PMC:7200337 / 17363-18766
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T101 | 41-53 | Body_part | denotes | Myeloid Cell | http://purl.org/sig/ont/fma/fma70339 |
| T102 | 49-53 | Body_part | denotes | Cell | http://purl.org/sig/ont/fma/fma68646 |
| T103 | 77-84 | Body_part | denotes | NK Cell | http://purl.org/sig/ont/fma/fma63147 |
| T104 | 80-84 | Body_part | denotes | Cell | http://purl.org/sig/ont/fma/fma68646 |
| T105 | 194-198 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T106 | 239-248 | Body_part | denotes | epithelia | http://purl.org/sig/ont/fma/fma9639 |
| T107 | 306-317 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T108 | 348-357 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
| T109 | 370-382 | Body_part | denotes | granulocytes | http://purl.org/sig/ont/fma/fma62854 |
| T110 | 387-398 | Body_part | denotes | lymphocytes | http://purl.org/sig/ont/fma/fma62863 |
| T111 | 454-463 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
| T112 | 523-531 | Body_part | denotes | monocyte | http://purl.org/sig/ont/fma/fma62864 |
| T113 | 540-551 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T114 | 698-710 | Body_part | denotes | neutrophilic | http://purl.org/sig/ont/fma/fma62860 |
| T115 | 777-790 | Body_part | denotes | myeloid cells | http://purl.org/sig/ont/fma/fma70339 |
| T116 | 785-790 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T117 | 868-876 | Body_part | denotes | Monocyte | http://purl.org/sig/ont/fma/fma62864 |
| T118 | 911-919 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
| T119 | 914-919 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T120 | 925-930 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T121 | 994-1002 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
| T122 | 997-1002 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T123 | 1059-1064 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T124 | 1082-1091 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
| T125 | 1229-1238 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
| T126 | 1246-1257 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T127 | 1267-1278 | Body_part | denotes | eosinophils | http://purl.org/sig/ont/fma/fma62861 |
| T128 | 1288-1299 | Body_part | denotes | neutrophils | http://purl.org/sig/ont/fma/fma62860 |
| T129 | 1310-1320 | Body_part | denotes | neutrophil | http://purl.org/sig/ont/fma/fma62860 |
| T130 | 1340-1344 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T10 | 239-248 | Body_part | denotes | epithelia | http://purl.obolibrary.org/obo/UBERON_0000483 |
| T11 | 925-930 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T118 | 9-17 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T119 | 20-29 | Disease | denotes | Infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T120 | 125-133 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T121 | 646-649 | Disease | denotes | CRS | http://purl.obolibrary.org/obo/MONDO_0007399|http://purl.obolibrary.org/obo/MONDO_0017361 |
| T123 | 752-760 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T124 | 1045-1049 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T125 | 1358-1402 | Disease | denotes | secondary hemophagocytic lymphohistiocytosis | http://purl.obolibrary.org/obo/MONDO_0015542 |
| T126 | 1368-1402 | Disease | denotes | hemophagocytic lymphohistiocytosis | http://purl.obolibrary.org/obo/MONDO_0015540 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T13152 | 49-53 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | Cell |
| T45733 | 54-64 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | Activation |
| T38010 | 77-84 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK Cell |
| T11301 | 348-357 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
| T3621 | 440-441 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | ɑ |
| T320 | 454-463 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
| T78868 | 523-531 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocyte |
| T1737 | 785-790 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T84467 | 868-876 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | Monocyte |
| T47301 | 894-896 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T48426 | 911-919 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
| T52652 | 925-930 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T31933 | 925-930 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T14324 | 994-1002 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
| T89373 | 1059-1064 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T45576 | 1082-1091 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
| T99791 | 1229-1238 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
| T48410 | 1340-1344 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T74 | 188-190 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T76 | 194-196 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T78 | 427-429 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T80 | 885-890 | Chemical | denotes | CXCL9 | http://purl.obolibrary.org/obo/CHEBI_138154 |
| T81 | 966-975 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T82 | 1175-1187 | Chemical | denotes | nitric oxide | http://purl.obolibrary.org/obo/CHEBI_16480 |
| T83 | 1182-1187 | Chemical | denotes | oxide | http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T77 | 49-64 | http://purl.obolibrary.org/obo/GO_0001775 | denotes | Cell Activation |
| T78 | 665-686 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
| T79 | 1340-1350 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | cell death |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 493 | 9-29 | Disease | denotes | SARS-CoV-2 Infection | MESH:C000657245 |
| 496 | 173-186 | Species | denotes | coronaviruses | Tax:11118 |
| 497 | 125-133 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 508 | 188-192 | Gene | denotes | IL-6 | Gene:3569 |
| 509 | 194-199 | Gene | denotes | IL-1β | Gene:3552 |
| 510 | 427-431 | Gene | denotes | IL-6 | Gene:3569 |
| 511 | 436-441 | Gene | denotes | TNF-ɑ | Gene:7124 |
| 512 | 885-896 | Gene | denotes | CXCL9/10/11 | Gene:4283 |
| 513 | 220-228 | Disease | denotes | infected | MESH:D007239 |
| 514 | 564-577 | Disease | denotes | dysfunctional | MESH:D009461 |
| 515 | 698-738 | Disease | denotes | neutrophilic NETosis and microthrombosis | MESH:C564275 |
| 516 | 752-760 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 517 | 1045-1058 | Disease | denotes | SARS-infected | MESH:D045169 |
| 526 | 1141-1145 | Gene | denotes | Arg1 | Gene:383 |
| 527 | 1147-1157 | Gene | denotes | arginase 1 | Gene:383 |
| 528 | 1159-1163 | Gene | denotes | iNOS | Gene:4843 |
| 529 | 1240-1244 | Gene | denotes | Macs | Gene:4082 |
| 530 | 1124-1126 | Gene | denotes | to | Gene:6999 |
| 531 | 1301-1308 | Disease | denotes | NETosis | |
| 532 | 1345-1350 | Disease | denotes | death | MESH:D003643 |
| 533 | 1358-1402 | Disease | denotes | secondary hemophagocytic lymphohistiocytosis | MESH:D051359 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T96 | 0-93 | Sentence | denotes | Figure 2 SARS-CoV-2 Infection Results in Myeloid Cell Activation and Changes NK Cell Function |
| T97 | 94-187 | Sentence | denotes | Based on data from preliminary COVID-19 studies and earlier studies in related coronaviruses. |
| T98 | 188-416 | Sentence | denotes | IL-6, IL-1β, and IFN-I/III from infected pulmonary epithelia can induce inflammatory programs in resident (alternate) macrophages while recruiting inflammatory monocytes, as well as granulocytes and lymphocytes from circulation. |
| T99 | 417-509 | Sentence | denotes | Sustained IL-6 and TNF-ɑ by incoming monocytes can drive several hyperinflammation cascades. |
| T100 | 510-632 | Sentence | denotes | Inflammatory monocyte-derived macrophages can amplify dysfunctional responses in various ways (listed in top-left corner). |
| T101 | 633-770 | Sentence | denotes | The systemic CRS- and sHLH-like inflammatory response can induce neutrophilic NETosis and microthrombosis, aggravating COVID-19 severity. |
| T102 | 771-867 | Sentence | denotes | Other myeloid cells, such as pDCs, are purported to have an IFN-dependent role in viral control. |
| T103 | 868-931 | Sentence | denotes | Monocyte-derived CXCL9/10/11 might recruit NK cells from blood. |
| T104 | 932-1092 | Sentence | denotes | Preliminary data suggest that the antiviral function of these NK cells might be regulated through crosstalk with SARS-infected cells and inflammatory monocytes. |
| T105 | 1093-1140 | Sentence | denotes | Dashed lines indicate pathways to be confirmed. |
| T106 | 1141-1403 | Sentence | denotes | Arg1, arginase 1; iNOS, inducible-nitric oxide synthase; Inflamm., inflammatory; Mono., monocytes; Macs, macrophages; Eosino, eosinophils; Neutro, neutrophils; NETosis, neutrophil extracellular trap cell death; SHLH, secondary hemophagocytic lymphohistiocytosis. |