PMC:7200337 / 28826-29513 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T285","span":{"begin":2,"end":7},"obj":"Body_part"},{"id":"T286","span":{"begin":59,"end":64},"obj":"Body_part"},{"id":"T287","span":{"begin":75,"end":79},"obj":"Body_part"},{"id":"T288","span":{"begin":89,"end":97},"obj":"Body_part"},{"id":"T289","span":{"begin":154,"end":159},"obj":"Body_part"},{"id":"T290","span":{"begin":175,"end":180},"obj":"Body_part"},{"id":"T291","span":{"begin":195,"end":200},"obj":"Body_part"},{"id":"T292","span":{"begin":253,"end":257},"obj":"Body_part"},{"id":"T293","span":{"begin":334,"end":338},"obj":"Body_part"},{"id":"T294","span":{"begin":458,"end":463},"obj":"Body_part"},{"id":"T295","span":{"begin":493,"end":499},"obj":"Body_part"},{"id":"T296","span":{"begin":559,"end":564},"obj":"Body_part"}],"attributes":[{"id":"A285","pred":"fma_id","subj":"T285","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A286","pred":"fma_id","subj":"T286","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A287","pred":"fma_id","subj":"T287","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A288","pred":"fma_id","subj":"T288","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A289","pred":"fma_id","subj":"T289","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A290","pred":"fma_id","subj":"T290","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A291","pred":"fma_id","subj":"T291","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A292","pred":"fma_id","subj":"T292","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A293","pred":"fma_id","subj":"T293","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A294","pred":"fma_id","subj":"T294","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A295","pred":"fma_id","subj":"T295","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A296","pred":"fma_id","subj":"T296","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"T cells play a fundamental role in viral infections: CD4 T cells provide B cell help for antibody production and orchestrate the response of other immune cells, whereas CD8 T cells kill infected cells to reduce the viral burden. However, dysregulated T cell responses can result in immunopathology. To better understand the role of T cell responses in SARS-CoV-2 infection, the pursuit of two major questions is imperative: (1) what is the contribution of T cells to initial virus control and tissue damage in the context of COVID-19, and (2) how do memory T cells established thereafter contribute to protective immunity upon reinfection? Some tentative answers are beginning to emerge."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T33","span":{"begin":493,"end":499},"obj":"Body_part"}],"attributes":[{"id":"A33","pred":"uberon_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"T cells play a fundamental role in viral infections: CD4 T cells provide B cell help for antibody production and orchestrate the response of other immune cells, whereas CD8 T cells kill infected cells to reduce the viral burden. However, dysregulated T cell responses can result in immunopathology. To better understand the role of T cell responses in SARS-CoV-2 infection, the pursuit of two major questions is imperative: (1) what is the contribution of T cells to initial virus control and tissue damage in the context of COVID-19, and (2) how do memory T cells established thereafter contribute to protective immunity upon reinfection? Some tentative answers are beginning to emerge."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T194","span":{"begin":35,"end":51},"obj":"Disease"},{"id":"T195","span":{"begin":352,"end":360},"obj":"Disease"},{"id":"T196","span":{"begin":363,"end":372},"obj":"Disease"},{"id":"T197","span":{"begin":525,"end":533},"obj":"Disease"}],"attributes":[{"id":"A194","pred":"mondo_id","subj":"T194","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A195","pred":"mondo_id","subj":"T195","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A196","pred":"mondo_id","subj":"T196","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A197","pred":"mondo_id","subj":"T197","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"T cells play a fundamental role in viral infections: CD4 T cells provide B cell help for antibody production and orchestrate the response of other immune cells, whereas CD8 T cells kill infected cells to reduce the viral burden. However, dysregulated T cell responses can result in immunopathology. To better understand the role of T cell responses in SARS-CoV-2 infection, the pursuit of two major questions is imperative: (1) what is the contribution of T cells to initial virus control and tissue damage in the context of COVID-19, and (2) how do memory T cells established thereafter contribute to protective immunity upon reinfection? Some tentative answers are beginning to emerge."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T313","span":{"begin":0,"end":7},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T314","span":{"begin":13,"end":14},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T315","span":{"begin":53,"end":56},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T316","span":{"begin":57,"end":64},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T317","span":{"begin":73,"end":79},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T318","span":{"begin":154,"end":159},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T319","span":{"begin":169,"end":172},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T61712","span":{"begin":173,"end":180},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T321","span":{"begin":195,"end":200},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T322","span":{"begin":251,"end":257},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T323","span":{"begin":332,"end":338},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T324","span":{"begin":456,"end":463},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T325","span":{"begin":475,"end":480},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T326","span":{"begin":557,"end":564},"obj":"http://purl.obolibrary.org/obo/CL_0000084"}],"text":"T cells play a fundamental role in viral infections: CD4 T cells provide B cell help for antibody production and orchestrate the response of other immune cells, whereas CD8 T cells kill infected cells to reduce the viral burden. However, dysregulated T cell responses can result in immunopathology. To better understand the role of T cell responses in SARS-CoV-2 infection, the pursuit of two major questions is imperative: (1) what is the contribution of T cells to initial virus control and tissue damage in the context of COVID-19, and (2) how do memory T cells established thereafter contribute to protective immunity upon reinfection? Some tentative answers are beginning to emerge."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T118","span":{"begin":35,"end":51},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T119","span":{"begin":89,"end":108},"obj":"http://purl.obolibrary.org/obo/GO_0002377"},{"id":"T120","span":{"begin":550,"end":556},"obj":"http://purl.obolibrary.org/obo/GO_0007613"}],"text":"T cells play a fundamental role in viral infections: CD4 T cells provide B cell help for antibody production and orchestrate the response of other immune cells, whereas CD8 T cells kill infected cells to reduce the viral burden. However, dysregulated T cell responses can result in immunopathology. To better understand the role of T cell responses in SARS-CoV-2 infection, the pursuit of two major questions is imperative: (1) what is the contribution of T cells to initial virus control and tissue damage in the context of COVID-19, and (2) how do memory T cells established thereafter contribute to protective immunity upon reinfection? Some tentative answers are beginning to emerge."}

{"project":"LitCovid-PubTator","denotations":[{"id":"932","span":{"begin":53,"end":56},"obj":"Gene"},{"id":"933","span":{"begin":169,"end":172},"obj":"Gene"},{"id":"934","span":{"begin":677,"end":679},"obj":"Gene"},{"id":"935","span":{"begin":599,"end":601},"obj":"Gene"},{"id":"936","span":{"begin":464,"end":466},"obj":"Gene"},{"id":"937","span":{"begin":299,"end":301},"obj":"Gene"},{"id":"938","span":{"begin":201,"end":203},"obj":"Gene"},{"id":"939","span":{"begin":35,"end":51},"obj":"Disease"},{"id":"940","span":{"begin":186,"end":194},"obj":"Disease"},{"id":"941","span":{"begin":352,"end":372},"obj":"Disease"},{"id":"942","span":{"begin":525,"end":533},"obj":"Disease"},{"id":"943","span":{"begin":550,"end":558},"obj":"Disease"}],"attributes":[{"id":"A932","pred":"tao:has_database_id","subj":"932","obj":"Gene:920"},{"id":"A933","pred":"tao:has_database_id","subj":"933","obj":"Gene:925"},{"id":"A934","pred":"tao:has_database_id","subj":"934","obj":"Gene:6999"},{"id":"A935","pred":"tao:has_database_id","subj":"935","obj":"Gene:6999"},{"id":"A936","pred":"tao:has_database_id","subj":"936","obj":"Gene:6999"},{"id":"A937","pred":"tao:has_database_id","subj":"937","obj":"Gene:6999"},{"id":"A938","pred":"tao:has_database_id","subj":"938","obj":"Gene:6999"},{"id":"A939","pred":"tao:has_database_id","subj":"939","obj":"MESH:D001102"},{"id":"A940","pred":"tao:has_database_id","subj":"940","obj":"MESH:D007239"},{"id":"A941","pred":"tao:has_database_id","subj":"941","obj":"MESH:C000657245"},{"id":"A942","pred":"tao:has_database_id","subj":"942","obj":"MESH:C000657245"},{"id":"A943","pred":"tao:has_database_id","subj":"943","obj":"MESH:D008569"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"T cells play a fundamental role in viral infections: CD4 T cells provide B cell help for antibody production and orchestrate the response of other immune cells, whereas CD8 T cells kill infected cells to reduce the viral burden. However, dysregulated T cell responses can result in immunopathology. To better understand the role of T cell responses in SARS-CoV-2 infection, the pursuit of two major questions is imperative: (1) what is the contribution of T cells to initial virus control and tissue damage in the context of COVID-19, and (2) how do memory T cells established thereafter contribute to protective immunity upon reinfection? Some tentative answers are beginning to emerge."}

{"project":"LitCovid-sentences","denotations":[{"id":"T162","span":{"begin":0,"end":228},"obj":"Sentence"},{"id":"T163","span":{"begin":229,"end":298},"obj":"Sentence"},{"id":"T164","span":{"begin":299,"end":639},"obj":"Sentence"},{"id":"T165","span":{"begin":640,"end":687},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"T cells play a fundamental role in viral infections: CD4 T cells provide B cell help for antibody production and orchestrate the response of other immune cells, whereas CD8 T cells kill infected cells to reduce the viral burden. However, dysregulated T cell responses can result in immunopathology. To better understand the role of T cell responses in SARS-CoV-2 infection, the pursuit of two major questions is imperative: (1) what is the contribution of T cells to initial virus control and tissue damage in the context of COVID-19, and (2) how do memory T cells established thereafter contribute to protective immunity upon reinfection? Some tentative answers are beginning to emerge."}