PMC:7212949 / 5763-6501 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T7","span":{"begin":24,"end":28},"obj":"Body_part"},{"id":"T8","span":{"begin":187,"end":198},"obj":"Body_part"},{"id":"T9","span":{"begin":255,"end":266},"obj":"Body_part"},{"id":"T10","span":{"begin":331,"end":335},"obj":"Body_part"},{"id":"T11","span":{"begin":425,"end":436},"obj":"Body_part"},{"id":"T12","span":{"begin":470,"end":479},"obj":"Body_part"},{"id":"T13","span":{"begin":496,"end":505},"obj":"Body_part"},{"id":"T14","span":{"begin":550,"end":560},"obj":"Body_part"},{"id":"T15","span":{"begin":584,"end":594},"obj":"Body_part"},{"id":"T16","span":{"begin":608,"end":619},"obj":"Body_part"},{"id":"T17","span":{"begin":608,"end":613},"obj":"Body_part"},{"id":"T18","span":{"begin":624,"end":630},"obj":"Body_part"},{"id":"T19","span":{"begin":639,"end":642},"obj":"Body_part"},{"id":"T20","span":{"begin":655,"end":677},"obj":"Body_part"},{"id":"T21","span":{"begin":672,"end":677},"obj":"Body_part"},{"id":"T22","span":{"begin":692,"end":697},"obj":"Body_part"},{"id":"T23","span":{"begin":714,"end":730},"obj":"Body_part"},{"id":"T24","span":{"begin":725,"end":730},"obj":"Body_part"}],"attributes":[{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma62863"},{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma62499"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma62499"},{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma63194"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma63194"},{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma63182"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma62863"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma5034"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma9671"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma7196"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma62501"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A22","pred":"fma_id","subj":"T22","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A23","pred":"fma_id","subj":"T23","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A24","pred":"fma_id","subj":"T24","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Histopathology • Gross: Lung consolidation\n• Early phase: Pulmonary edema with hyaline membrane formation\n• Organizing phase: Cellular fibromyxoid organizing exudates in alveoli\n• Scanty lymphocytic interstitial infiltrate\n• Vacuolated and multinucleated pneumocytes\n• Viral inclusions not detected. • Gross: Diffuse hemorrhage on lung surface\n• Serous, fibrinous and hemorrhagic inflammation in alveoli with desquamation of pneumocytes and hyaline-membrane formation\n• Capillary engorgement and capillary microthrombosis, thromboemboli in bronchial arterioles\n• Hemorrhagic necrosis lymphocyte depletion in lymph nodes and spleen\n• Viral RNA detected in type II alveolar cells, interstitial cells and bronchiolar epithelial cells N/A N/A"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T13","span":{"begin":24,"end":28},"obj":"Body_part"},{"id":"T14","span":{"begin":331,"end":335},"obj":"Body_part"},{"id":"T15","span":{"begin":470,"end":479},"obj":"Body_part"},{"id":"T16","span":{"begin":496,"end":505},"obj":"Body_part"},{"id":"T17","span":{"begin":550,"end":560},"obj":"Body_part"},{"id":"T18","span":{"begin":608,"end":619},"obj":"Body_part"},{"id":"T19","span":{"begin":608,"end":613},"obj":"Body_part"},{"id":"T20","span":{"begin":624,"end":630},"obj":"Body_part"}],"attributes":[{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/UBERON_0001982"},{"id":"A16","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_0001982"},{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0001980"},{"id":"A18","pred":"uberon_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/UBERON_0000029"},{"id":"A19","pred":"uberon_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/UBERON_0002391"},{"id":"A20","pred":"uberon_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/UBERON_0002106"}],"text":"Histopathology • Gross: Lung consolidation\n• Early phase: Pulmonary edema with hyaline membrane formation\n• Organizing phase: Cellular fibromyxoid organizing exudates in alveoli\n• Scanty lymphocytic interstitial infiltrate\n• Vacuolated and multinucleated pneumocytes\n• Viral inclusions not detected. • Gross: Diffuse hemorrhage on lung surface\n• Serous, fibrinous and hemorrhagic inflammation in alveoli with desquamation of pneumocytes and hyaline-membrane formation\n• Capillary engorgement and capillary microthrombosis, thromboemboli in bronchial arterioles\n• Hemorrhagic necrosis lymphocyte depletion in lymph nodes and spleen\n• Viral RNA detected in type II alveolar cells, interstitial cells and bronchiolar epithelial cells N/A N/A"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T39","span":{"begin":58,"end":73},"obj":"Disease"},{"id":"T40","span":{"begin":380,"end":392},"obj":"Disease"}],"attributes":[{"id":"A39","pred":"mondo_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/MONDO_0006932"},{"id":"A40","pred":"mondo_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"}],"text":"Histopathology • Gross: Lung consolidation\n• Early phase: Pulmonary edema with hyaline membrane formation\n• Organizing phase: Cellular fibromyxoid organizing exudates in alveoli\n• Scanty lymphocytic interstitial infiltrate\n• Vacuolated and multinucleated pneumocytes\n• Viral inclusions not detected. • Gross: Diffuse hemorrhage on lung surface\n• Serous, fibrinous and hemorrhagic inflammation in alveoli with desquamation of pneumocytes and hyaline-membrane formation\n• Capillary engorgement and capillary microthrombosis, thromboemboli in bronchial arterioles\n• Hemorrhagic necrosis lymphocyte depletion in lymph nodes and spleen\n• Viral RNA detected in type II alveolar cells, interstitial cells and bronchiolar epithelial cells N/A N/A"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T27","span":{"begin":24,"end":28},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T28","span":{"begin":24,"end":28},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T29","span":{"begin":87,"end":95},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T30","span":{"begin":108,"end":118},"obj":"http://purl.obolibrary.org/obo/OBI_0000245"},{"id":"T31","span":{"begin":147,"end":157},"obj":"http://purl.obolibrary.org/obo/OBI_0000245"},{"id":"T32","span":{"begin":225,"end":235},"obj":"http://purl.obolibrary.org/obo/GO_0005773"},{"id":"T33","span":{"begin":331,"end":335},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T34","span":{"begin":331,"end":335},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T35","span":{"begin":449,"end":457},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T36","span":{"begin":608,"end":619},"obj":"http://purl.obolibrary.org/obo/UBERON_0000029"},{"id":"T37","span":{"begin":624,"end":630},"obj":"http://purl.obolibrary.org/obo/UBERON_0002106"},{"id":"T38","span":{"begin":672,"end":677},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T39","span":{"begin":679,"end":697},"obj":"http://purl.obolibrary.org/obo/CL_0000178"},{"id":"T40","span":{"begin":714,"end":724},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T41","span":{"begin":725,"end":730},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T42","span":{"begin":733,"end":734},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T43","span":{"begin":737,"end":738},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Histopathology • Gross: Lung consolidation\n• Early phase: Pulmonary edema with hyaline membrane formation\n• Organizing phase: Cellular fibromyxoid organizing exudates in alveoli\n• Scanty lymphocytic interstitial infiltrate\n• Vacuolated and multinucleated pneumocytes\n• Viral inclusions not detected. • Gross: Diffuse hemorrhage on lung surface\n• Serous, fibrinous and hemorrhagic inflammation in alveoli with desquamation of pneumocytes and hyaline-membrane formation\n• Capillary engorgement and capillary microthrombosis, thromboemboli in bronchial arterioles\n• Hemorrhagic necrosis lymphocyte depletion in lymph nodes and spleen\n• Viral RNA detected in type II alveolar cells, interstitial cells and bronchiolar epithelial cells N/A N/A"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T3","span":{"begin":660,"end":662},"obj":"Chemical"}],"attributes":[{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"}],"text":"Histopathology • Gross: Lung consolidation\n• Early phase: Pulmonary edema with hyaline membrane formation\n• Organizing phase: Cellular fibromyxoid organizing exudates in alveoli\n• Scanty lymphocytic interstitial infiltrate\n• Vacuolated and multinucleated pneumocytes\n• Viral inclusions not detected. • Gross: Diffuse hemorrhage on lung surface\n• Serous, fibrinous and hemorrhagic inflammation in alveoli with desquamation of pneumocytes and hyaline-membrane formation\n• Capillary engorgement and capillary microthrombosis, thromboemboli in bronchial arterioles\n• Hemorrhagic necrosis lymphocyte depletion in lymph nodes and spleen\n• Viral RNA detected in type II alveolar cells, interstitial cells and bronchiolar epithelial cells N/A N/A"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T2","span":{"begin":96,"end":105},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T3","span":{"begin":380,"end":392},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T4","span":{"begin":458,"end":467},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T5","span":{"begin":575,"end":583},"obj":"http://purl.obolibrary.org/obo/GO_0070265"},{"id":"T6","span":{"begin":575,"end":583},"obj":"http://purl.obolibrary.org/obo/GO_0019835"},{"id":"T7","span":{"begin":575,"end":583},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T8","span":{"begin":575,"end":583},"obj":"http://purl.obolibrary.org/obo/GO_0001906"}],"text":"Histopathology • Gross: Lung consolidation\n• Early phase: Pulmonary edema with hyaline membrane formation\n• Organizing phase: Cellular fibromyxoid organizing exudates in alveoli\n• Scanty lymphocytic interstitial infiltrate\n• Vacuolated and multinucleated pneumocytes\n• Viral inclusions not detected. • Gross: Diffuse hemorrhage on lung surface\n• Serous, fibrinous and hemorrhagic inflammation in alveoli with desquamation of pneumocytes and hyaline-membrane formation\n• Capillary engorgement and capillary microthrombosis, thromboemboli in bronchial arterioles\n• Hemorrhagic necrosis lymphocyte depletion in lymph nodes and spleen\n• Viral RNA detected in type II alveolar cells, interstitial cells and bronchiolar epithelial cells N/A N/A"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T30","span":{"begin":58,"end":73},"obj":"Phenotype"},{"id":"T31","span":{"begin":409,"end":421},"obj":"Phenotype"}],"attributes":[{"id":"A30","pred":"hp_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/HP_0100598"},{"id":"A31","pred":"hp_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/HP_0040189"}],"text":"Histopathology • Gross: Lung consolidation\n• Early phase: Pulmonary edema with hyaline membrane formation\n• Organizing phase: Cellular fibromyxoid organizing exudates in alveoli\n• Scanty lymphocytic interstitial infiltrate\n• Vacuolated and multinucleated pneumocytes\n• Viral inclusions not detected. • Gross: Diffuse hemorrhage on lung surface\n• Serous, fibrinous and hemorrhagic inflammation in alveoli with desquamation of pneumocytes and hyaline-membrane formation\n• Capillary engorgement and capillary microthrombosis, thromboemboli in bronchial arterioles\n• Hemorrhagic necrosis lymphocyte depletion in lymph nodes and spleen\n• Viral RNA detected in type II alveolar cells, interstitial cells and bronchiolar epithelial cells N/A N/A"}

{"project":"LitCovid-sentences","denotations":[{"id":"T73","span":{"begin":0,"end":23},"obj":"Sentence"},{"id":"T74","span":{"begin":24,"end":42},"obj":"Sentence"},{"id":"T75","span":{"begin":43,"end":57},"obj":"Sentence"},{"id":"T76","span":{"begin":58,"end":105},"obj":"Sentence"},{"id":"T77","span":{"begin":106,"end":125},"obj":"Sentence"},{"id":"T78","span":{"begin":126,"end":177},"obj":"Sentence"},{"id":"T79","span":{"begin":178,"end":222},"obj":"Sentence"},{"id":"T80","span":{"begin":223,"end":266},"obj":"Sentence"},{"id":"T81","span":{"begin":267,"end":308},"obj":"Sentence"},{"id":"T82","span":{"begin":309,"end":343},"obj":"Sentence"},{"id":"T83","span":{"begin":344,"end":467},"obj":"Sentence"},{"id":"T84","span":{"begin":468,"end":560},"obj":"Sentence"},{"id":"T85","span":{"begin":561,"end":630},"obj":"Sentence"},{"id":"T86","span":{"begin":631,"end":738},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Histopathology • Gross: Lung consolidation\n• Early phase: Pulmonary edema with hyaline membrane formation\n• Organizing phase: Cellular fibromyxoid organizing exudates in alveoli\n• Scanty lymphocytic interstitial infiltrate\n• Vacuolated and multinucleated pneumocytes\n• Viral inclusions not detected. • Gross: Diffuse hemorrhage on lung surface\n• Serous, fibrinous and hemorrhagic inflammation in alveoli with desquamation of pneumocytes and hyaline-membrane formation\n• Capillary engorgement and capillary microthrombosis, thromboemboli in bronchial arterioles\n• Hemorrhagic necrosis lymphocyte depletion in lymph nodes and spleen\n• Viral RNA detected in type II alveolar cells, interstitial cells and bronchiolar epithelial cells N/A N/A"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T71","span":{"begin":24,"end":28},"obj":"UBERON:0002048"},{"id":"T72","span":{"begin":58,"end":67},"obj":"UBERON:0002048"},{"id":"T73","span":{"begin":87,"end":95},"obj":"GO:0016020;GO:0044091"},{"id":"T74","span":{"begin":96,"end":105},"obj":"GO:0044091"},{"id":"T75","span":{"begin":170,"end":177},"obj":"UBERON:0003215"},{"id":"T76","span":{"begin":187,"end":198},"obj":"CL:0000542"},{"id":"T77","span":{"begin":199,"end":211},"obj":"UBERON:0005169"},{"id":"T78","span":{"begin":240,"end":254},"obj":"GO:0005634;CL:0000228"},{"id":"T79","span":{"begin":255,"end":266},"obj":"CL:0000322"},{"id":"T80","span":{"begin":275,"end":285},"obj":"GO:0016234"},{"id":"T81","span":{"begin":331,"end":335},"obj":"UBERON:0002048"},{"id":"T82","span":{"begin":396,"end":403},"obj":"UBERON:0003215"},{"id":"T83","span":{"begin":425,"end":436},"obj":"CL:0000322"},{"id":"T84","span":{"begin":449,"end":457},"obj":"GO:0016020"},{"id":"T85","span":{"begin":470,"end":479},"obj":"UBERON:0001982"},{"id":"T86","span":{"begin":496,"end":505},"obj":"UBERON:0001982"},{"id":"T87","span":{"begin":506,"end":521},"obj":"GO:0007596"},{"id":"T88","span":{"begin":540,"end":549},"obj":"UBERON:0002031"},{"id":"T89","span":{"begin":550,"end":560},"obj":"UBERON:0001980"},{"id":"T90","span":{"begin":584,"end":594},"obj":"CL:0000542"},{"id":"T91","span":{"begin":608,"end":619},"obj":"UBERON:0000029"},{"id":"T92","span":{"begin":624,"end":630},"obj":"UBERON:0002106"},{"id":"T93","span":{"begin":655,"end":662},"obj":"CL:0002063"},{"id":"T94","span":{"begin":663,"end":671},"obj":"CL:0002063;UBERON:0003215"},{"id":"T95","span":{"begin":672,"end":677},"obj":"CL:0002063"},{"id":"T96","span":{"begin":679,"end":691},"obj":"UBERON:0005169"},{"id":"T97","span":{"begin":702,"end":713},"obj":"UBERON:0002031"},{"id":"T98","span":{"begin":714,"end":724},"obj":"UBERON:0000483"},{"id":"T497","span":{"begin":182,"end":187},"obj":"UBERON:0000948"},{"id":"T498","span":{"begin":243,"end":248},"obj":"CHEBI:29108;CHEBI:29108"},{"id":"T499","span":{"begin":258,"end":260},"obj":"CHEBI:29103;CHEBI:29103"},{"id":"T500","span":{"begin":270,"end":272},"obj":"CHEBI:18420;CHEBI:18420"},{"id":"T501","span":{"begin":272,"end":274},"obj":"CHEBI:62964;CHEBI:62964"},{"id":"T502","span":{"begin":365,"end":372},"obj":"UBERON:0000948"},{"id":"T503","span":{"begin":466,"end":477},"obj":"UBERON:0002349"},{"id":"T504","span":{"begin":478,"end":485},"obj":"UBERON:0007195"},{"id":"T505","span":{"begin":511,"end":518},"obj":"UBERON:0000055"},{"id":"T506","span":{"begin":522,"end":533},"obj":"CL:0000542"},{"id":"T507","span":{"begin":567,"end":578},"obj":"CL:0000187"},{"id":"T508","span":{"begin":579,"end":584},"obj":"GO:0019835"}],"text":"Histopathology • Gross: Lung consolidation\n• Early phase: Pulmonary edema with hyaline membrane formation\n• Organizing phase: Cellular fibromyxoid organizing exudates in alveoli\n• Scanty lymphocytic interstitial infiltrate\n• Vacuolated and multinucleated pneumocytes\n• Viral inclusions not detected. • Gross: Diffuse hemorrhage on lung surface\n• Serous, fibrinous and hemorrhagic inflammation in alveoli with desquamation of pneumocytes and hyaline-membrane formation\n• Capillary engorgement and capillary microthrombosis, thromboemboli in bronchial arterioles\n• Hemorrhagic necrosis lymphocyte depletion in lymph nodes and spleen\n• Viral RNA detected in type II alveolar cells, interstitial cells and bronchiolar epithelial cells N/A N/A"}