PMC:7205724 / 20563-21300 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"696","span":{"begin":77,"end":86},"obj":"Species"},{"id":"697","span":{"begin":87,"end":96},"obj":"Disease"},{"id":"713","span":{"begin":735,"end":736},"obj":"Gene"},{"id":"714","span":{"begin":722,"end":723},"obj":"Gene"},{"id":"715","span":{"begin":579,"end":580},"obj":"Gene"},{"id":"716","span":{"begin":520,"end":521},"obj":"Gene"},{"id":"717","span":{"begin":508,"end":509},"obj":"Gene"},{"id":"718","span":{"begin":376,"end":377},"obj":"Gene"},{"id":"719","span":{"begin":177,"end":192},"obj":"Species"},{"id":"720","span":{"begin":210,"end":215},"obj":"Species"},{"id":"721","span":{"begin":258,"end":261},"obj":"Species"},{"id":"722","span":{"begin":369,"end":375},"obj":"Species"},{"id":"723","span":{"begin":514,"end":519},"obj":"Species"},{"id":"724","span":{"begin":573,"end":578},"obj":"Species"},{"id":"725","span":{"begin":728,"end":734},"obj":"Species"},{"id":"726","span":{"begin":463,"end":481},"obj":"Disease"},{"id":"727","span":{"begin":541,"end":547},"obj":"CellLine"}],"attributes":[{"id":"A696","pred":"tao:has_database_id","subj":"696","obj":"Tax:2697049"},{"id":"A697","pred":"tao:has_database_id","subj":"697","obj":"MESH:D007239"},{"id":"A713","pred":"tao:has_database_id","subj":"713","obj":"Gene:43740568"},{"id":"A714","pred":"tao:has_database_id","subj":"714","obj":"Gene:43740568"},{"id":"A715","pred":"tao:has_database_id","subj":"715","obj":"Gene:43740568"},{"id":"A716","pred":"tao:has_database_id","subj":"716","obj":"Gene:43740568"},{"id":"A717","pred":"tao:has_database_id","subj":"717","obj":"Gene:43740568"},{"id":"A718","pred":"tao:has_database_id","subj":"718","obj":"Gene:43740568"},{"id":"A719","pred":"tao:has_database_id","subj":"719","obj":"Tax:10090"},{"id":"A720","pred":"tao:has_database_id","subj":"720","obj":"Tax:9606"},{"id":"A721","pred":"tao:has_database_id","subj":"721","obj":"Tax:10116"},{"id":"A722","pred":"tao:has_database_id","subj":"722","obj":"Tax:2697049"},{"id":"A723","pred":"tao:has_database_id","subj":"723","obj":"Tax:2697049"},{"id":"A724","pred":"tao:has_database_id","subj":"724","obj":"Tax:2697049"},{"id":"A725","pred":"tao:has_database_id","subj":"725","obj":"Tax:2697049"},{"id":"A726","pred":"tao:has_database_id","subj":"726","obj":"MESH:D002303"},{"id":"A727","pred":"tao:has_database_id","subj":"727","obj":"CVCL:0574"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"6.1.1 Hypothesis: A mAb against the binding domain of the virus can inhibit SARS-CoV2 infection\nRecently, hybridoma supernatants containing antibody repertoires from immunized transgenic mice that express the human immunoglobulin heavy and light chains and rat origin immunoglobulin constant regions were used to detect antibodies that can cross neutralize SARS-S and SARS-2-S [26]. One chimeric 47D11 H2L2 antibody displayed such a cross-neutralizing activity, decreased syncytia formation induced by SARS-S and SARS2-S, and could protect VeroE6 cells against SARS-S and SARS2-S pseudotyped virus [26]. It may lie in its similar affinities for interacting with the same domain of the S1 subunit, i.e., S1B, of each SARS-S and SARS-2-S."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T151","span":{"begin":141,"end":149},"obj":"Body_part"},{"id":"T152","span":{"begin":216,"end":230},"obj":"Body_part"},{"id":"T153","span":{"begin":269,"end":283},"obj":"Body_part"},{"id":"T154","span":{"begin":408,"end":416},"obj":"Body_part"},{"id":"T155","span":{"begin":548,"end":553},"obj":"Body_part"}],"attributes":[{"id":"A151","pred":"fma_id","subj":"T151","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A152","pred":"fma_id","subj":"T152","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A153","pred":"fma_id","subj":"T153","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A154","pred":"fma_id","subj":"T154","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A155","pred":"fma_id","subj":"T155","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"6.1.1 Hypothesis: A mAb against the binding domain of the virus can inhibit SARS-CoV2 infection\nRecently, hybridoma supernatants containing antibody repertoires from immunized transgenic mice that express the human immunoglobulin heavy and light chains and rat origin immunoglobulin constant regions were used to detect antibodies that can cross neutralize SARS-S and SARS-2-S [26]. One chimeric 47D11 H2L2 antibody displayed such a cross-neutralizing activity, decreased syncytia formation induced by SARS-S and SARS2-S, and could protect VeroE6 cells against SARS-S and SARS2-S pseudotyped virus [26]. It may lie in its similar affinities for interacting with the same domain of the S1 subunit, i.e., S1B, of each SARS-S and SARS-2-S."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T151","span":{"begin":77,"end":81},"obj":"Disease"},{"id":"T152","span":{"begin":87,"end":96},"obj":"Disease"},{"id":"T153","span":{"begin":358,"end":362},"obj":"Disease"},{"id":"T154","span":{"begin":369,"end":373},"obj":"Disease"},{"id":"T155","span":{"begin":503,"end":507},"obj":"Disease"},{"id":"T156","span":{"begin":562,"end":566},"obj":"Disease"},{"id":"T157","span":{"begin":717,"end":721},"obj":"Disease"},{"id":"T158","span":{"begin":728,"end":732},"obj":"Disease"}],"attributes":[{"id":"A151","pred":"mondo_id","subj":"T151","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A152","pred":"mondo_id","subj":"T152","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A153","pred":"mondo_id","subj":"T153","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A154","pred":"mondo_id","subj":"T154","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A155","pred":"mondo_id","subj":"T155","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A156","pred":"mondo_id","subj":"T156","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A157","pred":"mondo_id","subj":"T157","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A158","pred":"mondo_id","subj":"T158","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"6.1.1 Hypothesis: A mAb against the binding domain of the virus can inhibit SARS-CoV2 infection\nRecently, hybridoma supernatants containing antibody repertoires from immunized transgenic mice that express the human immunoglobulin heavy and light chains and rat origin immunoglobulin constant regions were used to detect antibodies that can cross neutralize SARS-S and SARS-2-S [26]. One chimeric 47D11 H2L2 antibody displayed such a cross-neutralizing activity, decreased syncytia formation induced by SARS-S and SARS2-S, and could protect VeroE6 cells against SARS-S and SARS2-S pseudotyped virus [26]. It may lie in its similar affinities for interacting with the same domain of the S1 subunit, i.e., S1B, of each SARS-S and SARS-2-S."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T240","span":{"begin":19,"end":20},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T241","span":{"begin":59,"end":64},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T242","span":{"begin":107,"end":116},"obj":"http://purl.obolibrary.org/obo/CLO_0036932"},{"id":"T243","span":{"begin":210,"end":215},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T244","span":{"begin":432,"end":433},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T245","span":{"begin":453,"end":461},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T246","span":{"begin":541,"end":553},"obj":"http://purl.obolibrary.org/obo/CLO_0051719"},{"id":"T247","span":{"begin":593,"end":598},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T248","span":{"begin":686,"end":688},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"}],"text":"6.1.1 Hypothesis: A mAb against the binding domain of the virus can inhibit SARS-CoV2 infection\nRecently, hybridoma supernatants containing antibody repertoires from immunized transgenic mice that express the human immunoglobulin heavy and light chains and rat origin immunoglobulin constant regions were used to detect antibodies that can cross neutralize SARS-S and SARS-2-S [26]. One chimeric 47D11 H2L2 antibody displayed such a cross-neutralizing activity, decreased syncytia formation induced by SARS-S and SARS2-S, and could protect VeroE6 cells against SARS-S and SARS2-S pseudotyped virus [26]. It may lie in its similar affinities for interacting with the same domain of the S1 subunit, i.e., S1B, of each SARS-S and SARS-2-S."}

{"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T19","span":{"begin":216,"end":230},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"},{"id":"T20","span":{"begin":269,"end":283},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A20","pred":"meddra_id","subj":"T20","obj":"http://purl.bioontology.org/ontology/MEDDRA/10021496"},{"id":"A19","pred":"meddra_id","subj":"T19","obj":"http://purl.bioontology.org/ontology/MEDDRA/10021496"}],"text":"6.1.1 Hypothesis: A mAb against the binding domain of the virus can inhibit SARS-CoV2 infection\nRecently, hybridoma supernatants containing antibody repertoires from immunized transgenic mice that express the human immunoglobulin heavy and light chains and rat origin immunoglobulin constant regions were used to detect antibodies that can cross neutralize SARS-S and SARS-2-S [26]. One chimeric 47D11 H2L2 antibody displayed such a cross-neutralizing activity, decreased syncytia formation induced by SARS-S and SARS2-S, and could protect VeroE6 cells against SARS-S and SARS2-S pseudotyped virus [26]. It may lie in its similar affinities for interacting with the same domain of the S1 subunit, i.e., S1B, of each SARS-S and SARS-2-S."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T95","span":{"begin":59,"end":64},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T96","span":{"begin":87,"end":96},"obj":"http://purl.obolibrary.org/obo/IDO_0000586"},{"id":"T97","span":{"begin":548,"end":553},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T98","span":{"begin":593,"end":598},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"text":"6.1.1 Hypothesis: A mAb against the binding domain of the virus can inhibit SARS-CoV2 infection\nRecently, hybridoma supernatants containing antibody repertoires from immunized transgenic mice that express the human immunoglobulin heavy and light chains and rat origin immunoglobulin constant regions were used to detect antibodies that can cross neutralize SARS-S and SARS-2-S [26]. One chimeric 47D11 H2L2 antibody displayed such a cross-neutralizing activity, decreased syncytia formation induced by SARS-S and SARS2-S, and could protect VeroE6 cells against SARS-S and SARS2-S pseudotyped virus [26]. It may lie in its similar affinities for interacting with the same domain of the S1 subunit, i.e., S1B, of each SARS-S and SARS-2-S."}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T196","span":{"begin":77,"end":86},"obj":"Species"},{"id":"T197","span":{"begin":188,"end":192},"obj":"Species"},{"id":"T199","span":{"begin":210,"end":215},"obj":"Species"},{"id":"T200","span":{"begin":258,"end":261},"obj":"Species"},{"id":"T202","span":{"begin":358,"end":362},"obj":"Species"},{"id":"T203","span":{"begin":369,"end":375},"obj":"Species"},{"id":"T204","span":{"begin":503,"end":507},"obj":"Species"},{"id":"T205","span":{"begin":514,"end":519},"obj":"Species"},{"id":"T206","span":{"begin":562,"end":566},"obj":"Species"},{"id":"T207","span":{"begin":573,"end":578},"obj":"Species"},{"id":"T208","span":{"begin":717,"end":721},"obj":"Species"},{"id":"T209","span":{"begin":728,"end":734},"obj":"Species"}],"attributes":[{"id":"A200","pred":"ncbi_taxonomy_id","subj":"T200","obj":"NCBItxid:10116"},{"id":"A201","pred":"ncbi_taxonomy_id","subj":"T200","obj":"NCBItxid:10114"},{"id":"A202","pred":"ncbi_taxonomy_id","subj":"T202","obj":"NCBItxid:694009"},{"id":"A196","pred":"ncbi_taxonomy_id","subj":"T196","obj":"NCBItxid:2697049"},{"id":"A207","pred":"ncbi_taxonomy_id","subj":"T207","obj":"NCBItxid:2697049"},{"id":"A206","pred":"ncbi_taxonomy_id","subj":"T206","obj":"NCBItxid:694009"},{"id":"A204","pred":"ncbi_taxonomy_id","subj":"T204","obj":"NCBItxid:694009"},{"id":"A199","pred":"ncbi_taxonomy_id","subj":"T199","obj":"NCBItxid:9606"},{"id":"A208","pred":"ncbi_taxonomy_id","subj":"T208","obj":"NCBItxid:694009"},{"id":"A203","pred":"ncbi_taxonomy_id","subj":"T203","obj":"NCBItxid:2697049"},{"id":"A205","pred":"ncbi_taxonomy_id","subj":"T205","obj":"NCBItxid:2697049"},{"id":"A197","pred":"ncbi_taxonomy_id","subj":"T197","obj":"NCBItxid:10095"},{"id":"A198","pred":"ncbi_taxonomy_id","subj":"T197","obj":"NCBItxid:10088"},{"id":"A209","pred":"ncbi_taxonomy_id","subj":"T209","obj":"NCBItxid:2697049"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"6.1.1 Hypothesis: A mAb against the binding domain of the virus can inhibit SARS-CoV2 infection\nRecently, hybridoma supernatants containing antibody repertoires from immunized transgenic mice that express the human immunoglobulin heavy and light chains and rat origin immunoglobulin constant regions were used to detect antibodies that can cross neutralize SARS-S and SARS-2-S [26]. One chimeric 47D11 H2L2 antibody displayed such a cross-neutralizing activity, decreased syncytia formation induced by SARS-S and SARS2-S, and could protect VeroE6 cells against SARS-S and SARS2-S pseudotyped virus [26]. It may lie in its similar affinities for interacting with the same domain of the S1 subunit, i.e., S1B, of each SARS-S and SARS-2-S."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T166","span":{"begin":0,"end":18},"obj":"Sentence"},{"id":"T167","span":{"begin":19,"end":96},"obj":"Sentence"},{"id":"T168","span":{"begin":97,"end":383},"obj":"Sentence"},{"id":"T169","span":{"begin":384,"end":604},"obj":"Sentence"},{"id":"T170","span":{"begin":605,"end":737},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"6.1.1 Hypothesis: A mAb against the binding domain of the virus can inhibit SARS-CoV2 infection\nRecently, hybridoma supernatants containing antibody repertoires from immunized transgenic mice that express the human immunoglobulin heavy and light chains and rat origin immunoglobulin constant regions were used to detect antibodies that can cross neutralize SARS-S and SARS-2-S [26]. One chimeric 47D11 H2L2 antibody displayed such a cross-neutralizing activity, decreased syncytia formation induced by SARS-S and SARS2-S, and could protect VeroE6 cells against SARS-S and SARS2-S pseudotyped virus [26]. It may lie in its similar affinities for interacting with the same domain of the S1 subunit, i.e., S1B, of each SARS-S and SARS-2-S."}

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{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T30","span":{"begin":482,"end":491},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"6.1.1 Hypothesis: A mAb against the binding domain of the virus can inhibit SARS-CoV2 infection\nRecently, hybridoma supernatants containing antibody repertoires from immunized transgenic mice that express the human immunoglobulin heavy and light chains and rat origin immunoglobulin constant regions were used to detect antibodies that can cross neutralize SARS-S and SARS-2-S [26]. One chimeric 47D11 H2L2 antibody displayed such a cross-neutralizing activity, decreased syncytia formation induced by SARS-S and SARS2-S, and could protect VeroE6 cells against SARS-S and SARS2-S pseudotyped virus [26]. It may lie in its similar affinities for interacting with the same domain of the S1 subunit, i.e., S1B, of each SARS-S and SARS-2-S."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T151","span":{"begin":141,"end":149},"obj":"Body_part"},{"id":"T152","span":{"begin":216,"end":230},"obj":"Body_part"},{"id":"T153","span":{"begin":269,"end":283},"obj":"Body_part"},{"id":"T154","span":{"begin":408,"end":416},"obj":"Body_part"},{"id":"T155","span":{"begin":548,"end":553},"obj":"Body_part"}],"attributes":[{"id":"A151","pred":"fma_id","subj":"T151","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A153","pred":"fma_id","subj":"T153","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A155","pred":"fma_id","subj":"T155","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A154","pred":"fma_id","subj":"T154","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A152","pred":"fma_id","subj":"T152","obj":"http://purl.org/sig/ont/fma/fma62871"}],"text":"6.1.1 Hypothesis: A mAb against the binding domain of the virus can inhibit SARS-CoV2 infection\nRecently, hybridoma supernatants containing antibody repertoires from immunized transgenic mice that express the human immunoglobulin heavy and light chains and rat origin immunoglobulin constant regions were used to detect antibodies that can cross neutralize SARS-S and SARS-2-S [26]. One chimeric 47D11 H2L2 antibody displayed such a cross-neutralizing activity, decreased syncytia formation induced by SARS-S and SARS2-S, and could protect VeroE6 cells against SARS-S and SARS2-S pseudotyped virus [26]. It may lie in its similar affinities for interacting with the same domain of the S1 subunit, i.e., S1B, of each SARS-S and SARS-2-S."}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T146","span":{"begin":77,"end":86},"obj":"Disease"},{"id":"T147","span":{"begin":87,"end":96},"obj":"Disease"},{"id":"T148","span":{"begin":358,"end":362},"obj":"Disease"},{"id":"T149","span":{"begin":369,"end":373},"obj":"Disease"},{"id":"T150","span":{"begin":503,"end":507},"obj":"Disease"},{"id":"T151","span":{"begin":562,"end":566},"obj":"Disease"},{"id":"T152","span":{"begin":717,"end":721},"obj":"Disease"},{"id":"T153","span":{"begin":728,"end":732},"obj":"Disease"}],"attributes":[{"id":"A151","pred":"mondo_id","subj":"T151","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A147","pred":"mondo_id","subj":"T147","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A150","pred":"mondo_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A149","pred":"mondo_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A148","pred":"mondo_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A152","pred":"mondo_id","subj":"T152","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A146","pred":"mondo_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A153","pred":"mondo_id","subj":"T153","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"6.1.1 Hypothesis: A mAb against the binding domain of the virus can inhibit SARS-CoV2 infection\nRecently, hybridoma supernatants containing antibody repertoires from immunized transgenic mice that express the human immunoglobulin heavy and light chains and rat origin immunoglobulin constant regions were used to detect antibodies that can cross neutralize SARS-S and SARS-2-S [26]. One chimeric 47D11 H2L2 antibody displayed such a cross-neutralizing activity, decreased syncytia formation induced by SARS-S and SARS2-S, and could protect VeroE6 cells against SARS-S and SARS2-S pseudotyped virus [26]. It may lie in its similar affinities for interacting with the same domain of the S1 subunit, i.e., S1B, of each SARS-S and SARS-2-S."}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T26","span":{"begin":482,"end":491},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"6.1.1 Hypothesis: A mAb against the binding domain of the virus can inhibit SARS-CoV2 infection\nRecently, hybridoma supernatants containing antibody repertoires from immunized transgenic mice that express the human immunoglobulin heavy and light chains and rat origin immunoglobulin constant regions were used to detect antibodies that can cross neutralize SARS-S and SARS-2-S [26]. One chimeric 47D11 H2L2 antibody displayed such a cross-neutralizing activity, decreased syncytia formation induced by SARS-S and SARS2-S, and could protect VeroE6 cells against SARS-S and SARS2-S pseudotyped virus [26]. It may lie in its similar affinities for interacting with the same domain of the S1 subunit, i.e., S1B, of each SARS-S and SARS-2-S."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T26","span":{"begin":482,"end":491},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"6.1.1 Hypothesis: A mAb against the binding domain of the virus can inhibit SARS-CoV2 infection\nRecently, hybridoma supernatants containing antibody repertoires from immunized transgenic mice that express the human immunoglobulin heavy and light chains and rat origin immunoglobulin constant regions were used to detect antibodies that can cross neutralize SARS-S and SARS-2-S [26]. One chimeric 47D11 H2L2 antibody displayed such a cross-neutralizing activity, decreased syncytia formation induced by SARS-S and SARS2-S, and could protect VeroE6 cells against SARS-S and SARS2-S pseudotyped virus [26]. It may lie in its similar affinities for interacting with the same domain of the S1 subunit, i.e., S1B, of each SARS-S and SARS-2-S."}

{"project":"LitCovid-sentences","denotations":[{"id":"T166","span":{"begin":0,"end":18},"obj":"Sentence"},{"id":"T167","span":{"begin":19,"end":96},"obj":"Sentence"},{"id":"T168","span":{"begin":97,"end":383},"obj":"Sentence"},{"id":"T169","span":{"begin":384,"end":604},"obj":"Sentence"},{"id":"T170","span":{"begin":605,"end":737},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"6.1.1 Hypothesis: A mAb against the binding domain of the virus can inhibit SARS-CoV2 infection\nRecently, hybridoma supernatants containing antibody repertoires from immunized transgenic mice that express the human immunoglobulin heavy and light chains and rat origin immunoglobulin constant regions were used to detect antibodies that can cross neutralize SARS-S and SARS-2-S [26]. One chimeric 47D11 H2L2 antibody displayed such a cross-neutralizing activity, decreased syncytia formation induced by SARS-S and SARS2-S, and could protect VeroE6 cells against SARS-S and SARS2-S pseudotyped virus [26]. It may lie in its similar affinities for interacting with the same domain of the S1 subunit, i.e., S1B, of each SARS-S and SARS-2-S."}