PMC:7212949 / 57306-59941
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T313 | 363-366 | Body_part | denotes | CNS | http://purl.org/sig/ont/fma/fma55675 |
T314 | 516-522 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
T315 | 547-553 | Body_part | denotes | mental | http://purl.org/sig/ont/fma/fma264279 |
T316 | 723-742 | Body_part | denotes | Corticospinal tract | http://purl.org/sig/ont/fma/fma265580 |
T317 | 843-847 | Body_part | denotes | Head | http://purl.org/sig/ont/fma/fma7154 |
T318 | 916-936 | Body_part | denotes | left temporal region | http://purl.org/sig/ont/fma/fma74807 |
T319 | 999-1002 | Body_part | denotes | CSF | http://purl.org/sig/ont/fma/fma20935 |
T320 | 1025-1028 | Body_part | denotes | CSF | http://purl.org/sig/ont/fma/fma20935 |
T321 | 1072-1076 | Body_part | denotes | Head | http://purl.org/sig/ont/fma/fma7154 |
T322 | 1179-1184 | Body_part | denotes | Brain | http://purl.org/sig/ont/fma/fma50801 |
T323 | 1257-1271 | Body_part | denotes | temporal lobes | http://purl.org/sig/ont/fma/fma61825 |
T324 | 1296-1301 | Body_part | denotes | Brain | http://purl.org/sig/ont/fma/fma50801 |
T325 | 1416-1419 | Body_part | denotes | CSF | http://purl.org/sig/ont/fma/fma20935 |
T326 | 1465-1468 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
T327 | 1473-1480 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T328 | 1528-1531 | Body_part | denotes | CSF | http://purl.org/sig/ont/fma/fma20935 |
T329 | 1656-1662 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
T330 | 1746-1749 | Body_part | denotes | CNS | http://purl.org/sig/ont/fma/fma55675 |
T331 | 1786-1796 | Body_part | denotes | lymphocyte | http://purl.org/sig/ont/fma/fma62863 |
T332 | 1801-1809 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
T333 | 1879-1885 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
T334 | 1920-1931 | Body_part | denotes | neutrophils | http://purl.org/sig/ont/fma/fma62860 |
T335 | 1956-1966 | Body_part | denotes | lymphocyte | http://purl.org/sig/ont/fma/fma62863 |
T336 | 2414-2422 | Body_part | denotes | Cytokine | http://purl.org/sig/ont/fma/fma84050 |
T337 | 2575-2584 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T172 | 723-742 | Body_part | denotes | Corticospinal tract | http://purl.obolibrary.org/obo/UBERON_0002707 |
T173 | 843-847 | Body_part | denotes | Head | http://purl.obolibrary.org/obo/UBERON_0000033 |
T174 | 1072-1076 | Body_part | denotes | Head | http://purl.obolibrary.org/obo/UBERON_0000033 |
T175 | 1179-1184 | Body_part | denotes | Brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
T176 | 1257-1271 | Body_part | denotes | temporal lobes | http://purl.obolibrary.org/obo/UBERON_0001871 |
T177 | 1296-1301 | Body_part | denotes | Brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T477 | 0-8 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T478 | 434-437 | Disease | denotes | PNS | http://purl.obolibrary.org/obo/MONDO_0018215 |
T479 | 563-570 | Disease | denotes | Anosmia | http://purl.obolibrary.org/obo/MONDO_0010528 |
T480 | 670-702 | Disease | denotes | Acute necrotizing encephalopathy | http://purl.obolibrary.org/obo/MONDO_0003336 |
T481 | 688-702 | Disease | denotes | encephalopathy | http://purl.obolibrary.org/obo/MONDO_0005560 |
T482 | 1397-1403 | Disease | denotes | stroke | http://purl.obolibrary.org/obo/MONDO_0005098|http://purl.obolibrary.org/obo/MONDO_0011057 |
T484 | 1603-1606 | Disease | denotes | CVA | http://purl.obolibrary.org/obo/MONDO_0005098|http://purl.obolibrary.org/obo/MONDO_0011057 |
T486 | 1663-1669 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
T487 | 1886-1892 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
T488 | 2148-2169 | Disease | denotes | coagulation disorders | http://purl.obolibrary.org/obo/MONDO_0001531 |
T489 | 2187-2201 | Disease | denotes | encephalopathy | http://purl.obolibrary.org/obo/MONDO_0005560 |
T490 | 2317-2325 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T491 | 2376-2382 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
T492 | 2439-2448 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
T493 | 2456-2472 | Disease | denotes | viral infections | http://purl.obolibrary.org/obo/MONDO_0005108 |
T494 | 2559-2573 | Disease | denotes | encephalopathy | http://purl.obolibrary.org/obo/MONDO_0005560 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T597 | 1879-1885 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | muscle |
T572 | 363-366 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | CNS |
T573 | 363-366 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | CNS |
T574 | 434-437 | http://purl.obolibrary.org/obo/UBERON_0000010 | denotes | PNS |
T575 | 434-437 | http://www.ebi.ac.uk/efo/EFO_0000891 | denotes | PNS |
T576 | 507-522 | http://purl.obolibrary.org/obo/UBERON_0001134 | denotes | Skeletal muscle |
T577 | 507-522 | http://purl.obolibrary.org/obo/UBERON_0014892 | denotes | Skeletal muscle |
T578 | 507-522 | http://www.ebi.ac.uk/efo/EFO_0000888 | denotes | Skeletal muscle |
T579 | 798-800 | http://purl.obolibrary.org/obo/CLO_0001313 | denotes | 36 |
T580 | 836-837 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T581 | 843-847 | http://purl.obolibrary.org/obo/UBERON_0000033 | denotes | Head |
T582 | 843-847 | http://www.ebi.ac.uk/efo/EFO_0000964 | denotes | Head |
T583 | 1021-1022 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T584 | 1047-1053 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
T585 | 1072-1076 | http://purl.obolibrary.org/obo/UBERON_0000033 | denotes | Head |
T586 | 1072-1076 | http://www.ebi.ac.uk/efo/EFO_0000964 | denotes | Head |
T587 | 1179-1184 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | Brain |
T588 | 1179-1184 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | Brain |
T589 | 1296-1301 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | Brain |
T590 | 1296-1301 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | Brain |
T591 | 1341-1343 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
T592 | 1647-1662 | http://purl.obolibrary.org/obo/UBERON_0001134 | denotes | skeletal muscle |
T593 | 1647-1662 | http://purl.obolibrary.org/obo/UBERON_0014892 | denotes | skeletal muscle |
T594 | 1647-1662 | http://www.ebi.ac.uk/efo/EFO_0000888 | denotes | skeletal muscle |
T595 | 1746-1749 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | CNS |
T596 | 1746-1749 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | CNS |
T598 | 1879-1885 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | muscle |
T599 | 1879-1885 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | muscle |
T600 | 1879-1885 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | muscle |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T16999 | 868-871 | Chemical | denotes | EEG | http://purl.obolibrary.org/obo/CHEBI_73494 |
T52268 | 1473-1480 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T10362 | 1539-1542 | Chemical | denotes | EEG | http://purl.obolibrary.org/obo/CHEBI_73494 |
T39600 | 1603-1606 | Chemical | denotes | CVA | http://purl.obolibrary.org/obo/CHEBI_85264 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T72 | 2148-2159 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | coagulation |
T73 | 2456-2472 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infections |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T348 | 396-405 | Phenotype | denotes | dizziness | http://purl.obolibrary.org/obo/HP_0002321 |
T349 | 415-423 | Phenotype | denotes | headache | http://purl.obolibrary.org/obo/HP_0002315 |
T350 | 466-476 | Phenotype | denotes | hypogeusia | http://purl.obolibrary.org/obo/HP_0000224 |
T351 | 488-496 | Phenotype | denotes | hyposmia | http://purl.obolibrary.org/obo/HP_0004409 |
T352 | 563-570 | Phenotype | denotes | Anosmia | http://purl.obolibrary.org/obo/HP_0000458 |
T353 | 571-579 | Phenotype | denotes | hyposmia | http://purl.obolibrary.org/obo/HP_0004409 |
T354 | 627-637 | Phenotype | denotes | hypogeusia | http://purl.obolibrary.org/obo/HP_0000224 |
T355 | 670-702 | Phenotype | denotes | Acute necrotizing encephalopathy | http://purl.obolibrary.org/obo/HP_0006965 |
T356 | 705-714 | Phenotype | denotes | Agitation | http://purl.obolibrary.org/obo/HP_0000713 |
T357 | 988-996 | Phenotype | denotes | seizures | http://purl.obolibrary.org/obo/HP_0001250 |
T358 | 1347-1373 | Phenotype | denotes | Leptomeningeal enhancement | http://purl.obolibrary.org/obo/HP_0032070 |
T359 | 1388-1403 | Phenotype | denotes | Ischemic stroke | http://purl.obolibrary.org/obo/HP_0002140 |
T360 | 1489-1500 | Phenotype | denotes | Low albumin | http://purl.obolibrary.org/obo/HP_0003073 |
T361 | 2187-2201 | Phenotype | denotes | encephalopathy | http://purl.obolibrary.org/obo/HP_0001298 |
T362 | 2414-2428 | Phenotype | denotes | Cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
T363 | 2559-2573 | Phenotype | denotes | encephalopathy | http://purl.obolibrary.org/obo/HP_0001298 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T581 | 0-8 | Sentence | denotes | COVID-19 |
T582 | 9-311 | Sentence | denotes | Study Mao et al (2020)N = 214, confirmed casesRetrospective study Filatov et al (2020)N = 1, suspectedCase report Bagheri et al (2020)N = 10069, with olfactory dysfunctionCross-sectional Poyiadji et al (2020)N = 1, confirmed casesCase report Helms et al (2020)N = 58, confirmed casesRetrospective study |
T583 | 312-354 | Sentence | denotes | Clinical features • Neurological symptoms: |
T584 | 355-360 | Sentence | denotes | 36.4% |
T585 | 361-376 | Sentence | denotes | • CNS symptoms: |
T586 | 377-431 | Sentence | denotes | 24.8%, most common dizziness (16.8%), headache (13.1%) |
T587 | 432-447 | Sentence | denotes | • PNS symptoms: |
T588 | 448-504 | Sentence | denotes | 8.9%, most common hypogeusia (5.6%) and hyposmia (5.1%). |
T589 | 505-532 | Sentence | denotes | • Skeletal muscle symptoms: |
T590 | 533-588 | Sentence | denotes | 10.7% Altered mental status • Anosmia/hyposmia (48.23%) |
T591 | 589-613 | Sentence | denotes | • Sudden onset in 76.24% |
T592 | 614-647 | Sentence | denotes | • Associated hypogeusia in 83.38% |
T593 | 648-659 | Sentence | denotes | • Duration: |
T594 | 660-720 | Sentence | denotes | 0-30 days Acute necrotizing encephalopathy • Agitation (69%) |
T595 | 721-754 | Sentence | denotes | • Corticospinal tract signs (67%) |
T596 | 755-772 | Sentence | denotes | • Confusion (65%) |
T597 | 773-802 | Sentence | denotes | • Dysexecutive syndrome (36%) |
T598 | 803-865 | Sentence | denotes | Key findings on investigations N/A • CT Head: no acute changes |
T599 | 866-996 | Sentence | denotes | • EEG: bilateral slowing and focal slowing in the left temporal region with sharply countered waves, possible subclinical seizures |
T600 | 997-1064 | Sentence | denotes | • CSF studies: normal N/A • CSF unremarkable (not tested for COVID) |
T601 | 1065-1139 | Sentence | denotes | • NCCT Head: symmetric hypoattenuation within the bilateral medial thalami |
T602 | 1140-1172 | Sentence | denotes | • CT angiogram, venogram: normal |
T603 | 1173-1344 | Sentence | denotes | • MRI Brain: hemorrhagic rim enhancing lesions within the bilateral thalami, medial temporal lobes, and subinsular regions Brain MRI:• Perfusion abnormalities (100% of 11) |
T604 | 1345-1385 | Sentence | denotes | • Leptomeningeal enhancement (62% of 13) |
T605 | 1386-1415 | Sentence | denotes | • Ischemic stroke (23% of 13) |
T606 | 1416-1453 | Sentence | denotes | CSF (N = 7):• Oligoclonal bands (29%) |
T607 | 1454-1486 | Sentence | denotes | • Elevated IgG and protein (14%) |
T608 | 1487-1506 | Sentence | denotes | • Low albumin (57%) |
T609 | 1507-1538 | Sentence | denotes | • Negative RT-PCR in CSF (100%) |
T610 | 1539-1551 | Sentence | denotes | EEG (N = 8): |
T611 | 1552-1563 | Sentence | denotes | Nonspecific |
T612 | 1564-1729 | Sentence | denotes | Key study findings and message • Acute CVA (5.7%), impaired consciousness (14.8%), skeletal muscle injury (19.3%) more likely in severe disease (P < 0.05, P < 0.001) |
T613 | 1730-1862 | Sentence | denotes | • Patients with CNS symptoms more likely to have lower `lymphocyte and platelet counts and higher BUN (P < 0.05, P < 0.01, P < 0.05) |
T614 | 1863-2014 | Sentence | denotes | • Patients with muscle injury more likely to have higher neutrophils, CRP, D-dimer and lower lymphocyte count (P < 0.05, P < 0.001, P < 0.05, P < 0.01) |
T615 | 2015-2325 | Sentence | denotes | • Neurologic symptoms may be due to direct viral pathogenicity via hematogenous or retrograde neuronal spread, immunosuppression, or coagulation disorders Can present with encephalopathy acutely or during hospitalization • High correlation between reported olfactory symptoms and regional reporting of COVID-19 |
T616 | 2326-2413 | Sentence | denotes | • Olfactory symptoms may be due to neuroepithelia injury and damage to olfactory roots. |
T617 | 2414-2635 | Sentence | denotes | Cytokine storm (known in influenza, other viral infections, more common in pediatrics) Mechanism unknown, may be due to critical illness–related encephalopathy, cytokines, medication-induced or direct viral pathogenicity. |
LitCovid-PMC-OGER-BB
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1409 | 9-19 | CHEBI:16737;CHEBI:16737 | denotes | Study Mao |
T1410 | 117-125 | SP_7 | denotes | eport Ba |
T1411 | 176-180 | UBERON:0002048 | denotes | tion |
T1412 | 395-403 | SP_7 | denotes | dizzine |
T1413 | 495-503 | SP_7 | denotes | a (5.1%) |
T1414 | 698-706 | GO:0031982 | denotes | athy • A |
T1415 | 752-757 | UBERON:0002100 | denotes | %) • |
T1416 | 828-833 | NCBITaxon:10239 | denotes | tions |
T1417 | 888-896 | SP_7 | denotes | ng and f |
T1418 | 976-984 | SP_7 | denotes | subclini |
T1419 | 1033-1037 | SP_10 | denotes | mark |
T1420 | 1137-1141 | SP_10 | denotes | mi • |
T1421 | 1176-1184 | SP_10 | denotes | RI Brain |
T1422 | 1231-1240 | CL:0000738 | denotes | bilateral |
T1423 | 1376-1384 | CL:0000775 | denotes | 2% of 13 |
T1424 | 1502-1510 | SP_10 | denotes | 57%) • N |
T1425 | 1729-1737 | CL:0000233 | denotes | • Patie |
T1426 | 1996-2004 | SP_10 | denotes | < 0.05, |
T1427 | 2006-2014 | SP_9 | denotes | < 0.01) |
T1428 | 2019-2027 | SP_7 | denotes | urologic |
T1429 | 2034-2039 | SP_10 | denotes | ms ma |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
1339 | 0-8 | Disease | denotes | COVID-19 | MESH:C000657245 |
1340 | 169-185 | Disease | denotes | dysfunctionCross | |
1545 | 2317-2325 | Disease | denotes | COVID-19 | MESH:C000657245 |