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PMC:7200337 / 84379-87514 JSONTXT

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2_test

Id Subject Object Predicate Lexical cue
32505227-32272008-46575401 2669-2673 32272008 denotes 2020
32505227-32122468-46575402 2730-2734 32122468 denotes 2020
T29195 2669-2673 32272008 denotes 2020
T83732 2730-2734 32122468 denotes 2020

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T691 141-149 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T692 206-208 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T693 431-433 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T694 639-641 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T695 1729-1731 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T696 2503-2508 Body_part denotes chest http://purl.org/sig/ont/fma/fma9576
T697 2817-2819 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T94 2503-2508 Body_part denotes chest http://purl.obolibrary.org/obo/UBERON_0001443

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T484 20-28 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T485 132-136 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T486 384-392 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T487 399-407 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T488 410-419 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T489 544-552 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T490 555-564 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T491 692-696 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T492 827-831 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T493 994-1002 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T494 1058-1066 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T495 1481-1485 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T496 2064-2072 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T497 2152-2156 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T498 2827-2835 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T913 72-80 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T914 291-292 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T915 328-333 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T916 335-336 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T917 508-509 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T918 666-667 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T919 1017-1029 http://purl.obolibrary.org/obo/OBI_0000245 denotes Organization
T920 1810-1811 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T921 2003-2004 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T922 2345-2346 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T923 2503-2508 http://www.ebi.ac.uk/efo/EFO_0000965 denotes chest
T924 3036-3038 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T925 3126-3128 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T250 82-97 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T251 99-102 Chemical denotes CSs http://purl.obolibrary.org/obo/CHEBI_50858
T252 111-119 Chemical denotes adjuvant http://purl.obolibrary.org/obo/CHEBI_60809
T253 206-208 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462
T254 431-433 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462
T255 639-641 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462
T256 974-989 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T257 1088-1093 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T258 1186-1204 Chemical denotes methylprednisolone http://purl.obolibrary.org/obo/CHEBI_6888
T259 1433-1436 Chemical denotes CSs http://purl.obolibrary.org/obo/CHEBI_50858
T260 1499-1517 Chemical denotes methylprednisolone http://purl.obolibrary.org/obo/CHEBI_6888
T261 1642-1645 Chemical denotes CSs http://purl.obolibrary.org/obo/CHEBI_50858
T262 1729-1731 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462
T263 1740-1745 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T264 1884-1898 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T265 2021-2029 Chemical denotes adjuvant http://purl.obolibrary.org/obo/CHEBI_60809
T266 2030-2033 Chemical denotes CSs http://purl.obolibrary.org/obo/CHEBI_50858
T267 2201-2204 Chemical denotes CSs http://purl.obolibrary.org/obo/CHEBI_50858
T268 2228-2230 Chemical denotes Lu http://purl.obolibrary.org/obo/CHEBI_33382
T269 2409-2427 Chemical denotes methylprednisolone http://purl.obolibrary.org/obo/CHEBI_6888
T270 2564-2570 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T271 2817-2819 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462
T272 3002-3005 Chemical denotes CSs http://purl.obolibrary.org/obo/CHEBI_50858
T273 3065-3080 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T49 141-155 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T50 2521-2526 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T195 300-315 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2773 20-28 Disease denotes COVID-19 MESH:C000657245
2791 431-433 Gene denotes CS Gene:1431
2792 206-208 Gene denotes CS Gene:1431
2793 639-641 Gene denotes CS Gene:1431
2794 360-368 Species denotes patients Tax:9606
2795 374-382 Species denotes MERS-CoV Tax:1335626
2796 384-392 Species denotes SARS-CoV Tax:694009
2797 580-588 Species denotes patients Tax:9606
2798 678-686 Species denotes patients Tax:9606
2799 841-849 Species denotes patients Tax:9606
2800 132-136 Disease denotes ARDS MESH:D012128
2801 399-419 Disease denotes SARS-CoV-2 infection MESH:C000657245
2802 471-480 Disease denotes mortality MESH:D003643
2803 544-564 Disease denotes SARS-CoV-2 infection MESH:C000657245
2804 602-611 Disease denotes mortality MESH:D003643
2805 692-696 Disease denotes ARDS MESH:D012128
2806 994-1002 Disease denotes COVID-19 MESH:C000657245
2807 1058-1066 Disease denotes COVID-19 MESH:C000657245
2839 2817-2819 Gene denotes CS Gene:1431
2840 1729-1731 Gene denotes CS Gene:1431
2841 2962-2964 Gene denotes to Gene:6999
2842 2518-2520 Gene denotes to Gene:6999
2843 1918-1920 Gene denotes to Gene:6999
2844 1692-1694 Gene denotes to Gene:6999
2845 1663-1665 Gene denotes to Gene:6999
2846 1416-1418 Gene denotes to Gene:6999
2847 1388-1390 Gene denotes to Gene:6999
2848 1137-1139 Gene denotes to Gene:6999
2849 1164-1172 Species denotes patients Tax:9606
2850 1358-1366 Species denotes patients Tax:9606
2851 1467-1475 Species denotes patients Tax:9606
2852 1620-1628 Species denotes patients Tax:9606
2853 1846-1854 Species denotes patients Tax:9606
2854 2041-2049 Species denotes patients Tax:9606
2855 2138-2146 Species denotes patients Tax:9606
2856 2374-2382 Species denotes patients Tax:9606
2857 3016-3024 Species denotes patients Tax:9606
2858 1186-1204 Chemical denotes methylprednisolone MESH:D008775
2859 1499-1517 Chemical denotes methylprednisolone MESH:D008775
2860 2409-2427 Chemical denotes methylprednisolone MESH:D008775
2861 2564-2570 Chemical denotes oxygen MESH:D010100
2862 1481-1485 Disease denotes ARDS MESH:D012128
2863 1530-1539 Disease denotes mortality MESH:D003643
2864 2064-2072 Disease denotes COVID-19 MESH:C000657245
2865 2106-2115 Disease denotes mortality MESH:D003643
2866 2152-2156 Disease denotes ARDS MESH:D012128
2867 2329-2338 Disease denotes mortality MESH:D003643
2868 2521-2526 Disease denotes fever MESH:D005334
2869 2827-2835 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T481 0-36 Sentence denotes Corticosteroids for COVID-19 Therapy
T482 37-156 Sentence denotes Because of their anti-inflammatory activity, corticosteroids (CSs) are an adjuvant therapy for ARDS and cytokine storm.
T483 157-334 Sentence denotes However, the broad immunosuppression mediated by CS does raise the possibility that treatment could interfere with the development of a proper immune response against the virus.
T484 335-507 Sentence denotes A meta-analysis of 5,270 patients with MERS-CoV, SARS-CoV-1, or SARS-CoV-2 infection found that CS treatment was associated with higher mortality rate (Yang et al., 2020c).
T485 508-725 Sentence denotes A more recent meta-analysis of only SARS-CoV-2 infection assessed 2,636 patients and found no mortality difference associated with CS treatment, including in a subset of patients with ARDS (Gangopadhyay et al., 2020).
T486 726-873 Sentence denotes Other studies have reported associations with delayed viral clearance and increased complications in SARS and MERS patients (Sanders et al., 2020).
T487 874-1038 Sentence denotes In fact, the interim guidelines updated by the WHO on March 13, 2020 advise against giving systemic corticosteroids for COVID-19 (World Health Organization, 2020a).
T488 1039-1083 Sentence denotes Yet, new data from COVID-19 are conflicting.
T489 1084-1302 Sentence denotes One group reported no significant difference in time to viral clearance between patients who received methylprednisolone orally (mild disease) or intravenously (i.v.) (severe) and those who did not (Fang et al., 2020).
T490 1303-1564 Sentence denotes Retrospective studies from groups in China report that patients who were transferred to the ICU were less likely to have received CSs (Wang et al., 2020b) and that patients with ARDS who received methylprednisolone had reduced mortality risk (Wu et al., 2020a).
T491 1565-1809 Sentence denotes In contrast, another retrospective analysis found that patients who received CSs were more likely to have either been admitted to the ICU or perished, although the CS-treated group also had significantly more comorbidities (Wang et al., 2020c).
T492 1810-2002 Sentence denotes A smaller observational study of 31 patients found no association between corticosteroid treatment and time to viral clearance, length of hospital stay, or symptom duration (Zha et al., 2020).
T493 2003-2246 Sentence denotes A larger study of adjuvant CSs in 244 patients with critical COVID-19 found no association with 28-day mortality; subgroup analysis of patients with ARDS found no association between treatment with CSs and clinical outcomes (Lu et al., 2020b).
T494 2247-2344 Sentence denotes They also found that increased dosage was significantly associated with increased mortality risk.
T495 2345-2600 Sentence denotes A retrospective review of 46 patients, of whom 26 received i.v. methylprednisolone, found that early, low-dose administration significantly improved SpO2 and chest CT, time to fever resolution, and time on supplemental oxygen therapy (Wang et al., 2020h).
T496 2601-2788 Sentence denotes Others have published perspectives in support of early (Lee et al., 2020) and short-term, low-dose administration (Shang et al., 2020) based on anecdotal evidence but not clinical trials.
T497 2789-2935 Sentence denotes Most of the current data on CS use in COVID-19 are from observational studies and support either modest clinical benefit or no meaningful effects.
T498 2936-3135 Sentence denotes Larger RCTs are necessary to understand the risks and benefits of CSs for these patients; there are 22 trials evaluating various corticosteroids registered on ClinicalTrials.gov as of April 27, 2020.