PMC:7205724 / 21404-21806
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
739 | 263-267 | Gene | denotes | ACE2 | Gene:59272 |
740 | 397-401 | Gene | denotes | ACE2 | Gene:59272 |
741 | 350-351 | Gene | denotes | S | Gene:43740568 |
742 | 149-150 | Gene | denotes | S | Gene:43740568 |
743 | 136-137 | Gene | denotes | S | Gene:43740568 |
744 | 98-99 | Gene | denotes | S | Gene:43740568 |
745 | 76-77 | Gene | denotes | S | Gene:43740568 |
746 | 91-97 | Species | denotes | SARS-2 | Tax:2697049 |
747 | 142-148 | Species | denotes | SARS-2 | Tax:2697049 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T158 | 177-185 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T159 | 71-75 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T160 | 91-95 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T161 | 131-135 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T162 | 142-146 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T163 | 345-349 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T253 | 14-15 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T254 | 57-59 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
T255 | 57-59 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
T256 | 257-259 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
T257 | 257-259 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
T258 | 379-381 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
T259 | 379-381 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T168 | 57-59 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
T169 | 257-259 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
T170 | 379-381 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
LitCovid-sample-MedDRA
Id | Subject | Object | Predicate | Lexical cue | meddra_id |
---|---|---|---|---|---|
T21 | 296-319 | http://purl.bioontology.org/ontology/MEDDRA/10022891 | denotes | neutralizing antibodies | http://purl.bioontology.org/ontology/MEDDRA/10058063 |
LitCovid-sample-PD-NCBITaxon
Id | Subject | Object | Predicate | Lexical cue | ncbi_taxonomy_id |
---|---|---|---|---|---|
T211 | 71-75 | Species | denotes | SARS | NCBItxid:694009 |
T212 | 91-97 | Species | denotes | SARS-2 | NCBItxid:2697049 |
T213 | 131-135 | Species | denotes | SARS | NCBItxid:694009 |
T214 | 142-148 | Species | denotes | SARS-2 | NCBItxid:2697049 |
T215 | 345-349 | Species | denotes | SARS | NCBItxid:694009 |
LitCovid-sample-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T173 | 0-100 | Sentence | denotes | 47D11 carried a higher affinity for interacting with the S2 subunit of SARS-S than that of SARS-2-S. |
T174 | 101-282 | Sentence | denotes | It is important that for both SARS-S and SARS-2-S, the binding of the 47D11 antibody to the target – the S1B domain – does not block the binding of S1B and S2 to ACE2 receptor [26]. |
T175 | 283-402 | Sentence | denotes | By contrast, neutralizing antibodies that specifically target SARS-S could compete with S1B and S2 for binding to ACE2. |
LitCovid-sample-Pubtator
Id | Subject | Object | Predicate | Lexical cue | pubann:denotes |
---|---|---|---|---|---|
745 | 76-77 | Gene | denotes | S | Gene:43740568 |
746 | 91-97 | Species | denotes | SARS-2 | Tax:2697049 |
744 | 98-99 | Gene | denotes | S | Gene:43740568 |
743 | 136-137 | Gene | denotes | S | Gene:43740568 |
747 | 142-148 | Species | denotes | SARS-2 | Tax:2697049 |
742 | 149-150 | Gene | denotes | S | Gene:43740568 |
739 | 263-267 | Gene | denotes | ACE2 | Gene:59272 |
741 | 350-351 | Gene | denotes | S | Gene:43740568 |
740 | 397-401 | Gene | denotes | ACE2 | Gene:59272 |
LitCovid-sample-UniProt
Id | Subject | Object | Predicate | Lexical cue | uniprot_id |
---|---|---|---|---|---|
T2070 | 206-209 | Protein | denotes | S1B | https://www.uniprot.org/uniprot/P47835 |
T2071 | 249-252 | Protein | denotes | S1B | https://www.uniprot.org/uniprot/P47835 |
T2072 | 371-374 | Protein | denotes | S1B | https://www.uniprot.org/uniprot/P47835 |
LitCovid-sample-Enju
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T22398 | 0-5 | NN | denotes | 47D11 |
T15962 | 6-13 | VBD | denotes | carried |
T83196 | 14-15 | DT | denotes | a |
T61532 | 16-22 | JJR | denotes | higher |
T47874 | 23-31 | NN | denotes | affinity |
T77580 | 32-35 | IN | denotes | for |
T95631 | 36-47 | VBG | denotes | interacting |
T94847 | 48-52 | IN | denotes | with |
T20163 | 53-56 | DT | denotes | the |
T18520 | 57-59 | NN | denotes | S2 |
T89003 | 60-67 | NN | denotes | subunit |
T41606 | 68-70 | IN | denotes | of |
T4784 | 71-77 | NN | denotes | SARS-S |
T32288 | 78-82 | IN | denotes | than |
T68894 | 83-87 | DT | denotes | that |
T97000 | 88-90 | IN | denotes | of |
T32517 | 91-100 | NN | denotes | SARS-2-S. |
T24633 | 101-103 | PRP | denotes | It |
T45480 | 104-106 | VBZ | denotes | is |
T10954 | 107-116 | JJ | denotes | important |
T96386 | 117-121 | IN | denotes | that |
T80967 | 122-125 | IN | denotes | for |
T24571 | 126-130 | DT | denotes | both |
T18211 | 131-137 | NN | denotes | SARS-S |
T39196 | 138-141 | CC | denotes | and |
T83081 | 142-150 | NN | denotes | SARS-2-S |
T70298 | 150-151 | -COMMA- | denotes | , |
T91479 | 152-155 | DT | denotes | the |
T56884 | 156-163 | NN | denotes | binding |
T11559 | 164-166 | IN | denotes | of |
T2922 | 167-170 | DT | denotes | the |
T11592 | 171-176 | NN | denotes | 47D11 |
T36887 | 177-185 | NN | denotes | antibody |
T46706 | 186-188 | TO | denotes | to |
T40788 | 189-192 | DT | denotes | the |
T37833 | 193-199 | NN | denotes | target |
T37378 | 200-201 | VBZ | denotes | – |
T15003 | 202-205 | DT | denotes | the |
T4372 | 206-209 | NN | denotes | S1B |
T31100 | 210-216 | NN | denotes | domain |
T82065 | 217-218 | NN | denotes | – |
T43926 | 219-223 | VBZ | denotes | does |
T69422 | 224-227 | RB | denotes | not |
T3419 | 228-233 | VB | denotes | block |
T21955 | 234-237 | DT | denotes | the |
T12942 | 238-245 | NN | denotes | binding |
T83444 | 246-248 | IN | denotes | of |
T49120 | 249-252 | NN | denotes | S1B |
T55070 | 253-256 | CC | denotes | and |
T98634 | 257-259 | NN | denotes | S2 |
T48321 | 260-262 | TO | denotes | to |
T80580 | 263-267 | NN | denotes | ACE2 |
T18877 | 268-276 | NN | denotes | receptor |
T18503 | 277-278 | -LRB- | denotes | [ |
T33177 | 278-280 | CD | denotes | 26 |
T92006 | 280-281 | -RRB- | denotes | ] |
T53652 | 283-285 | IN | denotes | By |
T58622 | 286-294 | NN | denotes | contrast |
T35381 | 294-295 | -COMMA- | denotes | , |
T41843 | 296-308 | VBG | denotes | neutralizing |
T81589 | 309-319 | NNS | denotes | antibodies |
T68196 | 320-324 | WDT | denotes | that |
T30816 | 325-337 | RB | denotes | specifically |
T53446 | 338-344 | NN | denotes | target |
T89813 | 345-351 | NN | denotes | SARS-S |
T95236 | 352-357 | MD | denotes | could |
T7888 | 358-365 | VB | denotes | compete |
T34125 | 366-370 | IN | denotes | with |
T82101 | 371-374 | NN | denotes | S1B |
T1902 | 375-378 | CC | denotes | and |
T24277 | 379-381 | NN | denotes | S2 |
T37015 | 382-385 | IN | denotes | for |
T86465 | 386-393 | VBG | denotes | binding |
T1893 | 394-396 | TO | denotes | to |
T91196 | 397-401 | NN | denotes | ACE2 |
R37108 | T22398 | T15962 | arg1Of | 47D11,carried |
R43602 | T47874 | T15962 | arg2Of | affinity,carried |
R3397 | T47874 | T83196 | arg1Of | affinity,a |
R69683 | T47874 | T61532 | arg1Of | affinity,higher |
R78190 | T47874 | T77580 | arg1Of | affinity,for |
R68969 | T95631 | T77580 | arg2Of | interacting,for |
R15040 | T95631 | T94847 | arg1Of | interacting,with |
R25517 | T89003 | T94847 | arg2Of | subunit,with |
R53417 | T89003 | T20163 | arg1Of | subunit,the |
R3997 | T89003 | T18520 | arg1Of | subunit,S2 |
R34556 | T89003 | T41606 | arg1Of | subunit,of |
R37706 | T4784 | T41606 | arg2Of | SARS-S,of |
R45826 | T47874 | T32288 | arg1Of | affinity,than |
R81151 | T68894 | T32288 | arg2Of | that,than |
R10947 | T68894 | T97000 | arg1Of | that,of |
R87567 | T32517 | T97000 | arg2Of | SARS-2-S.,of |
R92430 | T24633 | T45480 | arg1Of | It,is |
R27880 | T10954 | T45480 | arg2Of | important,is |
R16446 | T47874 | T45480 | modOf | affinity,is |
R5059 | T24633 | T10954 | arg1Of | It,important |
R77514 | T47874 | T96386 | arg1Of | affinity,that |
R45591 | T37378 | T96386 | arg2Of | –,that |
R6871 | T96386 | T80967 | arg1Of | that,for |
R86711 | T39196 | T80967 | arg2Of | and,for |
R85187 | T39196 | T24571 | arg1Of | and,both |
R57766 | T18211 | T39196 | arg1Of | SARS-S,and |
R60594 | T83081 | T39196 | arg2Of | SARS-2-S,and |
R15467 | T37378 | T70298 | arg1Of | –,"," |
R5494 | T56884 | T91479 | arg1Of | binding,the |
R79151 | T56884 | T11559 | arg1Of | binding,of |
R6992 | T36887 | T11559 | arg2Of | antibody,of |
R62361 | T36887 | T2922 | arg1Of | antibody,the |
R48343 | T36887 | T11592 | arg1Of | antibody,47D11 |
R35747 | T56884 | T46706 | arg1Of | binding,to |
R10371 | T37833 | T46706 | arg2Of | target,to |
R36916 | T37833 | T40788 | arg1Of | target,the |
R17566 | T56884 | T37378 | arg1Of | binding,– |
R23617 | T3419 | T37378 | arg2Of | block,– |
R26619 | T82065 | T15003 | arg1Of | –,the |
R64854 | T82065 | T4372 | arg1Of | –,S1B |
R97129 | T82065 | T31100 | arg1Of | –,domain |
R47400 | T82065 | T43926 | arg1Of | –,does |
R34720 | T3419 | T43926 | arg2Of | block,does |
R55812 | T3419 | T69422 | arg1Of | block,not |
R51826 | T82065 | T3419 | arg1Of | –,block |
R99609 | T12942 | T3419 | arg2Of | binding,block |
R35148 | T12942 | T21955 | arg1Of | binding,the |
R30150 | T12942 | T83444 | arg1Of | binding,of |
R36055 | T55070 | T83444 | arg2Of | and,of |
R9737 | T49120 | T55070 | arg1Of | S1B,and |
R3528 | T98634 | T55070 | arg2Of | S2,and |
R55511 | T12942 | T48321 | arg1Of | binding,to |
R91010 | T18877 | T48321 | arg2Of | receptor,to |
R37042 | T18877 | T80580 | arg1Of | receptor,ACE2 |
R82088 | T18877 | T18503 | arg1Of | receptor,[ |
R55576 | T33177 | T18503 | arg2Of | 26,[ |
R41077 | T92006 | T18503 | arg3Of | ],[ |
R68866 | T41843 | T53652 | arg1Of | neutralizing,By |
R80894 | T58622 | T53652 | arg2Of | contrast,By |
R42535 | T41843 | T35381 | arg1Of | neutralizing,"," |
R99048 | T81589 | T41843 | arg1Of | antibodies,neutralizing |
R45757 | T81589 | T68196 | arg1Of | antibodies,that |
R2391 | T7888 | T30816 | arg1Of | compete,specifically |
R14961 | T89813 | T53446 | arg1Of | SARS-S,target |
R96775 | T89813 | T95236 | arg1Of | SARS-S,could |
R6780 | T7888 | T95236 | arg2Of | compete,could |
R40504 | T89813 | T7888 | arg1Of | SARS-S,compete |
R84230 | T81589 | T7888 | arg2Of | antibodies,compete |
R48027 | T7888 | T34125 | arg1Of | compete,with |
R59163 | T1902 | T34125 | arg2Of | and,with |
R39175 | T82101 | T1902 | arg1Of | S1B,and |
R95020 | T24277 | T1902 | arg2Of | S2,and |
R6420 | T1902 | T37015 | arg1Of | and,for |
R67300 | T86465 | T37015 | arg2Of | binding,for |
R53767 | T86465 | T1893 | arg1Of | binding,to |
R3636 | T91196 | T1893 | arg2Of | ACE2,to |
LitCovid-sample-PD-FMA
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T158 | 177-185 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
LitCovid-sample-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T154 | 71-75 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T155 | 91-95 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T156 | 131-135 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T157 | 142-146 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T158 | 345-349 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T173 | 0-100 | Sentence | denotes | 47D11 carried a higher affinity for interacting with the S2 subunit of SARS-S than that of SARS-2-S. |
T174 | 101-282 | Sentence | denotes | It is important that for both SARS-S and SARS-2-S, the binding of the 47D11 antibody to the target – the S1B domain – does not block the binding of S1B and S2 to ACE2 receptor [26]. |
T175 | 283-402 | Sentence | denotes | By contrast, neutralizing antibodies that specifically target SARS-S could compete with S1B and S2 for binding to ACE2. |