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PMC:7204663 / 6578-7573 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
65 3-21 Chemical denotes Hydroxychloroquine MESH:D006886
70 71-89 Chemical denotes hydroxychloroquine MESH:D006886
71 334-352 Chemical denotes hydroxychloroquine MESH:D006886
72 500-518 Chemical denotes hydroxychloroquine MESH:D006886
73 879-897 Chemical denotes hydroxychloroquine MESH:D006886

2_test

Id Subject Object Predicate Lexical cue
32389720-3179169-48149097 600-601 3179169 denotes 9
T38067 600-601 3179169 denotes 9

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T35 126-135 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T36 150-157 Body_part denotes cytosol http://purl.org/sig/ont/fma/fma66836
T37 261-270 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T38 366-372 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T39 644-648 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T40 664-671 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T41 733-742 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T42 925-930 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 925-930 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T59 126-135 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T60 217-218 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T61 261-270 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T62 366-372 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T63 733-742 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T64 925-930 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T65 925-930 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T66 956-957 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T46 71-89 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T47 205-209 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T48 334-352 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T49 500-518 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T50 632-636 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T51 879-897 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T54 0-21 Sentence denotes 3 Hydroxychloroquine
T55 22-271 Sentence denotes When the above described concepts are applied to hydroxychloroquine, the expected accumulation ratio in lysosomes compared with cytosol is calculated as 56 000-fold; therefore, after drug intake a large fraction of the dose will reside in lysosomes.
T56 272-388 Sentence denotes This is confirmed by the known pharmacokinetic parameters for hydroxychloroquine derived from plasma concentrations.
T57 389-603 Sentence denotes After intravenous administration to healthy volunteers (average weight 63.5 kg), the volume of distribution of hydroxychloroquine was reported to be over 44 000 L, which is equivalent to approximately 700 L/kg [9].
T58 604-762 Sentence denotes This means that most of the drug in the body resides in the tissues, which is consistent with the predicted extraordinarily high lysosomal accumulation ratio.
T59 763-863 Sentence denotes Furthermore, it explains the very long half-life (approximately 40 days) reported in the same study.
T60 864-995 Sentence denotes In this study, hydroxychloroquine could still be detected in blood more than 6 months after a single dose administration of 310 mg.