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PMC:7200337 / 66764-68348 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T620 161-170 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T621 567-570 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T622 811-815 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T623 919-927 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T399 143-151 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T400 230-238 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T401 428-447 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T402 973-981 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T403 1335-1354 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T781 72-75 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T782 94-95 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T783 540-545 http://purl.obolibrary.org/obo/PR_000001380 denotes IL-2R
T784 547-551 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T785 1037-1039 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T69698 282-284 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T190 540-542 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T45248 547-549 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T84 553-555 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T21224 564-566 Chemical denotes GM http://purl.obolibrary.org/obo/CHEBI_74120
T87 811-813 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T89 821-823 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T91 1021-1023 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T93 1027-1029 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T95 1034-1036 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T61341 1231-1236 Chemical denotes IP-10 http://purl.obolibrary.org/obo/CHEBI_138157
T84432 1231-1233 Chemical denotes IP http://purl.obolibrary.org/obo/CHEBI_74076
T99 1238-1241 Chemical denotes MCP http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099
T37885 1249-1251 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T6533 1296-1298 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T45920 1442-1444 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T40 428-447 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T41 1335-1354 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T174 540-545 http://purl.obolibrary.org/obo/GO_0004911 denotes IL-2R
T175 1249-1255 http://purl.obolibrary.org/obo/GO_0005152 denotes IL-1ra

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2142 282-286 Gene denotes IL-6 Gene:3569
2143 540-545 Gene denotes IL-2R Gene:3559
2144 547-551 Gene denotes IL-8 Gene:3576
2145 553-558 Gene denotes IL-10 Gene:3586
2146 564-570 Gene denotes GM-CSF Gene:1437
2147 811-816 Gene denotes IL-1β Gene:3552
2148 821-825 Gene denotes IL-4 Gene:3565
2149 1021-1025 Gene denotes IL-6 Gene:3569
2150 1027-1032 Gene denotes IL-10 Gene:3586
2151 1034-1039 Gene denotes IL-18 Gene:3606
2152 1041-1046 Gene denotes CTACK Gene:10850
2153 1052-1057 Gene denotes IFN-γ Gene:3458
2154 1231-1236 Gene denotes IP-10 Gene:3627
2155 1249-1255 Gene denotes IL-1ra Gene:3554
2156 1296-1300 Gene denotes IL-6 Gene:3569
2157 1442-1446 Gene denotes IL-6 Gene:3569
2158 711-713 Gene denotes to Gene:6999
2159 324-332 Species denotes patients Tax:9606
2160 360-368 Species denotes patients Tax:9606
2161 691-699 Species denotes patients Tax:9606
2162 982-990 Species denotes patients Tax:9606
2163 128-137 Disease denotes mortality MESH:D003643
2164 143-151 Disease denotes COVID-19 MESH:C000657245
2165 230-238 Disease denotes COVID-19 MESH:C000657245
2166 345-359 Disease denotes critically ill MESH:D016638
2167 428-447 Disease denotes respiratory failure MESH:D012131
2168 973-981 Disease denotes COVID-19 MESH:C000657245
2169 1335-1354 Disease denotes respiratory failure MESH:D012131

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T373 0-152 Sentence denotes Immunological biomarkers are particularly important, as immunopathology has been suggested as a primary driver of morbidity and mortality with COVID-19.
T374 153-258 Sentence denotes Several cytokines and other immunologic parameters have been correlated with COVID-19 severity (Table 1).
T375 259-529 Sentence denotes Most notably, elevated IL-6 levels were detected in hospitalized patients, especially critically ill patients, in several studies and are associated with ICU admission, respiratory failure, and poor prognosis (Chen et al., 2020g, Huang et al., 2020b, Liu et al., 2020f).
T376 530-780 Sentence denotes Increased IL-2R, IL-8, IL-10, and GM-CSF have been associated with disease severity as well, but studies are limited, and further studies with larger cohorts of patients are needed to indicate predictive power (Gong et al., 2020, Zhou et al., 2020b).
T377 781-900 Sentence denotes Conflicting results regarding IL-1β and IL-4 have been reported (Fu et al., 2020, Gong et al., 2020, Wen et al., 2020).
T378 901-1192 Sentence denotes Although elevated cytokine concentrations have been widely described in COVID-19 patients, the vast majority (including IL-6, IL-10, IL-18, CTACK, and IFN-γ) do not seem to have prognostic value, because they do not always differentiate moderate cases from severe cases (Yang et al., 2020b).
T379 1193-1256 Sentence denotes This stratification was possible with IP-10, MCP-3, and IL-1ra.
T380 1257-1584 Sentence denotes While there are reports that levels of IL-6 at first assessment might predict respiratory failure (Herold et al., 2020), other publications with longitudinal analyses demonstrated that IL-6 increases fairly late during the disease’s course, consequently compromising its prognostic value at earlier stages (Zhou et al., 2020a).