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PMC:7201239 / 20539-22011 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
835 0-4 Gene denotes ACE2 Gene:59272
836 153-157 Gene denotes ACE2 Gene:59272
837 250-254 Gene denotes ACE2 Gene:59272
838 310-314 Gene denotes ACE2 Gene:59272
839 453-457 Gene denotes ACE2 Gene:59272
840 527-531 Gene denotes ACE2 Gene:59272
841 548-552 Gene denotes ACE2 Gene:59272
842 623-627 Gene denotes ACE2 Gene:59272
843 1021-1025 Gene denotes ACE2 Gene:59272
844 1108-1112 Gene denotes ACE2 Gene:59272
845 1162-1166 Gene denotes ACE2 Gene:59272
846 1187-1191 Gene denotes ACE2 Gene:59272
847 1401-1405 Gene denotes ACE2 Gene:59272
848 1410-1415 Gene denotes AngII Gene:11606
849 440-448 Gene denotes Ang (1–7 Gene:7108
850 109-119 Species denotes SARS-CoV-2 Tax:2697049
851 232-235 Species denotes men Tax:9606
852 279-284 Species denotes women Tax:9606
853 295-301 Species denotes people Tax:9606
854 535-538 Species denotes men Tax:9606
855 606-609 Species denotes men Tax:9606
856 633-638 Species denotes women Tax:9606
857 701-706 Species denotes women Tax:9606
858 873-876 Species denotes men Tax:9606
859 1441-1449 Species denotes patients Tax:9606
860 69-78 Disease denotes infection MESH:D007239
861 198-218 Disease denotes SARS-CoV-2 infection MESH:C000657245
862 801-810 Disease denotes infection MESH:D007239
863 935-943 Disease denotes COVID-19 MESH:C000657245
864 963-978 Disease denotes CoV-2 infection MESH:C000657245
865 1211-1219 Disease denotes COVID-19 MESH:C000657245
866 1307-1326 Disease denotes multi-organ failure MESH:D009102
867 1432-1440 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T160 5-12 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T161 20-35 Body_part denotes surface of lung http://purl.org/sig/ont/fma/fma17530
T162 36-61 Body_part denotes alveolar epithelial cells http://purl.org/sig/ont/fma/fma62499
T163 56-61 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T164 86-103 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T165 269-273 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T166 569-573 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T167 589-601 Body_part denotes X chromosome http://purl.org/sig/ont/fma/fma84055
T168 1003-1007 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T169 1008-1015 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T170 1167-1171 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T171 1192-1199 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T172 1273-1280 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T173 1286-1290 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T174 1313-1318 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T45 31-35 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T46 86-103 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T47 269-273 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T48 1286-1290 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T49 1313-1318 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T156 69-103 Disease denotes infection of the respiratory tract http://purl.obolibrary.org/obo/MONDO_0024355
T157 69-78 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T158 109-117 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T159 109-113 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T160 198-206 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T161 198-202 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T162 209-218 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T163 801-810 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T164 935-943 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T165 958-966 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T166 958-962 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T167 969-988 Disease denotes infection and viral http://purl.obolibrary.org/obo/MONDO_0005108
T168 969-978 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T169 1211-1219 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T170 1307-1326 Disease denotes multi-organ failure http://purl.obolibrary.org/obo/MONDO_0043726
T171 1432-1440 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T311 31-35 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T312 31-35 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T313 45-55 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T314 56-61 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T315 241-242 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T316 269-273 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T317 269-273 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T318 472-477 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T319 472-477 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T320 483-489 http://purl.obolibrary.org/obo/UBERON_0003100 denotes female
T321 567-568 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T322 569-573 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T323 1123-1128 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T324 1286-1290 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T325 1286-1290 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T326 1313-1318 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T182 5-12 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T183 430-433 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T184 434-436 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T185 440-443 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T186 1192-1199 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T34 1148-1158 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T77 0-120 Sentence denotes ACE2 protein at the surface of lung alveolar epithelial cells allows infection of the respiratory tract with SARS-CoV-2.
T78 121-219 Sentence denotes It can be hypothesized that the ACE2 levels correlate with susceptibility to SARS-CoV-2 infection.
T79 220-539 Sentence denotes Apparently, men have a higher ACE2 expression in lung than women and Asian people express ACE2 higher than Caucasian and African American populations.37 This is in agreement with the finding that conversion of Ang II to Ang (1–7) by ACE2 was higher in males than female,100 suggesting an over-expression of ACE2 in men.
T80 540-944 Sentence denotes Because ACE2 is encoded by a gene located on the X chromosome and men express more ACE2 than women it could be speculated that depending the allele expressed by women, they could be considered of lower sensitivity against the most severe adverse effects of the infection.99 , 101 All clinical reports published to date indicate that men represent between 66% and 75% of the most severe cases of COVID-19.
T81 945-1200 Sentence denotes During early SARS-CoV-2 infection and viral spread within body tissues, the ACE2 function is likely impaired either by steric hindrance of the peptidase domain of ACE2 following virus binding or by down regulation of ACE2 mRNA expression and ACE2 protein.
T82 1201-1356 Sentence denotes In severe COVID-19 disease, the presence of the viral receptor on other tissues than lung may explain the multi-organ failure sometimes observed in clinic.
T83 1357-1472 Sentence denotes We therefore suggest that quantification of ACE2 and AngII be added to the COVID-19 patients biological monitoring.

2_test

Id Subject Object Predicate Lexical cue
32414646-23013041-62239838 811-813 23013041 denotes 99
32414646-31262355-62239839 816-819 31262355 denotes 101