PMC:7211620 / 9173-10239 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7211620","sourcedb":"PMC","sourceid":"7211620","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7211620","text":"Diagnosis of IPA in ICU patients without classical risk factors for IPA remains challenging. The well-established criteria of the European Organization for Research and Treatment of Cancer/Mycoses Study Group (EORTC/MSG) [14] are not applicable for many of the ICU patients due to a missing host factor. Thus, new diagnostic criteria for ICU patients were established to overcome these limitations [4]. This criteria base on clinical signs and symptoms compatible with IPA, abnormal chest imaging of the lungs and microbiological evidence of presence of Aspergillus. This criteria turned out to be superior to the EORCT/MSG criteria in the ICU setting [4]. Also the patient reported in this case report would not have been classified as IPA according to the EORTC/MSG criteria from 2008 due to a missing host factor. Recently, in the influenza and aspergillosis trial, GM in serum and bronchoalveolar lavage fluid was added to the ICU criteria as an additional mycological criterium to overcome the limitation of imperfect culture sensitivity for aspergillosis 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