PMC:7205724 / 19731-20478 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"665","span":{"begin":62,"end":71},"obj":"Species"},{"id":"679","span":{"begin":214,"end":218},"obj":"Gene"},{"id":"680","span":{"begin":112,"end":121},"obj":"Species"},{"id":"681","span":{"begin":247,"end":256},"obj":"Species"},{"id":"682","span":{"begin":325,"end":333},"obj":"Species"},{"id":"683","span":{"begin":407,"end":416},"obj":"Species"},{"id":"684","span":{"begin":475,"end":483},"obj":"Species"},{"id":"685","span":{"begin":584,"end":593},"obj":"Species"},{"id":"686","span":{"begin":598,"end":606},"obj":"Species"},{"id":"687","span":{"begin":101,"end":110},"obj":"Disease"},{"id":"688","span":{"begin":257,"end":266},"obj":"Disease"},{"id":"689","span":{"begin":455,"end":464},"obj":"Disease"},{"id":"690","span":{"begin":545,"end":554},"obj":"Disease"},{"id":"691","span":{"begin":190,"end":192},"obj":"CellLine"}],"attributes":[{"id":"A665","pred":"tao:has_database_id","subj":"665","obj":"Tax:2697049"},{"id":"A679","pred":"tao:has_database_id","subj":"679","obj":"Gene:103231639"},{"id":"A680","pred":"tao:has_database_id","subj":"680","obj":"Tax:2697049"},{"id":"A681","pred":"tao:has_database_id","subj":"681","obj":"Tax:2697049"},{"id":"A682","pred":"tao:has_database_id","subj":"682","obj":"Tax:694009"},{"id":"A683","pred":"tao:has_database_id","subj":"683","obj":"Tax:2697049"},{"id":"A684","pred":"tao:has_database_id","subj":"684","obj":"Tax:694009"},{"id":"A685","pred":"tao:has_database_id","subj":"685","obj":"Tax:2697049"},{"id":"A686","pred":"tao:has_database_id","subj":"686","obj":"Tax:694009"},{"id":"A687","pred":"tao:has_database_id","subj":"687","obj":"MESH:D007239"},{"id":"A688","pred":"tao:has_database_id","subj":"688","obj":"MESH:D007239"},{"id":"A689","pred":"tao:has_database_id","subj":"689","obj":"MESH:D007239"},{"id":"A690","pred":"tao:has_database_id","subj":"690","obj":"MESH:D007239"},{"id":"A691","pred":"tao:has_database_id","subj":"691","obj":"CVCL:4582"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"5.2 Rational: Recombinant type I IFN can effectively inhibit SARS-CoV2 replication\nIn 24–48 h after infection, SARS-CoV2 replication reaches titer that causes the cytopathic effect in Vero E6 cells, which express ACE2 and thus are susceptible to SARS-CoV2 infection [25]. It is similar to the viral replication kinetics for SARS-CoV [25]. Pretreatment with recombinant type I IFN could effectively inhibit SARS-CoV2 replication at both 24 and 48 h after infection [25]. For SARS-CoV, such an effect was present at 24 h but absent at 48 h after infection [25]. The difference between SARS-CoV2 and SARS-CoV in response to type I IFN treatment may be due to differences in structural proteins of these viruses, including NSP3, ORF3b, and ORF6 [25]."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T147","span":{"begin":193,"end":198},"obj":"Body_part"},{"id":"T148","span":{"begin":683,"end":691},"obj":"Body_part"}],"attributes":[{"id":"A147","pred":"fma_id","subj":"T147","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A148","pred":"fma_id","subj":"T148","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"5.2 Rational: Recombinant type I IFN can effectively inhibit SARS-CoV2 replication\nIn 24–48 h after infection, SARS-CoV2 replication reaches titer that causes the cytopathic effect in Vero E6 cells, which express ACE2 and thus are susceptible to SARS-CoV2 infection [25]. It is similar to the viral replication kinetics for SARS-CoV [25]. Pretreatment with recombinant type I IFN could effectively inhibit SARS-CoV2 replication at both 24 and 48 h after infection [25]. For SARS-CoV, such an effect was present at 24 h but absent at 48 h after infection [25]. The difference between SARS-CoV2 and SARS-CoV in response to type I IFN treatment may be due to differences in structural proteins of these viruses, including NSP3, ORF3b, and ORF6 [25]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T139","span":{"begin":62,"end":66},"obj":"Disease"},{"id":"T140","span":{"begin":101,"end":110},"obj":"Disease"},{"id":"T141","span":{"begin":112,"end":116},"obj":"Disease"},{"id":"T142","span":{"begin":247,"end":251},"obj":"Disease"},{"id":"T143","span":{"begin":257,"end":266},"obj":"Disease"},{"id":"T144","span":{"begin":325,"end":333},"obj":"Disease"},{"id":"T145","span":{"begin":407,"end":411},"obj":"Disease"},{"id":"T146","span":{"begin":455,"end":464},"obj":"Disease"},{"id":"T147","span":{"begin":475,"end":483},"obj":"Disease"},{"id":"T148","span":{"begin":545,"end":554},"obj":"Disease"},{"id":"T149","span":{"begin":584,"end":588},"obj":"Disease"},{"id":"T150","span":{"begin":598,"end":606},"obj":"Disease"}],"attributes":[{"id":"A139","pred":"mondo_id","subj":"T139","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A140","pred":"mondo_id","subj":"T140","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A141","pred":"mondo_id","subj":"T141","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A142","pred":"mondo_id","subj":"T142","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A143","pred":"mondo_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A144","pred":"mondo_id","subj":"T144","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A145","pred":"mondo_id","subj":"T145","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A146","pred":"mondo_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A147","pred":"mondo_id","subj":"T147","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A148","pred":"mondo_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A149","pred":"mondo_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A150","pred":"mondo_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"5.2 Rational: Recombinant type I IFN can effectively inhibit SARS-CoV2 replication\nIn 24–48 h after infection, SARS-CoV2 replication reaches titer that causes the cytopathic effect in Vero E6 cells, which express ACE2 and thus are susceptible to SARS-CoV2 infection [25]. It is similar to the viral replication kinetics for SARS-CoV [25]. Pretreatment with recombinant type I IFN could effectively inhibit SARS-CoV2 replication at both 24 and 48 h after infection [25]. For SARS-CoV, such an effect was present at 24 h but absent at 48 h after infection [25]. The difference between SARS-CoV2 and SARS-CoV in response to type I IFN treatment may be due to differences in structural proteins of these viruses, including NSP3, ORF3b, and ORF6 [25]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T233","span":{"begin":90,"end":92},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"},{"id":"T234","span":{"begin":185,"end":198},"obj":"http://purl.obolibrary.org/obo/CLO_0051719"},{"id":"T235","span":{"begin":444,"end":446},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"},{"id":"T236","span":{"begin":534,"end":536},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"},{"id":"T237","span":{"begin":701,"end":708},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"text":"5.2 Rational: Recombinant type I IFN can effectively inhibit SARS-CoV2 replication\nIn 24–48 h after infection, SARS-CoV2 replication reaches titer that causes the cytopathic effect in Vero E6 cells, which express ACE2 and thus are susceptible to SARS-CoV2 infection [25]. It is similar to the viral replication kinetics for SARS-CoV [25]. Pretreatment with recombinant type I IFN could effectively inhibit SARS-CoV2 replication at both 24 and 48 h after infection [25]. For SARS-CoV, such an effect was present at 24 h but absent at 48 h after infection [25]. The difference between SARS-CoV2 and SARS-CoV in response to type I IFN treatment may be due to differences in structural proteins of these viruses, including NSP3, ORF3b, and ORF6 [25]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T166","span":{"begin":683,"end":691},"obj":"Chemical"}],"attributes":[{"id":"A166","pred":"chebi_id","subj":"T166","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"5.2 Rational: Recombinant type I IFN can effectively inhibit SARS-CoV2 replication\nIn 24–48 h after infection, SARS-CoV2 replication reaches titer that causes the cytopathic effect in Vero E6 cells, which express ACE2 and thus are susceptible to SARS-CoV2 infection [25]. It is similar to the viral replication kinetics for SARS-CoV [25]. Pretreatment with recombinant type I IFN could effectively inhibit SARS-CoV2 replication at both 24 and 48 h after infection [25]. For SARS-CoV, such an effect was present at 24 h but absent at 48 h after infection [25]. The difference between SARS-CoV2 and SARS-CoV in response to type I IFN treatment may be due to differences in structural proteins of these viruses, including NSP3, ORF3b, and ORF6 [25]."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T84","span":{"begin":72,"end":83},"obj":"http://purl.obolibrary.org/obo/IDO_0000608"},{"id":"T85","span":{"begin":101,"end":110},"obj":"http://purl.obolibrary.org/obo/IDO_0000586"},{"id":"T86","span":{"begin":122,"end":133},"obj":"http://purl.obolibrary.org/obo/IDO_0000608"},{"id":"T87","span":{"begin":193,"end":198},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T88","span":{"begin":232,"end":243},"obj":"http://purl.obolibrary.org/obo/IDO_0000467"},{"id":"T89","span":{"begin":257,"end":266},"obj":"http://purl.obolibrary.org/obo/IDO_0000586"},{"id":"T90","span":{"begin":300,"end":311},"obj":"http://purl.obolibrary.org/obo/IDO_0000608"},{"id":"T91","span":{"begin":417,"end":428},"obj":"http://purl.obolibrary.org/obo/IDO_0000608"},{"id":"T92","span":{"begin":455,"end":464},"obj":"http://purl.obolibrary.org/obo/IDO_0000586"},{"id":"T93","span":{"begin":545,"end":554},"obj":"http://purl.obolibrary.org/obo/IDO_0000586"},{"id":"T94","span":{"begin":701,"end":708},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"text":"5.2 Rational: Recombinant type I IFN can effectively inhibit SARS-CoV2 replication\nIn 24–48 h after infection, SARS-CoV2 replication reaches titer that causes the cytopathic effect in Vero E6 cells, which express ACE2 and thus are susceptible to SARS-CoV2 infection [25]. It is similar to the viral replication kinetics for SARS-CoV [25]. Pretreatment with recombinant type I IFN could effectively inhibit SARS-CoV2 replication at both 24 and 48 h after infection [25]. For SARS-CoV, such an effect was present at 24 h but absent at 48 h after infection [25]. The difference between SARS-CoV2 and SARS-CoV in response to type I IFN treatment may be due to differences in structural proteins of these viruses, including NSP3, ORF3b, and ORF6 [25]."}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T108","span":{"begin":683,"end":691},"obj":"Chemical"}],"attributes":[{"id":"A108","pred":"chebi_id","subj":"T108","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"5.2 Rational: Recombinant type I IFN can effectively inhibit SARS-CoV2 replication\nIn 24–48 h after infection, SARS-CoV2 replication reaches titer that causes the cytopathic effect in Vero E6 cells, which express ACE2 and thus are susceptible to SARS-CoV2 infection [25]. It is similar to the viral replication kinetics for SARS-CoV [25]. Pretreatment with recombinant type I IFN could effectively inhibit SARS-CoV2 replication at both 24 and 48 h after infection [25]. For SARS-CoV, such an effect was present at 24 h but absent at 48 h after infection [25]. The difference between SARS-CoV2 and SARS-CoV in response to type I IFN treatment may be due to differences in structural proteins of these viruses, including NSP3, ORF3b, and ORF6 [25]."}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T186","span":{"begin":62,"end":71},"obj":"Species"},{"id":"T187","span":{"begin":112,"end":121},"obj":"Species"},{"id":"T188","span":{"begin":247,"end":256},"obj":"Species"},{"id":"T189","span":{"begin":325,"end":333},"obj":"Species"},{"id":"T190","span":{"begin":407,"end":416},"obj":"Species"},{"id":"T191","span":{"begin":475,"end":483},"obj":"Species"},{"id":"T192","span":{"begin":584,"end":593},"obj":"Species"},{"id":"T193","span":{"begin":598,"end":606},"obj":"Species"},{"id":"T194","span":{"begin":701,"end":708},"obj":"Species"}],"attributes":[{"id":"A191","pred":"ncbi_taxonomy_id","subj":"T191","obj":"NCBItxid:694009"},{"id":"A187","pred":"ncbi_taxonomy_id","subj":"T187","obj":"NCBItxid:2697049"},{"id":"A188","pred":"ncbi_taxonomy_id","subj":"T188","obj":"NCBItxid:2697049"},{"id":"A192","pred":"ncbi_taxonomy_id","subj":"T192","obj":"NCBItxid:2697049"},{"id":"A193","pred":"ncbi_taxonomy_id","subj":"T193","obj":"NCBItxid:694009"},{"id":"A194","pred":"ncbi_taxonomy_id","subj":"T194","obj":"NCBItxid:10239"},{"id":"A189","pred":"ncbi_taxonomy_id","subj":"T189","obj":"NCBItxid:694009"},{"id":"A186","pred":"ncbi_taxonomy_id","subj":"T186","obj":"NCBItxid:2697049"},{"id":"A190","pred":"ncbi_taxonomy_id","subj":"T190","obj":"NCBItxid:2697049"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"5.2 Rational: Recombinant type I IFN can effectively inhibit SARS-CoV2 replication\nIn 24–48 h after infection, SARS-CoV2 replication reaches titer that causes the cytopathic effect in Vero E6 cells, which express ACE2 and thus are susceptible to SARS-CoV2 infection [25]. It is similar to the viral replication kinetics for SARS-CoV [25]. Pretreatment with recombinant type I IFN could effectively inhibit SARS-CoV2 replication at both 24 and 48 h after infection [25]. For SARS-CoV, such an effect was present at 24 h but absent at 48 h after infection [25]. The difference between SARS-CoV2 and SARS-CoV in response to type I IFN treatment may be due to differences in structural proteins of these viruses, including NSP3, ORF3b, and ORF6 [25]."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T157","span":{"begin":0,"end":14},"obj":"Sentence"},{"id":"T158","span":{"begin":15,"end":83},"obj":"Sentence"},{"id":"T159","span":{"begin":84,"end":272},"obj":"Sentence"},{"id":"T160","span":{"begin":273,"end":339},"obj":"Sentence"},{"id":"T161","span":{"begin":340,"end":470},"obj":"Sentence"},{"id":"T162","span":{"begin":471,"end":560},"obj":"Sentence"},{"id":"T163","span":{"begin":561,"end":747},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"5.2 Rational: Recombinant type I IFN can effectively inhibit SARS-CoV2 replication\nIn 24–48 h after infection, SARS-CoV2 replication reaches titer that causes the cytopathic effect in Vero E6 cells, which express ACE2 and thus are susceptible to SARS-CoV2 infection [25]. It is similar to the viral replication kinetics for SARS-CoV [25]. Pretreatment with recombinant type I IFN could effectively inhibit SARS-CoV2 replication at both 24 and 48 h after infection [25]. For SARS-CoV, such an effect was present at 24 h but absent at 48 h after infection [25]. The difference between SARS-CoV2 and SARS-CoV in response to type I IFN treatment may be due to differences in structural proteins of these viruses, including NSP3, ORF3b, and ORF6 [25]."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"665","span":{"begin":62,"end":71},"obj":"Species"},{"id":"687","span":{"begin":101,"end":110},"obj":"Disease"},{"id":"680","span":{"begin":112,"end":121},"obj":"Species"},{"id":"691","span":{"begin":190,"end":192},"obj":"CellLine"},{"id":"679","span":{"begin":214,"end":218},"obj":"Gene"},{"id":"681","span":{"begin":247,"end":256},"obj":"Species"},{"id":"688","span":{"begin":257,"end":266},"obj":"Disease"},{"id":"682","span":{"begin":325,"end":333},"obj":"Species"},{"id":"683","span":{"begin":407,"end":416},"obj":"Species"},{"id":"689","span":{"begin":455,"end":464},"obj":"Disease"},{"id":"684","span":{"begin":475,"end":483},"obj":"Species"},{"id":"690","span":{"begin":545,"end":554},"obj":"Disease"},{"id":"685","span":{"begin":584,"end":593},"obj":"Species"},{"id":"686","span":{"begin":598,"end":606},"obj":"Species"}],"attributes":[{"id":"A688","pred":"pubann:denotes","subj":"688","obj":"MESH:D007239"},{"id":"A681","pred":"pubann:denotes","subj":"681","obj":"Tax:2697049"},{"id":"A685","pred":"pubann:denotes","subj":"685","obj":"Tax:2697049"},{"id":"A687","pred":"pubann:denotes","subj":"687","obj":"MESH:D007239"},{"id":"A684","pred":"pubann:denotes","subj":"684","obj":"Tax:694009"},{"id":"A689","pred":"pubann:denotes","subj":"689","obj":"MESH:D007239"},{"id":"A679","pred":"pubann:denotes","subj":"679","obj":"Gene:103231639"},{"id":"A680","pred":"pubann:denotes","subj":"680","obj":"Tax:2697049"},{"id":"A691","pred":"pubann:denotes","subj":"691","obj":"CVCL:4582"},{"id":"A683","pred":"pubann:denotes","subj":"683","obj":"Tax:2697049"},{"id":"A682","pred":"pubann:denotes","subj":"682","obj":"Tax:694009"},{"id":"A690","pred":"pubann:denotes","subj":"690","obj":"MESH:D007239"},{"id":"A665","pred":"pubann:denotes","subj":"665","obj":"Tax:2697049"},{"id":"A686","pred":"pubann:denotes","subj":"686","obj":"Tax:694009"}],"text":"5.2 Rational: Recombinant type I IFN can effectively inhibit SARS-CoV2 replication\nIn 24–48 h after infection, SARS-CoV2 replication reaches titer that causes the cytopathic effect in Vero E6 cells, which express ACE2 and thus are susceptible to SARS-CoV2 infection [25]. It is similar to the viral replication kinetics for SARS-CoV [25]. Pretreatment with recombinant type I IFN could effectively inhibit SARS-CoV2 replication at both 24 and 48 h after infection [25]. For SARS-CoV, such an effect was present at 24 h but absent at 48 h after infection [25]. The difference between SARS-CoV2 and SARS-CoV in response to type I IFN treatment may be due to differences in structural proteins of these viruses, including NSP3, ORF3b, and ORF6 [25]."}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T1989","span":{"begin":672,"end":691},"obj":"Protein"},{"id":"T1992","span":{"begin":720,"end":724},"obj":"Protein"},{"id":"T2033","span":{"begin":737,"end":741},"obj":"Protein"}],"attributes":[{"id":"A1989","pred":"uniprot_id","subj":"T1989","obj":"https://www.uniprot.org/uniprot/Q6LEG6"},{"id":"A1990","pred":"uniprot_id","subj":"T1989","obj":"https://www.uniprot.org/uniprot/Q04766"},{"id":"A1991","pred":"uniprot_id","subj":"T1989","obj":"https://www.uniprot.org/uniprot/Q04765"},{"id":"A1992","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/Q9QNA7"},{"id":"A1993","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/Q9PY95"},{"id":"A1994","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/Q9ICB2"},{"id":"A1995","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/Q91ME7"},{"id":"A1996","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/Q8UZL8"},{"id":"A1997","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/Q8B6X8"},{"id":"A1998","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/Q8B6X7"},{"id":"A1999","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/Q86504"},{"id":"A2000","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/Q86196"},{"id":"A2001","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/Q85014"},{"id":"A2002","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/Q82054"},{"id":"A2003","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/Q82053"},{"id":"A2004","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/Q82052"},{"id":"A2005","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/Q82051"},{"id":"A2006","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/Q82050"},{"id":"A2007","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/Q82049"},{"id":"A2008","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/Q65701"},{"id":"A2009","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/Q5Y9A9"},{"id":"A2010","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/Q5K037"},{"id":"A2011","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/Q45UF3"},{"id":"A2012","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/Q3ZK63"},{"id":"A2013","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/Q27PP2"},{"id":"A2014","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/Q0H8C1"},{"id":"A2015","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/Q00721"},{"id":"A2016","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/P34717"},{"id":"A2017","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/P27586"},{"id":"A2018","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/P04514"},{"id":"A2019","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/P03536"},{"id":"A2020","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/B3SRX7"},{"id":"A2021","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/B3SRW9"},{"id":"A2022","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/B3SRV3"},{"id":"A2023","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/B3SRU5"},{"id":"A2024","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/B3SRS9"},{"id":"A2025","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/B3SRS1"},{"id":"A2026","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/B3SRR3"},{"id":"A2027","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/B3SRQ5"},{"id":"A2028","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/B2BRG4"},{"id":"A2029","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/A4ZCW4"},{"id":"A2030","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/A3DSK9"},{"id":"A2031","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/A2T3N5"},{"id":"A2032","pred":"uniprot_id","subj":"T1992","obj":"https://www.uniprot.org/uniprot/A1YTU9"},{"id":"A2033","pred":"uniprot_id","subj":"T2033","obj":"https://www.uniprot.org/uniprot/P51707"},{"id":"A2034","pred":"uniprot_id","subj":"T2033","obj":"https://www.uniprot.org/uniprot/P42541"},{"id":"A2035","pred":"uniprot_id","subj":"T2033","obj":"https://www.uniprot.org/uniprot/P0DTC6"}],"text":"5.2 Rational: Recombinant type I IFN can effectively inhibit SARS-CoV2 replication\nIn 24–48 h after infection, SARS-CoV2 replication reaches titer that causes the cytopathic effect in Vero E6 cells, which express ACE2 and thus are susceptible to SARS-CoV2 infection [25]. It is similar to the viral replication kinetics for SARS-CoV [25]. Pretreatment with recombinant type I IFN could effectively inhibit SARS-CoV2 replication at both 24 and 48 h after infection [25]. For SARS-CoV, such an effect was present at 24 h but absent at 48 h after infection [25]. The difference between SARS-CoV2 and SARS-CoV in response to type I IFN treatment may be due to differences in structural proteins of these viruses, including NSP3, ORF3b, and ORF6 [25]."}

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{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T27","span":{"begin":294,"end":311},"obj":"http://purl.obolibrary.org/obo/GO_0019058"},{"id":"T28","span":{"begin":294,"end":311},"obj":"http://purl.obolibrary.org/obo/GO_0019079"},{"id":"T29","span":{"begin":610,"end":632},"obj":"http://purl.obolibrary.org/obo/GO_0034340"}],"text":"5.2 Rational: Recombinant type I IFN can effectively inhibit SARS-CoV2 replication\nIn 24–48 h after infection, SARS-CoV2 replication reaches titer that causes the cytopathic effect in Vero E6 cells, which express ACE2 and thus are susceptible to SARS-CoV2 infection [25]. It is similar to the viral replication kinetics for SARS-CoV [25]. Pretreatment with recombinant type I IFN could effectively inhibit SARS-CoV2 replication at both 24 and 48 h after infection [25]. For SARS-CoV, such an effect was present at 24 h but absent at 48 h after infection [25]. The difference between SARS-CoV2 and SARS-CoV in response to type I IFN treatment may be due to differences in structural proteins of these viruses, including NSP3, ORF3b, and ORF6 [25]."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T147","span":{"begin":193,"end":198},"obj":"Body_part"},{"id":"T148","span":{"begin":683,"end":691},"obj":"Body_part"}],"attributes":[{"id":"A147","pred":"fma_id","subj":"T147","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A148","pred":"fma_id","subj":"T148","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"5.2 Rational: Recombinant type I IFN can effectively inhibit SARS-CoV2 replication\nIn 24–48 h after infection, SARS-CoV2 replication reaches titer that causes the cytopathic effect in Vero E6 cells, which express ACE2 and thus are susceptible to SARS-CoV2 infection [25]. It is similar to the viral replication kinetics for SARS-CoV [25]. Pretreatment with recombinant type I IFN could effectively inhibit SARS-CoV2 replication at both 24 and 48 h after infection [25]. For SARS-CoV, such an effect was present at 24 h but absent at 48 h after infection [25]. The difference between SARS-CoV2 and SARS-CoV in response to type I IFN treatment may be due to differences in structural proteins of these viruses, including NSP3, ORF3b, and ORF6 [25]."}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T134","span":{"begin":62,"end":71},"obj":"Disease"},{"id":"T135","span":{"begin":101,"end":110},"obj":"Disease"},{"id":"T136","span":{"begin":112,"end":121},"obj":"Disease"},{"id":"T137","span":{"begin":247,"end":256},"obj":"Disease"},{"id":"T138","span":{"begin":257,"end":266},"obj":"Disease"},{"id":"T139","span":{"begin":325,"end":333},"obj":"Disease"},{"id":"T140","span":{"begin":407,"end":416},"obj":"Disease"},{"id":"T141","span":{"begin":455,"end":464},"obj":"Disease"},{"id":"T142","span":{"begin":475,"end":483},"obj":"Disease"},{"id":"T143","span":{"begin":545,"end":554},"obj":"Disease"},{"id":"T144","span":{"begin":584,"end":593},"obj":"Disease"},{"id":"T145","span":{"begin":598,"end":606},"obj":"Disease"}],"attributes":[{"id":"A141","pred":"mondo_id","subj":"T141","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A142","pred":"mondo_id","subj":"T142","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A139","pred":"mondo_id","subj":"T139","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A140","pred":"mondo_id","subj":"T140","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A136","pred":"mondo_id","subj":"T136","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A143","pred":"mondo_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A144","pred":"mondo_id","subj":"T144","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A134","pred":"mondo_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A135","pred":"mondo_id","subj":"T135","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A145","pred":"mondo_id","subj":"T145","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A137","pred":"mondo_id","subj":"T137","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A138","pred":"mondo_id","subj":"T138","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"5.2 Rational: Recombinant type I IFN can effectively inhibit SARS-CoV2 replication\nIn 24–48 h after infection, SARS-CoV2 replication reaches titer that causes the cytopathic effect in Vero E6 cells, which express ACE2 and thus are susceptible to SARS-CoV2 infection [25]. It is similar to the viral replication kinetics for SARS-CoV [25]. Pretreatment with recombinant type I IFN could effectively inhibit SARS-CoV2 replication at both 24 and 48 h after infection [25]. For SARS-CoV, such an effect was present at 24 h but absent at 48 h after infection [25]. The difference between SARS-CoV2 and SARS-CoV in response to type I IFN treatment may be due to differences in structural proteins of these viruses, including NSP3, ORF3b, and ORF6 [25]."}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T23","span":{"begin":294,"end":311},"obj":"http://purl.obolibrary.org/obo/GO_0019079"},{"id":"T24","span":{"begin":294,"end":311},"obj":"http://purl.obolibrary.org/obo/GO_0019058"},{"id":"T25","span":{"begin":610,"end":632},"obj":"http://purl.obolibrary.org/obo/GO_0034340"}],"text":"5.2 Rational: Recombinant type I IFN can effectively inhibit SARS-CoV2 replication\nIn 24–48 h after infection, SARS-CoV2 replication reaches titer that causes the cytopathic effect in Vero E6 cells, which express ACE2 and thus are susceptible to SARS-CoV2 infection [25]. It is similar to the viral replication kinetics for SARS-CoV [25]. Pretreatment with recombinant type I IFN could effectively inhibit SARS-CoV2 replication at both 24 and 48 h after infection [25]. For SARS-CoV, such an effect was present at 24 h but absent at 48 h after infection [25]. The difference between SARS-CoV2 and SARS-CoV in response to type I IFN treatment may be due to differences in structural proteins of these viruses, including NSP3, ORF3b, and ORF6 [25]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T23","span":{"begin":294,"end":311},"obj":"http://purl.obolibrary.org/obo/GO_0019079"},{"id":"T24","span":{"begin":294,"end":311},"obj":"http://purl.obolibrary.org/obo/GO_0019058"},{"id":"T25","span":{"begin":610,"end":632},"obj":"http://purl.obolibrary.org/obo/GO_0034340"}],"text":"5.2 Rational: Recombinant type I IFN can effectively inhibit SARS-CoV2 replication\nIn 24–48 h after infection, SARS-CoV2 replication reaches titer that causes the cytopathic effect in Vero E6 cells, which express ACE2 and thus are susceptible to SARS-CoV2 infection [25]. It is similar to the viral replication kinetics for SARS-CoV [25]. Pretreatment with recombinant type I IFN could effectively inhibit SARS-CoV2 replication at both 24 and 48 h after infection [25]. For SARS-CoV, such an effect was present at 24 h but absent at 48 h after infection [25]. The difference between SARS-CoV2 and SARS-CoV in response to type I IFN treatment may be due to differences in structural proteins of these viruses, including NSP3, ORF3b, and ORF6 [25]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T157","span":{"begin":0,"end":14},"obj":"Sentence"},{"id":"T158","span":{"begin":15,"end":83},"obj":"Sentence"},{"id":"T159","span":{"begin":84,"end":272},"obj":"Sentence"},{"id":"T160","span":{"begin":273,"end":339},"obj":"Sentence"},{"id":"T161","span":{"begin":340,"end":470},"obj":"Sentence"},{"id":"T162","span":{"begin":471,"end":560},"obj":"Sentence"},{"id":"T163","span":{"begin":561,"end":747},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"5.2 Rational: Recombinant type I IFN can effectively inhibit SARS-CoV2 replication\nIn 24–48 h after infection, SARS-CoV2 replication reaches titer that causes the cytopathic effect in Vero E6 cells, which express ACE2 and thus are susceptible to SARS-CoV2 infection [25]. It is similar to the viral replication kinetics for SARS-CoV [25]. Pretreatment with recombinant type I IFN could effectively inhibit SARS-CoV2 replication at both 24 and 48 h after infection [25]. For SARS-CoV, such an effect was present at 24 h but absent at 48 h after infection [25]. The difference between SARS-CoV2 and SARS-CoV in response to type I IFN treatment may be due to differences in structural proteins of these viruses, including NSP3, ORF3b, and ORF6 [25]."}