PMC:7200337 / 89533-90124 JSONTXT

{"project":"2_test","denotations":[{"id":"32505227-32303591-46575410","span":{"begin":231,"end":235},"obj":"32303591"},{"id":"T3033","span":{"begin":231,"end":235},"obj":"32303591"}],"text":"Hyperinflammatory responses and elevated levels of inflammatory cytokines, including IL-6, -8, and -10, have been shown to correlate with COVID-19 severity (Chen et al., 2020h, Diao et al., 2020, Gong et al., 2020, Moore and June, 2020, Wan et al., 2020a, Xu et al., 2020b). The drivers of this cytokine storm remain to be established, but they are likely triggered initially by a combination of viral PAMPs and host danger signals. The heterogeneous response between patients suggests other factors are involved, possibly including the SARS-CoV-2 receptor, ACE2 (Hirano and Murakami, 2020)."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T706","span":{"begin":64,"end":73},"obj":"Body_part"},{"id":"T707","span":{"begin":295,"end":303},"obj":"Body_part"}],"attributes":[{"id":"A706","pred":"fma_id","subj":"T706","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A707","pred":"fma_id","subj":"T707","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"Hyperinflammatory responses and elevated levels of inflammatory cytokines, including IL-6, -8, and -10, have been shown to correlate with COVID-19 severity (Chen et al., 2020h, Diao et al., 2020, Gong et al., 2020, Moore and June, 2020, Wan et al., 2020a, Xu et al., 2020b). The drivers of this cytokine storm remain to be established, but they are likely triggered initially by a combination of viral PAMPs and host danger signals. The heterogeneous response between patients suggests other factors are involved, possibly including the SARS-CoV-2 receptor, ACE2 (Hirano and Murakami, 2020)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T510","span":{"begin":138,"end":146},"obj":"Disease"},{"id":"T511","span":{"begin":537,"end":545},"obj":"Disease"}],"attributes":[{"id":"A510","pred":"mondo_id","subj":"T510","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A511","pred":"mondo_id","subj":"T511","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Hyperinflammatory responses and elevated levels of inflammatory cytokines, including IL-6, -8, and -10, have been shown to correlate with COVID-19 severity (Chen et al., 2020h, Diao et al., 2020, Gong et al., 2020, Moore and June, 2020, Wan et al., 2020a, Xu et al., 2020b). The drivers of this cytokine storm remain to be established, but they are likely triggered initially by a combination of viral PAMPs and host danger signals. The heterogeneous response between patients suggests other factors are involved, possibly including the SARS-CoV-2 receptor, ACE2 (Hirano and Murakami, 2020)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T944","span":{"begin":379,"end":380},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T945","span":{"begin":424,"end":431},"obj":"http://purl.obolibrary.org/obo/SO_0000418"}],"text":"Hyperinflammatory responses and elevated levels of inflammatory cytokines, including IL-6, -8, and -10, have been shown to correlate with COVID-19 severity (Chen et al., 2020h, Diao et al., 2020, Gong et al., 2020, Moore and June, 2020, Wan et al., 2020a, Xu et al., 2020b). The drivers of this cytokine storm remain to be established, but they are likely triggered initially by a combination of viral PAMPs and host danger signals. The heterogeneous response between patients suggests other factors are involved, possibly including the SARS-CoV-2 receptor, ACE2 (Hirano and Murakami, 2020)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T277","span":{"begin":85,"end":87},"obj":"Chemical"}],"attributes":[{"id":"A277","pred":"chebi_id","subj":"T277","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A278","pred":"chebi_id","subj":"T277","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"}],"text":"Hyperinflammatory responses and elevated levels of inflammatory cytokines, including IL-6, -8, and -10, have been shown to correlate with COVID-19 severity (Chen et al., 2020h, Diao et al., 2020, Gong et al., 2020, Moore and June, 2020, Wan et al., 2020a, Xu et al., 2020b). The drivers of this cytokine storm remain to be established, but they are likely triggered initially by a combination of viral PAMPs and host danger signals. The heterogeneous response between patients suggests other factors are involved, possibly including the SARS-CoV-2 receptor, ACE2 (Hirano and Murakami, 2020)."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T51","span":{"begin":295,"end":309},"obj":"Phenotype"}],"attributes":[{"id":"A51","pred":"hp_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/HP_0033041"}],"text":"Hyperinflammatory responses and elevated levels of inflammatory cytokines, including IL-6, -8, and -10, have been shown to correlate with COVID-19 severity (Chen et al., 2020h, Diao et al., 2020, Gong et al., 2020, Moore and June, 2020, Wan et al., 2020a, Xu et al., 2020b). The drivers of this cytokine storm remain to be established, but they are likely triggered initially by a combination of viral PAMPs and host danger signals. The heterogeneous response between patients suggests other factors are involved, possibly including the SARS-CoV-2 receptor, ACE2 (Hirano and Murakami, 2020)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"2927","span":{"begin":85,"end":102},"obj":"Gene"},{"id":"2928","span":{"begin":558,"end":562},"obj":"Gene"},{"id":"2929","span":{"begin":317,"end":319},"obj":"Gene"},{"id":"2930","span":{"begin":120,"end":122},"obj":"Gene"},{"id":"2931","span":{"begin":468,"end":476},"obj":"Species"},{"id":"2932","span":{"begin":537,"end":547},"obj":"Species"},{"id":"2933","span":{"begin":138,"end":146},"obj":"Disease"}],"attributes":[{"id":"A2927","pred":"tao:has_database_id","subj":"2927","obj":"Gene:3569"},{"id":"A2928","pred":"tao:has_database_id","subj":"2928","obj":"Gene:59272"},{"id":"A2929","pred":"tao:has_database_id","subj":"2929","obj":"Gene:6999"},{"id":"A2930","pred":"tao:has_database_id","subj":"2930","obj":"Gene:6999"},{"id":"A2931","pred":"tao:has_database_id","subj":"2931","obj":"Tax:9606"},{"id":"A2932","pred":"tao:has_database_id","subj":"2932","obj":"Tax:2697049"},{"id":"A2933","pred":"tao:has_database_id","subj":"2933","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Hyperinflammatory responses and elevated levels of inflammatory cytokines, including IL-6, -8, and -10, have been shown to correlate with COVID-19 severity (Chen et al., 2020h, Diao et al., 2020, Gong et al., 2020, Moore and June, 2020, Wan et al., 2020a, Xu et al., 2020b). The drivers of this cytokine storm remain to be established, but they are likely triggered initially by a combination of viral PAMPs and host danger signals. The heterogeneous response between patients suggests other factors are involved, possibly including the SARS-CoV-2 receptor, ACE2 (Hirano and Murakami, 2020)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T512","span":{"begin":0,"end":274},"obj":"Sentence"},{"id":"T513","span":{"begin":275,"end":432},"obj":"Sentence"},{"id":"T514","span":{"begin":433,"end":591},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Hyperinflammatory responses and elevated levels of inflammatory cytokines, including IL-6, -8, and -10, have been shown to correlate with COVID-19 severity (Chen et al., 2020h, Diao et al., 2020, Gong et al., 2020, Moore and June, 2020, Wan et al., 2020a, Xu et al., 2020b). The drivers of this cytokine storm remain to be established, but they are likely triggered initially by a combination of viral PAMPs and host danger signals. The heterogeneous response between patients suggests other factors are involved, possibly including the SARS-CoV-2 receptor, ACE2 (Hirano and Murakami, 2020)."}