PMC:7200337 / 88294-89513 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7200337","sourcedb":"PMC","sourceid":"7200337","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7200337","text":"Recently, there has been a growing interest in the potential therapeutic impact of modulating the IFN response to disable COVID-19 pathogenesis. Before the current pandemic, groups have studied the role of IFNs in other betacoronavirus infections. One study of 40 patients with SARS-CoV-1 infection described unresolved elevated type I IFNs and ISGs in those with poor outcomes (Cameron et al., 2007). Others report that exogenous type I IFN does not improve outcomes when given with ribavirin in patients with MERS-CoV infection (Arabi et al., 2020), suggesting that the role of IFN as a therapeutic or prophylactic option may be strain or species specific (Sheahan et al., 2020). Interestingly, a recent study by Mount Sinai virology groups revealed that type I IFN signaling is impaired in the early response to SARS-CoV-2; in vitro, SARS-CoV-2 may be more susceptible to type I IFN than SARS-CoV-1 is (Blanco-Melo et al., 2020). Based on additional evidence that IFN responses to betacoronaviruses are altered as compared to other respiratory viruses (Blanco-Melo et al., 2020, Channappanavar et al., 2016, Okabayashi et al., 2006), trials of IFN-I/III administration have been initiated (NCT04343976, NCT04331899).","tracks":[{"project":"2_test","denotations":[{"id":"32505227-17537853-46575405","span":{"begin":395,"end":399},"obj":"17537853"},{"id":"32505227-31925415-46575406","span":{"begin":545,"end":549},"obj":"31925415"},{"id":"32505227-31924756-46575407","span":{"begin":675,"end":679},"obj":"31924756"},{"id":"32505227-26867177-46575408","span":{"begin":1105,"end":1109},"obj":"26867177"},{"id":"32505227-16482545-46575409","span":{"begin":1130,"end":1134},"obj":"16482545"},{"id":"T67437","span":{"begin":395,"end":399},"obj":"17537853"},{"id":"T59534","span":{"begin":545,"end":549},"obj":"31925415"},{"id":"T50703","span":{"begin":675,"end":679},"obj":"31924756"},{"id":"T33795","span":{"begin":1105,"end":1109},"obj":"26867177"},{"id":"T23514","span":{"begin":1130,"end":1134},"obj":"16482545"}],"attributes":[{"subj":"32505227-17537853-46575405","pred":"source","obj":"2_test"},{"subj":"32505227-31925415-46575406","pred":"source","obj":"2_test"},{"subj":"32505227-31924756-46575407","pred":"source","obj":"2_test"},{"subj":"32505227-26867177-46575408","pred":"source","obj":"2_test"},{"subj":"32505227-16482545-46575409","pred":"source","obj":"2_test"},{"subj":"T67437","pred":"source","obj":"2_test"},{"subj":"T59534","pred":"source","obj":"2_test"},{"subj":"T50703","pred":"source","obj":"2_test"},{"subj":"T33795","pred":"source","obj":"2_test"},{"subj":"T23514","pred":"source","obj":"2_test"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T502","span":{"begin":122,"end":130},"obj":"Disease"},{"id":"T503","span":{"begin":236,"end":246},"obj":"Disease"},{"id":"T504","span":{"begin":278,"end":286},"obj":"Disease"},{"id":"T505","span":{"begin":289,"end":298},"obj":"Disease"},{"id":"T506","span":{"begin":520,"end":529},"obj":"Disease"},{"id":"T507","span":{"begin":815,"end":823},"obj":"Disease"},{"id":"T508","span":{"begin":837,"end":845},"obj":"Disease"},{"id":"T509","span":{"begin":891,"end":899},"obj":"Disease"}],"attributes":[{"id":"A502","pred":"mondo_id","subj":"T502","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A503","pred":"mondo_id","subj":"T503","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A504","pred":"mondo_id","subj":"T504","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A505","pred":"mondo_id","subj":"T505","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A506","pred":"mondo_id","subj":"T506","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A507","pred":"mondo_id","subj":"T507","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A508","pred":"mondo_id","subj":"T508","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A509","pred":"mondo_id","subj":"T509","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T502","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T503","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T504","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T505","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T506","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T507","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T508","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T509","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T938","span":{"begin":16,"end":19},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T939","span":{"begin":25,"end":26},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T940","span":{"begin":587,"end":588},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T941","span":{"begin":697,"end":698},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T942","span":{"begin":768,"end":777},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T943","span":{"begin":1047,"end":1054},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"attributes":[{"subj":"T938","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T939","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T940","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T941","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T942","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T943","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T276","span":{"begin":484,"end":493},"obj":"Chemical"}],"attributes":[{"id":"A276","pred":"chebi_id","subj":"T276","obj":"http://purl.obolibrary.org/obo/CHEBI_63580"},{"subj":"T276","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T200","span":{"begin":131,"end":143},"obj":"http://purl.obolibrary.org/obo/GO_0009405"},{"id":"T201","span":{"begin":768,"end":777},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"attributes":[{"subj":"T200","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T201","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"2902","span":{"begin":1147,"end":1156},"obj":"Gene"},{"id":"2903","span":{"begin":1026,"end":1028},"ob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