{"begin":514,"end":515},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T49","span":{"begin":602,"end":603},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T50","span":{"begin":891,"end":892},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T51","span":{"begin":1001,"end":1007},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T52","span":{"begin":1001,"end":1007},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T53","span":{"begin":1001,"end":1007},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T54","span":{"begin":1001,"end":1007},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T55","span":{"begin":1079,"end":1080},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T56","span":{"begin":1367,"end":1368},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T57","span":{"begin":1382,"end":1383},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T58","span":{"begin":1427,"end":1434},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T59","span":{"begin":1525,"end":1526},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T60","span":{"begin":1729,"end":1736},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T61","span":{"begin":3029,"end":3030},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T62","span":{"begin":3247,"end":3248},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T46","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T53","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T60","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T61","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T62","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T21","span":{"begin":1317,"end":1319},"obj":"Chemical"},{"id":"T22","span":{"begin":1547,"end":1549},"obj":"Chemical"},{"id":"T23","span":{"begin":2154,"end":2158},"obj":"Chemical"},{"id":"T24","span":{"begin":2220,"end":2224},"obj":"Chemical"}],"attributes":[{"id":"A21","pred":"chebi_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/CHEBI_73907"},{"id":"A22","pred":"chebi_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/CHEBI_73907"},{"id":"A23","pred":"chebi_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A24","pred":"chebi_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T35","span":{"begin":818,"end":826},"obj":"Phenotype"},{"id":"T36","span":{"begin":958,"end":963},"obj":"Phenotype"},{"id":"T37","span":{"begin":965,"end":970},"obj":"Phenotype"},{"id":"T38","span":{"begin":972,"end":991},"obj":"Phenotype"},{"id":"T39","span":{"begin":993,"end":999},"obj":"Phenotype"},{"id":"T40","span":{"begin":1001,"end":1012},"obj":"Phenotype"},{"id":"T41","span":{"begin":1014,"end":1022},"obj":"Phenotype"},{"id":"T42","span":{"begin":1024,"end":1035},"obj":"Phenotype"},{"id":"T43","span":{"begin":1044,"end":1057},"obj":"Phenotype"},{"id":"T44","span":{"begin":1131,"end":1147},"obj":"Phenotype"},{"id":"T45","span":{"begin":1153,"end":1167},"obj":"Phenotype"},{"id":"T46","span":{"begin":1218,"end":1234},"obj":"Phenotype"},{"id":"T47","span":{"begin":1236,"end":1250},"obj":"Phenotype"},{"id":"T48","span":{"begin":1256,"end":1264},"obj":"Phenotype"},{"id":"T49","span":{"begin":1564,"end":1580},"obj":"Phenotype"},{"id":"T50","span":{"begin":1582,"end":1596},"obj":"Phenotype"},{"id":"T51","span":{"begin":1602,"end":1610},"obj":"Phenotype"}],"attributes":[{"id":"A35","pred":"hp_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/HP_0002014"},{"id":"A36","pred":"hp_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/HP_0001945"},{"id":"A37","pred":"hp_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/HP_0012735"},{"id":"A38","pred":"hp_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"id":"A39","pred":"hp_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/HP_0025143"},{"id":"A40","pred":"hp_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/HP_0003326"},{"id":"A41","pred":"hp_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/HP_0002315"},{"id":"A42","pred":"hp_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/HP_0033050"},{"id":"A43","pred":"hp_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/HP_0000223"},{"id":"A44","pred":"hp_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/HP_0002017"},{"id":"A45","pred":"hp_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/HP_0002027"},{"id":"A46","pred":"hp_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/HP_0002017"},{"id":"A47","pred":"hp_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/HP_0002027"},{"id":"A48","pred":"hp_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/HP_0002014"},{"id":"A49","pred":"hp_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/HP_0002017"},{"id":"A50","pred":"hp_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/HP_0002027"},{"id":"A51","pred":"hp_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/HP_0002014"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T2","span":{"begin":1052,"end":1057},"obj":"http://purl.obolibrary.org/obo/GO_0050909"}],"attributes":[{"subj":"T2","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T29","span":{"begin":0,"end":17},"obj":"Sentence"},{"id":"T30","span":{"begin":18,"end":129},"obj":"Sentence"},{"id":"T31","span":{"begin":130,"end":268},"obj":"Sentence"},{"id":"T32","span":{"begin":269,"end":584},"obj":"Sentence"},{"id":"T33","span":{"begin":585,"end":664},"obj":"Sentence"},{"id":"T34","span":{"begin":665,"end":709},"obj":"Sentence"},{"id":"T35","span":{"begin":710,"end":761},"obj":"Sentence"},{"id":"T36","span":{"begin":762,"end":775},"obj":"Sentence"},{"id":"T37","span":{"begin":776,"end":785},"obj":"Sentence"},{"id":"T38","span":{"begin":786,"end":1168},"obj":"Sentence"},{"id":"T39","span":{"begin":1169,"end":1378},"obj":"Sentence"},{"id":"T40","span":{"begin":1379,"end":1456},"obj":"Sentence"},{"id":"T41","span":{"begin":1457,"end":1670},"obj":"Sentence"},{"id":"T42","span":{"begin":1671,"end":1814},"obj":"Sentence"},{"id":"T43","span":{"begin":1815,"end":1955},"obj":"Sentence"},{"id":"T44","span":{"begin":1956,"end":2181},"obj":"Sentence"},{"id":"T45","span":{"begin":2182,"end":2311},"obj":"Sentence"},{"id":"T46","span":{"begin":2313,"end":2366},"obj":"Sentence"},{"id":"T47","span":{"begin":2367,"end":2491},"obj":"Sentence"},{"id":"T48","span":{"begin":2492,"end":2661},"obj":"Sentence"},{"id":"T49","span":{"begin":2662,"end":2756},"obj":"Sentence"},{"id":"T50","span":{"begin":2758,"end":2773},"obj":"Sentence"},{"id":"T51","span":{"begin":2774,"end":2915},"obj":"Sentence"},{"id":"T52","span":{"begin":2916,"end":2984},"obj":"Sentence"},{"id":"T53","span":{"begin":2985,"end":3111},"obj":"Sentence"},{"id":"T54","span":{"begin":3112,"end":3258},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T29","pred":"source","obj":"LitCovid-sentences"},{"subj":"T30","pred":"source","obj":"LitCovid-sentences"},{"subj":"T31","pred":"source","obj":"LitCovid-sentences"},{"subj":"T32","pred":"source","obj":"LitCovid-sentences"},{"subj":"T33","pred":"source","obj":"LitCovid-sentences"},{"subj":"T34","pred":"source","obj":"LitCovid-sentences"},{"subj":"T35","pred":"source","obj":"LitCovid-sentences"},{"subj":"T36","pred":"source","obj":"LitCovid-sentences"},{"subj":"T37","pred":"source","obj":"LitCovid-sentences"},{"subj":"T38","pred":"source","obj":"LitCovid-sentences"},{"subj":"T39","pred":"source","obj":"LitCovid-sentences"},{"subj":"T40","pred":"source","obj":"LitCovid-sentences"},{"subj":"T41","pred":"source","obj":"LitCovid-sentences"},{"subj":"T42","pred":"source","obj":"LitCovid-sentences"},{"subj":"T43","pred":"source","obj":"LitCovid-sentences"},{"subj":"T44","pred":"source","obj":"LitCovid-sentences"},{"subj":"T45","pred":"source","obj":"LitCovid-sentences"},{"subj":"T46","pred":"source","obj":"LitCovid-sentences"},{"subj":"T47","pred":"source","obj":"LitCovid-sentences"},{"subj":"T48","pred":"source","obj":"LitCovid-sentences"},{"subj":"T49","pred":"source","obj":"LitCovid-sentences"},{"subj":"T50","pred":"source","obj":"LitCovid-sentences"},{"subj":"T51","pred":"source","obj":"LitCovid-sentences"},{"subj":"T52","pred":"source","obj":"LitCovid-sentences"},{"subj":"T53","pred":"source","obj":"LitCovid-sentences"},{"subj":"T54","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"227","span":{"begin":1547,"end":1549},"obj":"Gene"},{"id":"228","span":{"begin":1317,"end":1319},"obj":"Gene"},{"id":"229","span":{"begin":1475,"end":1483},"obj":"Species"},{"id":"230","span":{"begin":1820,"end":1828},"obj":"Species"},{"id":"231","span":{"begin":1974,"end":1982},"obj":"Species"},{"id":"232","span":{"begin":2200,"end":2208},"obj":"Species"},{"id":"233","span":{"begin":818,"end":826},"obj":"Disease"},{"id":"234","span":{"begin":938,"end":946},"obj":"Disease"},{"id":"235","span":{"begin":958,"end":963},"obj":"Disease"},{"id":"236","span":{"begin":965,"end":970},"obj":"Disease"},{"id":"237","span":{"begin":972,"end":991},"obj":"Disease"},{"id":"238","span":{"begin":1001,"end":1012},"obj":"Disease"},{"id":"239","span":{"begin":1014,"end":1022},"obj":"Disease"},{"id":"240","span":{"begin":1024,"end":1035},"obj":"Disease"},{"id":"241","span":{"begin":1131,"end":1137},"obj":"Disease"},{"id":"242","span":{"begin":1139,"end":1147},"obj":"Disease"},{"id":"243","span":{"begin":1153,"end":1167},"obj":"Disease"},{"id":"244","span":{"begin":1218,"end":1224},"obj":"Disease"},{"id":"245","span":{"begin":1226,"end":1234},"obj":"Disease"},{"id":"246","span":{"begin":1236,"end":1250},"obj":"Disease"},{"id":"247","span":{"begin":1256,"end":1264},"obj":"Disease"},{"id":"248","span":{"begin":1304,"end":1312},"obj":"Disease"},{"id":"249","span":{"begin":1341,"end":1346},"obj":"Disease"},{"id":"250","span":{"begin":1389,"end":1397},"obj":"Disease"},{"id":"251","span":{"begin":1418,"end":1426},"obj":"Disease"},{"id":"252","span":{"begin":1508,"end":1516},"obj":"Disease"},{"id":"253","span":{"begin":1564,"end":1570},"obj":"Disease"},{"id":"254","span":{"begin":1572,"end":1580},"obj":"Disease"},{"id":"255","span":{"begin":1582,"end":1596},"obj":"Disease"},{"id":"256","span":{"begin":1602,"end":1610},"obj":"Disease"},{"id":"257","span":{"begin":1768,"end":1776},"obj":"Disease"},{"id":"258","span":{"begin":1909,"end":1917},"obj":"Disease"},{"id":"259","span":{"begin":2007,"end":2015},"obj":"Disease"},{"id":"260","span":{"begin":2173,"end":2181},"obj":"Disease"},{"id":"261","span":{"begin":2239,"end":2247},"obj":"Disease"},{"id":"263","span":{"begin":737,"end":761},"obj":"Disease"},{"id":"266","span":{"begin":96,"end":104},"obj":"Disease"},{"id":"267","span":{"begin":105,"end":114},"obj":"Disease"},{"id":"270","span":{"begin":2916,"end":2924},"obj":"Species"},{"id":"271","span":{"begin":3183,"end":3191},"obj":"Species"}],"attributes":[{"id":"A227","pred":"tao:has_database_id","subj":"227","obj":"Gene:2770"},{"id":"A228","pred":"tao:has_database_id","subj":"228","obj":"Gene:2770"},{"id":"A229","pred":"tao:has_database_id","subj":"229","obj":"Tax:9606"},{"id":"A230","pred":"tao:has_database_id","subj":"230","obj":"Tax:9606"},{"id":"A231","pred":"tao:has_database_id","subj":"231","obj":"Tax:9606"},{"id":"A232","pred":"tao:has_database_id","subj":"232","obj":"Tax:9606"},{"id":"A233","pred":"tao:has_database_id","subj":"233","obj":"MESH:D003967"},{"id":"A234","pred":"tao:has_database_id","subj":"234","obj":"MESH:C000657245"},{"id":"A235","pred":"tao:has_database_id","subj":"235","obj":"MESH:D005334"},{"id":"A236","pred":"tao:has_database_id","subj":"236","obj":"MESH:D003371"},{"id":"A237","pred":"tao:has_database_id","subj":"237","obj":"MESH:D004417"},{"id":"A238","pred":"tao:has_database_id","subj":"238","obj":"MESH:D063806"},{"id":"A239","pred":"tao:has_database_id","subj":"239","obj":"MESH:D006261"},{"id":"A240","pred":"tao:has_database_id","subj":"240","obj":"MESH:D010608"},{"id":"A241","pred":"tao:has_database_id","subj":"241","obj":"MESH:D009325"},{"id":"A242","pred":"tao:has_database_id","subj":"242","obj":"MESH:D014839"},{"id":"A243","pred":"tao:has_database_id","subj":"243","obj":"MESH:D015746"},{"id":"A244","pred":"tao:has_database_id","subj":"244","obj":"MESH:D009325"},{"id":"A245","pred":"tao:has_database_id","subj":"245","obj":"MESH:D014839"},{"id":"A246","pred":"tao:has_database_id","subj":"246","obj":"MESH:D015746"},{"id":"A247","pred":"tao:has_database_id","subj":"247","obj":"MESH:D003967"},{"id":"A248","pred":"tao:has_database_id","subj":"248","obj":"MESH:C000657245"},{"id":"A249","pred":"tao:has_database_id","subj":"249","obj":"MESH:C000657245"},{"id":"A250","pred":"tao:has_database_id","subj":"250","obj":"MESH:C000657245"},{"id":"A251","pred":"tao:has_database_id","subj":"251","obj":"MESH:C000657245"},{"id":"A252","pred":"tao:has_database_id","subj":"252","obj":"MESH:C000657245"},{"id":"A253","pred":"tao:has_database_id","subj":"253","obj":"MESH:D009325"},{"id":"A254","pred":"tao:has_database_id","subj":"254","obj":"MESH:D014839"},{"id":"A255","pred":"tao:has_database_id","subj":"255","obj":"MESH:D015746"},{"id":"A256","pred":"tao:has_database_id","subj":"256","obj":"MESH:D003967"},{"id":"A257","pred":"tao:has_database_id","subj":"257","obj":"MESH:C000657245"},{"id":"A258","pred":"tao:has_database_id","subj":"258","obj":"MESH:C000657245"},{"id":"A259","pred":"tao:has_database_id","subj":"259","obj":"MESH:C000657245"},{"id":"A260","pred":"tao:has_database_id","subj":"260","obj":"MESH:C000657245"},{"id":"A261","pred":"tao:has_database_id","subj":"261","obj":"MESH:C000657245"},{"id":"A263","pred":"tao:has_database_id","subj":"263","obj":"MESH:C000657245"},{"id":"A266","pred":"tao:has_database_id","subj":"266","obj":"MESH:C000657245"},{"id":"A267","pred":"tao:has_database_id","subj":"267","obj":"MESH:D007239"},{"id":"A270","pred":"tao:has_database_id","subj":"270","obj":"Tax:9606"},{"id":"A271","pred":"tao:has_database_id","subj":"271","obj":"Tax:9606"},{"subj":"227","pred":"source","obj":"LitCovid-PubTator"},{"subj":"228","pred":"source","obj":"LitCovid-PubTator"},{"subj":"229","pred":"source","obj":"LitCovid-PubTator"},{"subj":"230","pred":"source","obj":"LitCovid-PubTator"},{"subj":"231","pred":"source","obj":"LitCovid-PubTator"},{"subj":"232","pred":"source","obj":"LitCovid-PubTator"},{"subj":"233","pred":"source","obj":"LitCovid-PubTator"},{"subj":"234","pred":"source","obj":"LitCovid-PubTator"},{"subj":"235","pred":"source","obj":"LitCovid-PubTator"},{"subj":"236","pred":"source","obj":"LitCovid-PubTator"},{"subj":"237","pred":"source","obj":"LitCovid-PubTator"},{"subj":"238","pred":"source","obj":"LitCovid-PubTator"},{"subj":"239","pred":"source","obj":"LitCovid-PubTator"},{"subj":"240","pred":"source","obj":"LitCovid-PubTator"},{"subj":"241","pred":"source","obj":"LitCovid-PubTator"},{"subj":"242","pred":"source","obj":"LitCovid-PubTator"},{"subj":"243","pred":"source","obj":"LitCovid-PubTator"},{"subj":"244","pred":"source","obj":"LitCovid-PubTator"},{"subj":"245","pred":"source","obj":"LitCovid-PubTator"},{"subj":"246","pred":"source","obj":"LitCovid-PubTator"},{"subj":"247","pred":"source","obj":"LitCovid-PubTator"},{"subj":"248","pred":"source","obj":"LitCovid-PubTator"},{"subj":"249","pred":"source","obj":"LitCovid-PubTator"},{"subj":"250","pred":"source","obj":"LitCovid-PubTator"},{"subj":"251","pred":"source","obj":"LitCovid-PubTator"},{"subj":"252","pred":"source","obj":"LitCovid-PubTator"},{"subj":"253","pred":"source","obj":"LitCovid-PubTator"},{"subj":"254","pred":"source","obj":"LitCovid-PubTator"},{"subj":"255","pred":"source","obj":"LitCovid-PubTator"},{"subj":"256","pred":"source","obj":"LitCovid-PubTator"},{"subj":"257","pred":"source","obj":"LitCovid-PubTator"},{"subj":"258","pred":"source","obj":"LitCovid-PubTator"},{"subj":"259","pred":"source","obj":"LitCovid-PubTator"},{"subj":"260","pred":"source","obj":"LitCovid-PubTator"},{"subj":"261","pred":"source","obj":"LitCovid-PubTator"},{"subj":"263","pred":"source","obj":"LitCovid-PubTator"},{"subj":"266","pred":"source","obj":"LitCovid-PubTator"},{"subj":"267","pred":"source","obj":"LitCovid-PubTator"},{"subj":"270","pred":"source","obj":"LitCovid-PubTator"},{"subj":"271","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93eca7","default":true},{"id":"LitCovid-PD-UBERON","color":"#ec9398"},{"id":"LitCovid-PD-MONDO","color":"#93b2ec"},{"id":"LitCovid-PD-CLO","color":"#ccec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93e6"},{"id":"LitCovid-PD-HP","color":"#93ecd7"},{"id":"LitCovid-PD-GO-BP","color":"#ecbd93"},{"id":"LitCovid-sentences","color":"#a393ec"},{"id":"LitCovid-PubTator","color":"#9cec93"}]}]}}