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PMC:7200337 / 88294-89513 JSONTXT

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2_test

Id Subject Object Predicate Lexical cue
32505227-17537853-46575405 395-399 17537853 denotes 2007
32505227-31925415-46575406 545-549 31925415 denotes 2020
32505227-31924756-46575407 675-679 31924756 denotes 2020
32505227-26867177-46575408 1105-1109 26867177 denotes 2016
32505227-16482545-46575409 1130-1134 16482545 denotes 2006
T67437 395-399 17537853 denotes 2007
T59534 545-549 31925415 denotes 2020
T50703 675-679 31924756 denotes 2020
T33795 1105-1109 26867177 denotes 2016
T23514 1130-1134 16482545 denotes 2006

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T502 122-130 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T503 236-246 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T504 278-286 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T505 289-298 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T506 520-529 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T507 815-823 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T508 837-845 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T509 891-899 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T938 16-19 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T939 25-26 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T940 587-588 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T941 697-698 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T942 768-777 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T943 1047-1054 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T276 484-493 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T200 131-143 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T201 768-777 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2902 1147-1156 Gene denotes IFN-I/III
2903 1026-1028 Gene denotes to Gene:6999
2904 981-983 Gene denotes to Gene:6999
2905 872-874 Gene denotes to Gene:6999
2906 812-814 Gene denotes to Gene:6999
2907 111-113 Gene denotes to Gene:6999
2908 220-235 Species denotes betacoronavirus Tax:694002
2909 264-272 Species denotes patients Tax:9606
2910 497-505 Species denotes patients Tax:9606
2911 815-825 Species denotes SARS-CoV-2 Tax:2697049
2912 837-847 Species denotes SARS-CoV-2 Tax:2697049
2913 891-899 Species denotes SARS-CoV Tax:694009
2914 984-1001 Species denotes betacoronaviruses Tax:694002
2915 484-493 Chemical denotes ribavirin MESH:D012254
2916 122-130 Disease denotes COVID-19 MESH:C000657245
2917 236-246 Disease denotes infections MESH:D007239
2918 278-298 Disease denotes SARS-CoV-1 infection MESH:C000657245
2919 511-529 Disease denotes MERS-CoV infection MESH:D018352

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T505 0-144 Sentence denotes Recently, there has been a growing interest in the potential therapeutic impact of modulating the IFN response to disable COVID-19 pathogenesis.
T506 145-247 Sentence denotes Before the current pandemic, groups have studied the role of IFNs in other betacoronavirus infections.
T507 248-401 Sentence denotes One study of 40 patients with SARS-CoV-1 infection described unresolved elevated type I IFNs and ISGs in those with poor outcomes (Cameron et al., 2007).
T508 402-681 Sentence denotes Others report that exogenous type I IFN does not improve outcomes when given with ribavirin in patients with MERS-CoV infection (Arabi et al., 2020), suggesting that the role of IFN as a therapeutic or prophylactic option may be strain or species specific (Sheahan et al., 2020).
T509 682-932 Sentence denotes Interestingly, a recent study by Mount Sinai virology groups revealed that type I IFN signaling is impaired in the early response to SARS-CoV-2; in vitro, SARS-CoV-2 may be more susceptible to type I IFN than SARS-CoV-1 is (Blanco-Melo et al., 2020).
T510 933-1219 Sentence denotes Based on additional evidence that IFN responses to betacoronaviruses are altered as compared to other respiratory viruses (Blanco-Melo et al., 2020, Channappanavar et al., 2016, Okabayashi et al., 2006), trials of IFN-I/III administration have been initiated (NCT04343976, NCT04331899).