PMC:7212949 / 51368-52178 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T284","span":{"begin":605,"end":614},"obj":"Body_part"},{"id":"T285","span":{"begin":651,"end":656},"obj":"Body_part"}],"attributes":[{"id":"A284","pred":"fma_id","subj":"T284","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A285","pred":"fma_id","subj":"T285","obj":"http://purl.org/sig/ont/fma/fma12274"}],"text":"Key study findings and message • ICU patients more likely to have ↑ Cr (P = 0.04), ↑ BUN (0.001)\n• Cr and urea increased with disease progression • ↑ Cr at admission more common in males, older patients, more severe disease (P \u003c 0.001, P \u003c 0.001, P = 0.026)\n• AKI, in hospital death, mechanical ventilation more common in patients with baseline ↑ Cr (P \u003c 0.001, P \u003c 0.001, P = 0.012)\n• Higher in hospital death rate with proteinuria, hematuria, baseline ↑ Cr, Urea, AKI Stage 2 or 3 (P \u003c 0.001; P = 0.003 for AKI stage 1)\n• Renal features may be due to direct viral effect, immune mediated, virus induced cytokines and mediators. No viral shedding in urine AKI associated with severe outcome (P \u003c 0.001) • ↑ Cr associated with in-hospital death\n(P = 0.045)\n• Higher incidence of AKI in nonsurvivors (P \u003c 0.001)"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T161","span":{"begin":651,"end":656},"obj":"Body_part"}],"attributes":[{"id":"A161","pred":"uberon_id","subj":"T161","obj":"http://purl.obolibrary.org/obo/UBERON_0001088"}],"text":"Key study findings and message • ICU patients more likely to have ↑ Cr (P = 0.04), ↑ BUN (0.001)\n• Cr and urea increased with disease progression • ↑ Cr at admission more common in males, older patients, more severe disease (P \u003c 0.001, P \u003c 0.001, P = 0.026)\n• AKI, in hospital death, mechanical ventilation more common in patients with baseline ↑ Cr (P \u003c 0.001, P \u003c 0.001, P = 0.012)\n• Higher in hospital death rate with proteinuria, hematuria, baseline ↑ Cr, Urea, AKI Stage 2 or 3 (P \u003c 0.001; P = 0.003 for AKI stage 1)\n• Renal features may be due to direct viral effect, immune mediated, virus induced cytokines and mediators. No viral shedding in urine AKI associated with severe outcome (P \u003c 0.001) • ↑ Cr associated with in-hospital death\n(P = 0.045)\n• Higher incidence of AKI in nonsurvivors (P \u003c 0.001)"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T387","span":{"begin":260,"end":263},"obj":"Disease"},{"id":"T388","span":{"begin":421,"end":432},"obj":"Disease"},{"id":"T389","span":{"begin":466,"end":469},"obj":"Disease"},{"id":"T390","span":{"begin":509,"end":512},"obj":"Disease"},{"id":"T391","span":{"begin":657,"end":660},"obj":"Disease"},{"id":"T392","span":{"begin":779,"end":782},"obj":"Disease"}],"attributes":[{"id":"A387","pred":"mondo_id","subj":"T387","obj":"http://purl.obolibrary.org/obo/MONDO_0002492"},{"id":"A388","pred":"mondo_id","subj":"T388","obj":"http://purl.obolibrary.org/obo/MONDO_0003634"},{"id":"A389","pred":"mondo_id","subj":"T389","obj":"http://purl.obolibrary.org/obo/MONDO_0002492"},{"id":"A390","pred":"mondo_id","subj":"T390","obj":"http://purl.obolibrary.org/obo/MONDO_0002492"},{"id":"A391","pred":"mondo_id","subj":"T391","obj":"http://purl.obolibrary.org/obo/MONDO_0002492"},{"id":"A392","pred":"mondo_id","subj":"T392","obj":"http://purl.obolibrary.org/obo/MONDO_0002492"}],"text":"Key study findings and message • ICU patients more likely to have ↑ Cr (P = 0.04), ↑ BUN (0.001)\n• Cr and urea increased with disease progression • ↑ Cr at admission more common in males, older patients, more severe disease (P \u003c 0.001, P \u003c 0.001, P = 0.026)\n• AKI, in hospital death, mechanical ventilation more common in patients with baseline ↑ Cr (P \u003c 0.001, P \u003c 0.001, P = 0.012)\n• Higher in hospital death rate with proteinuria, hematuria, baseline ↑ Cr, Urea, AKI Stage 2 or 3 (P \u003c 0.001; P = 0.003 for AKI stage 1)\n• Renal features may be due to direct viral effect, immune mediated, virus induced cytokines and mediators. No viral shedding in urine AKI associated with severe outcome (P \u003c 0.001) • ↑ Cr associated with in-hospital death\n(P = 0.045)\n• Higher incidence of AKI in nonsurvivors (P \u003c 0.001)"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T526","span":{"begin":181,"end":186},"obj":"http://purl.obolibrary.org/obo/UBERON_0003101"},{"id":"T527","span":{"begin":181,"end":186},"obj":"http://www.ebi.ac.uk/efo/EFO_0000970"},{"id":"T528","span":{"begin":591,"end":596},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"text":"Key study findings and message • ICU patients more likely to have ↑ Cr (P = 0.04), ↑ BUN (0.001)\n• Cr and urea increased with disease progression • ↑ Cr at admission more common in males, older patients, more severe disease (P \u003c 0.001, P \u003c 0.001, P = 0.026)\n• AKI, in hospital death, mechanical ventilation more common in patients with baseline ↑ Cr (P \u003c 0.001, P \u003c 0.001, P = 0.012)\n• Higher in hospital death rate with proteinuria, hematuria, baseline ↑ Cr, Urea, AKI Stage 2 or 3 (P \u003c 0.001; P = 0.003 for AKI stage 1)\n• Renal features may be due to direct viral effect, immune mediated, virus induced cytokines and mediators. No viral shedding in urine AKI associated with severe outcome (P \u003c 0.001) • ↑ Cr associated with in-hospital death\n(P = 0.045)\n• Higher incidence of AKI in nonsurvivors (P \u003c 0.001)"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T97202","span":{"begin":68,"end":70},"obj":"Chemical"},{"id":"T48861","span":{"begin":99,"end":101},"obj":"Chemical"},{"id":"T96705","span":{"begin":106,"end":110},"obj":"Chemical"},{"id":"T56050","span":{"begin":150,"end":152},"obj":"Chemical"},{"id":"T71302","span":{"begin":347,"end":349},"obj":"Chemical"},{"id":"T17251","span":{"begin":456,"end":458},"obj":"Chemical"},{"id":"T83463","span":{"begin":460,"end":464},"obj":"Chemical"},{"id":"T46727","span":{"begin":708,"end":710},"obj":"Chemical"}],"attributes":[{"id":"A57438","pred":"chebi_id","subj":"T97202","obj":"http://purl.obolibrary.org/obo/CHEBI_28073"},{"id":"A66161","pred":"chebi_id","subj":"T48861","obj":"http://purl.obolibrary.org/obo/CHEBI_28073"},{"id":"A83732","pred":"chebi_id","subj":"T96705","obj":"http://purl.obolibrary.org/obo/CHEBI_16199"},{"id":"A54974","pred":"chebi_id","subj":"T56050","obj":"http://purl.obolibrary.org/obo/CHEBI_28073"},{"id":"A13115","pred":"chebi_id","subj":"T71302","obj":"http://purl.obolibrary.org/obo/CHEBI_28073"},{"id":"A24602","pred":"chebi_id","subj":"T17251","obj":"http://purl.obolibrary.org/obo/CHEBI_28073"},{"id":"A34762","pred":"chebi_id","subj":"T83463","obj":"http://purl.obolibrary.org/obo/CHEBI_16199"},{"id":"A69878","pred":"chebi_id","subj":"T46727","obj":"http://purl.obolibrary.org/obo/CHEBI_28073"}],"text":"Key study findings and message • ICU patients more likely to have ↑ Cr (P = 0.04), ↑ BUN (0.001)\n• Cr and urea increased with disease progression • ↑ Cr at admission more common in males, older patients, more severe disease (P \u003c 0.001, P \u003c 0.001, P = 0.026)\n• AKI, in hospital death, mechanical ventilation more common in patients with baseline ↑ Cr (P \u003c 0.001, P \u003c 0.001, P = 0.012)\n• Higher in hospital death rate with proteinuria, hematuria, baseline ↑ Cr, Urea, AKI Stage 2 or 3 (P \u003c 0.001; P = 0.003 for AKI stage 1)\n• Renal features may be due to direct viral effect, immune mediated, virus induced cytokines and mediators. No viral shedding in urine AKI associated with severe outcome (P \u003c 0.001) • ↑ Cr associated with in-hospital death\n(P = 0.045)\n• Higher incidence of AKI in nonsurvivors (P \u003c 0.001)"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T66","span":{"begin":633,"end":647},"obj":"http://purl.obolibrary.org/obo/GO_0019076"}],"text":"Key study findings and message • ICU patients more likely to have ↑ Cr (P = 0.04), ↑ BUN (0.001)\n• Cr and urea increased with disease progression • ↑ Cr at admission more common in males, older patients, more severe disease (P \u003c 0.001, P \u003c 0.001, P = 0.026)\n• AKI, in hospital death, mechanical ventilation more common in patients with baseline ↑ Cr (P \u003c 0.001, P \u003c 0.001, P = 0.012)\n• Higher in hospital death rate with proteinuria, hematuria, baseline ↑ Cr, Urea, AKI Stage 2 or 3 (P \u003c 0.001; P = 0.003 for AKI stage 1)\n• Renal features may be due to direct viral effect, immune mediated, virus induced cytokines and mediators. No viral shedding in urine AKI associated with severe outcome (P \u003c 0.001) • ↑ Cr associated with in-hospital death\n(P = 0.045)\n• Higher incidence of AKI in nonsurvivors (P \u003c 0.001)"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T282","span":{"begin":421,"end":432},"obj":"Phenotype"},{"id":"T283","span":{"begin":434,"end":443},"obj":"Phenotype"}],"attributes":[{"id":"A282","pred":"hp_id","subj":"T282","obj":"http://purl.obolibrary.org/obo/HP_0000093"},{"id":"A283","pred":"hp_id","subj":"T283","obj":"http://purl.obolibrary.org/obo/HP_0000790"}],"text":"Key study findings and message • ICU patients more likely to have ↑ Cr (P = 0.04), ↑ BUN (0.001)\n• Cr and urea increased with disease progression • ↑ Cr at admission more common in males, older patients, more severe disease (P \u003c 0.001, P \u003c 0.001, P = 0.026)\n• AKI, in hospital death, mechanical ventilation more common in patients with baseline ↑ Cr (P \u003c 0.001, P \u003c 0.001, P = 0.012)\n• Higher in hospital death rate with proteinuria, hematuria, baseline ↑ Cr, Urea, AKI Stage 2 or 3 (P \u003c 0.001; P = 0.003 for AKI stage 1)\n• Renal features may be due to direct viral effect, immune mediated, virus induced cytokines and mediators. No viral shedding in urine AKI associated with severe outcome (P \u003c 0.001) • ↑ Cr associated with in-hospital death\n(P = 0.045)\n• Higher incidence of AKI in nonsurvivors (P \u003c 0.001)"}

{"project":"LitCovid-sentences","denotations":[{"id":"T525","span":{"begin":0,"end":96},"obj":"Sentence"},{"id":"T526","span":{"begin":97,"end":257},"obj":"Sentence"},{"id":"T527","span":{"begin":258,"end":383},"obj":"Sentence"},{"id":"T528","span":{"begin":384,"end":521},"obj":"Sentence"},{"id":"T529","span":{"begin":522,"end":629},"obj":"Sentence"},{"id":"T530","span":{"begin":630,"end":744},"obj":"Sentence"},{"id":"T531","span":{"begin":745,"end":756},"obj":"Sentence"},{"id":"T532","span":{"begin":757,"end":810},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Key study findings and message • ICU patients more likely to have ↑ Cr (P = 0.04), ↑ BUN (0.001)\n• Cr and urea increased with disease progression • ↑ Cr at admission more common in males, older patients, more severe disease (P \u003c 0.001, P \u003c 0.001, P = 0.026)\n• AKI, in hospital death, mechanical ventilation more common in patients with baseline ↑ Cr (P \u003c 0.001, P \u003c 0.001, P = 0.012)\n• Higher in hospital death rate with proteinuria, hematuria, baseline ↑ Cr, Urea, AKI Stage 2 or 3 (P \u003c 0.001; P = 0.003 for AKI stage 1)\n• Renal features may be due to direct viral effect, immune mediated, virus induced cytokines and mediators. No viral shedding in urine AKI associated with severe outcome (P \u003c 0.001) • ↑ Cr associated with in-hospital death\n(P = 0.045)\n• Higher incidence of AKI in nonsurvivors (P \u003c 0.001)"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T1296","span":{"begin":38,"end":52},"obj":"GO:0042052"},{"id":"T1297","span":{"begin":65,"end":71},"obj":"UBERON:0000055"},{"id":"T1298","span":{"begin":96,"end":103},"obj":"CHEBI:17234;CHEBI:17234"},{"id":"T1299","span":{"begin":106,"end":114},"obj":"SP_10"},{"id":"T1300","span":{"begin":130,"end":138},"obj":"SP_10"},{"id":"T1301","span":{"begin":174,"end":181},"obj":"CHEBI:17234;CHEBI:17234"},{"id":"T1302","span":{"begin":251,"end":256},"obj":"UBERON:0001021;GO:0007268"},{"id":"T1303","span":{"begin":257,"end":267},"obj":"GO:0006812"},{"id":"T1304","span":{"begin":430,"end":435},"obj":"NCBITaxon:10239"},{"id":"T1305","span":{"begin":489,"end":494},"obj":"NCBITaxon:10239"},{"id":"T1306","span":{"begin":592,"end":604},"obj":"UBERON:0000970"},{"id":"T1307","span":{"begin":662,"end":672},"obj":"UBERON:0001004"}],"text":"Key study findings and message • ICU patients more likely to have ↑ Cr (P = 0.04), ↑ BUN (0.001)\n• Cr and urea increased with disease progression • ↑ Cr at admission more common in males, older patients, more severe disease (P \u003c 0.001, P \u003c 0.001, P = 0.026)\n• AKI, in hospital death, mechanical ventilation more common in patients with baseline ↑ Cr (P \u003c 0.001, P \u003c 0.001, P = 0.012)\n• Higher in hospital death rate with proteinuria, hematuria, baseline ↑ Cr, Urea, AKI Stage 2 or 3 (P \u003c 0.001; P = 0.003 for AKI stage 1)\n• Renal features may be due to direct viral effect, immune mediated, virus induced cytokines and mediators. No viral shedding in urine AKI associated with severe outcome (P \u003c 0.001) • ↑ Cr associated with in-hospital death\n(P = 0.045)\n• Higher incidence of AKI in nonsurvivors (P \u003c 0.001)"}

{"project":"LitCovid-PubTator","denotations":[{"id":"1177","span":{"begin":37,"end":45},"obj":"Species"},{"id":"1178","span":{"begin":194,"end":202},"obj":"Species"},{"id":"1179","span":{"begin":322,"end":330},"obj":"Species"},{"id":"1182","span":{"begin":106,"end":110},"obj":"Chemical"},{"id":"1183","span":{"begin":460,"end":464},"obj":"Chemical"},{"id":"1190","span":{"begin":277,"end":282},"obj":"Disease"},{"id":"1191","span":{"begin":405,"end":410},"obj":"Disease"},{"id":"1192","span":{"begin":421,"end":432},"obj":"Disease"},{"id":"1193","span":{"begin":434,"end":443},"obj":"Disease"},{"id":"1194","span":{"begin":739,"end":744},"obj":"Disease"}],"attributes":[{"id":"A1177","pred":"tao:has_database_id","subj":"1177","obj":"Tax:9606"},{"id":"A1178","pred":"tao:has_database_id","subj":"1178","obj":"Tax:9606"},{"id":"A1179","pred":"tao:has_database_id","subj":"1179","obj":"Tax:9606"},{"id":"A1182","pred":"tao:has_database_id","subj":"1182","obj":"MESH:D014508"},{"id":"A1183","pred":"tao:has_database_id","subj":"1183","obj":"MESH:D014508"},{"id":"A1190","pred":"tao:has_database_id","subj":"1190","obj":"MESH:D003643"},{"id":"A1191","pred":"tao:has_database_id","subj":"1191","obj":"MESH:D003643"},{"id":"A1192","pred":"tao:has_database_id","subj":"1192","obj":"MESH:D011507"},{"id":"A1193","pred":"tao:has_database_id","subj":"1193","obj":"MESH:D006417"},{"id":"A1194","pred":"tao:has_database_id","subj":"1194","obj":"MESH:D003643"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Key study findings and message • ICU patients more likely to have ↑ Cr (P = 0.04), ↑ BUN (0.001)\n• Cr and urea increased with disease progression • ↑ Cr at admission more common in males, older patients, more severe disease (P \u003c 0.001, P \u003c 0.001, P = 0.026)\n• AKI, in hospital death, mechanical ventilation more common in patients with baseline ↑ Cr (P \u003c 0.001, P \u003c 0.001, P = 0.012)\n• Higher in hospital death rate with proteinuria, hematuria, baseline ↑ Cr, Urea, AKI Stage 2 or 3 (P \u003c 0.001; P = 0.003 for AKI stage 1)\n• Renal features may be due to direct viral effect, immune mediated, virus induced cytokines and mediators. No viral shedding in urine AKI associated with severe outcome (P \u003c 0.001) • ↑ Cr associated with in-hospital death\n(P = 0.045)\n• Higher incidence of AKI in nonsurvivors (P \u003c 0.001)"}