PMC:7200337 / 17363-18766 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T101","span":{"begin":41,"end":53},"obj":"Body_part"},{"id":"T102","span":{"begin":49,"end":53},"obj":"Body_part"},{"id":"T103","span":{"begin":77,"end":84},"obj":"Body_part"},{"id":"T104","span":{"begin":80,"end":84},"obj":"Body_part"},{"id":"T105","span":{"begin":194,"end":198},"obj":"Body_part"},{"id":"T106","span":{"begin":239,"end":248},"obj":"Body_part"},{"id":"T107","span":{"begin":306,"end":317},"obj":"Body_part"},{"id":"T108","span":{"begin":348,"end":357},"obj":"Body_part"},{"id":"T109","span":{"begin":370,"end":382},"obj":"Body_part"},{"id":"T110","span":{"begin":387,"end":398},"obj":"Body_part"},{"id":"T111","span":{"begin":454,"end":463},"obj":"Body_part"},{"id":"T112","span":{"begin":523,"end":531},"obj":"Body_part"},{"id":"T113","span":{"begin":540,"end":551},"obj":"Body_part"},{"id":"T114","span":{"begin":698,"end":710},"obj":"Body_part"},{"id":"T115","span":{"begin":777,"end":790},"obj":"Body_part"},{"id":"T116","span":{"begin":785,"end":790},"obj":"Body_part"},{"id":"T117","span":{"begin":868,"end":876},"obj":"Body_part"},{"id":"T118","span":{"begin":911,"end":919},"obj":"Body_part"},{"id":"T119","span":{"begin":914,"end":919},"obj":"Body_part"},{"id":"T120","span":{"begin":925,"end":930},"obj":"Body_part"},{"id":"T121","span":{"begin":994,"end":1002},"obj":"Body_part"},{"id":"T122","span":{"begin":997,"end":1002},"obj":"Body_part"},{"id":"T123","span":{"begin":1059,"end":1064},"obj":"Body_part"},{"id":"T124","span":{"begin":1082,"end":1091},"obj":"Body_part"},{"id":"T125","span":{"begin":1229,"end":1238},"obj":"Body_part"},{"id":"T126","span":{"begin":1246,"end":1257},"obj":"Body_part"},{"id":"T127","span":{"begin":1267,"end":1278},"obj":"Body_part"},{"id":"T128","span":{"begin":1288,"end":1299},"obj":"Body_part"},{"id":"T129","span":{"begin":1310,"end":1320},"obj":"Body_part"},{"id":"T130","span":{"begin":1340,"end":1344},"obj":"Body_part"}],"attributes":[{"id":"A101","pred":"fma_id","subj":"T101","obj":"http://purl.org/sig/ont/fma/fma70339"},{"id":"A102","pred":"fma_id","subj":"T102","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A103","pred":"fma_id","subj":"T103","obj":"http://purl.org/sig/ont/fma/fma63147"},{"id":"A104","pred":"fma_id","subj":"T104","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A105","pred":"fma_id","subj":"T105","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A106","pred":"fma_id","subj":"T106","obj":"http://purl.org/sig/ont/fma/fma9639"},{"id":"A107","pred":"fma_id","subj":"T107","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A108","pred":"fma_id","subj":"T108","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A109","pred":"fma_id","subj":"T109","obj":"http://purl.org/sig/ont/fma/fma62854"},{"id":"A110","pred":"fma_id","subj":"T110","obj":"http://purl.org/sig/ont/fma/fma62863"},{"id":"A111","pred":"fma_id","subj":"T111","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A112","pred":"fma_id","subj":"T112","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A113","pred":"fma_id","subj":"T113","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A114","pred":"fma_id","subj":"T114","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A115","pred":"fma_id","subj":"T115","obj":"http://purl.org/sig/ont/fma/fma70339"},{"id":"A116","pred":"fma_id","subj":"T116","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A117","pred":"fma_id","subj":"T117","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A118","pred":"fma_id","subj":"T118","obj":"http://purl.org/sig/ont/fma/fma63147"},{"id":"A119","pred":"fma_id","subj":"T119","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A120","pred":"fma_id","subj":"T120","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A121","pred":"fma_id","subj":"T121","obj":"http://purl.org/sig/ont/fma/fma63147"},{"id":"A122","pred":"fma_id","subj":"T122","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A123","pred":"fma_id","subj":"T123","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A124","pred":"fma_id","subj":"T124","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A125","pred":"fma_id","subj":"T125","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A126","pred":"fma_id","subj":"T126","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A127","pred":"fma_id","subj":"T127","obj":"http://purl.org/sig/ont/fma/fma62861"},{"id":"A128","pred":"fma_id","subj":"T128","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A129","pred":"fma_id","subj":"T129","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A130","pred":"fma_id","subj":"T130","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Figure 2 SARS-CoV-2 Infection Results in Myeloid Cell Activation and Changes NK Cell Function\nBased on data from preliminary COVID-19 studies and earlier studies in related coronaviruses.\nIL-6, IL-1β, and IFN-I/III from infected pulmonary epithelia can induce inflammatory programs in resident (alternate) macrophages while recruiting inflammatory monocytes, as well as granulocytes and lymphocytes from circulation. Sustained IL-6 and TNF-ɑ by incoming monocytes can drive several hyperinflammation cascades. Inflammatory monocyte-derived macrophages can amplify dysfunctional responses in various ways (listed in top-left corner). The systemic CRS- and sHLH-like inflammatory response can induce neutrophilic NETosis and microthrombosis, aggravating COVID-19 severity. Other myeloid cells, such as pDCs, are purported to have an IFN-dependent role in viral control. Monocyte-derived CXCL9/10/11 might recruit NK cells from blood. Preliminary data suggest that the antiviral function of these NK cells might be regulated through crosstalk with SARS-infected cells and inflammatory monocytes.\nDashed lines indicate pathways to be confirmed. Arg1, arginase 1; iNOS, inducible-nitric oxide synthase; Inflamm., inflammatory; Mono., monocytes; Macs, macrophages; Eosino, eosinophils; Neutro, neutrophils; NETosis, neutrophil extracellular trap cell death; SHLH, secondary hemophagocytic lymphohistiocytosis."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T10","span":{"begin":239,"end":248},"obj":"Body_part"},{"id":"T11","span":{"begin":925,"end":930},"obj":"Body_part"}],"attributes":[{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0000483"},{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"}],"text":"Figure 2 SARS-CoV-2 Infection Results in Myeloid Cell Activation and Changes NK Cell Function\nBased on data from preliminary COVID-19 studies and earlier studies in related coronaviruses.\nIL-6, IL-1β, and IFN-I/III from infected pulmonary epithelia can induce inflammatory programs in resident (alternate) macrophages while recruiting inflammatory monocytes, as well as granulocytes and lymphocytes from circulation. Sustained IL-6 and TNF-ɑ by incoming monocytes can drive several hyperinflammation cascades. Inflammatory monocyte-derived macrophages can amplify dysfunctional responses in various ways (listed in top-left corner). The systemic CRS- and sHLH-like inflammatory response can induce neutrophilic NETosis and microthrombosis, aggravating COVID-19 severity. Other myeloid cells, such as pDCs, are purported to have an IFN-dependent role in viral control. Monocyte-derived CXCL9/10/11 might recruit NK cells from blood. Preliminary data suggest that the antiviral function of these NK cells might be regulated through crosstalk with SARS-infected cells and inflammatory monocytes.\nDashed lines indicate pathways to be confirmed. Arg1, arginase 1; iNOS, inducible-nitric oxide synthase; Inflamm., inflammatory; Mono., monocytes; Macs, macrophages; Eosino, eosinophils; Neutro, neutrophils; NETosis, neutrophil extracellular trap cell death; SHLH, secondary hemophagocytic lymphohistiocytosis."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T118","span":{"begin":9,"end":17},"obj":"Disease"},{"id":"T119","span":{"begin":20,"end":29},"obj":"Disease"},{"id":"T120","span":{"begin":125,"end":133},"obj":"Disease"},{"id":"T121","span":{"begin":646,"end":649},"obj":"Disease"},{"id":"T123","span":{"begin":752,"end":760},"obj":"Disease"},{"id":"T124","span":{"begin":1045,"end":1049},"obj":"Disease"},{"id":"T125","span":{"begin":1358,"end":1402},"obj":"Disease"},{"id":"T126","span":{"begin":1368,"end":1402},"obj":"Disease"}],"attributes":[{"id":"A118","pred":"mondo_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A119","pred":"mondo_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A120","pred":"mondo_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A121","pred":"mondo_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/MONDO_0007399"},{"id":"A122","pred":"mondo_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/MONDO_0017361"},{"id":"A123","pred":"mondo_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A124","pred":"mondo_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A125","pred":"mondo_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/MONDO_0015542"},{"id":"A126","pred":"mondo_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/MONDO_0015540"}],"text":"Figure 2 SARS-CoV-2 Infection Results in Myeloid Cell Activation and Changes NK Cell Function\nBased on data from preliminary COVID-19 studies and earlier studies in related coronaviruses.\nIL-6, IL-1β, and IFN-I/III from infected pulmonary epithelia can induce inflammatory programs in resident (alternate) macrophages while recruiting inflammatory monocytes, as well as granulocytes and lymphocytes from circulation. Sustained IL-6 and TNF-ɑ by incoming monocytes can drive several hyperinflammation cascades. Inflammatory monocyte-derived macrophages can amplify dysfunctional responses in various ways (listed in top-left corner). The systemic CRS- and sHLH-like inflammatory response can induce neutrophilic NETosis and microthrombosis, aggravating COVID-19 severity. Other myeloid cells, such as pDCs, are purported to have an IFN-dependent role in viral control. Monocyte-derived CXCL9/10/11 might recruit NK cells from blood. Preliminary data suggest that the antiviral function of these NK cells might be regulated through crosstalk with SARS-infected cells and inflammatory monocytes.\nDashed lines indicate pathways to be confirmed. Arg1, arginase 1; iNOS, inducible-nitric oxide synthase; Inflamm., inflammatory; Mono., monocytes; Macs, macrophages; Eosino, eosinophils; Neutro, neutrophils; NETosis, neutrophil extracellular trap cell death; SHLH, secondary hemophagocytic lymphohistiocytosis."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T13152","span":{"begin":49,"end":53},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T45733","span":{"begin":54,"end":64},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T38010","span":{"begin":77,"end":84},"obj":"http://purl.obolibrary.org/obo/CL_0000623"},{"id":"T11301","span":{"begin":348,"end":357},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T3621","span":{"begin":440,"end":441},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T320","span":{"begin":454,"end":463},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T78868","span":{"begin":523,"end":531},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T1737","span":{"begin":785,"end":790},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T84467","span":{"begin":868,"end":876},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T47301","span":{"begin":894,"end":896},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T48426","span":{"begin":911,"end":919},"obj":"http://purl.obolibrary.org/obo/CL_0000623"},{"id":"T52652","span":{"begin":925,"end":930},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T31933","span":{"begin":925,"end":930},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T14324","span":{"begin":994,"end":1002},"obj":"http://purl.obolibrary.org/obo/CL_0000623"},{"id":"T89373","span":{"begin":1059,"end":1064},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T45576","span":{"begin":1082,"end":1091},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T99791","span":{"begin":1229,"end":1238},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T48410","span":{"begin":1340,"end":1344},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Figure 2 SARS-CoV-2 Infection Results in Myeloid Cell Activation and Changes NK Cell Function\nBased on data from preliminary COVID-19 studies and earlier studies in related coronaviruses.\nIL-6, IL-1β, and IFN-I/III from infected pulmonary epithelia can induce inflammatory programs in resident (alternate) macrophages while recruiting inflammatory monocytes, as well as granulocytes and lymphocytes from circulation. Sustained IL-6 and TNF-ɑ by incoming monocytes can drive several hyperinflammation cascades. Inflammatory monocyte-derived macrophages can amplify dysfunctional responses in various ways (listed in top-left corner). The systemic CRS- and sHLH-like inflammatory response can induce neutrophilic NETosis and microthrombosis, aggravating COVID-19 severity. Other myeloid cells, such as pDCs, are purported to have an IFN-dependent role in viral control. Monocyte-derived CXCL9/10/11 might recruit NK cells from blood. Preliminary data suggest that the antiviral function of these NK cells might be regulated through crosstalk with SARS-infected cells and inflammatory monocytes.\nDashed lines indicate pathways to be confirmed. Arg1, arginase 1; iNOS, inducible-nitric oxide synthase; Inflamm., inflammatory; Mono., monocytes; Macs, macrophages; Eosino, eosinophils; Neutro, neutrophils; NETosis, neutrophil extracellular trap cell death; SHLH, secondary hemophagocytic lymphohistiocytosis."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T74","span":{"begin":188,"end":190},"obj":"Chemical"},{"id":"T76","span":{"begin":194,"end":196},"obj":"Chemical"},{"id":"T78","span":{"begin":427,"end":429},"obj":"Chemical"},{"id":"T80","span":{"begin":885,"end":890},"obj":"Chemical"},{"id":"T81","span":{"begin":966,"end":975},"obj":"Chemical"},{"id":"T82","span":{"begin":1175,"end":1187},"obj":"Chemical"},{"id":"T83","span":{"begin":1182,"end":1187},"obj":"Chemical"}],"attributes":[{"id":"A74","pred":"chebi_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A75","pred":"chebi_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A76","pred":"chebi_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A77","pred":"chebi_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A78","pred":"chebi_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A79","pred":"chebi_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A80","pred":"chebi_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/CHEBI_138154"},{"id":"A81","pred":"chebi_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A82","pred":"chebi_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/CHEBI_16480"},{"id":"A83","pred":"chebi_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/CHEBI_25741"},{"id":"A84","pred":"chebi_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/CHEBI_29356"}],"text":"Figure 2 SARS-CoV-2 Infection Results in Myeloid Cell Activation and Changes NK Cell Function\nBased on data from preliminary COVID-19 studies and earlier studies in related coronaviruses.\nIL-6, IL-1β, and IFN-I/III from infected pulmonary epithelia can induce inflammatory programs in resident (alternate) macrophages while recruiting inflammatory monocytes, as well as granulocytes and lymphocytes from circulation. Sustained IL-6 and TNF-ɑ by incoming monocytes can drive several hyperinflammation cascades. Inflammatory monocyte-derived macrophages can amplify dysfunctional responses in various ways (listed in top-left corner). The systemic CRS- and sHLH-like inflammatory response can induce neutrophilic NETosis and microthrombosis, aggravating COVID-19 severity. Other myeloid cells, such as pDCs, are purported to have an IFN-dependent role in viral control. Monocyte-derived CXCL9/10/11 might recruit NK cells from blood. Preliminary data suggest that the antiviral function of these NK cells might be regulated through crosstalk with SARS-infected cells and inflammatory monocytes.\nDashed lines indicate pathways to be confirmed. Arg1, arginase 1; iNOS, inducible-nitric oxide synthase; Inflamm., inflammatory; Mono., monocytes; Macs, macrophages; Eosino, eosinophils; Neutro, neutrophils; NETosis, neutrophil extracellular trap cell death; SHLH, secondary hemophagocytic lymphohistiocytosis."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T77","span":{"begin":49,"end":64},"obj":"http://purl.obolibrary.org/obo/GO_0001775"},{"id":"T78","span":{"begin":665,"end":686},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T79","span":{"begin":1340,"end":1350},"obj":"http://purl.obolibrary.org/obo/GO_0008219"}],"text":"Figure 2 SARS-CoV-2 Infection Results in Myeloid Cell Activation and Changes NK Cell Function\nBased on data from preliminary COVID-19 studies and earlier studies in related coronaviruses.\nIL-6, IL-1β, and IFN-I/III from infected pulmonary epithelia can induce inflammatory programs in resident (alternate) macrophages while recruiting inflammatory monocytes, as well as granulocytes and lymphocytes from circulation. Sustained IL-6 and TNF-ɑ by incoming monocytes can drive several hyperinflammation cascades. Inflammatory monocyte-derived macrophages can amplify dysfunctional responses in various ways (listed in top-left corner). The systemic CRS- and sHLH-like inflammatory response can induce neutrophilic NETosis and microthrombosis, aggravating COVID-19 severity. Other myeloid cells, such as pDCs, are purported to have an IFN-dependent role in viral control. Monocyte-derived CXCL9/10/11 might recruit NK cells from blood. Preliminary data suggest that the antiviral function of these NK cells might be regulated through crosstalk with SARS-infected cells and inflammatory monocytes.\nDashed lines indicate pathways to be confirmed. Arg1, arginase 1; iNOS, inducible-nitric oxide synthase; Inflamm., inflammatory; Mono., monocytes; Macs, macrophages; Eosino, eosinophils; Neutro, neutrophils; NETosis, neutrophil extracellular trap cell death; SHLH, secondary hemophagocytic lymphohistiocytosis."}

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{"project":"LitCovid-sentences","denotations":[{"id":"T96","span":{"begin":0,"end":93},"obj":"Sentence"},{"id":"T97","span":{"begin":94,"end":187},"obj":"Sentence"},{"id":"T98","span":{"begin":188,"end":416},"obj":"Sentence"},{"id":"T99","span":{"begin":417,"end":509},"obj":"Sentence"},{"id":"T100","span":{"begin":510,"end":632},"obj":"Sentence"},{"id":"T101","span":{"begin":633,"end":770},"obj":"Sentence"},{"id":"T102","span":{"begin":771,"end":867},"obj":"Sentence"},{"id":"T103","span":{"begin":868,"end":931},"obj":"Sentence"},{"id":"T104","span":{"begin":932,"end":1092},"obj":"Sentence"},{"id":"T105","span":{"begin":1093,"end":1140},"obj":"Sentence"},{"id":"T106","span":{"begin":1141,"end":1403},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Figure 2 SARS-CoV-2 Infection Results in Myeloid Cell Activation and Changes NK Cell Function\nBased on data from preliminary COVID-19 studies and earlier studies in related coronaviruses.\nIL-6, IL-1β, and IFN-I/III from infected pulmonary epithelia can induce inflammatory programs in resident (alternate) macrophages while recruiting inflammatory monocytes, as well as granulocytes and lymphocytes from circulation. Sustained IL-6 and TNF-ɑ by incoming monocytes can drive several hyperinflammation cascades. Inflammatory monocyte-derived macrophages can amplify dysfunctional responses in various ways (listed in top-left corner). The systemic CRS- and sHLH-like inflammatory response can induce neutrophilic NETosis and microthrombosis, aggravating COVID-19 severity. Other myeloid cells, such as pDCs, are purported to have an IFN-dependent role in viral control. Monocyte-derived CXCL9/10/11 might recruit NK cells from blood. Preliminary data suggest that the antiviral function of these NK cells might be regulated through crosstalk with SARS-infected cells and inflammatory monocytes.\nDashed lines indicate pathways to be confirmed. Arg1, arginase 1; iNOS, inducible-nitric oxide synthase; Inflamm., inflammatory; Mono., monocytes; Macs, macrophages; Eosino, eosinophils; Neutro, neutrophils; NETosis, neutrophil extracellular trap cell death; SHLH, secondary hemophagocytic lymphohistiocytosis."}