PMC:7201239 / 20539-22011 JSON TXT

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LitCovid-PubTator

LitCovid-PD-FMA-UBERON

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T160","span":{"begin":5,"end":12},"obj":"Body_part"},{"id":"T161","span":{"begin":20,"end":35},"obj":"Body_part"},{"id":"T162","span":{"begin":36,"end":61},"obj":"Body_part"},{"id":"T163","span":{"begin":56,"end":61},"obj":"Body_part"},{"id":"T164","span":{"begin":86,"end":103},"obj":"Body_part"},{"id":"T165","span":{"begin":269,"end":273},"obj":"Body_part"},{"id":"T166","span":{"begin":569,"end":573},"obj":"Body_part"},{"id":"T167","span":{"begin":589,"end":601},"obj":"Body_part"},{"id":"T168","span":{"begin":1003,"end":1007},"obj":"Body_part"},{"id":"T169","span":{"begin":1008,"end":1015},"obj":"Body_part"},{"id":"T170","span":{"begin":1167,"end":1171},"obj":"Body_part"},{"id":"T171","span":{"begin":1192,"end":1199},"obj":"Body_part"},{"id":"T172","span":{"begin":1273,"end":1280},"obj":"Body_part"},{"id":"T173","span":{"begin":1286,"end":1290},"obj":"Body_part"},{"id":"T174","span":{"begin":1313,"end":1318},"obj":"Body_part"}],"attributes":[{"id":"A160","pred":"fma_id","subj":"T160","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A161","pred":"fma_id","subj":"T161","obj":"http://purl.org/sig/ont/fma/fma17530"},{"id":"A162","pred":"fma_id","subj":"T162","obj":"http://purl.org/sig/ont/fma/fma62499"},{"id":"A163","pred":"fma_id","subj":"T163","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A164","pred":"fma_id","subj":"T164","obj":"http://purl.org/sig/ont/fma/fma265130"},{"id":"A165","pred":"fma_id","subj":"T165","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A166","pred":"fma_id","subj":"T166","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A167","pred":"fma_id","subj":"T167","obj":"http://purl.org/sig/ont/fma/fma84055"},{"id":"A168","pred":"fma_id","subj":"T168","obj":"http://purl.org/sig/ont/fma/fma256135"},{"id":"A169","pred":"fma_id","subj":"T169","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A170","pred":"fma_id","subj":"T170","obj":"http://purl.org/sig/ont/fma/fma67122"},{"id":"A171","pred":"fma_id","subj":"T171","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A172","pred":"fma_id","subj":"T172","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A173","pred":"fma_id","subj":"T173","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A174","pred":"fma_id","subj":"T174","obj":"http://purl.org/sig/ont/fma/fma67498"}],"text":"ACE2 protein at the surface of lung alveolar epithelial cells allows infection of the respiratory tract with SARS-CoV-2. It can be hypothesized that the ACE2 levels correlate with susceptibility to SARS-CoV-2 infection. Apparently, men have a higher ACE2 expression in lung than women and Asian people express ACE2 higher than Caucasian and African American populations.37 This is in agreement with the finding that conversion of Ang II to Ang (1–7) by ACE2 was higher in males than female,100 suggesting an over-expression of ACE2 in men. Because ACE2 is encoded by a gene located on the X chromosome and men express more ACE2 than women it could be speculated that depending the allele expressed by women, they could be considered of lower sensitivity against the most severe adverse effects of the infection.99 , 101 All clinical reports published to date indicate that men represent between 66% and 75% of the most severe cases of COVID-19. During early SARS-CoV-2 infection and viral spread within body tissues, the ACE2 function is likely impaired either by steric hindrance of the peptidase domain of ACE2 following virus binding or by down regulation of ACE2 mRNA expression and ACE2 protein. In severe COVID-19 disease, the presence of the viral receptor on other tissues than lung may explain the multi-organ failure sometimes observed in clinic. We therefore suggest that quantification of ACE2 and AngII be added to the COVID-19 patients biological monitoring."}

LitCovid-PD-UBERON

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T45","span":{"begin":31,"end":35},"obj":"Body_part"},{"id":"T46","span":{"begin":86,"end":103},"obj":"Body_part"},{"id":"T47","span":{"begin":269,"end":273},"obj":"Body_part"},{"id":"T48","span":{"begin":1286,"end":1290},"obj":"Body_part"},{"id":"T49","span":{"begin":1313,"end":1318},"obj":"Body_part"}],"attributes":[{"id":"A45","pred":"uberon_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A46","pred":"uberon_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/UBERON_0000065"},{"id":"A47","pred":"uberon_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A48","pred":"uberon_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A49","pred":"uberon_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"}],"text":"ACE2 protein at the surface of lung alveolar epithelial cells allows infection of the respiratory tract with SARS-CoV-2. It can be hypothesized that the ACE2 levels correlate with susceptibility to SARS-CoV-2 infection. Apparently, men have a higher ACE2 expression in lung than women and Asian people express ACE2 higher than Caucasian and African American populations.37 This is in agreement with the finding that conversion of Ang II to Ang (1–7) by ACE2 was higher in males than female,100 suggesting an over-expression of ACE2 in men. Because ACE2 is encoded by a gene located on the X chromosome and men express more ACE2 than women it could be speculated that depending the allele expressed by women, they could be considered of lower sensitivity against the most severe adverse effects of the infection.99 , 101 All clinical reports published to date indicate that men represent between 66% and 75% of the most severe cases of COVID-19. During early SARS-CoV-2 infection and viral spread within body tissues, the ACE2 function is likely impaired either by steric hindrance of the peptidase domain of ACE2 following virus binding or by down regulation of ACE2 mRNA expression and ACE2 protein. In severe COVID-19 disease, the presence of the viral receptor on other tissues than lung may explain the multi-organ failure sometimes observed in clinic. We therefore suggest that quantification of ACE2 and AngII be added to the COVID-19 patients biological monitoring."}

LitCovid-PD-MONDO

LitCovid-PD-CLO

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T311","span":{"begin":31,"end":35},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T312","span":{"begin":31,"end":35},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T313","span":{"begin":45,"end":55},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T314","span":{"begin":56,"end":61},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T315","span":{"begin":241,"end":242},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T316","span":{"begin":269,"end":273},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T317","span":{"begin":269,"end":273},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T318","span":{"begin":472,"end":477},"obj":"http://purl.obolibrary.org/obo/UBERON_0003101"},{"id":"T319","span":{"begin":472,"end":477},"obj":"http://www.ebi.ac.uk/efo/EFO_0000970"},{"id":"T320","span":{"begin":483,"end":489},"obj":"http://purl.obolibrary.org/obo/UBERON_0003100"},{"id":"T321","span":{"begin":567,"end":568},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T322","span":{"begin":569,"end":573},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T323","span":{"begin":1123,"end":1128},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T324","span":{"begin":1286,"end":1290},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T325","span":{"begin":1286,"end":1290},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T326","span":{"begin":1313,"end":1318},"obj":"http://purl.obolibrary.org/obo/UBERON_0003103"}],"text":"ACE2 protein at the surface of lung alveolar epithelial cells allows infection of the respiratory tract with SARS-CoV-2. It can be hypothesized that the ACE2 levels correlate with susceptibility to SARS-CoV-2 infection. Apparently, men have a higher ACE2 expression in lung than women and Asian people express ACE2 higher than Caucasian and African American populations.37 This is in agreement with the finding that conversion of Ang II to Ang (1–7) by ACE2 was higher in males than female,100 suggesting an over-expression of ACE2 in men. Because ACE2 is encoded by a gene located on the X chromosome and men express more ACE2 than women it could be speculated that depending the allele expressed by women, they could be considered of lower sensitivity against the most severe adverse effects of the infection.99 , 101 All clinical reports published to date indicate that men represent between 66% and 75% of the most severe cases of COVID-19. During early SARS-CoV-2 infection and viral spread within body tissues, the ACE2 function is likely impaired either by steric hindrance of the peptidase domain of ACE2 following virus binding or by down regulation of ACE2 mRNA expression and ACE2 protein. In severe COVID-19 disease, the presence of the viral receptor on other tissues than lung may explain the multi-organ failure sometimes observed in clinic. We therefore suggest that quantification of ACE2 and AngII be added to the COVID-19 patients biological monitoring."}

LitCovid-PD-CHEBI

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T182","span":{"begin":5,"end":12},"obj":"Chemical"},{"id":"T183","span":{"begin":430,"end":433},"obj":"Chemical"},{"id":"T184","span":{"begin":434,"end":436},"obj":"Chemical"},{"id":"T185","span":{"begin":440,"end":443},"obj":"Chemical"},{"id":"T186","span":{"begin":1192,"end":1199},"obj":"Chemical"}],"attributes":[{"id":"A182","pred":"chebi_id","subj":"T182","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A183","pred":"chebi_id","subj":"T183","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A184","pred":"chebi_id","subj":"T184","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A185","pred":"chebi_id","subj":"T185","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A186","pred":"chebi_id","subj":"T186","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"ACE2 protein at the surface of lung alveolar epithelial cells allows infection of the respiratory tract with SARS-CoV-2. It can be hypothesized that the ACE2 levels correlate with susceptibility to SARS-CoV-2 infection. Apparently, men have a higher ACE2 expression in lung than women and Asian people express ACE2 higher than Caucasian and African American populations.37 This is in agreement with the finding that conversion of Ang II to Ang (1–7) by ACE2 was higher in males than female,100 suggesting an over-expression of ACE2 in men. Because ACE2 is encoded by a gene located on the X chromosome and men express more ACE2 than women it could be speculated that depending the allele expressed by women, they could be considered of lower sensitivity against the most severe adverse effects of the infection.99 , 101 All clinical reports published to date indicate that men represent between 66% and 75% of the most severe cases of COVID-19. During early SARS-CoV-2 infection and viral spread within body tissues, the ACE2 function is likely impaired either by steric hindrance of the peptidase domain of ACE2 following virus binding or by down regulation of ACE2 mRNA expression and ACE2 protein. In severe COVID-19 disease, the presence of the viral receptor on other tissues than lung may explain the multi-organ failure sometimes observed in clinic. We therefore suggest that quantification of ACE2 and AngII be added to the COVID-19 patients biological monitoring."}

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T34","span":{"begin":1148,"end":1158},"obj":"http://purl.obolibrary.org/obo/GO_0065007"}],"text":"ACE2 protein at the surface of lung alveolar epithelial cells allows infection of the respiratory tract with SARS-CoV-2. It can be hypothesized that the ACE2 levels correlate with susceptibility to SARS-CoV-2 infection. Apparently, men have a higher ACE2 expression in lung than women and Asian people express ACE2 higher than Caucasian and African American populations.37 This is in agreement with the finding that conversion of Ang II to Ang (1–7) by ACE2 was higher in males than female,100 suggesting an over-expression of ACE2 in men. Because ACE2 is encoded by a gene located on the X chromosome and men express more ACE2 than women it could be speculated that depending the allele expressed by women, they could be considered of lower sensitivity against the most severe adverse effects of the infection.99 , 101 All clinical reports published to date indicate that men represent between 66% and 75% of the most severe cases of COVID-19. During early SARS-CoV-2 infection and viral spread within body tissues, the ACE2 function is likely impaired either by steric hindrance of the peptidase domain of ACE2 following virus binding or by down regulation of ACE2 mRNA expression and ACE2 protein. In severe COVID-19 disease, the presence of the viral receptor on other tissues than lung may explain the multi-organ failure sometimes observed in clinic. We therefore suggest that quantification of ACE2 and AngII be added to the COVID-19 patients biological monitoring."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T77","span":{"begin":0,"end":120},"obj":"Sentence"},{"id":"T78","span":{"begin":121,"end":219},"obj":"Sentence"},{"id":"T79","span":{"begin":220,"end":539},"obj":"Sentence"},{"id":"T80","span":{"begin":540,"end":944},"obj":"Sentence"},{"id":"T81","span":{"begin":945,"end":1200},"obj":"Sentence"},{"id":"T82","span":{"begin":1201,"end":1356},"obj":"Sentence"},{"id":"T83","span":{"begin":1357,"end":1472},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"ACE2 protein at the surface of lung alveolar epithelial cells allows infection of the respiratory tract with SARS-CoV-2. It can be hypothesized that the ACE2 levels correlate with susceptibility to SARS-CoV-2 infection. Apparently, men have a higher ACE2 expression in lung than women and Asian people express ACE2 higher than Caucasian and African American populations.37 This is in agreement with the finding that conversion of Ang II to Ang (1–7) by ACE2 was higher in males than female,100 suggesting an over-expression of ACE2 in men. Because ACE2 is encoded by a gene located on the X chromosome and men express more ACE2 than women it could be speculated that depending the allele expressed by women, they could be considered of lower sensitivity against the most severe adverse effects of the infection.99 , 101 All clinical reports published to date indicate that men represent between 66% and 75% of the most severe cases of COVID-19. During early SARS-CoV-2 infection and viral spread within body tissues, the ACE2 function is likely impaired either by steric hindrance of the peptidase domain of ACE2 following virus binding or by down regulation of ACE2 mRNA expression and ACE2 protein. In severe COVID-19 disease, the presence of the viral receptor on other tissues than lung may explain the multi-organ failure sometimes observed in clinic. We therefore suggest that quantification of ACE2 and AngII be added to the COVID-19 patients biological monitoring."}

2_test

{"project":"2_test","denotations":[{"id":"32414646-23013041-62239838","span":{"begin":811,"end":813},"obj":"23013041"},{"id":"32414646-31262355-62239839","span":{"begin":816,"end":819},"obj":"31262355"}],"text":"ACE2 protein at the surface of lung alveolar epithelial cells allows infection of the respiratory tract with SARS-CoV-2. It can be hypothesized that the ACE2 levels correlate with susceptibility to SARS-CoV-2 infection. Apparently, men have a higher ACE2 expression in lung than women and Asian people express ACE2 higher than Caucasian and African American populations.37 This is in agreement with the finding that conversion of Ang II to Ang (1–7) by ACE2 was higher in males than female,100 suggesting an over-expression of ACE2 in men. Because ACE2 is encoded by a gene located on the X chromosome and men express more ACE2 than women it could be speculated that depending the allele expressed by women, they could be considered of lower sensitivity against the most severe adverse effects of the infection.99 , 101 All clinical reports published to date indicate that men represent between 66% and 75% of the most severe cases of COVID-19. During early SARS-CoV-2 infection and viral spread within body tissues, the ACE2 function is likely impaired either by steric hindrance of the peptidase domain of ACE2 following virus binding or by down regulation of ACE2 mRNA expression and ACE2 protein. In severe COVID-19 disease, the presence of the viral receptor on other tissues than lung may explain the multi-organ failure sometimes observed in clinic. We therefore suggest that quantification of ACE2 and AngII be added to the COVID-19 patients biological monitoring."}

PMC:7201239 / 20539-22011 JSONTXT

Annnotations TAB JSON ListView MergeView

PMC:7201239 / 20539-22011 JSON TXT