PMC:7205724 / 607-1761 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"50","span":{"begin":720,"end":723},"obj":"Gene"},{"id":"51","span":{"begin":903,"end":906},"obj":"Gene"},{"id":"52","span":{"begin":960,"end":963},"obj":"Gene"},{"id":"53","span":{"begin":4,"end":21},"obj":"Species"},{"id":"54","span":{"begin":23,"end":32},"obj":"Species"},{"id":"55","span":{"begin":86,"end":92},"obj":"Species"},{"id":"56","span":{"begin":177,"end":185},"obj":"Species"},{"id":"57","span":{"begin":243,"end":252},"obj":"Species"},{"id":"58","span":{"begin":284,"end":292},"obj":"Species"},{"id":"59","span":{"begin":389,"end":396},"obj":"Species"},{"id":"60","span":{"begin":836,"end":844},"obj":"Species"},{"id":"61","span":{"begin":941,"end":949},"obj":"Species"},{"id":"62","span":{"begin":1004,"end":1013},"obj":"Species"},{"id":"63","span":{"begin":1065,"end":1074},"obj":"Species"},{"id":"64","span":{"begin":860,"end":871},"obj":"Chemical"},{"id":"65","span":{"begin":58,"end":71},"obj":"Disease"},{"id":"66","span":{"begin":73,"end":81},"obj":"Disease"},{"id":"67","span":{"begin":155,"end":163},"obj":"Disease"},{"id":"68","span":{"begin":201,"end":209},"obj":"Disease"},{"id":"69","span":{"begin":305,"end":313},"obj":"Disease"},{"id":"70","span":{"begin":422,"end":430},"obj":"Disease"},{"id":"71","span":{"begin":454,"end":466},"obj":"Disease"},{"id":"72","span":{"begin":544,"end":552},"obj":"Disease"},{"id":"73","span":{"begin":660,"end":668},"obj":"Disease"},{"id":"74","span":{"begin":677,"end":682},"obj":"Disease"},{"id":"75","span":{"begin":759,"end":767},"obj":"Disease"},{"id":"76","span":{"begin":850,"end":858},"obj":"Disease"},{"id":"77","span":{"begin":1137,"end":1145},"obj":"Disease"}],"attributes":[{"id":"A50","pred":"tao:has_database_id","subj":"50","obj":"Gene:3569"},{"id":"A51","pred":"tao:has_database_id","subj":"51","obj":"Gene:3569"},{"id":"A52","pred":"tao:has_database_id","subj":"52","obj":"Gene:3569"},{"id":"A53","pred":"tao:has_database_id","subj":"53","obj":"Tax:2697049"},{"id":"A54","pred":"tao:has_database_id","subj":"54","obj":"Tax:2697049"},{"id":"A55","pred":"tao:has_database_id","subj":"55","obj":"Tax:9606"},{"id":"A56","pred":"tao:has_database_id","subj":"56","obj":"Tax:9606"},{"id":"A57","pred":"tao:has_database_id","subj":"57","obj":"Tax:2697049"},{"id":"A58","pred":"tao:has_database_id","subj":"58","obj":"Tax:9606"},{"id":"A59","pred":"tao:has_database_id","subj":"59","obj":"Tax:9606"},{"id":"A60","pred":"tao:has_database_id","subj":"60","obj":"Tax:9606"},{"id":"A61","pred":"tao:has_database_id","subj":"61","obj":"Tax:9606"},{"id":"A62","pred":"tao:has_database_id","subj":"62","obj":"Tax:2697049"},{"id":"A63","pred":"tao:has_database_id","subj":"63","obj":"Tax:2697049"},{"id":"A64","pred":"tao:has_database_id","subj":"64","obj":"MESH:C502936"},{"id":"A65","pred":"tao:has_database_id","subj":"65","obj":"MESH:D034062"},{"id":"A66","pred":"tao:has_database_id","subj":"66","obj":"MESH:C000657245"},{"id":"A67","pred":"tao:has_database_id","subj":"67","obj":"MESH:C000657245"},{"id":"A68","pred":"tao:has_database_id","subj":"68","obj":"MESH:C000657245"},{"id":"A69","pred":"tao:has_database_id","subj":"69","obj":"MESH:C000657245"},{"id":"A70","pred":"tao:has_database_id","subj":"70","obj":"MESH:C000657245"},{"id":"A71","pred":"tao:has_database_id","subj":"71","obj":"MESH:D007249"},{"id":"A72","pred":"tao:has_database_id","subj":"72","obj":"MESH:C000657245"},{"id":"A73","pred":"tao:has_database_id","subj":"73","obj":"MESH:C000657245"},{"id":"A74","pred":"tao:has_database_id","subj":"74","obj":"MESH:D003643"},{"id":"A75","pred":"tao:has_database_id","subj":"75","obj":"MESH:C000657245"},{"id":"A76","pred":"tao:has_database_id","subj":"76","obj":"MESH:C000657245"},{"id":"A77","pred":"tao:has_database_id","subj":"77","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The novel coronavirus, SARS-CoV2, can cause a potentially fatal disease, COVID-19, in humans. Here, we will provide an overview of therapeutic options for COVID-19. Plasma from patients recovered from COVID-19 that contains antibodies against SARS-CoV2 has shown promising results in patients with severe COVID-19. Also, IVIG, combined with moderate-dose of corticosteroids, might improve patient outcomes. Evidence links COVID-19 to variable degrees of inflammation. Studies show that the use of corticosteroids might accelerate recovery from COVID-19. There are, however, no controlled clinical trials that show whether the use of corticosteroids can reduce COVID-19-related death. Also, the pro-inflammatory cytokine IL6 is the best-documented cytokine in COVID-19 correlated with severity, criticality, viral load, and prognosis of patients with COVID-19. Tocilizumab, a monoclonal antibody against IL6, could confer clinical benefit in patients with high IL6 levels. Essential elements that process SARS-CoV2 cell entry and specific characteristics that allow SARS-CoV2 to escape the immune system have the potential as targets for COVID-19 therapy."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T2","span":{"begin":165,"end":171},"obj":"Body_part"},{"id":"T3","span":{"begin":711,"end":719},"obj":"Body_part"},{"id":"T4","span":{"begin":747,"end":755},"obj":"Body_part"},{"id":"T5","span":{"begin":886,"end":894},"obj":"Body_part"},{"id":"T6","span":{"begin":1014,"end":1018},"obj":"Body_part"},{"id":"T7","span":{"begin":1089,"end":1102},"obj":"Body_part"}],"attributes":[{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma9825"}],"text":"The novel coronavirus, SARS-CoV2, can cause a potentially fatal disease, COVID-19, in humans. Here, we will provide an overview of therapeutic options for COVID-19. Plasma from patients recovered from COVID-19 that contains antibodies against SARS-CoV2 has shown promising results in patients with severe COVID-19. Also, IVIG, combined with moderate-dose of corticosteroids, might improve patient outcomes. Evidence links COVID-19 to variable degrees of inflammation. Studies show that the use of corticosteroids might accelerate recovery from COVID-19. There are, however, no controlled clinical trials that show whether the use of corticosteroids can reduce COVID-19-related death. Also, the pro-inflammatory cytokine IL6 is the best-documented cytokine in COVID-19 correlated with severity, criticality, viral load, and prognosis of patients with COVID-19. Tocilizumab, a monoclonal antibody against IL6, could confer clinical benefit in patients with high IL6 levels. Essential elements that process SARS-CoV2 cell entry and specific characteristics that allow SARS-CoV2 to escape the immune system have the potential as targets for COVID-19 therapy."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":1089,"end":1102},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"}],"text":"The novel coronavirus, SARS-CoV2, can cause a potentially fatal disease, COVID-19, in humans. Here, we will provide an overview of therapeutic options for COVID-19. Plasma from patients recovered from COVID-19 that contains antibodies against SARS-CoV2 has shown promising results in patients with severe COVID-19. Also, IVIG, combined with moderate-dose of corticosteroids, might improve patient outcomes. Evidence links COVID-19 to variable degrees of inflammation. Studies show that the use of corticosteroids might accelerate recovery from COVID-19. There are, however, no controlled clinical trials that show whether the use of corticosteroids can reduce COVID-19-related death. Also, the pro-inflammatory cytokine IL6 is the best-documented cytokine in COVID-19 correlated with severity, criticality, viral load, and prognosis of patients with COVID-19. Tocilizumab, a monoclonal antibody against IL6, could confer clinical benefit in patients with high IL6 levels. Essential elements that process SARS-CoV2 cell entry and specific characteristics that allow SARS-CoV2 to escape the immune system have the potential as targets for COVID-19 therapy."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T6","span":{"begin":23,"end":27},"obj":"Disease"},{"id":"T7","span":{"begin":73,"end":81},"obj":"Disease"},{"id":"T8","span":{"begin":155,"end":163},"obj":"Disease"},{"id":"T9","span":{"begin":201,"end":209},"obj":"Disease"},{"id":"T10","span":{"begin":243,"end":247},"obj":"Disease"},{"id":"T11","span":{"begin":305,"end":313},"obj":"Disease"},{"id":"T12","span":{"begin":422,"end":430},"obj":"Disease"},{"id":"T13","span":{"begin":454,"end":466},"obj":"Disease"},{"id":"T14","span":{"begin":544,"end":552},"obj":"Disease"},{"id":"T15","span":{"begin":660,"end":668},"obj":"Disease"},{"id":"T16","span":{"begin":759,"end":767},"obj":"Disease"},{"id":"T17","span":{"begin":850,"end":858},"obj":"Disease"},{"id":"T18","span":{"begin":1004,"end":1008},"obj":"Disease"},{"id":"T19","span":{"begin":1065,"end":1069},"obj":"Disease"},{"id":"T20","span":{"begin":1137,"end":1145},"obj":"Disease"}],"attributes":[{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A18","pred":"mondo_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A19","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A20","pred":"mondo_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"The novel coronavirus, SARS-CoV2, can cause a potentially fatal disease, COVID-19, in humans. Here, we will provide an overview of therapeutic options for COVID-19. Plasma from patients recovered from COVID-19 that contains antibodies against SARS-CoV2 has shown promising results in patients with severe COVID-19. Also, IVIG, combined with moderate-dose of corticosteroids, might improve patient outcomes. Evidence links COVID-19 to variable degrees of inflammation. Studies show that the use of corticosteroids might accelerate recovery from COVID-19. There are, however, no controlled clinical trials that show whether the use of corticosteroids can reduce COVID-19-related death. Also, the pro-inflammatory cytokine IL6 is the best-documented cytokine in COVID-19 correlated with severity, criticality, viral load, and prognosis of patients with COVID-19. Tocilizumab, a monoclonal antibody against IL6, could confer clinical benefit in patients with high IL6 levels. Essential elements that process SARS-CoV2 cell entry and specific characteristics that allow SARS-CoV2 to escape the immune system have the potential as targets for COVID-19 therapy."}

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{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T6","span":{"begin":358,"end":373},"obj":"Chemical"},{"id":"T7","span":{"begin":497,"end":512},"obj":"Chemical"},{"id":"T8","span":{"begin":633,"end":648},"obj":"Chemical"}],"attributes":[{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"}],"text":"The novel coronavirus, SARS-CoV2, can cause a potentially fatal disease, COVID-19, in humans. Here, we will provide an overview of therapeutic options for COVID-19. Plasma from patients recovered from COVID-19 that contains antibodies against SARS-CoV2 has shown promising results in patients with severe COVID-19. Also, IVIG, combined with moderate-dose of corticosteroids, might improve patient outcomes. Evidence links COVID-19 to variable degrees of inflammation. Studies show that the use of corticosteroids might accelerate recovery from COVID-19. There are, however, no controlled clinical trials that show whether the use of corticosteroids can reduce COVID-19-related death. Also, the pro-inflammatory cytokine IL6 is the best-documented cytokine in COVID-19 correlated with severity, criticality, viral load, and prognosis of patients with COVID-19. Tocilizumab, a monoclonal antibody against IL6, could confer clinical benefit in patients with high IL6 levels. Essential elements that process SARS-CoV2 cell entry and specific characteristics that allow SARS-CoV2 to escape the immune system have the potential as targets for COVID-19 therapy."}

{"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T3","span":{"begin":807,"end":817},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A3","pred":"meddra_id","subj":"T3","obj":"http://purl.bioontology.org/ontology/MEDDRA/10062178"}],"text":"The novel coronavirus, SARS-CoV2, can cause a potentially fatal disease, COVID-19, in humans. Here, we will provide an overview of therapeutic options for COVID-19. Plasma from patients recovered from COVID-19 that contains antibodies against SARS-CoV2 has shown promising results in patients with severe COVID-19. Also, IVIG, combined with moderate-dose of corticosteroids, might improve patient outcomes. Evidence links COVID-19 to variable degrees of inflammation. Studies show that the use of corticosteroids might accelerate recovery from COVID-19. There are, however, no controlled clinical trials that show whether the use of corticosteroids can reduce COVID-19-related death. Also, the pro-inflammatory cytokine IL6 is the best-documented cytokine in COVID-19 correlated with severity, criticality, viral load, and prognosis of patients with COVID-19. Tocilizumab, a monoclonal antibody against IL6, could confer clinical benefit in patients with high IL6 levels. Essential elements that process SARS-CoV2 cell entry and specific characteristics that allow SARS-CoV2 to escape the immune system have the potential as targets for COVID-19 therapy."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T2","span":{"begin":64,"end":71},"obj":"http://purl.obolibrary.org/obo/OGMS_0000031"},{"id":"T3","span":{"begin":1014,"end":1018},"obj":"http://purl.obolibrary.org/obo/CL_0000000"}],"text":"The novel coronavirus, SARS-CoV2, can cause a potentially fatal disease, COVID-19, in humans. Here, we will provide an overview of therapeutic options for COVID-19. Plasma from patients recovered from COVID-19 that contains antibodies against SARS-CoV2 has shown promising results in patients with severe COVID-19. Also, IVIG, combined with moderate-dose of corticosteroids, might improve patient outcomes. Evidence links COVID-19 to variable degrees of inflammation. Studies show that the use of corticosteroids might accelerate recovery from COVID-19. There are, however, no controlled clinical trials that show whether the use of corticosteroids can reduce COVID-19-related death. Also, the pro-inflammatory cytokine IL6 is the best-documented cytokine in COVID-19 correlated with severity, criticality, viral load, and prognosis of patients with COVID-19. Tocilizumab, a monoclonal antibody against IL6, could confer clinical benefit in patients with high IL6 levels. Essential elements that process SARS-CoV2 cell entry and specific characteristics that allow SARS-CoV2 to escape the immune system have the potential as targets for COVID-19 therapy."}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T5","span":{"begin":358,"end":373},"obj":"Chemical"},{"id":"T6","span":{"begin":497,"end":512},"obj":"Chemical"},{"id":"T7","span":{"begin":633,"end":648},"obj":"Chemical"}],"attributes":[{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"}],"text":"The novel coronavirus, SARS-CoV2, can cause a potentially fatal disease, COVID-19, in humans. Here, we will provide an overview of therapeutic options for COVID-19. Plasma from patients recovered from COVID-19 that contains antibodies against SARS-CoV2 has shown promising results in patients with severe COVID-19. Also, IVIG, combined with moderate-dose of corticosteroids, might improve patient outcomes. Evidence links COVID-19 to variable degrees of inflammation. Studies show that the use of corticosteroids might accelerate recovery from COVID-19. There are, however, no controlled clinical trials that show whether the use of corticosteroids can reduce COVID-19-related death. Also, the pro-inflammatory cytokine IL6 is the best-documented cytokine in COVID-19 correlated with severity, criticality, viral load, and prognosis of patients with COVID-19. Tocilizumab, a monoclonal antibody against IL6, could confer clinical benefit in patients with high IL6 levels. Essential elements that process SARS-CoV2 cell entry and specific characteristics that allow SARS-CoV2 to escape the immune system have the potential as targets for COVID-19 therapy."}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T6","span":{"begin":23,"end":32},"obj":"Species"},{"id":"T7","span":{"begin":73,"end":81},"obj":"Species"},{"id":"T8","span":{"begin":86,"end":92},"obj":"Species"},{"id":"T9","span":{"begin":155,"end":163},"obj":"Species"},{"id":"T10","span":{"begin":201,"end":209},"obj":"Species"},{"id":"T11","span":{"begin":243,"end":252},"obj":"Species"},{"id":"T12","span":{"begin":305,"end":313},"obj":"Species"},{"id":"T13","span":{"begin":422,"end":430},"obj":"Species"},{"id":"T14","span":{"begin":544,"end":552},"obj":"Species"},{"id":"T15","span":{"begin":660,"end":668},"obj":"Species"},{"id":"T16","span":{"begin":759,"end":767},"obj":"Species"},{"id":"T17","span":{"begin":850,"end":858},"obj":"Species"},{"id":"T18","span":{"begin":1004,"end":1013},"obj":"Species"},{"id":"T19","span":{"begin":1065,"end":1074},"obj":"Species"},{"id":"T20","span":{"begin":1137,"end":1145},"obj":"Species"}],"attributes":[{"id":"A14","pred":"ncbi_taxonomy_id","subj":"T14","obj":"NCBItxid:2697049"},{"id":"A13","pred":"ncbi_taxonomy_id","subj":"T13","obj":"NCBItxid:2697049"},{"id":"A11","pred":"ncbi_taxonomy_id","subj":"T11","obj":"NCBItxid:2697049"},{"id":"A18","pred":"ncbi_taxonomy_id","subj":"T18","obj":"NCBItxid:2697049"},{"id":"A9","pred":"ncbi_taxonomy_id","subj":"T9","obj":"NCBItxid:2697049"},{"id":"A7","pred":"ncbi_taxonomy_id","subj":"T7","obj":"NCBItxid:2697049"},{"id":"A17","pred":"ncbi_taxonomy_id","subj":"T17","obj":"NCBItxid:2697049"},{"id":"A8","pred":"ncbi_taxonomy_id","subj":"T8","obj":"NCBItxid:9605"},{"id":"A15","pred":"ncbi_taxonomy_id","subj":"T15","obj":"NCBItxid:2697049"},{"id":"A6","pred":"ncbi_taxonomy_id","subj":"T6","obj":"NCBItxid:2697049"},{"id":"A10","pred":"ncbi_taxonomy_id","subj":"T10","obj":"NCBItxid:2697049"},{"id":"A20","pred":"ncbi_taxonomy_id","subj":"T20","obj":"NCBItxid:2697049"},{"id":"A19","pred":"ncbi_taxonomy_id","subj":"T19","obj":"NCBItxid:2697049"},{"id":"A16","pred":"ncbi_taxonomy_id","subj":"T16","obj":"NCBItxid:2697049"},{"id":"A12","pred":"ncbi_taxonomy_id","subj":"T12","obj":"NCBItxid:2697049"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"The novel coronavirus, SARS-CoV2, can cause a potentially fatal disease, COVID-19, in humans. Here, we will provide an overview of therapeutic options for COVID-19. Plasma from patients recovered from COVID-19 that contains antibodies against SARS-CoV2 has shown promising results in patients with severe COVID-19. Also, IVIG, combined with moderate-dose of corticosteroids, might improve patient outcomes. Evidence links COVID-19 to variable degrees of inflammation. Studies show that the use of corticosteroids might accelerate recovery from COVID-19. There are, however, no controlled clinical trials that show whether the use of corticosteroids can reduce COVID-19-related death. Also, the pro-inflammatory cytokine IL6 is the best-documented cytokine in COVID-19 correlated with severity, criticality, viral load, and prognosis of patients with COVID-19. Tocilizumab, a monoclonal antibody against IL6, could confer clinical benefit in patients with high IL6 levels. Essential elements that process SARS-CoV2 cell entry and specific characteristics that allow SARS-CoV2 to escape the immune system have the potential as targets for COVID-19 therapy."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T11","span":{"begin":0,"end":93},"obj":"Sentence"},{"id":"T12","span":{"begin":94,"end":164},"obj":"Sentence"},{"id":"T13","span":{"begin":165,"end":314},"obj":"Sentence"},{"id":"T14","span":{"begin":315,"end":406},"obj":"Sentence"},{"id":"T15","span":{"begin":407,"end":467},"obj":"Sentence"},{"id":"T16","span":{"begin":468,"end":553},"obj":"Sentence"},{"id":"T17","span":{"begin":554,"end":683},"obj":"Sentence"},{"id":"T18","span":{"begin":684,"end":859},"obj":"Sentence"},{"id":"T19","span":{"begin":860,"end":971},"obj":"Sentence"},{"id":"T20","span":{"begin":972,"end":1154},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The novel coronavirus, SARS-CoV2, can cause a potentially fatal disease, COVID-19, in humans. Here, we will provide an overview of therapeutic options for COVID-19. Plasma from patients recovered from COVID-19 that contains antibodies against SARS-CoV2 has shown promising results in patients with severe COVID-19. Also, IVIG, combined with moderate-dose of corticosteroids, might improve patient outcomes. Evidence links COVID-19 to variable degrees of inflammation. Studies show that the use of corticosteroids might accelerate recovery from COVID-19. There are, however, no controlled clinical trials that show whether the use of corticosteroids can reduce COVID-19-related death. Also, the pro-inflammatory cytokine IL6 is the best-documented cytokine in COVID-19 correlated with severity, criticality, viral load, and prognosis of patients with COVID-19. Tocilizumab, a monoclonal antibody against IL6, could confer clinical benefit in patients with high IL6 levels. Essential elements that process SARS-CoV2 cell entry and specific characteristics that allow SARS-CoV2 to escape the immune system have the potential as targets for COVID-19 therapy."}

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novel coronavirus, SARS-CoV2, can cause a potentially fatal disease, COVID-19, in humans. Here, we will provide an overview of therapeutic options for COVID-19. Plasma from patients recovered from COVID-19 that contains antibodies against SARS-CoV2 has shown promising results in patients with severe COVID-19. Also, IVIG, combined with moderate-dose of corticosteroids, might improve patient outcomes. Evidence links COVID-19 to variable degrees of inflammation. Studies show that the use of corticosteroids might accelerate recovery from COVID-19. There are, however, no controlled clinical trials that show whether the use of corticosteroids can reduce COVID-19-related death. Also, the pro-inflammatory cytokine IL6 is the best-documented cytokine in COVID-19 correlated with severity, criticality, viral load, and prognosis of patients with COVID-19. Tocilizumab, a monoclonal antibody against IL6, could confer clinical benefit in patients with high IL6 levels. Essential elements that process SARS-CoV2 cell entry and specific characteristics that allow SARS-CoV2 to escape the immune system have the potential as targets for COVID-19 therapy."}

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Here, we will provide an overview of therapeutic options for COVID-19. Plasma from patients recovered from COVID-19 that contains antibodies against SARS-CoV2 has shown promising results in patients with severe COVID-19. Also, IVIG, combined with moderate-dose of corticosteroids, might improve patient outcomes. Evidence links COVID-19 to variable degrees of inflammation. Studies show that the use of corticosteroids might accelerate recovery from COVID-19. There are, however, no controlled clinical trials that show whether the use of corticosteroids can reduce COVID-19-related death. Also, the pro-inflammatory cytokine IL6 is the best-documented cytokine in COVID-19 correlated with severity, criticality, viral load, and prognosis of patients with COVID-19. Tocilizumab, a monoclonal antibody against IL6, could confer clinical benefit in patients with high IL6 levels. Essential elements that process SARS-CoV2 cell entry and specific characteristics that allow SARS-CoV2 to escape the immune system have the potential as targets for COVID-19 therapy."}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T1","span":{"begin":454,"end":466},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T2","span":{"begin":677,"end":682},"obj":"http://purl.obolibrary.org/obo/GO_0016265"}],"text":"The novel coronavirus, SARS-CoV2, can cause a potentially fatal disease, COVID-19, in humans. Here, we will provide an overview of therapeutic options for COVID-19. Plasma from patients recovered from COVID-19 that contains antibodies against SARS-CoV2 has shown promising results in patients with severe COVID-19. Also, IVIG, combined with moderate-dose of corticosteroids, might improve patient outcomes. Evidence links COVID-19 to variable degrees of inflammation. Studies show that the use of corticosteroids might accelerate recovery from COVID-19. There are, however, no controlled clinical trials that show whether the use of corticosteroids can reduce COVID-19-related death. Also, the pro-inflammatory cytokine IL6 is the best-documented cytokine in COVID-19 correlated with severity, criticality, viral load, and prognosis of patients with COVID-19. Tocilizumab, a monoclonal antibody against IL6, could confer clinical benefit in patients with high IL6 levels. Essential elements that process SARS-CoV2 cell entry and specific characteristics that allow SARS-CoV2 to escape the immune system have the potential as targets for COVID-19 therapy."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T2","span":{"begin":165,"end":171},"obj":"Body_part"},{"id":"T3","span":{"begin":711,"end":719},"obj":"Body_part"},{"id":"T4","span":{"begin":747,"end":755},"obj":"Body_part"},{"id":"T5","span":{"begin":886,"end":894},"obj":"Body_part"},{"id":"T6","span":{"begin":1014,"end":1018},"obj":"Body_part"},{"id":"T7","span":{"begin":1089,"end":1102},"obj":"Body_part"}],"attributes":[{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma9825"}],"text":"The novel coronavirus, SARS-CoV2, can cause a potentially fatal disease, COVID-19, in humans. Here, we will provide an overview of therapeutic options for COVID-19. Plasma from patients recovered from COVID-19 that contains antibodies against SARS-CoV2 has shown promising results in patients with severe COVID-19. Also, IVIG, combined with moderate-dose of corticosteroids, might improve patient outcomes. Evidence links COVID-19 to variable degrees of inflammation. Studies show that the use of corticosteroids might accelerate recovery from COVID-19. There are, however, no controlled clinical trials that show whether the use of corticosteroids can reduce COVID-19-related death. Also, the pro-inflammatory cytokine IL6 is the best-documented cytokine in COVID-19 correlated with severity, criticality, viral load, and prognosis of patients with COVID-19. Tocilizumab, a monoclonal antibody against IL6, could confer clinical benefit in patients with high IL6 levels. Essential elements that process SARS-CoV2 cell entry and specific characteristics that allow SARS-CoV2 to escape the immune system have the potential as targets for COVID-19 therapy."}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T6","span":{"begin":23,"end":32},"obj":"Disease"},{"id":"T7","span":{"begin":73,"end":81},"obj":"Disease"},{"id":"T8","span":{"begin":155,"end":163},"obj":"Disease"},{"id":"T9","span":{"begin":201,"end":209},"obj":"Disease"},{"id":"T10","span":{"begin":243,"end":252},"obj":"Disease"},{"id":"T11","span":{"begin":305,"end":313},"obj":"Disease"},{"id":"T12","span":{"begin":422,"end":430},"obj":"Disease"},{"id":"T13","span":{"begin":454,"end":466},"obj":"Disease"},{"id":"T14","span":{"begin":544,"end":552},"obj":"Disease"},{"id":"T15","span":{"begin":660,"end":668},"obj":"Disease"},{"id":"T16","span":{"begin":759,"end":767},"obj":"Disease"},{"id":"T17","span":{"begin":850,"end":858},"obj":"Disease"},{"id":"T18","span":{"begin":1004,"end":1013},"obj":"Disease"},{"id":"T19","span":{"begin":1065,"end":1074},"obj":"Disease"},{"id":"T20","span":{"begin":1137,"end":1145},"obj":"Disease"}],"attributes":[{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A20","pred":"mondo_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A18","pred":"mondo_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A19","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"The novel coronavirus, SARS-CoV2, can cause a potentially fatal disease, COVID-19, in humans. Here, we will provide an overview of therapeutic options for COVID-19. Plasma from patients recovered from COVID-19 that contains antibodies against SARS-CoV2 has shown promising results in patients with severe COVID-19. Also, IVIG, combined with moderate-dose of corticosteroids, might improve patient outcomes. Evidence links COVID-19 to variable degrees of inflammation. Studies show that the use of corticosteroids might accelerate recovery from COVID-19. There are, however, no controlled clinical trials that show whether the use of corticosteroids can reduce COVID-19-related death. Also, the pro-inflammatory cytokine IL6 is the best-documented cytokine in COVID-19 correlated with severity, criticality, viral load, and prognosis of patients with COVID-19. Tocilizumab, a monoclonal antibody against IL6, could confer clinical benefit in patients with high IL6 levels. Essential elements that process SARS-CoV2 cell entry and specific characteristics that allow SARS-CoV2 to escape the immune system have the potential as targets for COVID-19 therapy."}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T1","span":{"begin":454,"end":466},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"The novel coronavirus, SARS-CoV2, can cause a potentially fatal disease, COVID-19, in humans. Here, we will provide an overview of therapeutic options for COVID-19. Plasma from patients recovered from COVID-19 that contains antibodies against SARS-CoV2 has shown promising results in patients with severe COVID-19. Also, IVIG, combined with moderate-dose of corticosteroids, might improve patient outcomes. Evidence links COVID-19 to variable degrees of inflammation. Studies show that the use of corticosteroids might accelerate recovery from COVID-19. There are, however, no controlled clinical trials that show whether the use of corticosteroids can reduce COVID-19-related death. Also, the pro-inflammatory cytokine IL6 is the best-documented cytokine in COVID-19 correlated with severity, criticality, viral load, and prognosis of patients with COVID-19. Tocilizumab, a monoclonal antibody against IL6, could confer clinical benefit in patients with high IL6 levels. Essential elements that process SARS-CoV2 cell entry and specific characteristics that allow SARS-CoV2 to escape the immune system have the potential as targets for COVID-19 therapy."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":454,"end":466},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"The novel coronavirus, SARS-CoV2, can cause a potentially fatal disease, COVID-19, in humans. Here, we will provide an overview of therapeutic options for COVID-19. Plasma from patients recovered from COVID-19 that contains antibodies against SARS-CoV2 has shown promising results in patients with severe COVID-19. Also, IVIG, combined with moderate-dose of corticosteroids, might improve patient outcomes. Evidence links COVID-19 to variable degrees of inflammation. Studies show that the use of corticosteroids might accelerate recovery from COVID-19. There are, however, no controlled clinical trials that show whether the use of corticosteroids can reduce COVID-19-related death. Also, the pro-inflammatory cytokine IL6 is the best-documented cytokine in COVID-19 correlated with severity, criticality, viral load, and prognosis of patients with COVID-19. Tocilizumab, a monoclonal antibody against IL6, could confer clinical benefit in patients with high IL6 levels. Essential elements that process SARS-CoV2 cell entry and specific characteristics that allow SARS-CoV2 to escape the immune system have the potential as targets for COVID-19 therapy."}

{"project":"LitCovid-sentences","denotations":[{"id":"T11","span":{"begin":0,"end":93},"obj":"Sentence"},{"id":"T12","span":{"begin":94,"end":164},"obj":"Sentence"},{"id":"T13","span":{"begin":165,"end":314},"obj":"Sentence"},{"id":"T14","span":{"begin":315,"end":406},"obj":"Sentence"},{"id":"T15","span":{"begin":407,"end":467},"obj":"Sentence"},{"id":"T16","span":{"begin":468,"end":553},"obj":"Sentence"},{"id":"T17","span":{"begin":554,"end":683},"obj":"Sentence"},{"id":"T18","span":{"begin":684,"end":859},"obj":"Sentence"},{"id":"T19","span":{"begin":860,"end":971},"obj":"Sentence"},{"id":"T20","span":{"begin":972,"end":1154},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The novel coronavirus, SARS-CoV2, can cause a potentially fatal disease, COVID-19, in humans. Here, we will provide an overview of therapeutic options for COVID-19. Plasma from patients recovered from COVID-19 that contains antibodies against SARS-CoV2 has shown promising results in patients with severe COVID-19. Also, IVIG, combined with moderate-dose of corticosteroids, might improve patient outcomes. Evidence links COVID-19 to variable degrees of inflammation. Studies show that the use of corticosteroids might accelerate recovery from COVID-19. There are, however, no controlled clinical trials that show whether the use of corticosteroids can reduce COVID-19-related death. Also, the pro-inflammatory cytokine IL6 is the best-documented cytokine in COVID-19 correlated with severity, criticality, viral load, and prognosis of patients with COVID-19. Tocilizumab, a monoclonal antibody against IL6, could confer clinical benefit in patients with high IL6 levels. Essential elements that process SARS-CoV2 cell entry and specific characteristics that allow SARS-CoV2 to escape the immune system have the potential as targets for COVID-19 therapy."}