PMC:7201239 / 0-1070
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 5 | 0-4 | Gene | denotes | ACE2 | Gene:59272 |
| 6 | 46-56 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 7 | 58-70 | Disease | denotes | hypertension | MESH:D006973 |
| 8 | 72-91 | Disease | denotes | multi-organ failure | MESH:D009102 |
| 9 | 97-105 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 39 | 702-735 | Gene | denotes | angiotensin I converting enzyme 2 | Gene:59272 |
| 40 | 737-741 | Gene | denotes | ACE2 | Gene:59272 |
| 41 | 974-978 | Gene | denotes | ACE2 | Gene:59272 |
| 42 | 990-994 | Gene | denotes | ACE2 | Gene:59272 |
| 46 | 668-673 | Gene | denotes | spike | Gene:43740568 |
| 47 | 136-183 | Species | denotes | severe acute respiratory syndrome coronavirus 2 | Tax:2697049 |
| 48 | 185-195 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 49 | 221-227 | Species | denotes | people | Tax:9606 |
| 50 | 356-364 | Species | denotes | SARS-CoV | Tax:694009 |
| 51 | 447-454 | Species | denotes | patient | Tax:9606 |
| 52 | 535-541 | Species | denotes | humans | Tax:9606 |
| 53 | 562-574 | Species | denotes | homo sapiens | Tax:9606 |
| 54 | 657-667 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 55 | 696-701 | Species | denotes | human | Tax:9606 |
| 56 | 899-905 | Species | denotes | Humans | Tax:9606 |
| 57 | 1036-1041 | Species | denotes | human | Tax:9606 |
| 60 | 879-890 | Chemical | denotes | aldosterone | MESH:D000450 |
| 61 | 292-300 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 62 | 333-339 | Disease | denotes | deaths | MESH:D003643 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T1 | 78-83 | Body_part | denotes | organ | http://purl.org/sig/ont/fma/fma67498 |
| T2 | 674-681 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T3 | 790-805 | Body_part | denotes | surface of lung | http://purl.org/sig/ont/fma/fma17530 |
| T4 | 806-822 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
| T5 | 817-822 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T6 | 833-840 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 78-83 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
| T2 | 801-805 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 46-54 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T2 | 46-50 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T3 | 58-70 | Disease | denotes | hypertension | http://purl.obolibrary.org/obo/MONDO_0005044 |
| T4 | 72-91 | Disease | denotes | multi-organ failure | http://purl.obolibrary.org/obo/MONDO_0043726 |
| T5 | 97-105 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T6 | 136-183 | Disease | denotes | severe acute respiratory syndrome coronavirus 2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T7 | 136-169 | Disease | denotes | severe acute respiratory syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T8 | 185-193 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T9 | 185-189 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T10 | 292-300 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T11 | 356-364 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T12 | 356-360 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T13 | 657-665 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T14 | 657-661 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 78-83 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organ |
| T2 | 198-201 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T3 | 249-252 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T4 | 354-355 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T5 | 370-375 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T6 | 405-406 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T7 | 456-457 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T8 | 535-541 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | humans |
| T9 | 562-574 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | homo sapiens |
| T10 | 578-579 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T11 | 611-616 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T12 | 696-701 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T13 | 761-762 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T14 | 801-822 | http://purl.obolibrary.org/obo/CL_0000082 | denotes | lung epithelial cells |
| T15 | 899-905 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | Humans |
| T16 | 1036-1041 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T1 | 674-681 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T2 | 702-713 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T3 | 749-757 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T4 | 867-878 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T5 | 879-890 | Chemical | denotes | aldosterone | http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 58-70 | Phenotype | denotes | hypertension | http://purl.obolibrary.org/obo/HP_0000822 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-27 | Sentence | denotes | ACE2 receptor polymorphism: |
| T2 | 28-121 | Sentence | denotes | Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome |
| T3 | 123-131 | Sentence | denotes | Abstract |
| T4 | 132-340 | Sentence | denotes | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged in Chinese people in December 2019 and has currently spread worldwide causing the COVID-19 pandemic with more than 150,000 deaths. |
| T5 | 341-625 | Sentence | denotes | In order for a SARS-CoV like virus circulating in wild life for a very long time to infect the index case-patient, a number of conditions must be met, foremost among which is the encounter with humans and the presence in homo sapiens of a cellular receptor allowing the virus to bind. |
| T6 | 626-743 | Sentence | denotes | Recently it was shown that the SARS-CoV-2 spike protein, binds to the human angiotensin I converting enzyme 2 (ACE2). |
| T7 | 744-898 | Sentence | denotes | This molecule is a peptidase expressed at the surface of lung epithelial cells and other tissues, that regulates the renin-angiotensin-aldosterone system. |
| T8 | 899-979 | Sentence | denotes | Humans are not equal with respect to the expression levels of the cellular ACE2. |
| T9 | 980-1054 | Sentence | denotes | Moreover, ACE2 polymorphisms were recently described in human populations. |