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PMC:7205724 / 21302-21806 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
729 67-72 Species denotes human Tax:9606
739 365-369 Gene denotes ACE2 Gene:59272
740 499-503 Gene denotes ACE2 Gene:59272
741 452-453 Gene denotes S Gene:43740568
742 251-252 Gene denotes S Gene:43740568
743 238-239 Gene denotes S Gene:43740568
744 200-201 Gene denotes S Gene:43740568
745 178-179 Gene denotes S Gene:43740568
746 193-199 Species denotes SARS-2 Tax:2697049
747 244-250 Species denotes SARS-2 Tax:2697049

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T156 73-77 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T157 78-83 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T158 279-287 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T21 73-77 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T159 173-177 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T160 193-197 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T161 233-237 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T162 244-248 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T163 447-451 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T249 67-72 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T250 73-77 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T251 73-77 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T252 78-101 http://purl.obolibrary.org/obo/CL_0001034 denotes cells as it is in vitro
T253 116-117 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T254 159-161 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T255 159-161 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T256 359-361 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T257 359-361 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T258 481-483 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T259 481-483 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T168 159-161 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T169 359-361 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T170 481-483 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387

LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T21 398-421 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes neutralizing antibodies http://purl.bioontology.org/ontology/MEDDRA/10058063

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T99 78-83 http://purl.obolibrary.org/obo/CL_0000000 denotes cells

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T210 67-72 Species denotes human NCBItxid:9606
T211 173-177 Species denotes SARS NCBItxid:694009
T212 193-199 Species denotes SARS-2 NCBItxid:2697049
T213 233-237 Species denotes SARS NCBItxid:694009
T214 244-250 Species denotes SARS-2 NCBItxid:2697049
T215 447-451 Species denotes SARS NCBItxid:694009

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T171 0-16 Sentence denotes 6.1.2 Rational:
T172 17-101 Sentence denotes The chimeric 47D11 H2L2 might not be effective in human lung cells as it is in vitro
T173 102-202 Sentence denotes 47D11 carried a higher affinity for interacting with the S2 subunit of SARS-S than that of SARS-2-S.
T174 203-384 Sentence denotes It is important that for both SARS-S and SARS-2-S, the binding of the 47D11 antibody to the target – the S1B domain – does not block the binding of S1B and S2 to ACE2 receptor [26].
T175 385-504 Sentence denotes By contrast, neutralizing antibodies that specifically target SARS-S could compete with S1B and S2 for binding to ACE2.

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T21 73-77 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
729 67-72 Species denotes human Tax:9606
745 178-179 Gene denotes S Gene:43740568
746 193-199 Species denotes SARS-2 Tax:2697049
744 200-201 Gene denotes S Gene:43740568
743 238-239 Gene denotes S Gene:43740568
747 244-250 Species denotes SARS-2 Tax:2697049
742 251-252 Gene denotes S Gene:43740568
739 365-369 Gene denotes ACE2 Gene:59272
741 452-453 Gene denotes S Gene:43740568
740 499-503 Gene denotes ACE2 Gene:59272

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T2070 308-311 Protein denotes S1B https://www.uniprot.org/uniprot/P47835
T2071 351-354 Protein denotes S1B https://www.uniprot.org/uniprot/P47835
T2072 473-476 Protein denotes S1B https://www.uniprot.org/uniprot/P47835

LitCovid-sample-Enju

Id Subject Object Predicate Lexical cue
T63608 0-5 CD denotes 6.1.2
T11815 7-15 NNP denotes Rational
T73902 15-16 -COLON- denotes :
T21134 17-20 DT denotes The
T30867 21-29 JJ denotes chimeric
T42126 30-35 NN denotes 47D11
T93924 36-40 NN denotes H2L2
T85248 41-46 MD denotes might
T92338 47-50 RB denotes not
T49873 51-53 VB denotes be
T69919 54-63 JJ denotes effective
T60557 64-66 IN denotes in
T77242 67-72 JJ denotes human
T86725 73-77 NN denotes lung
T18333 78-83 NNS denotes cells
T22947 84-86 IN denotes as
T22184 87-89 PRP denotes it
T1922 90-92 VBZ denotes is
T72123 93-95 FW denotes in
T38972 96-101 FW denotes vitro
T22398 102-107 NN denotes 47D11
T15962 108-115 VBD denotes carried
T83196 116-117 DT denotes a
T61532 118-124 JJR denotes higher
T47874 125-133 NN denotes affinity
T77580 134-137 IN denotes for
T95631 138-149 VBG denotes interacting
T94847 150-154 IN denotes with
T20163 155-158 DT denotes the
T18520 159-161 NN denotes S2
T89003 162-169 NN denotes subunit
T41606 170-172 IN denotes of
T4784 173-179 NN denotes SARS-S
T32288 180-184 IN denotes than
T68894 185-189 DT denotes that
T97000 190-192 IN denotes of
T32517 193-202 NN denotes SARS-2-S.
T24633 203-205 PRP denotes It
T45480 206-208 VBZ denotes is
T10954 209-218 JJ denotes important
T96386 219-223 IN denotes that
T80967 224-227 IN denotes for
T24571 228-232 DT denotes both
T18211 233-239 NN denotes SARS-S
T39196 240-243 CC denotes and
T83081 244-252 NN denotes SARS-2-S
T70298 252-253 -COMMA- denotes ,
T91479 254-257 DT denotes the
T56884 258-265 NN denotes binding
T11559 266-268 IN denotes of
T2922 269-272 DT denotes the
T11592 273-278 NN denotes 47D11
T36887 279-287 NN denotes antibody
T46706 288-290 TO denotes to
T40788 291-294 DT denotes the
T37833 295-301 NN denotes target
T37378 302-303 VBZ denotes –
T15003 304-307 DT denotes the
T4372 308-311 NN denotes S1B
T31100 312-318 NN denotes domain
T82065 319-320 NN denotes –
T43926 321-325 VBZ denotes does
T69422 326-329 RB denotes not
T3419 330-335 VB denotes block
T21955 336-339 DT denotes the
T12942 340-347 NN denotes binding
T83444 348-350 IN denotes of
T49120 351-354 NN denotes S1B
T55070 355-358 CC denotes and
T98634 359-361 NN denotes S2
T48321 362-364 TO denotes to
T80580 365-369 NN denotes ACE2
T18877 370-378 NN denotes receptor
T18503 379-380 -LRB- denotes [
T33177 380-382 CD denotes 26
T92006 382-383 -RRB- denotes ]
T53652 385-387 IN denotes By
T58622 388-396 NN denotes contrast
T35381 396-397 -COMMA- denotes ,
T41843 398-410 VBG denotes neutralizing
T81589 411-421 NNS denotes antibodies
T68196 422-426 WDT denotes that
T30816 427-439 RB denotes specifically
T53446 440-446 NN denotes target
T89813 447-453 NN denotes SARS-S
T95236 454-459 MD denotes could
T7888 460-467 VB denotes compete
T34125 468-472 IN denotes with
T82101 473-476 NN denotes S1B
T1902 477-480 CC denotes and
T24277 481-483 NN denotes S2
T37015 484-487 IN denotes for
T86465 488-495 VBG denotes binding
T1893 496-498 TO denotes to
T91196 499-503 NN denotes ACE2
R6870 T11815 T63608 arg1Of Rational,6.1.2
R99987 T11815 T73902 arg1Of Rational,:
R39394 T93924 T21134 arg1Of H2L2,The
R27252 T93924 T30867 arg1Of H2L2,chimeric
R91021 T93924 T42126 arg1Of H2L2,47D11
R85301 T93924 T85248 arg1Of H2L2,might
R68664 T49873 T85248 arg2Of be,might
R85602 T49873 T92338 arg1Of be,not
R73472 T93924 T49873 arg1Of H2L2,be
R56902 T69919 T49873 arg2Of effective,be
R30813 T93924 T69919 arg1Of H2L2,effective
R6463 T49873 T60557 arg1Of be,in
R98023 T18333 T60557 arg2Of cells,in
R22781 T18333 T77242 arg1Of cells,human
R95568 T18333 T86725 arg1Of cells,lung
R57926 T49873 T22947 arg1Of be,as
R49211 T1922 T22947 arg2Of is,as
R60499 T22184 T1922 arg1Of it,is
R70730 T38972 T72123 arg1Of vitro,in
R68061 T1922 T38972 arg1Of is,vitro
R37108 T22398 T15962 arg1Of 47D11,carried
R43602 T47874 T15962 arg2Of affinity,carried
R3397 T47874 T83196 arg1Of affinity,a
R69683 T47874 T61532 arg1Of affinity,higher
R78190 T47874 T77580 arg1Of affinity,for
R68969 T95631 T77580 arg2Of interacting,for
R15040 T95631 T94847 arg1Of interacting,with
R25517 T89003 T94847 arg2Of subunit,with
R53417 T89003 T20163 arg1Of subunit,the
R3997 T89003 T18520 arg1Of subunit,S2
R34556 T89003 T41606 arg1Of subunit,of
R37706 T4784 T41606 arg2Of SARS-S,of
R45826 T47874 T32288 arg1Of affinity,than
R81151 T68894 T32288 arg2Of that,than
R10947 T68894 T97000 arg1Of that,of
R87567 T32517 T97000 arg2Of SARS-2-S.,of
R92430 T24633 T45480 arg1Of It,is
R27880 T10954 T45480 arg2Of important,is
R16446 T47874 T45480 modOf affinity,is
R5059 T24633 T10954 arg1Of It,important
R77514 T47874 T96386 arg1Of affinity,that
R45591 T37378 T96386 arg2Of –,that
R6871 T96386 T80967 arg1Of that,for
R86711 T39196 T80967 arg2Of and,for
R85187 T39196 T24571 arg1Of and,both
R57766 T18211 T39196 arg1Of SARS-S,and
R60594 T83081 T39196 arg2Of SARS-2-S,and
R15467 T37378 T70298 arg1Of –,","
R5494 T56884 T91479 arg1Of binding,the
R79151 T56884 T11559 arg1Of binding,of
R6992 T36887 T11559 arg2Of antibody,of
R62361 T36887 T2922 arg1Of antibody,the
R48343 T36887 T11592 arg1Of antibody,47D11
R35747 T56884 T46706 arg1Of binding,to
R10371 T37833 T46706 arg2Of target,to
R36916 T37833 T40788 arg1Of target,the
R17566 T56884 T37378 arg1Of binding,–
R23617 T3419 T37378 arg2Of block,–
R26619 T82065 T15003 arg1Of –,the
R64854 T82065 T4372 arg1Of –,S1B
R97129 T82065 T31100 arg1Of –,domain
R47400 T82065 T43926 arg1Of –,does
R34720 T3419 T43926 arg2Of block,does
R55812 T3419 T69422 arg1Of block,not
R51826 T82065 T3419 arg1Of –,block
R99609 T12942 T3419 arg2Of binding,block
R35148 T12942 T21955 arg1Of binding,the
R30150 T12942 T83444 arg1Of binding,of
R36055 T55070 T83444 arg2Of and,of
R9737 T49120 T55070 arg1Of S1B,and
R3528 T98634 T55070 arg2Of S2,and
R55511 T12942 T48321 arg1Of binding,to
R91010 T18877 T48321 arg2Of receptor,to
R37042 T18877 T80580 arg1Of receptor,ACE2
R82088 T18877 T18503 arg1Of receptor,[
R55576 T33177 T18503 arg2Of 26,[
R41077 T92006 T18503 arg3Of ],[
R68866 T41843 T53652 arg1Of neutralizing,By
R80894 T58622 T53652 arg2Of contrast,By
R42535 T41843 T35381 arg1Of neutralizing,","
R99048 T81589 T41843 arg1Of antibodies,neutralizing
R45757 T81589 T68196 arg1Of antibodies,that
R2391 T7888 T30816 arg1Of compete,specifically
R14961 T89813 T53446 arg1Of SARS-S,target
R96775 T89813 T95236 arg1Of SARS-S,could
R6780 T7888 T95236 arg2Of compete,could
R40504 T89813 T7888 arg1Of SARS-S,compete
R84230 T81589 T7888 arg2Of antibodies,compete
R48027 T7888 T34125 arg1Of compete,with
R59163 T1902 T34125 arg2Of and,with
R39175 T82101 T1902 arg1Of S1B,and
R95020 T24277 T1902 arg2Of S2,and
R6420 T1902 T37015 arg1Of and,for
R67300 T86465 T37015 arg2Of binding,for
R53767 T86465 T1893 arg1Of binding,to
R3636 T91196 T1893 arg2Of ACE2,to

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T5 73-77 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T156 73-77 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T157 78-83 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T158 279-287 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T154 173-177 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T155 193-197 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T156 233-237 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T157 244-248 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T158 447-451 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T171 0-16 Sentence denotes 6.1.2 Rational:
T172 17-101 Sentence denotes The chimeric 47D11 H2L2 might not be effective in human lung cells as it is in vitro
T173 102-202 Sentence denotes 47D11 carried a higher affinity for interacting with the S2 subunit of SARS-S than that of SARS-2-S.
T174 203-384 Sentence denotes It is important that for both SARS-S and SARS-2-S, the binding of the 47D11 antibody to the target – the S1B domain – does not block the binding of S1B and S2 to ACE2 receptor [26].
T175 385-504 Sentence denotes By contrast, neutralizing antibodies that specifically target SARS-S could compete with S1B and S2 for binding to ACE2.