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PMC:7200337 / 96228-98521 JSONTXT

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2_test

Id Subject Object Predicate Lexical cue
32505227-32416259-46575428 986-990 32416259 denotes 2020
32505227-32416259-46575430 1476-1480 32416259 denotes 2020
32505227-32155444-46575431 1894-1898 32155444 denotes 2020
T94852 986-990 32416259 denotes 2020
T64637 1476-1480 32416259 denotes 2020
T33611 1894-1898 32155444 denotes 2020

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T741 323-328 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T742 449-456 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T743 592-600 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T744 771-779 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T745 874-885 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T746 1100-1110 Body_part denotes Antibodies http://purl.org/sig/ont/fma/fma62871
T747 1142-1150 Body_part denotes Antibody http://purl.org/sig/ont/fma/fma62871
T748 2086-2094 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T553 0-8 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T554 15-23 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T555 113-121 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T556 171-179 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T557 240-248 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T558 365-373 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T559 376-385 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T560 436-444 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T561 508-516 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T562 725-733 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T563 799-807 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T564 956-964 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T565 1076-1084 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T566 1220-1228 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T567 1369-1377 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T568 1546-1554 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T984 97-98 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T985 139-145 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T986 264-265 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T987 321-328 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T988 570-571 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T989 1251-1256 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T990 1315-1320 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T991 1400-1405 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T992 1490-1495 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T993 1571-1577 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T994 1598-1600 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T995 1649-1651 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T996 1664-1669 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T997 1695-1705 http://purl.obolibrary.org/obo/CLO_0036932 denotes hybridomas
T998 1774-1776 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T999 1779-1781 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T1000 1855-1860 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T1001 1878-1879 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T1002 1929-1931 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T1003 1941-1943 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T1004 1957-1958 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T1005 1978-1980 http://purl.obolibrary.org/obo/CLO_0001022 denotes Li
T1006 1978-1980 http://purl.obolibrary.org/obo/CLO_0007314 denotes Li
T1007 1999-2001 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T1008 2011-2013 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T1009 2027-2028 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T1010 2029-2031 http://purl.obolibrary.org/obo/CLO_0001022 denotes Li
T1011 2029-2031 http://purl.obolibrary.org/obo/CLO_0007314 denotes Li
T1012 2052-2054 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T1013 2055-2060 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1014 2152-2153 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T1015 2165-2170 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1016 2178-2179 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T1017 2182-2183 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T1018 2233-2238 http://purl.obolibrary.org/obo/NCBITaxon_9796 denotes horse
T1019 2256-2257 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T1020 2258-2261 http://purl.obolibrary.org/obo/NCBITaxon_9596 denotes Pan
T1021 2277-2278 http://purl.obolibrary.org/obo/CLO_0001020 denotes A

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T313 449-456 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T314 629-636 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T315 874-885 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T316 874-879 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T317 880-885 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T318 1978-1980 Chemical denotes Li http://purl.obolibrary.org/obo/CHEBI_30145
T319 2029-2031 Chemical denotes Li http://purl.obolibrary.org/obo/CHEBI_30145

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T212 314-320 http://purl.obolibrary.org/obo/GO_0007613 denotes memory

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3184 1180-1184 Gene denotes ACE2 Gene:59272
3185 1924-1928 Gene denotes ACE2 Gene:70008
3186 1936-1940 Gene denotes ACE2 Gene:70008
3187 1229-1237 Species denotes patients Tax:9606
3188 1369-1377 Species denotes SARS-CoV Tax:694009
3189 1380-1388 Species denotes patients Tax:9606
3190 1546-1554 Species denotes SARS-CoV Tax:694009
3191 1560-1568 Species denotes MERS-CoV Tax:1335626
3192 1735-1739 Species denotes mice Tax:10090
3193 1652-1663 Species denotes recombinant Tax:575864
3194 1719-1729 Species denotes transgenic Tax:10090
3195 1251-1256 Species denotes human Tax:9606
3196 1315-1320 Species denotes human Tax:9606
3197 1400-1405 Species denotes human Tax:9606
3198 1490-1495 Species denotes human Tax:9606
3199 1664-1669 Species denotes human Tax:9606
3200 1855-1860 Species denotes mouse Tax:10090
3201 2055-2060 Species denotes human Tax:9606
3202 2165-2170 Species denotes human Tax:9606
3203 1220-1228 Disease denotes COVID-19 MESH:C000657245
3204 2145-2151 Disease denotes IVIg N MESH:C536108
3205 2171-2177 Disease denotes IVIg N MESH:C536108
3208 1065-1067 Gene denotes to Gene:6999
3209 1076-1086 Species denotes SARS-CoV-2 Tax:2697049
3229 447-448 Gene denotes S Gene:43740568
3230 919-921 Gene denotes to Gene:6999
3231 717-719 Gene denotes to Gene:6999
3232 641-643 Gene denotes to Gene:6999
3233 0-8 Species denotes SARS-CoV Tax:694009
3234 15-25 Species denotes SARS-CoV-2 Tax:2697049
3235 113-121 Species denotes SARS-CoV Tax:694009
3236 171-181 Species denotes SARS-CoV-2 Tax:2697049
3237 436-446 Species denotes SARS-CoV-2 Tax:2697049
3238 508-518 Species denotes SARS-CoV-2 Tax:2697049
3239 725-735 Species denotes SARS-CoV-2 Tax:2697049
3240 799-809 Species denotes SARS-CoV-2 Tax:2697049
3241 956-966 Species denotes SARS-CoV-2 Tax:2697049
3242 124-128 Chemical denotes nAbs
3243 560-564 Chemical denotes s309
3244 690-696 Chemical denotes CR3022
3245 912-918 Chemical denotes CR3022
3246 240-248 Disease denotes COVID-19 MESH:C000657245
3247 365-385 Disease denotes SARS-CoV-1 infection MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T554 0-90 Sentence denotes SARS-CoV-1 and SARS-CoV-2 consensus sequences share about 80% identity (Tai et al., 2020).
T555 91-260 Sentence denotes Thus, a wide range of SARS-CoV-1 nAbs have been tested for crossreactivity with SARS-CoV-2, as they could help speed up the development of potential COVID-19 treatments.
T556 261-386 Sentence denotes In a recent study, antibodies were isolated from the memory B cells of an individual who recovered from SARS-CoV-1 infection.
T557 387-540 Sentence denotes While 8 out of 25 isolated antibodies could bind SARS-CoV-2 S protein, one of them (s309; see Table 3 ) also neutralizes SARS-CoV-2 (Pinto et al., 2020).
T558 541-676 Sentence denotes The combination of s309 with a weakly neutralizing antibody that could bind another RBD epitope led to enhanced neutralization potency.
T559 677-830 Sentence denotes In addition, CR3022 (Table 3) was found to bind SARS-CoV-2 RBD (Tian et al., 2020b), but this antibody did not neutralize SARS-CoV-2 (Yuan et al., 2020).
T560 831-1045 Sentence denotes Computational simulations identified three amino acids that could be modified on CR3022 to enhance its binding affinity with SARS-CoV-2 RBD (Giron et al., 2020), potentially augmenting its neutralization potential.
T561 1046-1110 Sentence denotes Table 3 Strategies to Isolate SARS-CoV-2 Neutralizing Antibodies
T562 1111-1206 Sentence denotes Ab Source Clone Target Type of Antibody Neutralization Inhibition of ACE2/RBD Binding Reference
T563 1207-1294 Sentence denotes Derived from COVID-19 patients 31B532D4 RBD human monoclonal yes yes Chen et al., 2020a
T564 1295-1355 Sentence denotes P2C-2F6P2C-1F11 RBD human monoclonal yes yes Ju et al., 2020
T565 1356-1480 Sentence denotes Derived from SARS-CoV-1 patients CR3022 RBD human monoclonal no no Tian et al., 2020b, Yuan et al., 2020, Giron et al., 2020
T566 1481-1532 Sentence denotes S309 RBD human monoclonal yes no Pinto et al., 2020
T567 1533-1642 Sentence denotes Derived from SARS-CoV-1 or MERS-CoV-1 animal models R325R302R007 S1 rabbit monoclonal yes no Sun et al., 2020
T568 1643-1766 Sentence denotes 47D11 S1 recombinant human monoclonal (derived from hybridomas of immunized transgenic H2L2 mice) yes no Wang et al., 2020a
T569 1767-1841 Sentence denotes VHH-72-Fc S Fc-fusion derived from camelids VHH yes yes Wrapp et al., 2020
T570 1842-1917 Sentence denotes S polyclonal mouse antibodies yes N/A Walls et al., 2020, Yuan et al., 2020
T571 1918-1994 Sentence denotes Other ACE2-Fc RBD ACE2-Fc fusion yes N/A Lei et al., 2020a, Li et al., 2020d
T572 1995-2045 Sentence denotes RBD-Fc ACE2 RBD-Fc fusion yes N/A Li et al., 2020d
T573 2046-2144 Sentence denotes N3130 S1 human monoclonal single domain antibody isolated by phage display yes no Wu et al., 2020c
T574 2145-2220 Sentence denotes IVIg N/A polyclonal human IVIg N/A N/A Díez et al., 2020, Shao et al., 2020
T575 2221-2274 Sentence denotes F(ab′)2 RBD horse polyclonal yes N/A Pan et al., 2020
T576 2275-2293 Sentence denotes N/A, not assessed.