PMC:7205724 / 21302-21806 JSONTXT

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    LitCovid-PubTator

    {"project":"LitCovid-PubTator","denotations":[{"id":"729","span":{"begin":67,"end":72},"obj":"Species"},{"id":"739","span":{"begin":365,"end":369},"obj":"Gene"},{"id":"740","span":{"begin":499,"end":503},"obj":"Gene"},{"id":"741","span":{"begin":452,"end":453},"obj":"Gene"},{"id":"742","span":{"begin":251,"end":252},"obj":"Gene"},{"id":"743","span":{"begin":238,"end":239},"obj":"Gene"},{"id":"744","span":{"begin":200,"end":201},"obj":"Gene"},{"id":"745","span":{"begin":178,"end":179},"obj":"Gene"},{"id":"746","span":{"begin":193,"end":199},"obj":"Species"},{"id":"747","span":{"begin":244,"end":250},"obj":"Species"}],"attributes":[{"id":"A729","pred":"tao:has_database_id","subj":"729","obj":"Tax:9606"},{"id":"A739","pred":"tao:has_database_id","subj":"739","obj":"Gene:59272"},{"id":"A740","pred":"tao:has_database_id","subj":"740","obj":"Gene:59272"},{"id":"A741","pred":"tao:has_database_id","subj":"741","obj":"Gene:43740568"},{"id":"A742","pred":"tao:has_database_id","subj":"742","obj":"Gene:43740568"},{"id":"A743","pred":"tao:has_database_id","subj":"743","obj":"Gene:43740568"},{"id":"A744","pred":"tao:has_database_id","subj":"744","obj":"Gene:43740568"},{"id":"A745","pred":"tao:has_database_id","subj":"745","obj":"Gene:43740568"},{"id":"A746","pred":"tao:has_database_id","subj":"746","obj":"Tax:2697049"},{"id":"A747","pred":"tao:has_database_id","subj":"747","obj":"Tax:2697049"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"6.1.2 Rational: The chimeric 47D11 H2L2 might not be effective in human lung cells as it is in vitro\n47D11 carried a higher affinity for interacting with the S2 subunit of SARS-S than that of SARS-2-S. It is important that for both SARS-S and SARS-2-S, the binding of the 47D11 antibody to the target – the S1B domain – does not block the binding of S1B and S2 to ACE2 receptor [26]. By contrast, neutralizing antibodies that specifically target SARS-S could compete with S1B and S2 for binding to ACE2."}

    LitCovid-PD-FMA-UBERON

    {"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T156","span":{"begin":73,"end":77},"obj":"Body_part"},{"id":"T157","span":{"begin":78,"end":83},"obj":"Body_part"},{"id":"T158","span":{"begin":279,"end":287},"obj":"Body_part"}],"attributes":[{"id":"A156","pred":"fma_id","subj":"T156","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A157","pred":"fma_id","subj":"T157","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A158","pred":"fma_id","subj":"T158","obj":"http://purl.org/sig/ont/fma/fma62871"}],"text":"6.1.2 Rational: The chimeric 47D11 H2L2 might not be effective in human lung cells as it is in vitro\n47D11 carried a higher affinity for interacting with the S2 subunit of SARS-S than that of SARS-2-S. It is important that for both SARS-S and SARS-2-S, the binding of the 47D11 antibody to the target – the S1B domain – does not block the binding of S1B and S2 to ACE2 receptor [26]. By contrast, neutralizing antibodies that specifically target SARS-S could compete with S1B and S2 for binding to ACE2."}

    LitCovid-PD-UBERON

    {"project":"LitCovid-PD-UBERON","denotations":[{"id":"T21","span":{"begin":73,"end":77},"obj":"Body_part"}],"attributes":[{"id":"A21","pred":"uberon_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"6.1.2 Rational: The chimeric 47D11 H2L2 might not be effective in human lung cells as it is in vitro\n47D11 carried a higher affinity for interacting with the S2 subunit of SARS-S than that of SARS-2-S. It is important that for both SARS-S and SARS-2-S, the binding of the 47D11 antibody to the target – the S1B domain – does not block the binding of S1B and S2 to ACE2 receptor [26]. By contrast, neutralizing antibodies that specifically target SARS-S could compete with S1B and S2 for binding to ACE2."}

    LitCovid-PD-MONDO

    {"project":"LitCovid-PD-MONDO","denotations":[{"id":"T159","span":{"begin":173,"end":177},"obj":"Disease"},{"id":"T160","span":{"begin":193,"end":197},"obj":"Disease"},{"id":"T161","span":{"begin":233,"end":237},"obj":"Disease"},{"id":"T162","span":{"begin":244,"end":248},"obj":"Disease"},{"id":"T163","span":{"begin":447,"end":451},"obj":"Disease"}],"attributes":[{"id":"A159","pred":"mondo_id","subj":"T159","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A160","pred":"mondo_id","subj":"T160","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A161","pred":"mondo_id","subj":"T161","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A162","pred":"mondo_id","subj":"T162","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A163","pred":"mondo_id","subj":"T163","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"6.1.2 Rational: The chimeric 47D11 H2L2 might not be effective in human lung cells as it is in vitro\n47D11 carried a higher affinity for interacting with the S2 subunit of SARS-S than that of SARS-2-S. It is important that for both SARS-S and SARS-2-S, the binding of the 47D11 antibody to the target – the S1B domain – does not block the binding of S1B and S2 to ACE2 receptor [26]. By contrast, neutralizing antibodies that specifically target SARS-S could compete with S1B and S2 for binding to ACE2."}

    LitCovid-PD-CLO

    {"project":"LitCovid-PD-CLO","denotations":[{"id":"T249","span":{"begin":67,"end":72},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T250","span":{"begin":73,"end":77},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T251","span":{"begin":73,"end":77},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T252","span":{"begin":78,"end":101},"obj":"http://purl.obolibrary.org/obo/CL_0001034"},{"id":"T253","span":{"begin":116,"end":117},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T254","span":{"begin":159,"end":161},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T255","span":{"begin":159,"end":161},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T256","span":{"begin":359,"end":361},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T257","span":{"begin":359,"end":361},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T258","span":{"begin":481,"end":483},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T259","span":{"begin":481,"end":483},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"}],"text":"6.1.2 Rational: The chimeric 47D11 H2L2 might not be effective in human lung cells as it is in vitro\n47D11 carried a higher affinity for interacting with the S2 subunit of SARS-S than that of SARS-2-S. It is important that for both SARS-S and SARS-2-S, the binding of the 47D11 antibody to the target – the S1B domain – does not block the binding of S1B and S2 to ACE2 receptor [26]. By contrast, neutralizing antibodies that specifically target SARS-S could compete with S1B and S2 for binding to ACE2."}

    LitCovid-PD-CHEBI

    {"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T168","span":{"begin":159,"end":161},"obj":"Chemical"},{"id":"T169","span":{"begin":359,"end":361},"obj":"Chemical"},{"id":"T170","span":{"begin":481,"end":483},"obj":"Chemical"}],"attributes":[{"id":"A168","pred":"chebi_id","subj":"T168","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A169","pred":"chebi_id","subj":"T169","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A170","pred":"chebi_id","subj":"T170","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"}],"text":"6.1.2 Rational: The chimeric 47D11 H2L2 might not be effective in human lung cells as it is in vitro\n47D11 carried a higher affinity for interacting with the S2 subunit of SARS-S than that of SARS-2-S. It is important that for both SARS-S and SARS-2-S, the binding of the 47D11 antibody to the target – the S1B domain – does not block the binding of S1B and S2 to ACE2 receptor [26]. By contrast, neutralizing antibodies that specifically target SARS-S could compete with S1B and S2 for binding to ACE2."}

    LitCovid-sample-MedDRA

    {"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T21","span":{"begin":398,"end":421},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A21","pred":"meddra_id","subj":"T21","obj":"http://purl.bioontology.org/ontology/MEDDRA/10058063"}],"text":"6.1.2 Rational: The chimeric 47D11 H2L2 might not be effective in human lung cells as it is in vitro\n47D11 carried a higher affinity for interacting with the S2 subunit of SARS-S than that of SARS-2-S. It is important that for both SARS-S and SARS-2-S, the binding of the 47D11 antibody to the target – the S1B domain – does not block the binding of S1B and S2 to ACE2 receptor [26]. By contrast, neutralizing antibodies that specifically target SARS-S could compete with S1B and S2 for binding to ACE2."}

    LitCovid-sample-PD-IDO

    {"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T99","span":{"begin":78,"end":83},"obj":"http://purl.obolibrary.org/obo/CL_0000000"}],"text":"6.1.2 Rational: The chimeric 47D11 H2L2 might not be effective in human lung cells as it is in vitro\n47D11 carried a higher affinity for interacting with the S2 subunit of SARS-S than that of SARS-2-S. It is important that for both SARS-S and SARS-2-S, the binding of the 47D11 antibody to the target – the S1B domain – does not block the binding of S1B and S2 to ACE2 receptor [26]. By contrast, neutralizing antibodies that specifically target SARS-S could compete with S1B and S2 for binding to ACE2."}

    LitCovid-sample-PD-NCBITaxon

    {"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T210","span":{"begin":67,"end":72},"obj":"Species"},{"id":"T211","span":{"begin":173,"end":177},"obj":"Species"},{"id":"T212","span":{"begin":193,"end":199},"obj":"Species"},{"id":"T213","span":{"begin":233,"end":237},"obj":"Species"},{"id":"T214","span":{"begin":244,"end":250},"obj":"Species"},{"id":"T215","span":{"begin":447,"end":451},"obj":"Species"}],"attributes":[{"id":"A213","pred":"ncbi_taxonomy_id","subj":"T213","obj":"NCBItxid:694009"},{"id":"A210","pred":"ncbi_taxonomy_id","subj":"T210","obj":"NCBItxid:9606"},{"id":"A212","pred":"ncbi_taxonomy_id","subj":"T212","obj":"NCBItxid:2697049"},{"id":"A211","pred":"ncbi_taxonomy_id","subj":"T211","obj":"NCBItxid:694009"},{"id":"A215","pred":"ncbi_taxonomy_id","subj":"T215","obj":"NCBItxid:694009"},{"id":"A214","pred":"ncbi_taxonomy_id","subj":"T214","obj":"NCBItxid:2697049"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"6.1.2 Rational: The chimeric 47D11 H2L2 might not be effective in human lung cells as it is in vitro\n47D11 carried a higher affinity for interacting with the S2 subunit of SARS-S than that of SARS-2-S. It is important that for both SARS-S and SARS-2-S, the binding of the 47D11 antibody to the target – the S1B domain – does not block the binding of S1B and S2 to ACE2 receptor [26]. By contrast, neutralizing antibodies that specifically target SARS-S could compete with S1B and S2 for binding to ACE2."}

    LitCovid-sample-sentences

    {"project":"LitCovid-sample-sentences","denotations":[{"id":"T171","span":{"begin":0,"end":16},"obj":"Sentence"},{"id":"T172","span":{"begin":17,"end":101},"obj":"Sentence"},{"id":"T173","span":{"begin":102,"end":202},"obj":"Sentence"},{"id":"T174","span":{"begin":203,"end":384},"obj":"Sentence"},{"id":"T175","span":{"begin":385,"end":504},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"6.1.2 Rational: The chimeric 47D11 H2L2 might not be effective in human lung cells as it is in vitro\n47D11 carried a higher affinity for interacting with the S2 subunit of SARS-S than that of SARS-2-S. It is important that for both SARS-S and SARS-2-S, the binding of the 47D11 antibody to the target – the S1B domain – does not block the binding of S1B and S2 to ACE2 receptor [26]. By contrast, neutralizing antibodies that specifically target SARS-S could compete with S1B and S2 for binding to ACE2."}

    LitCovid-sample-PD-UBERON

    {"project":"LitCovid-sample-PD-UBERON","denotations":[{"id":"T21","span":{"begin":73,"end":77},"obj":"Body_part"}],"attributes":[{"id":"A21","pred":"uberon_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"6.1.2 Rational: The chimeric 47D11 H2L2 might not be effective in human lung cells as it is in vitro\n47D11 carried a higher affinity for interacting with the S2 subunit of SARS-S than that of SARS-2-S. It is important that for both SARS-S and SARS-2-S, the binding of the 47D11 antibody to the target – the S1B domain – does not block the binding of S1B and S2 to ACE2 receptor [26]. By contrast, neutralizing antibodies that specifically target SARS-S could compete with S1B and S2 for binding to ACE2."}

    LitCovid-sample-Pubtator

    {"project":"LitCovid-sample-Pubtator","denotations":[{"id":"729","span":{"begin":67,"end":72},"obj":"Species"},{"id":"745","span":{"begin":178,"end":179},"obj":"Gene"},{"id":"746","span":{"begin":193,"end":199},"obj":"Species"},{"id":"744","span":{"begin":200,"end":201},"obj":"Gene"},{"id":"743","span":{"begin":238,"end":239},"obj":"Gene"},{"id":"747","span":{"begin":244,"end":250},"obj":"Species"},{"id":"742","span":{"begin":251,"end":252},"obj":"Gene"},{"id":"739","span":{"begin":365,"end":369},"obj":"Gene"},{"id":"741","span":{"begin":452,"end":453},"obj":"Gene"},{"id":"740","span":{"begin":499,"end":503},"obj":"Gene"}],"attributes":[{"id":"A743","pred":"pubann:denotes","subj":"743","obj":"Gene:43740568"},{"id":"A742","pred":"pubann:denotes","subj":"742","obj":"Gene:43740568"},{"id":"A740","pred":"pubann:denotes","subj":"740","obj":"Gene:59272"},{"id":"A746","pred":"pubann:denotes","subj":"746","obj":"Tax:2697049"},{"id":"A739","pred":"pubann:denotes","subj":"739","obj":"Gene:59272"},{"id":"A744","pred":"pubann:denotes","subj":"744","obj":"Gene:43740568"},{"id":"A747","pred":"pubann:denotes","subj":"747","obj":"Tax:2697049"},{"id":"A741","pred":"pubann:denotes","subj":"741","obj":"Gene:43740568"},{"id":"A745","pred":"pubann:denotes","subj":"745","obj":"Gene:43740568"},{"id":"A729","pred":"pubann:denotes","subj":"729","obj":"Tax:9606"}],"text":"6.1.2 Rational: The chimeric 47D11 H2L2 might not be effective in human lung cells as it is in vitro\n47D11 carried a higher affinity for interacting with the S2 subunit of SARS-S than that of SARS-2-S. It is important that for both SARS-S and SARS-2-S, the binding of the 47D11 antibody to the target – the S1B domain – does not block the binding of S1B and S2 to ACE2 receptor [26]. By contrast, neutralizing antibodies that specifically target SARS-S could compete with S1B and S2 for binding to ACE2."}

    LitCovid-sample-UniProt

    {"project":"LitCovid-sample-UniProt","denotations":[{"id":"T2070","span":{"begin":308,"end":311},"obj":"Protein"},{"id":"T2071","span":{"begin":351,"end":354},"obj":"Protein"},{"id":"T2072","span":{"begin":473,"end":476},"obj":"Protein"}],"attributes":[{"id":"A2070","pred":"uniprot_id","subj":"T2070","obj":"https://www.uniprot.org/uniprot/P47835"},{"id":"A2071","pred":"uniprot_id","subj":"T2071","obj":"https://www.uniprot.org/uniprot/P47835"},{"id":"A2072","pred":"uniprot_id","subj":"T2072","obj":"https://www.uniprot.org/uniprot/P47835"}],"text":"6.1.2 Rational: The chimeric 47D11 H2L2 might not be effective in human lung cells as it is in vitro\n47D11 carried a higher affinity for interacting with the S2 subunit of SARS-S than that of SARS-2-S. It is important that for both SARS-S and SARS-2-S, the binding of the 47D11 antibody to the target – the S1B domain – does not block the binding of S1B and S2 to ACE2 receptor [26]. By contrast, neutralizing antibodies that specifically target SARS-S could compete with S1B and S2 for binding to ACE2."}

    LitCovid-sample-Enju

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Rational: The chimeric 47D11 H2L2 might not be effective in human lung cells as it is in vitro\n47D11 carried a higher affinity for interacting with the S2 subunit of SARS-S than that of SARS-2-S. It is important that for both SARS-S and SARS-2-S, the binding of the 47D11 antibody to the target – the S1B domain – does not block the binding of S1B and S2 to ACE2 receptor [26]. By contrast, neutralizing antibodies that specifically target SARS-S could compete with S1B and S2 for binding to ACE2."}

    LitCovid-sample-PD-MAT

    {"project":"LitCovid-sample-PD-MAT","denotations":[{"id":"T5","span":{"begin":73,"end":77},"obj":"http://purl.obolibrary.org/obo/MAT_0000135"}],"text":"6.1.2 Rational: The chimeric 47D11 H2L2 might not be effective in human lung cells as it is in vitro\n47D11 carried a higher affinity for interacting with the S2 subunit of SARS-S than that of SARS-2-S. It is important that for both SARS-S and SARS-2-S, the binding of the 47D11 antibody to the target – the S1B domain – does not block the binding of S1B and S2 to ACE2 receptor [26]. By contrast, neutralizing antibodies that specifically target SARS-S could compete with S1B and S2 for binding to ACE2."}

    LitCovid-sample-PD-FMA

    {"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T156","span":{"begin":73,"end":77},"obj":"Body_part"},{"id":"T157","span":{"begin":78,"end":83},"obj":"Body_part"},{"id":"T158","span":{"begin":279,"end":287},"obj":"Body_part"}],"attributes":[{"id":"A156","pred":"fma_id","subj":"T156","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A158","pred":"fma_id","subj":"T158","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A157","pred":"fma_id","subj":"T157","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"6.1.2 Rational: The chimeric 47D11 H2L2 might not be effective in human lung cells as it is in vitro\n47D11 carried a higher affinity for interacting with the S2 subunit of SARS-S than that of SARS-2-S. It is important that for both SARS-S and SARS-2-S, the binding of the 47D11 antibody to the target – the S1B domain – does not block the binding of S1B and S2 to ACE2 receptor [26]. By contrast, neutralizing antibodies that specifically target SARS-S could compete with S1B and S2 for binding to ACE2."}

    LitCovid-sample-PD-MONDO

    {"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T154","span":{"begin":173,"end":177},"obj":"Disease"},{"id":"T155","span":{"begin":193,"end":197},"obj":"Disease"},{"id":"T156","span":{"begin":233,"end":237},"obj":"Disease"},{"id":"T157","span":{"begin":244,"end":248},"obj":"Disease"},{"id":"T158","span":{"begin":447,"end":451},"obj":"Disease"}],"attributes":[{"id":"A157","pred":"mondo_id","subj":"T157","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A156","pred":"mondo_id","subj":"T156","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A155","pred":"mondo_id","subj":"T155","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A154","pred":"mondo_id","subj":"T154","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A158","pred":"mondo_id","subj":"T158","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"6.1.2 Rational: The chimeric 47D11 H2L2 might not be effective in human lung cells as it is in vitro\n47D11 carried a higher affinity for interacting with the S2 subunit of SARS-S than that of SARS-2-S. It is important that for both SARS-S and SARS-2-S, the binding of the 47D11 antibody to the target – the S1B domain – does not block the binding of S1B and S2 to ACE2 receptor [26]. By contrast, neutralizing antibodies that specifically target SARS-S could compete with S1B and S2 for binding to ACE2."}

    LitCovid-sentences

    {"project":"LitCovid-sentences","denotations":[{"id":"T171","span":{"begin":0,"end":16},"obj":"Sentence"},{"id":"T172","span":{"begin":17,"end":101},"obj":"Sentence"},{"id":"T173","span":{"begin":102,"end":202},"obj":"Sentence"},{"id":"T174","span":{"begin":203,"end":384},"obj":"Sentence"},{"id":"T175","span":{"begin":385,"end":504},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"6.1.2 Rational: The chimeric 47D11 H2L2 might not be effective in human lung cells as it is in vitro\n47D11 carried a higher affinity for interacting with the S2 subunit of SARS-S than that of SARS-2-S. It is important that for both SARS-S and SARS-2-S, the binding of the 47D11 antibody to the target – the S1B domain – does not block the binding of S1B and S2 to ACE2 receptor [26]. By contrast, neutralizing antibodies that specifically target SARS-S could compete with S1B and S2 for binding to ACE2."}