PMC:7200337 / 47642-48873 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7200337","sourcedb":"PMC","sourceid":"7200337","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7200337","text":"There is great interest in understanding the lifespan of B cell memory responses to SARS-CoV-2. Protection from reinfection has direct medical and social consequences as the world works to develop vaccination strategies and resume normal activities. In COVID-19 patients, evidence of near-universal seroconversion and the lack of substantial descriptions of reinfection point to a robust antibody response, which, along with the T cell memory response, would offer protection to reinfection. Indeed, a case study of a single patient described induction of CD38HiCD27Hi antibody-secreting cells (ASCs), concomitant with an increase in circulating follicular T helper cells (Tfh) cells (Thevarajan et al., 2020), and a scRNA-seq study of PBMCs from critically ill and recently recovered individuals revealed a plasma cell population (Guo et al., 2020). In addition, IgG memory cells specific to the RBD have been identified in the blood of COVID-19 patients (Ju et al., 2020). Consistent with the development of immunity after COVID-19 infection, a recent study of SARS-CoV-2 infection in rhesus macaques found that two macaques that had resolved the primary infection were resistant to reinfection 28 days later (Bao et al., 2020b).","tracks":[{"project":"2_test","denotations":[{"id":"32505227-32284614-46575343","span":{"begin":704,"end":708},"obj":"32284614"},{"id":"T8258","span":{"begin":704,"end":708},"obj":"32284614"}],"attributes":[{"subj":"32505227-32284614-46575343","pred":"source","obj":"2_test"},{"subj":"T8258","pred":"source","obj":"2_test"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T481","span":{"begin":59,"end":63},"obj":"Body_part"},{"id":"T482","span":{"begin":388,"end":396},"obj":"Body_part"},{"id":"T483","span":{"begin":431,"end":435},"obj":"Body_part"},{"id":"T484","span":{"begin":569,"end":577},"obj":"Body_part"},{"id":"T485","span":{"begin":588,"end":593},"obj":"Body_part"},{"id":"T486","span":{"begin":657,"end":671},"obj":"Body_part"},{"id":"T487","span":{"begin":666,"end":671},"obj":"Body_part"},{"id":"T488","span":{"begin":678,"end":683},"obj":"Body_part"},{"id":"T489","span":{"begin":808,"end":819},"obj":"Body_part"},{"id":"T490","span":{"begin":815,"end":819},"obj":"Body_part"},{"id":"T491","span":{"begin":864,"end":867},"obj":"Body_part"},{"id":"T492","span":{"begin":875,"end":880},"obj":"Body_part"},{"id":"T493","span":{"begin":929,"end":934},"obj":"Body_part"}],"attributes":[{"id":"A481","pred":"fma_id","subj":"T481","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A482","pred":"fma_id","subj":"T482","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A483","pred":"fma_id","subj":"T483","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A484","pred":"fma_id","subj":"T484","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A485","pred":"fma_id","subj":"T485","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A486","pred":"fma_id","subj":"T486","obj":"http://purl.org/sig/ont/fma/fma70572"},{"id":"A487","pred":"fma_id","subj":"T487","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A488","pred":"fma_id","subj":"T488","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A489","pred":"fma_id","subj":"T489","obj":"http://purl.org/sig/ont/fma/fma70574"},{"id":"A490","pred":"fma_id","subj":"T490","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A491","pred":"fma_id","subj":"T491","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A492","pred":"fma_id","subj":"T492","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A493","pred":"fma_id","subj":"T493","obj":"http://purl.org/sig/ont/fma/fma9670"},{"subj":"T481","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T482","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T483","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T484","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T485","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T486","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T487","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T488","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T489","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T490","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T491","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T492","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T493","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T52","span":{"begin":929,"end":934},"obj":"Body_part"}],"attributes":[{"id":"A52","pred":"uberon_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T300","span":{"begin":84,"end":92},"obj":"Disease"},{"id":"T301","span":{"begin":253,"end":261},"obj":"Disease"},{"id":"T302","span":{"begin":938,"end":946},"obj":"Disease"},{"id":"T303","span":{"begin":1025,"end":1033},"obj":"Disease"},{"id":"T304","span":{"begin":1034,"end":1043},"obj":"Disease"},{"id":"T305","span":{"begin":1063,"end":1071},"obj":"Disease"},{"id":"T306","span":{"begin":1074,"end":1083},"obj":"Disease"},{"id":"T307","span":{"begin":1157,"end":1166},"obj":"Disease"}],"attributes":[{"id":"A300","pred":"mondo_id","subj":"T300","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A301","pred":"mondo_id","subj":"T301","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A302","pred":"mondo_id","subj":"T302","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A303","pred":"mondo_id","subj":"T303","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A304","pred":"mondo_id","subj":"T304","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A305","pred":"mondo_id","subj":"T305","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A306","pred":"mondo_id","subj":"T306","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A307","pred":"mondo_id","subj":"T307","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"subj":"T300","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T301","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T302","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T303","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T304","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T305","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T306","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T307","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T598","span":{"begin":57,"end":63},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T599","span":{"begin":124,"end":127},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T600","span":{"begin":238,"end":248},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T601","span":{"begin":379,"end":380},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T602","span":{"begin":429,"end":435},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T603","span":{"begin":500,"end":501},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T604","span":{"begin":516,"end":517},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T605","span":{"begin":588,"end":593},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T606","span":{"begin":657,"end":671},"obj":"http://purl.obolibrary.org/obo/CL_0000912"},{"id":"T607","span":{"begin":678,"end":683},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T608","span":{"begin":715,"end":716},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T609","span":{"begin":806,"end":807},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T610","span":{"begin":808,"end":819},"obj":"http://purl.obolibrary.org/obo/CL_0000786"},{"id":"T611","span":{"begin":875,"end":880},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T612","span":{"begin":929,"end":934},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T613","span":{"begin":929,"end":934},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T614","span":{"begin":1045,"end":1046},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T615","span":{"begin":1087,"end":1102},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9544"}],"attributes":[{"subj":"T598","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T599","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T600","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T601","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T602","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T603","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T604","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T605","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T606","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T607","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T608","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T609","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T610","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T611","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T612","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T613","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T614","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T615","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T235","span":{"begin":832,"end":835},"obj":"Chemical"}],"attributes":[{"id":"A235","pred":"chebi_id","subj":"T235","obj":"http://purl.obolibrary.org/obo/CHEBI_16750"},{"subj":"T235","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T153","span":{"begin":64,"end":70},"obj":"http://purl.obolibrary.org/obo/GO_0007613"},{"id":"T154","span":{"begin":436,"end":442},"obj":"http://purl.obolibrary.org/obo/GO_0007613"},{"id":"T155","span":{"begin":868,"end":874},"obj":"http://purl.obolibrary.org/obo/GO_0007613"}],"attributes":[{"subj":"T153","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T154","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T155","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1579","span":{"begin":890,"end":892},"obj":"Gene"},{"id":"1580","span":{"begin":476,"end":478},"obj":"Gene"},{"id":"1581","span":{"begin":376,"end":378},"obj":"Gene"},{"id":"1582","span":{"begin":186,"end":188},"obj":"Gene"},{"id":"1583","span":{"begin":81,"end":83},"obj":"Gene"},{"id":"1584","span":{"begin":84,"end":94},"obj":"Species"},{"id":"1585","span":{"begin":262,"end":270},"obj":"Species"},{"id":"1586","span":{"begin":525,"end":532},"obj":"Species"},{"id":"1587","span":{"begin":947,"end":955},"obj":"Species"},{"id":"1588","span":{"begin":1087,"end":1102},"obj":"Species"},{"id":"1589","span":{"begin":253,"end":261},"obj":"Disease"},{"id":"1590","span":{"begin":747,"end":761},"obj":"Disease"},{"id":"1591","span":{"begin":938,"end":946},"obj":"Disease"},{"id":"1592","span":{"begin":1025,"end":1033},"obj":"Disease"},{"id":"1593","span":{"begin":1034,"end":1043},"obj":"Disease"},{"id":"1594","span":{"begin":1063,"end":1083},"obj":"Disease"},{"id":"1595","span":{"begin":1157,"end":1166},"obj":"Disease"}],"attributes":[{"id":"A1579","pred":"tao:has_database_id","subj":"1579","obj":"Gene:6999"},{"id":"A1580","pred":"tao:has_database_id","subj":"1580","obj":"Gene:6999"},{"id":"A1581","pred":"tao:has_database_id","subj":"1581","obj":"Gene:6999"},{"id":"A1582","pred":"tao:has_database_id","subj":"1582","obj":"Gene:6999"},{"id":"A1583","pred":"tao:has_database_id","subj":"1583","obj":"Gene:6999"},{"id":"A1584","pred":"tao:has_database_id","subj":"1584","obj":"Tax:2697049"},{"id":"A1585","pred":"tao:has_database_id","subj":"1585","obj":"Tax:9606"},{"id":"A1586","pred":"tao:has_database_id","subj":"1586","obj":"Tax:9606"},{"id":"A1587","pred":"tao:has_database_id","subj":"1587","obj":"Tax:9606"},{"id":"A1588","pred":"tao:has_database_id","subj":"1588","obj":"Tax:9544"},{"id":"A1589","pred":"tao:has_database_id","subj":"1589","obj":"MESH:C000657245"},{"id":"A1590","pred":"tao:has_database_id","subj":"1590","obj":"MESH:D016638"},{"id":"A1591","pred":"tao:has_database_id","subj":"1591","obj":"MESH:C000657245"},{"id":"A1592","pred":"tao:has_database_id","subj":"1592","obj":"MESH:C000657245"},{"id":"A1593","pred":"tao:has_database_id","subj":"1593","obj":"MESH:D007239"},{"id":"A1594","pred":"tao:has_database_id","subj":"1594","obj":"MESH:C000657245"},{"id":"A1595","pred":"tao:has_database_id","subj":"1595","obj":"MESH:D007239"},{"subj":"1579","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1580","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1581","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1582","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1583","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1584","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1585","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1586","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1587","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1588","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1589","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1590","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1591","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1592","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1593","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1594","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1595","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T262","span":{"begin":0,"end":95},"obj":"Sentence"},{"id":"T263","span":{"begin":96,"end":249},"obj":"Sentence"},{"id":"T264","span":{"begin":250,"end":491},"obj":"Sentence"},{"id":"T265","span":{"begin":492,"end":850},"obj":"Sentence"},{"id":"T266","span":{"begin":851,"end":974},"obj":"Sentence"},{"id":"T267","span":{"begin":975,"end":1231},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T262","pred":"source","obj":"LitCovid-sentences"},{"subj":"T263","pred":"source","obj":"LitCovid-sentences"},{"subj":"T264","pred":"source","obj":"LitCovid-sentences"},{"subj":"T265","pred":"source","obj":"LitCovid-sentences"},{"subj":"T266","pred":"source","obj":"LitCovid-sentences"},{"subj":"T267","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93ecdb","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#ecc193"},{"id":"LitCovid-PD-UBERON","color":"#a693ec"},{"id":"LitCovid-PD-MONDO","color":"#99ec93"},{"id":"LitCovid-PD-CLO","color":"#ec93b3"},{"id":"LitCovid-PD-CHEBI","color":"#93cdec"},{"id":"LitCovid-PD-GO-BP","color":"#e7ec93"},{"id":"LitCovid-PubTator","color":"#d793ec"},{"id":"LitCovid-sentences","color":"#93ecbd"}]}]}}