PMC:7200337 / 96228-98521 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7200337","sourcedb":"PMC","sourceid":"7200337","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7200337","text":"SARS-CoV-1 and SARS-CoV-2 consensus sequences share about 80% identity (Tai et al., 2020). Thus, a wide range of SARS-CoV-1 nAbs have been tested for crossreactivity with SARS-CoV-2, as they could help speed up the development of potential COVID-19 treatments. In a recent study, antibodies were isolated from the memory B cells of an individual who recovered from SARS-CoV-1 infection. While 8 out of 25 isolated antibodies could bind SARS-CoV-2 S protein, one of them (s309; see Table 3 ) also neutralizes SARS-CoV-2 (Pinto et al., 2020). The combination of s309 with a weakly neutralizing antibody that could bind another RBD epitope led to enhanced neutralization potency. In addition, CR3022 (Table 3) was found to bind SARS-CoV-2 RBD (Tian et al., 2020b), but this antibody did not neutralize SARS-CoV-2 (Yuan et al., 2020). Computational simulations identified three amino acids that could be modified on CR3022 to enhance its binding affinity with SARS-CoV-2 RBD (Giron et al., 2020), potentially augmenting its neutralization potential.\nTable 3 Strategies to Isolate SARS-CoV-2 Neutralizing Antibodies\nAb Source Clone Target Type of Antibody Neutralization Inhibition of ACE2/RBD Binding Reference\nDerived from COVID-19 patients 31B532D4 RBD human monoclonal yes yes Chen et al., 2020a\nP2C-2F6P2C-1F11 RBD human monoclonal yes yes Ju et al., 2020\nDerived from SARS-CoV-1 patients CR3022 RBD human monoclonal no no Tian et al., 2020b, Yuan et al., 2020, Giron et al., 2020\nS309 RBD human monoclonal yes no Pinto et al., 2020\nDerived from SARS-CoV-1 or MERS-CoV-1 animal models R325R302R007 S1 rabbit monoclonal yes no Sun et al., 2020\n47D11 S1 recombinant human monoclonal (derived from hybridomas of immunized transgenic H2L2 mice) yes no Wang et al., 2020a\nVHH-72-Fc S Fc-fusion derived from camelids VHH yes yes Wrapp et al., 2020\nS polyclonal mouse antibodies yes N/A Walls et al., 2020, Yuan et al., 2020\nOther ACE2-Fc RBD ACE2-Fc fusion yes N/A Lei et al., 2020a, Li et al., 2020d\nRBD-Fc ACE2 RBD-Fc fusion yes N/A Li et al., 2020d\nN3130 S1 human monoclonal single domain antibody isolated by phage display yes no Wu et al., 2020c\nIVIg N/A polyclonal human IVIg N/A N/A Díez et al., 2020, Shao et al., 2020\nF(ab′)2 RBD horse polyclonal yes N/A Pan et al., 2020\nN/A, not 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